JP4663233B2 - ベンジル脱離系を利用する高分子チオール結合プロドラッグ - Google Patents

ベンジル脱離系を利用する高分子チオール結合プロドラッグ Download PDF

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JP4663233B2
JP4663233B2 JP2003543529A JP2003543529A JP4663233B2 JP 4663233 B2 JP4663233 B2 JP 4663233B2 JP 2003543529 A JP2003543529 A JP 2003543529A JP 2003543529 A JP2003543529 A JP 2003543529A JP 4663233 B2 JP4663233 B2 JP 4663233B2
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JP2005513006A5 (https=
JP2005513006A6 (ja
JP2005513006A (ja
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チョー，ユン，ファン
グリーンウォルド，リチャード，ビー．
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エンゾン，インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2003543529A 2001-11-09 2002-11-08 ベンジル脱離系を利用する高分子チオール結合プロドラッグ Expired - Fee Related JP4663233B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34491201P 2001-11-09 2001-11-09
US60/344,912 2001-11-09
US36732002P 2002-03-25 2002-03-25
US60/367,320 2002-03-25
PCT/US2002/035871 WO2003041642A2 (en) 2001-11-09 2002-11-08 Polymeric thiol-linked prodrugs employing benzyl elimination systems

Related Child Applications (1)

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JP2010093856A Division JP2010195810A (ja) 2001-11-09 2010-04-15 ベンジル脱離系を利用する高分子チオール結合プロドラッグ

Publications (4)

Publication Number Publication Date
JP2005513006A JP2005513006A (ja) 2005-05-12
JP2005513006A6 JP2005513006A6 (ja) 2005-08-04
JP2005513006A5 JP2005513006A5 (https=) 2006-01-05
JP4663233B2 true JP4663233B2 (ja) 2011-04-06

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Family Applications (2)

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JP2003543529A Expired - Fee Related JP4663233B2 (ja) 2001-11-09 2002-11-08 ベンジル脱離系を利用する高分子チオール結合プロドラッグ
JP2010093856A Pending JP2010195810A (ja) 2001-11-09 2010-04-15 ベンジル脱離系を利用する高分子チオール結合プロドラッグ

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JP2010093856A Pending JP2010195810A (ja) 2001-11-09 2010-04-15 ベンジル脱離系を利用する高分子チオール結合プロドラッグ

Country Status (6)

Country Link
US (1) US7262164B2 (https=)
EP (1) EP1450844A4 (https=)
JP (2) JP4663233B2 (https=)
AU (1) AU2002359364A1 (https=)
CA (1) CA2465090C (https=)
WO (1) WO2003041642A2 (https=)

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DE60234858D1 (de) * 2001-11-09 2010-02-04 Enzon Inc Polyalkylenoxid-Konjugate von thiolhaltigen Arzneistoffen
WO2005070921A1 (en) * 2004-01-23 2005-08-04 Elan Pharmaceuticals, Inc. Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids
WO2006015318A2 (en) * 2004-07-30 2006-02-09 Biogen Idec Inc. Antibody conjugated to a drug moiety via a poptidic linker
ATE465205T1 (de) * 2005-12-05 2010-05-15 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
PT2155255E (pt) 2007-05-09 2013-10-15 Nitto Denko Corp Composições que incluem um composto hidrofóbico e um conjugado de poliaminoácido
US20090092664A1 (en) * 2007-10-08 2009-04-09 University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
US8680108B2 (en) * 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
EP2655374B1 (en) 2010-12-20 2019-10-23 Incyte Holdings Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
KR102507287B1 (ko) 2011-09-02 2023-03-07 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
SI3831833T1 (sl) 2015-02-27 2023-03-31 Incyte Holdings Corporation Postopki za pripravo inhibitorja PI3K
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2019010231A1 (en) * 2017-07-05 2019-01-10 Duke University APPARATUS AS TARGETED PRODRUGS FOR PROSTATE CANCER AND METHODS OF MAKING AND USING THE SAME
CA3101323A1 (en) 2018-06-01 2019-12-05 Incyte Corporation Dosing regimen for the treatment of pi3k related disorders

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US2944902A (en) * 1956-07-30 1960-07-12 Eastman Kodak Co Sensitization of photographic emulsions with ionic polyalkylene oxide salts
DE2343147C2 (de) * 1973-08-27 1982-06-09 Henkel KGaA, 4000 Düsseldorf Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung
US4479002A (en) * 1975-12-01 1984-10-23 Union Carbide Corporation Carbamate-carbamoyl fluoride compounds
US4623715A (en) * 1984-10-22 1986-11-18 Hoechst Aktiengeselleschaft Novel peptides which are active on the central nervous system and have an action on the cholinergic system
US4772586A (en) * 1985-01-23 1988-09-20 Medical College Of Ohio Novel derivatives of arginine vasopressin antagonists
US5112739A (en) 1988-08-02 1992-05-12 Polaroid Corporation Enzyme controlled release system
JPH05132431A (ja) * 1990-03-28 1993-05-28 Nippon Oil & Fats Co Ltd 高分子化薬剤およびその製造法
US5130126A (en) * 1990-07-09 1992-07-14 Nippon Oil & Fats Co., Ltd. Polymer-drug conjugate and a method of producing it
US5245032A (en) * 1990-09-20 1993-09-14 Union Carbide Chemicals & Plastics Technology Corporation Catalytic processes for the preparation of n,n,n-trisubstituted nitrogen-containing compounds
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AU7932494A (en) * 1993-10-13 1995-05-04 Valence Technology, Inc. Solid electrolytes containing oxyalkylene solvents and/or oxyalkylene polymers and electrolytic cells produced therefrom
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US6255361B1 (en) * 1995-11-21 2001-07-03 Acushnet Company Golf ball compositions and method of making same
CA2245922A1 (en) * 1996-12-13 1998-06-18 Shun-Ichi Ikeda Dc 107 derivatives (2)
WO1999030727A1 (en) * 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
DE60234858D1 (de) * 2001-11-09 2010-02-04 Enzon Inc Polyalkylenoxid-Konjugate von thiolhaltigen Arzneistoffen

Also Published As

Publication number Publication date
EP1450844A2 (en) 2004-09-01
CA2465090C (en) 2010-02-02
US7262164B2 (en) 2007-08-28
EP1450844A4 (en) 2009-07-29
JP2005513006A (ja) 2005-05-12
JP2010195810A (ja) 2010-09-09
WO2003041642A3 (en) 2004-04-01
US20030157052A1 (en) 2003-08-21
CA2465090A1 (en) 2003-05-22
AU2002359364A1 (en) 2003-05-26
WO2003041642A2 (en) 2003-05-22

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