JP4615311B2 - ウイルスベクターおよびその遺伝子治療のための使用 - Google Patents

ウイルスベクターおよびその遺伝子治療のための使用 Download PDF

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JP4615311B2
JP4615311B2 JP2004544141A JP2004544141A JP4615311B2 JP 4615311 B2 JP4615311 B2 JP 4615311B2 JP 2004544141 A JP2004544141 A JP 2004544141A JP 2004544141 A JP2004544141 A JP 2004544141A JP 4615311 B2 JP4615311 B2 JP 4615311B2
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vector
sequence
tumor
cells
vectors
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JP2006511212A (ja
JP2006511212A5 (enExample
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ヴェーラー ラインハルト
シュニーダース フランク
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Provecs Medical GmbH
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/14Antivirals for RNA viruses
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5434IL-12
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70532B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10041Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C12N2840/206Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
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  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004544141A 2002-10-11 2003-10-10 ウイルスベクターおよびその遺伝子治療のための使用 Expired - Fee Related JP4615311B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10248141A DE10248141B4 (de) 2002-10-11 2002-10-11 Nukleinsäuren und deren Verwendung für die Gentherapie
PCT/EP2003/011252 WO2004035799A2 (de) 2002-10-11 2003-10-10 Virale vektoren und deren verwendung für die gentherapie

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010192832A Division JP2011036251A (ja) 2002-10-11 2010-08-30 ウイルスベクターおよびその遺伝子治療のための使用

Publications (3)

Publication Number Publication Date
JP2006511212A JP2006511212A (ja) 2006-04-06
JP2006511212A5 JP2006511212A5 (enExample) 2006-11-24
JP4615311B2 true JP4615311B2 (ja) 2011-01-19

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Family Applications (2)

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JP2004544141A Expired - Fee Related JP4615311B2 (ja) 2002-10-11 2003-10-10 ウイルスベクターおよびその遺伝子治療のための使用
JP2010192832A Pending JP2011036251A (ja) 2002-10-11 2010-08-30 ウイルスベクターおよびその遺伝子治療のための使用

Family Applications After (1)

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JP2010192832A Pending JP2011036251A (ja) 2002-10-11 2010-08-30 ウイルスベクターおよびその遺伝子治療のための使用

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US (1) US8067227B2 (enExample)
EP (1) EP1556411B1 (enExample)
JP (2) JP4615311B2 (enExample)
AU (1) AU2003273983A1 (enExample)
CY (1) CY1114777T1 (enExample)
DE (1) DE10248141B4 (enExample)
DK (1) DK1556411T3 (enExample)
ES (1) ES2440951T3 (enExample)
PT (1) PT1556411E (enExample)
SI (1) SI1556411T1 (enExample)
WO (1) WO2004035799A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069272A2 (en) * 2003-02-05 2004-08-19 Movecare Ltd Adjuvant combination for use in the immunization of a mamal comprising il2 and il12
DE102005055128B4 (de) * 2005-11-15 2015-04-02 Universität Rostock Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor
CN102174479B (zh) * 2011-03-02 2013-04-03 北京锤特生物科技有限公司 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用
CA3101783C (en) 2011-10-11 2023-01-31 Universitat Zurich Prorektorat Mnw Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
US11951157B2 (en) 2011-10-11 2024-04-09 Universitat Zurich Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
AU2016251687C1 (en) 2015-04-22 2023-07-27 CureVac SE RNA containing composition for treatment of tumor diseases
WO2017106795A1 (en) * 2015-12-18 2017-06-22 Oncosec Medical Incorporated Plasmid constructs for heterologous protein expression and methods of use
EP3211000B1 (en) 2016-02-25 2019-01-30 Provecs Medical GmbH Novel immunostimulating vector system
KR102469450B1 (ko) 2016-05-18 2022-11-22 모더나티엑스, 인크. 인터류킨-12 (il12)를 코딩하는 폴리뉴클레오티드 및 그의 용도
EP3589308A1 (en) 2017-02-28 2020-01-08 Sanofi Therapeutic rna
CN110582300B (zh) 2017-05-02 2024-08-02 尼克塔治疗公司 肿瘤免疫治疗性治疗方法
CN111936622B (zh) * 2018-01-19 2024-05-28 可隆生命科学株式会社 重组痘苗病毒和包含其的药物组合物
US11230699B2 (en) * 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573764A (en) * 1994-01-21 1996-11-12 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease
WO2000041508A2 (en) 1999-01-15 2000-07-20 Mount Sinai School Of Medicine Of The City University Of New York Combination therapy of cancer by the activation of co-stimulatory molecules expressed by immune cells and cytokines
KR20020010206A (ko) * 2000-07-27 2002-02-04 이시우 인터루킨 12와 보조활성인자 b7.1 유전자를 함유하는dna 벡터 및 이벡터가 도입된 항암 세포백신
EP2336339A3 (en) * 2000-09-25 2011-09-14 The Regents of the University of Michigan Production of viral vectors

Also Published As

Publication number Publication date
AU2003273983A8 (en) 2004-05-04
WO2004035799A3 (de) 2004-06-10
EP1556411A2 (de) 2005-07-27
EP1556411B1 (de) 2013-10-02
US8067227B2 (en) 2011-11-29
WO2004035799A2 (de) 2004-04-29
CY1114777T1 (el) 2016-12-14
PT1556411E (pt) 2014-01-07
ES2440951T3 (es) 2014-01-31
JP2006511212A (ja) 2006-04-06
DE10248141A1 (de) 2004-09-02
JP2011036251A (ja) 2011-02-24
AU2003273983A1 (en) 2004-05-04
US20060153805A1 (en) 2006-07-13
SI1556411T1 (sl) 2014-01-31
DE10248141B4 (de) 2007-04-19
DK1556411T3 (da) 2014-01-20

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