JP4615311B2 - ウイルスベクターおよびその遺伝子治療のための使用 - Google Patents

ウイルスベクターおよびその遺伝子治療のための使用 Download PDF

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Publication number
JP4615311B2
JP4615311B2 JP2004544141A JP2004544141A JP4615311B2 JP 4615311 B2 JP4615311 B2 JP 4615311B2 JP 2004544141 A JP2004544141 A JP 2004544141A JP 2004544141 A JP2004544141 A JP 2004544141A JP 4615311 B2 JP4615311 B2 JP 4615311B2
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vector
sequence
tumor
cells
vectors
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JP2006511212A (ja
JP2006511212A5 (OSRAM
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ヴェーラー ラインハルト
シュニーダース フランク
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Provecs Medical GmbH
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P31/14Antivirals for RNA viruses
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5434IL-12
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
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    • C07K14/55IL-2
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70532B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
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    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10041Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C12N2840/206Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004544141A 2002-10-11 2003-10-10 ウイルスベクターおよびその遺伝子治療のための使用 Expired - Fee Related JP4615311B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10248141A DE10248141B4 (de) 2002-10-11 2002-10-11 Nukleinsäuren und deren Verwendung für die Gentherapie
PCT/EP2003/011252 WO2004035799A2 (de) 2002-10-11 2003-10-10 Virale vektoren und deren verwendung für die gentherapie

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010192832A Division JP2011036251A (ja) 2002-10-11 2010-08-30 ウイルスベクターおよびその遺伝子治療のための使用

Publications (3)

Publication Number Publication Date
JP2006511212A JP2006511212A (ja) 2006-04-06
JP2006511212A5 JP2006511212A5 (OSRAM) 2006-11-24
JP4615311B2 true JP4615311B2 (ja) 2011-01-19

Family

ID=32102775

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004544141A Expired - Fee Related JP4615311B2 (ja) 2002-10-11 2003-10-10 ウイルスベクターおよびその遺伝子治療のための使用
JP2010192832A Pending JP2011036251A (ja) 2002-10-11 2010-08-30 ウイルスベクターおよびその遺伝子治療のための使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010192832A Pending JP2011036251A (ja) 2002-10-11 2010-08-30 ウイルスベクターおよびその遺伝子治療のための使用

Country Status (11)

Country Link
US (1) US8067227B2 (OSRAM)
EP (1) EP1556411B1 (OSRAM)
JP (2) JP4615311B2 (OSRAM)
AU (1) AU2003273983A1 (OSRAM)
CY (1) CY1114777T1 (OSRAM)
DE (1) DE10248141B4 (OSRAM)
DK (1) DK1556411T3 (OSRAM)
ES (1) ES2440951T3 (OSRAM)
PT (1) PT1556411E (OSRAM)
SI (1) SI1556411T1 (OSRAM)
WO (1) WO2004035799A2 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069272A2 (en) * 2003-02-05 2004-08-19 Movecare Ltd Adjuvant combination for use in the immunization of a mamal comprising il2 and il12
DE102005055128B4 (de) * 2005-11-15 2015-04-02 Universität Rostock Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor
CN102174479B (zh) * 2011-03-02 2013-04-03 北京锤特生物科技有限公司 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用
US11951157B2 (en) 2011-10-11 2024-04-09 Universitat Zurich Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
ES2888249T3 (es) 2011-10-11 2022-01-03 Univ Zuerich Medicamento de combinación que comprende IL-12 y un agente para el bloqueo de moléculas inhibidoras de linfocitos T para terapia tumoral
RU2749113C2 (ru) 2015-04-22 2021-06-04 Куревак Аг Содержащая рнк композиция для лечения опухолевых заболеваний
SG10201913163PA (en) 2015-12-18 2020-03-30 Oncosec Medical Inc Plasmid constructs for heterologous protein expression and methods of use
EP3211000B1 (en) * 2016-02-25 2019-01-30 Provecs Medical GmbH Novel immunostimulating vector system
EP3458083B1 (en) 2016-05-18 2022-11-02 ModernaTX, Inc. Polynucleotides encoding interleukin-12 (il12) and uses thereof
UY37621A (es) 2017-02-28 2018-09-28 Sanofi Sa Arn terapéutico que codifica citoquinas
MX2019013071A (es) 2017-05-02 2019-12-11 Nektar Therapeutics Metodo de tratamiento inmunoterapeutico de un tumor.
US20220347244A1 (en) * 2018-01-19 2022-11-03 Kolon Life Science, Inc. Recombinant vaccinia virus and pharmaceutical composition comprising same
US11230699B2 (en) * 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573764A (en) * 1994-01-21 1996-11-12 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease
WO2000041508A2 (en) 1999-01-15 2000-07-20 Mount Sinai School Of Medicine Of The City University Of New York Combination therapy of cancer by the activation of co-stimulatory molecules expressed by immune cells and cytokines
KR20020010206A (ko) * 2000-07-27 2002-02-04 이시우 인터루킨 12와 보조활성인자 b7.1 유전자를 함유하는dna 벡터 및 이벡터가 도입된 항암 세포백신
EP2336339A3 (en) * 2000-09-25 2011-09-14 The Regents of the University of Michigan Production of viral vectors

Also Published As

Publication number Publication date
WO2004035799A3 (de) 2004-06-10
WO2004035799A2 (de) 2004-04-29
JP2006511212A (ja) 2006-04-06
PT1556411E (pt) 2014-01-07
US8067227B2 (en) 2011-11-29
DE10248141A1 (de) 2004-09-02
AU2003273983A8 (en) 2004-05-04
SI1556411T1 (sl) 2014-01-31
ES2440951T3 (es) 2014-01-31
DE10248141B4 (de) 2007-04-19
JP2011036251A (ja) 2011-02-24
AU2003273983A1 (en) 2004-05-04
US20060153805A1 (en) 2006-07-13
CY1114777T1 (el) 2016-12-14
EP1556411B1 (de) 2013-10-02
EP1556411A2 (de) 2005-07-27
DK1556411T3 (da) 2014-01-20

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