JP4612418B2 - 吸入器 - Google Patents

吸入器 Download PDF

Info

Publication number
JP4612418B2
JP4612418B2 JP2004537331A JP2004537331A JP4612418B2 JP 4612418 B2 JP4612418 B2 JP 4612418B2 JP 2004537331 A JP2004537331 A JP 2004537331A JP 2004537331 A JP2004537331 A JP 2004537331A JP 4612418 B2 JP4612418 B2 JP 4612418B2
Authority
JP
Japan
Prior art keywords
indicator member
inhaler
wheel
flow path
air flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2004537331A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006500094A (ja
JP2006500094A5 (https=
Inventor
ダンカン・グラント・ヤング
サイモン・ポール・ウェルズ
アンドルー・ジェイムズ・レッジウェイ
グレアム・キース・レイシー
ジュリアン・フランシス・ラルフ・スウォン
Original Assignee
アベンティス・フアーマ・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アベンティス・フアーマ・リミテッド filed Critical アベンティス・フアーマ・リミテッド
Publication of JP2006500094A publication Critical patent/JP2006500094A/ja
Publication of JP2006500094A5 publication Critical patent/JP2006500094A5/ja
Application granted granted Critical
Publication of JP4612418B2 publication Critical patent/JP4612418B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G06M1/041—Design features of general application for driving the stage of lowest order for drum-type indicating means
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/14—Design features of general application for transferring a condition from one stage to a higher stage
    • G06M1/16—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/14—Design features of general application for transferring a condition from one stage to a higher stage
    • G06M1/16—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism
    • G06M1/163—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism with drums
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G06M1/241—Drums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2004537331A 2002-09-21 2003-09-17 吸入器 Expired - Lifetime JP4612418B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0222023.4A GB0222023D0 (en) 2002-09-21 2002-09-21 Inhaler
PCT/GB2003/004137 WO2004026380A2 (en) 2002-09-21 2003-09-17 Inhaler

Publications (3)

Publication Number Publication Date
JP2006500094A JP2006500094A (ja) 2006-01-05
JP2006500094A5 JP2006500094A5 (https=) 2006-09-07
JP4612418B2 true JP4612418B2 (ja) 2011-01-12

Family

ID=9944580

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004537331A Expired - Lifetime JP4612418B2 (ja) 2002-09-21 2003-09-17 吸入器

Country Status (14)

Country Link
EP (1) EP1542750B1 (https=)
JP (1) JP4612418B2 (https=)
KR (1) KR20050046800A (https=)
CN (1) CN1684731A (https=)
AT (1) ATE423590T1 (https=)
AU (1) AU2003267633A1 (https=)
BR (1) BR0314127A (https=)
CA (1) CA2499486A1 (https=)
DE (1) DE60326366D1 (https=)
GB (1) GB0222023D0 (https=)
MX (1) MXPA05003056A (https=)
RU (1) RU2323749C2 (https=)
WO (1) WO2004026380A2 (https=)
ZA (1) ZA200502219B (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0328635D0 (en) 2003-12-10 2004-01-14 3M Innovative Properties Co Dose counter for dispensers
DK1730676T3 (da) 2004-02-16 2013-11-04 Glaxo Group Ltd Tælleenhed til anvendelse med en medikamentfordeler
JP2007533387A (ja) 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
GB0409197D0 (en) 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
GB2414187B (en) 2004-05-21 2007-03-07 Bespak Plc Dispensing apparatus
PT1616592E (pt) 2004-07-16 2010-12-10 Almirall Sa Inalador para administração de fármacos em pó e um cartucho de pó para utilização com este inalador
NZ553181A (en) * 2004-08-12 2010-08-27 Teijin Pharma Ltd Counter mechanism of feeder and feeder having counter mechanism
GB2429166A (en) * 2005-07-27 2007-02-21 Cambridge Consultants Inhaler counter
GB0518400D0 (en) * 2005-09-09 2005-10-19 Clinical Designs Ltd Dispenser
GB0519151D0 (en) 2005-09-20 2005-10-26 Aventis Pharma Ltd Inhaler
GB0600070D0 (en) * 2006-01-04 2006-02-15 Campling Nicholas J Dose counter
GB0605150D0 (en) 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
US8479732B2 (en) 2006-04-21 2013-07-09 3M Innovative Properties Company Dose counter
GB0610541D0 (en) 2006-05-26 2006-07-05 Bespak Plc Improvements in or relating to dispensing apparatus
GB2438396B (en) 2006-05-26 2008-10-01 Bespak Plc Improvements in or relating to dispensing apparatus
EP2037999B1 (en) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Smart parenteral administration system
DK2142516T3 (da) 2007-03-30 2013-04-15 Sanofi Sa Pyrimidinhydrazidforbindelser i ders egenskab af pgds-inhibitorer
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
CN101827626B (zh) * 2008-06-13 2015-03-18 曼金德公司 干粉吸入器和用于药物输送的系统
GB201020130D0 (en) * 2010-11-26 2011-01-12 Vectura Delivery Devices Ltd Inhaler
DE202008017185U1 (de) * 2008-12-30 2010-05-12 Siegfried Generics International Ag Dosiervorrichtung
US9125999B2 (en) 2009-05-18 2015-09-08 Adamis Pharmaceuticals Corporation Dry powder inhaler dose counters
CN107875155A (zh) 2009-10-08 2018-04-06 赛诺菲 苯基噁二唑衍生物在制备治疗变应性或炎性疾病的药物中的用途
KR20120114368A (ko) 2010-02-01 2012-10-16 프로테우스 디지털 헬스, 인코포레이티드 양 손목을 이용한 데이터 수집 시스템
KR101798128B1 (ko) 2010-02-01 2017-11-16 프로테우스 디지털 헬스, 인코포레이티드 데이터 수집 시스템
EP2824111B1 (en) 2010-04-30 2017-03-22 Alexion Pharmaceuticals, Inc. Anti-C5A Antibodies and Methods for Using the Antibodies
US9815890B2 (en) 2010-06-22 2017-11-14 The Regents Of The University Of Colorado, A Body Corporate Antibodies to the C3d fragment of complement component 3
GB201118842D0 (en) * 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser cap arrangement
US9603907B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Dry powder formulations of dNase I
US20150174158A1 (en) 2012-03-07 2015-06-25 Advanced Inhalation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
EP2845148A1 (en) 2012-05-04 2015-03-11 Sanofi SA Counting mechanism for a drug delivery device and drug delivery device
GB201223008D0 (en) * 2012-12-20 2013-01-30 Euro Celtique Sa Counter
ES2768648T3 (es) 2013-03-29 2020-06-23 Alexion Pharma Inc Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento
RU2544801C2 (ru) * 2013-06-11 2015-03-20 Открытое Акционерное Общество "Фармацевтическая Фабрика Санкт-Петербурга" Порошковый ингалятор
NZ631007A (en) 2014-03-07 2015-10-30 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
US20170304459A1 (en) 2014-10-10 2017-10-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
TW201636068A (zh) * 2015-01-13 2016-10-16 賽諾菲股份有限公司 藥物輸送裝置之組件
EP3294389B1 (en) * 2015-05-08 2020-07-22 Iconovo AB Dry powder inhaler comprising a locking mechanism
WO2017128170A1 (zh) * 2016-01-28 2017-08-03 扬子江药业集团有限公司 一种储库型干粉吸入器
ES2711774T3 (es) * 2016-03-21 2019-05-07 Joseph Feldman Aparato de pulverización nasal
JP2019517473A (ja) 2016-05-27 2019-06-24 アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 難治性全身型重症筋無力症の処置のための方法
GB201610450D0 (en) * 2016-06-15 2016-07-27 Tech Partnership The Plc Counting mechanism
MX2020000435A (es) 2017-07-14 2020-08-17 Cytomx Therapeutics Inc Anticuerpos anti-cd166 y usos de estos.
SI3658184T1 (sl) 2017-07-27 2024-01-31 Alexion Pharmaceuticals, Inc., Formulacije z visoko koncentracijo protiteles proti-C5
CA3080187A1 (en) 2017-10-26 2019-05-02 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) and atypical hemolytic uremic syndrome (ahus)
DE102018117731A1 (de) 2018-01-16 2019-07-18 F+K Innovationen Gmbh & Co. Kg Vorrichtung zur Dosierung von Flüssigkeit
US12404320B2 (en) 2018-05-31 2025-09-02 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) in pediatric patients
JP7577542B2 (ja) 2018-06-04 2024-11-05 アレクシオン ファーマシューティカルズ， インコーポレイテッド 小児患者における非典型溶血性尿毒症症候群（ａＨＵＳ）の治療のための抗Ｃ５抗体の用量および投与
WO2020006266A1 (en) 2018-06-28 2020-01-02 Alexion Pharmaceuticals, Inc. Methods of producing anti-c5 antibodies
CN112996561A (zh) 2018-10-30 2021-06-18 亚力兄制药公司 用于治疗阵发性睡眠性血红蛋白尿症(pnh)的抗c5抗体的皮下剂量和施用
KR102840400B1 (ko) 2018-12-12 2025-08-04 카이트 파마 인코포레이티드 키메라 항원 수용체 및 car-t 세포 및 사용 방법
JP7455144B2 (ja) 2019-04-29 2024-03-25 インスメッド インコーポレイテッド トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法
GB2585205B (en) * 2019-07-01 2021-08-11 Merxin Ltd Ratchet mechanism
CN110559528B (zh) * 2019-10-12 2024-06-07 万通(苏州)定量阀系统有限公司 一种带计数器的气雾剂给药器推钮
IL297538A (en) 2020-04-24 2022-12-01 Millennium Pharm Inc Anti-cd19 antibodies and uses thereof
US20230277524A1 (en) 2020-05-22 2023-09-07 Trailhead Biosystems Inc. Combination therapy for treatment of viral infections
KR20230096998A (ko) 2020-10-28 2023-06-30 인스메드 인코포레이티드 트레프로스티닐 전구약물의 건조 분말 조성물 및 이의 사용 방법
JP7829595B2 (ja) 2021-04-09 2026-03-13 武田薬品工業株式会社 補体因子ｄを標的とする抗体及びその使用
PE20241789A1 (es) 2021-04-26 2024-09-06 Millennium Pharm Inc Anticuerpos anti-clec12a y usos de los mismos
IL307940A (en) 2021-04-26 2023-12-01 Millennium Pharm Inc Anti-ADGRE2 antibodies and their uses
KR20240099161A (ko) 2021-10-20 2024-06-28 다케다 야쿠힌 고교 가부시키가이샤 Bcma를 표적화하는 조성물 및 이의 사용 방법
CN114177443B (zh) * 2021-12-31 2025-01-03 上海臣邦医药科技股份有限公司 一种粉雾剂给药装置的计数器结构
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof
CN120771399B (zh) * 2025-09-11 2025-12-02 苏州嘉树医疗科技有限公司 一种计量指示装置和喷雾器

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014492A2 (en) * 1992-12-18 1994-07-07 Schering Corporation Inhaler for powdered medications
FR2721106B1 (fr) * 1994-06-10 1996-09-13 Step Compteur de doses pour inhalateurs.
SE9404140D0 (sv) * 1994-11-29 1994-11-29 Astra Ab Dose indicating device
DE59605366D1 (de) * 1995-12-07 2000-07-06 Jago Pharma Ag Muttenz Inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers
PT883415E (pt) * 1996-02-21 2002-10-31 Schering Corp Inalador para medicacao em po
FR2799858B1 (fr) * 1999-10-19 2002-01-18 Valois Sa Compteur de doses et distributeur de produit fluide incorporant un tel compteur
SE0100034D0 (sv) * 2001-01-04 2001-01-04 Astrazeneca Ab A delivery device

Also Published As

Publication number Publication date
ZA200502219B (en) 2005-09-16
JP2006500094A (ja) 2006-01-05
GB0222023D0 (en) 2002-10-30
CA2499486A1 (en) 2004-04-01
ATE423590T1 (de) 2009-03-15
EP1542750B1 (en) 2009-02-25
WO2004026380A2 (en) 2004-04-01
CN1684731A (zh) 2005-10-19
EP1542750A2 (en) 2005-06-22
RU2005111770A (ru) 2006-01-20
WO2004026380A3 (en) 2004-08-26
KR20050046800A (ko) 2005-05-18
BR0314127A (pt) 2005-07-26
RU2323749C2 (ru) 2008-05-10
AU2003267633A1 (en) 2004-04-08
DE60326366D1 (de) 2009-04-09
MXPA05003056A (es) 2005-05-27

Similar Documents

Publication Publication Date Title
JP4612418B2 (ja) 吸入器
US8083127B2 (en) Slave wheel counter mechanism useable with an inhaler
JP5096341B2 (ja) 粉末吸入器用の機械的な投与量カウンタ
EP1730676B1 (en) Counter for use with a medicament dispenser
US6769601B2 (en) Inhaler with a dose counter
EP1616592B9 (en) Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge for use with this inhaler
WO2001031578A1 (en) Mechanical doses counter in a powder inhaler
US20220134027A1 (en) Dose Feedback Mechanisms and Assemblies for User Feedback
WO2020163463A9 (en) Dose feedback mechanisms and assemblies for user feedback
WO2020163468A1 (en) Dose feedback mechanisms and assemblies for user feedback
HK1101722B (en) Counter for use with a medicament dispenser
HK1105136B (en) Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060720

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060720

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090616

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090910

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090917

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091216

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100706

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100910

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20101005

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20101015

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131022

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4612418

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term