JP4564846B2 - アロイル−ピペリジン誘導体 - Google Patents
アロイル−ピペリジン誘導体 Download PDFInfo
- Publication number
- JP4564846B2 JP4564846B2 JP2004535464A JP2004535464A JP4564846B2 JP 4564846 B2 JP4564846 B2 JP 4564846B2 JP 2004535464 A JP2004535464 A JP 2004535464A JP 2004535464 A JP2004535464 A JP 2004535464A JP 4564846 B2 JP4564846 B2 JP 4564846B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pharmaceutically acceptable
- acceptable salt
- compounds
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
で示される新規N−(3,5−ビス−トリフルオロメチル−ベンゾイル)−2−ベンジル−4−(キノロイルアミノ)−ピペリジン;その使用;その製法方法および本発明の化合物を含んでなる医薬組成物に関する。
で示される化合物に関する。
そして、所望により当該方法により得られる異性体の混合物を分離し、そして所望の異性体を単離することを含んでなる。
MS(ES+): [M+1]+=636および[M+23]+=658.
[M+1]+=636および[M+23]+=658
Claims (7)
- 1−オキシ−キノリン−4−カルボン酸 [(2R,4S)−1−(3,5−ビス−トリフルオロメチル−ベンゾイル)−2−(4−クロロ−ベンジル)−ピペリジン−4−イル]−アミドである請求項1に記載の化合物、または医薬上許容されるその塩。
- 2−ヒドロキシ−キノリン−4−カルボン酸 [(2R,4S)−1−(3,5−ビス−トリフルオロメチル−ベンゾイル)−2−(4−クロロ−ベンジル)−ピペリジン−4−イル]−アミドである請求項1に記載の化合物、または医薬上許容されるその塩。
- ヒトまたは動物の処置に使用するための請求項1〜3のいずれか1項に記載の化合物、または医薬上許容されるその塩。
- 請求項1〜3のいずれか1項に記載の化合物、または医薬上許容されるその塩を含んでなる医薬組成物。
- 請求項1〜3のいずれか1項に記載の化合物、または医薬上許容されるその塩を含んでなるサブスタンスPにより誘導される障害の処置用医薬組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0220953.4A GB0220953D0 (en) | 2002-09-10 | 2002-09-10 | Organic compounds |
PCT/EP2003/010007 WO2004024714A1 (en) | 2002-09-10 | 2003-09-09 | Aroyl-piperidine derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2006502171A JP2006502171A (ja) | 2006-01-19 |
JP2006502171A5 JP2006502171A5 (ja) | 2006-10-26 |
JP4564846B2 true JP4564846B2 (ja) | 2010-10-20 |
Family
ID=9943781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004535464A Expired - Fee Related JP4564846B2 (ja) | 2002-09-10 | 2003-09-09 | アロイル−ピペリジン誘導体 |
Country Status (9)
Country | Link |
---|---|
US (2) | US7678814B2 (ja) |
EP (1) | EP1539737A1 (ja) |
JP (1) | JP4564846B2 (ja) |
CN (1) | CN1681803A (ja) |
AU (1) | AU2003273398A1 (ja) |
BR (1) | BR0314164A (ja) |
CA (1) | CA2498285C (ja) |
GB (1) | GB0220953D0 (ja) |
WO (1) | WO2004024714A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0220953D0 (en) * | 2002-09-10 | 2002-10-23 | Novartis Ag | Organic compounds |
AU2008218248A1 (en) * | 2007-02-23 | 2008-08-28 | Avera Pharmaceuticals, Inc. | Pharmaceutical formulation |
ES2672099T3 (es) | 2011-07-04 | 2018-06-12 | Irbm - Science Park S.P.A. | Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal |
US20210015834A1 (en) | 2018-02-26 | 2021-01-21 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
US20230134843A1 (en) | 2020-03-11 | 2023-05-04 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6115A (ja) * | 1984-06-12 | 1986-01-06 | Kyowa Hakko Kogyo Co Ltd | リポキシゲナ−ゼ代謝産物に起因する疾患の予防治療剤 |
MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
TW397825B (en) | 1994-10-14 | 2000-07-11 | Novartis Ag | Aroyl-piperidine derivatives |
RU2156250C2 (ru) | 1995-04-24 | 2000-09-20 | Новартис Аг | Производные хромона, способ их получения и фармацевтическая композиция |
AU2898297A (en) | 1996-05-24 | 1998-01-05 | Novartis Ag | Use of substance p antagonists for treating social phobia |
AR018376A1 (es) | 1998-05-26 | 2001-11-14 | Novartis Ag | Composiciones farmaceuticas que se pueden dispersar de una manera espontanea y el uso de las mismas para la manufactura de un medicamento |
AU5624599A (en) | 1998-08-25 | 2000-03-14 | Lothar Farber | Pharmaceutical uses |
WO2002012192A1 (en) * | 2000-08-09 | 2002-02-14 | F. Hoffmann-La Roche Ag | Quinolene derivatives as anti-inflammation agents |
JP2002220386A (ja) * | 2000-10-02 | 2002-08-09 | Tanabe Seiyaku Co Ltd | ベンジルアミン誘導体、その製法およびその合成中間体 |
GB0220953D0 (en) * | 2002-09-10 | 2002-10-23 | Novartis Ag | Organic compounds |
-
2002
- 2002-09-10 GB GBGB0220953.4A patent/GB0220953D0/en not_active Ceased
-
2003
- 2003-09-09 WO PCT/EP2003/010007 patent/WO2004024714A1/en active Application Filing
- 2003-09-09 EP EP03755553A patent/EP1539737A1/en not_active Withdrawn
- 2003-09-09 JP JP2004535464A patent/JP4564846B2/ja not_active Expired - Fee Related
- 2003-09-09 US US10/527,518 patent/US7678814B2/en not_active Expired - Fee Related
- 2003-09-09 AU AU2003273398A patent/AU2003273398A1/en not_active Abandoned
- 2003-09-09 CA CA2498285A patent/CA2498285C/en not_active Expired - Fee Related
- 2003-09-09 BR BR0314164-0A patent/BR0314164A/pt not_active IP Right Cessation
- 2003-09-09 CN CNA038212552A patent/CN1681803A/zh active Pending
-
2010
- 2010-01-20 US US12/690,210 patent/US8193218B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20100120852A1 (en) | 2010-05-13 |
AU2003273398A1 (en) | 2004-04-30 |
US20060135558A1 (en) | 2006-06-22 |
CA2498285A1 (en) | 2004-03-25 |
US7678814B2 (en) | 2010-03-16 |
EP1539737A1 (en) | 2005-06-15 |
GB0220953D0 (en) | 2002-10-23 |
US8193218B2 (en) | 2012-06-05 |
CA2498285C (en) | 2011-07-26 |
JP2006502171A (ja) | 2006-01-19 |
CN1681803A (zh) | 2005-10-12 |
BR0314164A (pt) | 2005-07-19 |
WO2004024714A1 (en) | 2004-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3022951B2 (ja) | アロイル−ピペリジン誘導体 | |
JPH08169884A (ja) | シクロプロパクロメンカルボン酸誘導体 | |
US8193218B2 (en) | Aroyl-piperidine derivatives and method of treating disorders induced by substance P | |
AU714523B2 (en) | Chromone derivatives | |
JP2009520000A (ja) | カンナビノイドcb1受容体モジュレーターとしての4,5−ジヒドロ−(1h)−ピラゾール誘導体 | |
JP2013006879A (ja) | 光学活性なテトラヒドロナフタレン誘導体 | |
WO2005000845A2 (en) | Bicyclic derivatives as nk-1 and nk-2 antagonists | |
ZA200308344B (en) | Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same. | |
US8026232B2 (en) | Benzothiophene oxide derivative and salt thereof | |
JPH11180952A (ja) | 2−オキシインドール誘導体 | |
WO2004060884A1 (en) | [4-(3-aminomethylphenyl) piperidin-1-yl]- [5-(2-fluorophenylethynyl)furan-2-yl]-methanone as an inhibitor of mast cell tryptase | |
JPH07215965A (ja) | インドールスルホンアミド−置換ジヒドロピリジン類 | |
JPH0967347A (ja) | 環状アミン誘導体及びそれを含有する医薬組成物 | |
MXPA96001515A (en) | Chromone derivatives | |
JPH1171378A (ja) | トリアゾロ−1,4−ジアゼピン系化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060906 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060906 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100202 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100428 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100706 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100802 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130806 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |