JP4564654B2 - Ｖｌａ−４アンタゴニスト - Google Patents

Ｖｌａ−４アンタゴニスト Download PDF

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Publication number
JP4564654B2
JP4564654B2 JP2000528529A JP2000528529A JP4564654B2 JP 4564654 B2 JP4564654 B2 JP 4564654B2 JP 2000528529 A JP2000528529 A JP 2000528529A JP 2000528529 A JP2000528529 A JP 2000528529A JP 4564654 B2 JP4564654 B2 JP 4564654B2
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JP
Japan
Prior art keywords
substituted
alkyl
mixture
aryl
compound
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Expired - Fee Related
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JP2000528529A
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English (en)
Japanese (ja)
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JP2002501039A (ja
JP2002501039A5 (https=
Inventor
ソムポング・ワッタナシン
ペーター・ヨーゼフ・フォン・マット
Original Assignee
ノバルティス アーゲー
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Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
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Publication of JP2002501039A5 publication Critical patent/JP2002501039A5/ja
Application granted granted Critical
Publication of JP4564654B2 publication Critical patent/JP4564654B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000528529A 1998-01-23 1999-01-21 Ｖｌａ−４アンタゴニスト Expired - Fee Related JP4564654B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1233698A 1998-01-23 1998-01-23
US09/012,336 1998-01-23
US11072398P 1998-12-03 1998-12-03
US60/110,723 1998-12-03
PCT/EP1999/000384 WO1999037605A1 (en) 1998-01-23 1999-01-21 Vla-4 antagonists

Publications (3)

Publication Number Publication Date
JP2002501039A JP2002501039A (ja) 2002-01-15
JP2002501039A5 JP2002501039A5 (https=) 2006-03-02
JP4564654B2 true JP4564654B2 (ja) 2010-10-20

Family

ID=26683440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000528529A Expired - Fee Related JP4564654B2 (ja) 1998-01-23 1999-01-21 Ｖｌａ−４アンタゴニスト

Country Status (13)

Country Link
EP (1) EP1049665A1 (https=)
JP (1) JP4564654B2 (https=)
KR (1) KR20010034317A (https=)
CN (1) CN1294576A (https=)
AU (1) AU746174B2 (https=)
BR (1) BR9907733A (https=)
CA (1) CA2318639A1 (https=)
EE (1) EE200000428A (https=)
HU (1) HUP0100336A3 (https=)
ID (1) ID26665A (https=)
IL (1) IL137329A0 (https=)
NO (1) NO20003694L (https=)
WO (1) WO1999037605A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043372A1 (en) * 1999-01-22 2000-07-27 Elan Pharmaceuticals, Inc. Acyl derivatives which treat vla-4 related disorders
PL350050A1 (en) 1999-01-22 2002-10-21 Elan Pharm Inc Acyl derivatives which treat vla-4 related disorders
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
ATE264298T1 (de) 1999-03-01 2004-04-15 Elan Pharm Inc Alpha-aminoessigsäure derivate als alpha 4 beta 7-rezeptor antagonisten
CA2388686A1 (en) * 1999-12-07 2001-06-14 Sompong Wattanasin Vla-4 integrin antagonists
EP1244656A1 (en) * 1999-12-28 2002-10-02 Pfizer Products Inc. Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
DE10019755A1 (de) * 2000-04-20 2001-11-08 Bayer Ag Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten
GB2367816A (en) 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
GB2369357A (en) * 2000-10-09 2002-05-29 Bayer Ag Aliphatic, cyclic amino carboxylic acids as integrin antagonists
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200610754A (en) * 2004-06-14 2006-04-01 Daiichi Seiyaku Co Vla-4 inhibitor
GB0523576D0 (en) * 2005-11-18 2005-12-28 Theradeas Ltd Drug composition and its use in therapy
WO2007101165A1 (en) 2006-02-27 2007-09-07 Elan Pharmaceuticals, Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
EP2124996A4 (en) 2007-02-20 2010-03-24 Merrimack Pharmaceuticals Inc METHOD FOR TREATING MULTIPLE SCLEROSIS BY ADMINISTERING AN ALPHA FETOPROTEIN COMBINED WITH AN INTEGRINANT AGONIST
CA2721093A1 (en) 2008-04-11 2009-10-15 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
NZ505363A (en) * 1997-12-23 2005-02-25 Aventis Pharma Ltd Compounds containing substituted {2-[3-methoxy-4-(3-o-tolylureido)phenyl]acetylamino}- groups and pharmaceuticals thereof; useful as inhibitors of alpha4beta1 mediated cell division

Also Published As

Publication number Publication date
NO20003694L (no) 2000-09-20
JP2002501039A (ja) 2002-01-15
AU746174B2 (en) 2002-04-18
EE200000428A (et) 2001-12-17
WO1999037605A1 (en) 1999-07-29
NO20003694D0 (no) 2000-07-19
BR9907733A (pt) 2000-10-17
KR20010034317A (ko) 2001-04-25
EP1049665A1 (en) 2000-11-08
HUP0100336A2 (hu) 2001-07-30
HUP0100336A3 (en) 2002-11-28
IL137329A0 (en) 2001-07-24
CN1294576A (zh) 2001-05-09
ID26665A (id) 2001-01-25
AU2829299A (en) 1999-08-09
CA2318639A1 (en) 1999-07-29

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