JP4560616B2 - 細胞のＮＦ−κＢ活性化を調節するための組成物および方法 - Google Patents

細胞のＮＦ−κＢ活性化を調節するための組成物および方法 Download PDF

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JP4560616B2
JP4560616B2 JP53601398A JP53601398A JP4560616B2 JP 4560616 B2 JP4560616 B2 JP 4560616B2 JP 53601398 A JP53601398 A JP 53601398A JP 53601398 A JP53601398 A JP 53601398A JP 4560616 B2 JP4560616 B2 JP 4560616B2
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seq
ubiquitination
peptide
iκbα
phosphorylated
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Japanese (ja)
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JP2001512319A (ja
JP2001512319A5 (https=
Inventor
マニング，アンソニー
メリクリオ，フランク
マルカレイ，イリト
ベン−ネリアー，イノン
シェチェノバー，アーロン
ヤロン，アブラハム
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Celgene Corp
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Celgene Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Mobile Radio Communication Systems (AREA)
JP53601398A 1997-02-18 1998-02-18 細胞のＮＦ−κＢ活性化を調節するための組成物および方法 Expired - Fee Related JP4560616B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/802,322 US5932425A (en) 1997-02-18 1997-02-18 Compositions and methods for modulating cellular NF-κB activation
US08/802,322 1997-02-18
PCT/US1998/003163 WO1998036070A1 (en) 1997-02-18 1998-02-18 COMPOSITIONS AND METHODS FOR MODULATING CELLULAR NF-λB ACTIVATION

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009255576A Division JP2010063461A (ja) 1997-02-18 2009-11-06 細胞のＮＦ−κＢ活性化を調節するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2001512319A JP2001512319A (ja) 2001-08-21
JP2001512319A5 JP2001512319A5 (https=) 2005-10-06
JP4560616B2 true JP4560616B2 (ja) 2010-10-13

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Family Applications (2)

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JP53601398A Expired - Fee Related JP4560616B2 (ja) 1997-02-18 1998-02-18 細胞のＮＦ−κＢ活性化を調節するための組成物および方法
JP2009255576A Withdrawn JP2010063461A (ja) 1997-02-18 2009-11-06 細胞のＮＦ−κＢ活性化を調節するための組成物および方法

Family Applications After (1)

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JP2009255576A Withdrawn JP2010063461A (ja) 1997-02-18 2009-11-06 細胞のＮＦ−κＢ活性化を調節するための組成物および方法

Country Status (8)

Country Link
US (1) US5932425A (https=)
EP (1) EP1009824B1 (https=)
JP (2) JP4560616B2 (https=)
AT (1) ATE391177T1 (https=)
AU (1) AU6659198A (https=)
CA (1) CA2281920C (https=)
DE (1) DE69839326T2 (https=)
WO (1) WO1998036070A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0920518A1 (en) * 1996-08-26 1999-06-09 Signal Pharmaceuticals, Inc. Stimulus-inducible i (kappa)b kinase ikk] signalsome
US6896899B2 (en) * 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
DE69739663D1 (de) 1996-12-31 2009-12-31 Antioxidant Pharmaceuticals Co Pharmazeutische glutathionpräparate und methoden zu dern verabreichung
WO1999066065A2 (en) * 1998-06-13 1999-12-23 Zarpex Biosciences Limited Proteasomal activity
ES2361660T3 (es) 1998-12-10 2011-06-21 Signal Pharmaceuticals Llc Ubicutina-ligasa e3 humana para la modulación de nk-kappa b.
US6630312B2 (en) 1999-08-10 2003-10-07 Joslin Diabetes Center, Inc. Method for identifying compounds for treatment of insulin resistance
US6468755B1 (en) 1999-08-10 2002-10-22 Joslin Diabetes Center, Inc. Method for identifying compounds for treatment of insulin resistance
US20030104622A1 (en) * 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
FR2801902B1 (fr) * 1999-12-01 2005-03-04 Centre Nat Rech Scient Procedes de criblages fonctionnels d'agents aptes a moduler l'activite des complexes ubiquitine-ligases scf et leurs applications
WO2001079555A2 (en) 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Roles of jak/stat family members in tolerance induction
US20030044852A1 (en) * 2000-08-10 2003-03-06 Joslin Diabetes Center, Inc., A Massachusetts Corporation Methods for treatment of insulin resistance
US20060287337A1 (en) * 2001-11-09 2006-12-21 Proteologics, Inc. Trans-golgi network-associated processes, methods and compositions related thereto
AU2002349784A1 (en) * 2001-12-03 2003-06-17 Asahi Kasei Pharma Corporation Nf-kappab activating genes
FR2859733A1 (fr) * 2003-09-15 2005-03-18 Centre Nat Rech Scient Procede de criblage fonctionnel d'agents aptes a moduler l'activite des ubiquitine hydrolases et leurs applications
HUE034446T2 (en) * 2004-03-02 2018-02-28 Procter & Gamble Method for binding high internal phase emulsions (HIPE)
FR2867783B1 (fr) * 2004-03-16 2008-02-01 Cytomics Systems Procede de criblage d'agent modulant l'ubiquitination de la proteine ikbalpha et moyens destines a la mise en oeuvre dudit procede
US20070060537A1 (en) * 2005-04-28 2007-03-15 Proteologics, Inc. Methods and compositions for inhibiting viral infections
US20100292306A1 (en) * 2005-05-24 2010-11-18 Carlson C George Compositions And Methods For The Treatment Of Muscular Dystrophy
US20070202593A1 (en) * 2006-02-27 2007-08-30 Research Development Foundation Cell-Targeted IKB and Methods for the Use Thereof
TW200902025A (en) * 2007-04-11 2009-01-16 Alcon Res Ltd Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
WO2010044892A1 (en) * 2008-10-17 2010-04-22 President And Fellows Of Harvard College Diagnostic method based on large scale identification of post-translational modification of proteins
US20110082145A1 (en) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
NZ777336A (en) 2018-12-28 2026-02-27 Regeneron Pharma Treatment of respiratory disorders with arachidonate 15-lipoxygenase (alox15) inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122463A (en) * 1990-05-17 1992-06-16 Massachusetts Institute Of Technology Methods for trans-destabilization of specific proteins in vivo and dna molecules useful therefor
EP0905236A1 (en) * 1992-10-29 1999-03-31 Medical Research Council Transcription factor DP-1
DE4243770A1 (de) * 1992-12-23 1994-06-30 Behringwerke Ag Verfahren zur Herstellung von rekombinanten und synthetischen Peptiden und deren Verwendung
IL114615A0 (en) * 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
JPH11509085A (ja) * 1995-06-23 1999-08-17 テュラリク インコーポレイテッド インターロイキン−１レセプター関連プロテインキナーゼ及び検定
EP0920518A1 (en) * 1996-08-26 1999-06-09 Signal Pharmaceuticals, Inc. Stimulus-inducible i (kappa)b kinase ikk] signalsome

Also Published As

Publication number Publication date
EP1009824B1 (en) 2008-04-02
AU6659198A (en) 1998-09-08
WO1998036070A1 (en) 1998-08-20
JP2001512319A (ja) 2001-08-21
US5932425A (en) 1999-08-03
CA2281920C (en) 2010-05-04
CA2281920A1 (en) 1998-08-20
JP2010063461A (ja) 2010-03-25
ATE391177T1 (de) 2008-04-15
DE69839326T2 (de) 2009-04-16
DE69839326D1 (de) 2008-05-15
HK1028784A1 (en) 2001-03-02
EP1009824A1 (en) 2000-06-21

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