JP4542296B2 - ポリ(エーテル−チオエーテル)核酸、ポリ(エーテル−スルホキシド)核酸およびポリ(エーテル−スルホン)核酸 - Google Patents

ポリ(エーテル−チオエーテル)核酸、ポリ(エーテル−スルホキシド)核酸およびポリ(エーテル−スルホン)核酸 Download PDF

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JP4542296B2
JP4542296B2 JP2001520910A JP2001520910A JP4542296B2 JP 4542296 B2 JP4542296 B2 JP 4542296B2 JP 2001520910 A JP2001520910 A JP 2001520910A JP 2001520910 A JP2001520910 A JP 2001520910A JP 4542296 B2 JP4542296 B2 JP 4542296B2
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group
compound
nucleobase
ether
poly
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JP2003508062A5 (https=
JP2003508062A (ja
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デヴィッド セゲヴ,
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バイオ−ラッド ラボラトリーズ,インコーポレイティド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
JP2001520910A 1999-08-30 2000-07-21 ポリ(エーテル−チオエーテル)核酸、ポリ(エーテル−スルホキシド)核酸およびポリ(エーテル−スルホン)核酸 Expired - Fee Related JP4542296B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38499599A 1999-08-30 1999-08-30
US09/384,995 1999-08-30
US09/411,862 US6348583B1 (en) 1999-08-30 1999-10-04 Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
US09/411,862 1999-10-04
PCT/IL2000/000432 WO2001016365A1 (en) 1999-08-30 2000-07-21 Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids

Publications (3)

Publication Number Publication Date
JP2003508062A JP2003508062A (ja) 2003-03-04
JP2003508062A5 JP2003508062A5 (https=) 2007-06-28
JP4542296B2 true JP4542296B2 (ja) 2010-09-08

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JP2001520910A Expired - Fee Related JP4542296B2 (ja) 1999-08-30 2000-07-21 ポリ(エーテル−チオエーテル)核酸、ポリ(エーテル−スルホキシド)核酸およびポリ(エーテル−スルホン)核酸

Country Status (6)

Country Link
US (1) US6348583B1 (https=)
EP (1) EP1208234A4 (https=)
JP (1) JP4542296B2 (https=)
AU (1) AU769619B2 (https=)
CA (1) CA2382631C (https=)
WO (1) WO2001016365A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135191B2 (en) * 1997-09-04 2006-11-14 Zsolt Istvan Hertelendy Urogenital or anorectal transmucosal vaccine delivery system
AU2003222427B8 (en) * 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US8071740B2 (en) * 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
AU2002230058B2 (en) 2001-01-29 2005-11-17 Bio-Rad Laboratories, Inc. Nucleic acid derivatives
US6949368B2 (en) * 2001-01-30 2005-09-27 The Trustees Of Princeton University Compositions and methods for enhancing polynucleotide amplification reactions
WO2002077002A2 (en) * 2001-03-22 2002-10-03 Research Foundation Of The City University Of New York Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
JP2002338688A (ja) * 2001-05-15 2002-11-27 Sumitomo Chem Co Ltd 精ポリエーテルスルホンの製造方法
CA2463816C (en) 2001-10-19 2014-07-08 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
US7936453B2 (en) 2008-04-04 2011-05-03 Emcore Corporation Terahertz frequency domain spectrometer with integrated dual laser module
CN102271517B (zh) * 2008-11-06 2015-04-08 脉管生物生长有限公司 氧化的脂质化合物和其用途
KR101224828B1 (ko) * 2009-05-14 2013-01-22 (주)바이오니아 siRNA 접합체 및 그 제조방법
US9879012B2 (en) * 2012-03-29 2018-01-30 Regents Of The University Of Colorado, A Body Corporate Click nucleic acids
CA2968790A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
EP3527578A4 (en) * 2016-10-14 2020-07-15 Bonac Corporation NOVEL GLYCOSIDE COMPOUND AND PROCESS FOR PRODUCING THE SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3022967B2 (ja) * 1985-03-15 2000-03-21 アンチバイラルズ インコーポレイテッド 立体規則性ポリヌクレオチド結合ポリマー
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
US5656611A (en) * 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids

Also Published As

Publication number Publication date
CA2382631C (en) 2010-09-28
JP2003508062A (ja) 2003-03-04
AU6012600A (en) 2001-03-26
US6348583B1 (en) 2002-02-19
CA2382631A1 (en) 2001-03-08
EP1208234A1 (en) 2002-05-29
WO2001016365A1 (en) 2001-03-08
EP1208234A4 (en) 2009-12-30
AU769619B2 (en) 2004-01-29

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