JP4511108B2 - ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 - Google Patents

ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 Download PDF

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JP4511108B2
JP4511108B2 JP2002311540A JP2002311540A JP4511108B2 JP 4511108 B2 JP4511108 B2 JP 4511108B2 JP 2002311540 A JP2002311540 A JP 2002311540A JP 2002311540 A JP2002311540 A JP 2002311540A JP 4511108 B2 JP4511108 B2 JP 4511108B2
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protein
angiogenesis
receptor antagonist
endostatin
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JP2004002276A (ja
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ユアン チェン ウェン
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オンコリクス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57554—Prolactin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2002311540A 2002-05-31 2002-10-25 ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 Expired - Fee Related JP4511108B2 (ja)

Applications Claiming Priority (1)

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US38412102P 2002-05-31 2002-05-31

Related Child Applications (1)

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JP2009297192A Division JP5221510B2 (ja) 2002-05-31 2009-12-28 ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質

Publications (2)

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JP2004002276A JP2004002276A (ja) 2004-01-08
JP4511108B2 true JP4511108B2 (ja) 2010-07-28

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JP2002311540A Expired - Fee Related JP4511108B2 (ja) 2002-05-31 2002-10-25 ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質
JP2009297192A Expired - Fee Related JP5221510B2 (ja) 2002-05-31 2009-12-28 ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質

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US (2) US7339027B2 (enExample)
EP (1) EP1513549A4 (enExample)
JP (2) JP4511108B2 (enExample)
AU (1) AU2003240974A1 (enExample)
CA (1) CA2487291A1 (enExample)
WO (1) WO2003102148A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003300904A1 (en) * 2002-12-13 2004-07-09 The Ohio State University Antagonists for human prolactin
US7666583B2 (en) 2004-02-19 2010-02-23 Yale University Identification of cancer protein biomarkers using proteomic techniques
AU2011213758B2 (en) * 2004-02-19 2012-11-15 Yale University Identification of cancer protein biomarkers using proteomic techniques
US7507716B2 (en) * 2005-07-06 2009-03-24 Board Of Regents, The University Of Texas System Method for treating pain with prolactin antagonists
CA2635588C (en) * 2005-12-30 2015-11-10 Dyax Corp. Metalloproteinase binding proteins
WO2009135056A2 (en) * 2008-04-30 2009-11-05 Monsanto Technology Llc Recombinant dna vectors for expression of human prolactin antagonists
WO2013034116A1 (zh) * 2011-09-09 2013-03-14 清华大学 对atp结合位点进行突变的血管内皮抑制素突变体
US10314909B2 (en) 2011-10-21 2019-06-11 Dyax Corp. Combination therapy comprising an MMP-14 binding protein

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2813428B2 (ja) * 1989-08-17 1998-10-22 三菱電機株式会社 電界効果トランジスタ及び該電界効果トランジスタを用いた液晶表示装置
US5315129A (en) * 1990-08-20 1994-05-24 University Of Southern California Organic optoelectronic devices and methods
TW222345B (en) * 1992-02-25 1994-04-11 Semicondustor Energy Res Co Ltd Semiconductor and its manufacturing method
FR2719480B1 (fr) * 1994-05-05 1996-07-26 Agronomique Inst Nat Rech Compositions pharmaceutiques destinées à prévenir et/ou traiter l'expression du comportement de couvaison chez les oiseaux et plus particulièrement chez la dinde et leurs procédés de préparation.
US6278127B1 (en) * 1994-12-09 2001-08-21 Agere Systems Guardian Corp. Article comprising an organic thin film transistor adapted for biasing to form a N-type or a P-type transistor
US5854205A (en) * 1995-10-23 1998-12-29 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods
WO1999016889A1 (en) * 1997-10-01 1999-04-08 G.D. Searle & Co. Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment
EP1070122A4 (en) 1998-03-11 2004-11-10 Univ Texas INDUCTION OF APOPTIC OR CYTOTOXIC GENE EXPRESSION BY ADENOVIRUS-MEDIATED GENE TRANSFER
CN1308347C (zh) * 1999-04-28 2007-04-04 德克萨斯大学董事会 用于通过选择性抑制vegf来治疗癌症的组合物和方法
CA2404088A1 (en) * 2000-03-23 2001-09-27 Greenville Hospital System Bi-functional cancer treatment agents
JP2003000268A (ja) * 2000-08-25 2003-01-07 Pfizer Prod Inc 血管新生にかかわる疾患を診断および治療するための方法および組成物
JP4841751B2 (ja) * 2001-06-01 2011-12-21 株式会社半導体エネルギー研究所 有機半導体装置及びその作製方法
JP4136482B2 (ja) * 2002-06-20 2008-08-20 キヤノン株式会社 有機半導体素子、その製造方法および有機半導体装置
EP1684365A3 (en) * 2005-01-20 2008-08-13 Fuji Electric Holdings Co., Ltd. Transistor

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Publication number Publication date
EP1513549A2 (en) 2005-03-16
US20040127407A1 (en) 2004-07-01
EP1513549A4 (en) 2006-05-10
JP2010083896A (ja) 2010-04-15
US7339027B2 (en) 2008-03-04
US20090088375A1 (en) 2009-04-02
AU2003240974A8 (en) 2003-12-19
US8304381B2 (en) 2012-11-06
WO2003102148A2 (en) 2003-12-11
JP5221510B2 (ja) 2013-06-26
WO2003102148A3 (en) 2004-07-29
CA2487291A1 (en) 2003-12-11
AU2003240974A1 (en) 2003-12-19
JP2004002276A (ja) 2004-01-08

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