JP4504021B2 - N−ピラジニル−フェニルスルホンアミド、およびケモカイン介在疾患の処置におけるそれらの使用 - Google Patents
N−ピラジニル−フェニルスルホンアミド、およびケモカイン介在疾患の処置におけるそれらの使用 Download PDFInfo
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- JP4504021B2 JP4504021B2 JP2003559997A JP2003559997A JP4504021B2 JP 4504021 B2 JP4504021 B2 JP 4504021B2 JP 2003559997 A JP2003559997 A JP 2003559997A JP 2003559997 A JP2003559997 A JP 2003559997A JP 4504021 B2 JP4504021 B2 JP 4504021B2
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- Prior art keywords
- pyrazinyl
- methoxy
- dichloro
- benzenesulfonamide
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- AHBMLDRMXWBGNT-UHFFFAOYSA-N CCCOc1nc(Br)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O Chemical compound CCCOc1nc(Br)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O AHBMLDRMXWBGNT-UHFFFAOYSA-N 0.000 description 1
- HLAYGCLKUGRLLX-UHFFFAOYSA-N CN(C)c(nc(c(NS(c1cccc(Cl)c1Cl)(=O)=O)n1)OC)c1Cl Chemical compound CN(C)c(nc(c(NS(c1cccc(Cl)c1Cl)(=O)=O)n1)OC)c1Cl HLAYGCLKUGRLLX-UHFFFAOYSA-N 0.000 description 1
- BCQMFUGKQWDDEI-UHFFFAOYSA-N CNCc1cc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)ccc1 Chemical compound CNCc1cc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)ccc1 BCQMFUGKQWDDEI-UHFFFAOYSA-N 0.000 description 1
- ORVBKAIISVAIKO-UHFFFAOYSA-N COC(CCSc(nc1OC)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O)=O Chemical compound COC(CCSc(nc1OC)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O)=O ORVBKAIISVAIKO-UHFFFAOYSA-N 0.000 description 1
- DFXCUYHMELLMRC-UHFFFAOYSA-N COc(c(NS(c(cc1)cc(Cl)c1Cl)(=O)=O)n1)ncc1Cl Chemical compound COc(c(NS(c(cc1)cc(Cl)c1Cl)(=O)=O)n1)ncc1Cl DFXCUYHMELLMRC-UHFFFAOYSA-N 0.000 description 1
- ZTCRULQYAZGHGP-UHFFFAOYSA-N COc(c(NS(c(cccc1Cl)c1Cl)(=O)=O)n1)nc(SCCN)c1Cl Chemical compound COc(c(NS(c(cccc1Cl)c1Cl)(=O)=O)n1)nc(SCCN)c1Cl ZTCRULQYAZGHGP-UHFFFAOYSA-N 0.000 description 1
- SRCOWHPHXAQPMJ-UHFFFAOYSA-N COc1nc(CN2CCOCC2)cnc1NS(c1cccc(Cl)c1Cl)(=O)=O Chemical compound COc1nc(CN2CCOCC2)cnc1NS(c1cccc(Cl)c1Cl)(=O)=O SRCOWHPHXAQPMJ-UHFFFAOYSA-N 0.000 description 1
- LJDABEKXGZUMJD-UHFFFAOYSA-N COc1nc(CO)c(CO)nc1NS(c1cccc(Cl)c1Cl)(=O)=O Chemical compound COc1nc(CO)c(CO)nc1NS(c1cccc(Cl)c1Cl)(=O)=O LJDABEKXGZUMJD-UHFFFAOYSA-N 0.000 description 1
- YMNMLFAGQZPJAE-UHFFFAOYSA-N COc1nc(OCC#C)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O Chemical compound COc1nc(OCC#C)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O YMNMLFAGQZPJAE-UHFFFAOYSA-N 0.000 description 1
- DEVWIRJJOADTEB-UHFFFAOYSA-N C[Si+](C)(C)CCOCN(c(c(OCc1cnccc1)n1)ncc1Cl)S(c(cccc1Cl)c1Cl)(=O)=O Chemical compound C[Si+](C)(C)CCOCN(c(c(OCc1cnccc1)n1)ncc1Cl)S(c(cccc1Cl)c1Cl)(=O)=O DEVWIRJJOADTEB-UHFFFAOYSA-N 0.000 description 1
- STSCPYWFDIKLPN-UHFFFAOYSA-N Cc(nc1OC)cnc1NS(c(cc1)cc(Cl)c1Cl)(=O)=O Chemical compound Cc(nc1OC)cnc1NS(c(cc1)cc(Cl)c1Cl)(=O)=O STSCPYWFDIKLPN-UHFFFAOYSA-N 0.000 description 1
- DRCDIYBDYUOVCL-UHFFFAOYSA-N Cc(nc1OC)cnc1NS(c1cc(Cl)ccc1)(=O)=O Chemical compound Cc(nc1OC)cnc1NS(c1cc(Cl)ccc1)(=O)=O DRCDIYBDYUOVCL-UHFFFAOYSA-N 0.000 description 1
- DYFGZGBYCIWETP-UHFFFAOYSA-N Cc(nc1OCc2ccncc2)cnc1NS(c1cccc(Cl)c1Cl)(=O)=O Chemical compound Cc(nc1OCc2ccncc2)cnc1NS(c1cccc(Cl)c1Cl)(=O)=O DYFGZGBYCIWETP-UHFFFAOYSA-N 0.000 description 1
- UKDFMUXACDUWFL-UHFFFAOYSA-N Cc(nc1OCc2cnccc2)cnc1NS(c1cccc(Cl)c1Cl)(=O)=O Chemical compound Cc(nc1OCc2cnccc2)cnc1NS(c1cccc(Cl)c1Cl)(=O)=O UKDFMUXACDUWFL-UHFFFAOYSA-N 0.000 description 1
- FCKQAHVBDBNGQE-UHFFFAOYSA-N Cc1cc(COc(nc2OC)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)n[o]1 Chemical compound Cc1cc(COc(nc2OC)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)n[o]1 FCKQAHVBDBNGQE-UHFFFAOYSA-N 0.000 description 1
- NNTCWJRSPFQPBC-UHFFFAOYSA-N NCc1ccc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)[o]1 Chemical compound NCc1ccc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)[o]1 NNTCWJRSPFQPBC-UHFFFAOYSA-N 0.000 description 1
- CBINXWJEICTRDJ-UHFFFAOYSA-N O=Cc1ccc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)cc1 Chemical compound O=Cc1ccc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)cc1 CBINXWJEICTRDJ-UHFFFAOYSA-N 0.000 description 1
- FXZMNFNBGRRLGU-UHFFFAOYSA-N O=S(c(cccc1Cl)c1Cl)(Nc1ncc(-c2ccncc2)nc1OCc1cnccc1)=O Chemical compound O=S(c(cccc1Cl)c1Cl)(Nc1ncc(-c2ccncc2)nc1OCc1cnccc1)=O FXZMNFNBGRRLGU-UHFFFAOYSA-N 0.000 description 1
- XZIBJHQAYGYSAW-UHFFFAOYSA-N O=S(c1cccc(Cl)c1Cl)(Nc(nccn1)c1Cl)=O Chemical compound O=S(c1cccc(Cl)c1Cl)(Nc(nccn1)c1Cl)=O XZIBJHQAYGYSAW-UHFFFAOYSA-N 0.000 description 1
- SHAOVTARLGSLMO-UHFFFAOYSA-N OCCNCc1ccc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)cc1 Chemical compound OCCNCc1ccc(COc2nc(Cl)cnc2NS(c(cccc2Cl)c2Cl)(=O)=O)cc1 SHAOVTARLGSLMO-UHFFFAOYSA-N 0.000 description 1
- YNPFQWJBJJYCHQ-UHFFFAOYSA-N OCc(nc1OCc2cnccc2)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O Chemical compound OCc(nc1OCc2cnccc2)cnc1NS(c(cccc1Cl)c1Cl)(=O)=O YNPFQWJBJJYCHQ-UHFFFAOYSA-N 0.000 description 1
- HUNHGMOTJKCXTA-UHFFFAOYSA-N Oc1ccc(CCCOc2nc(Br)cnc2NS(c2cccc(Cl)c2Cl)(=O)=O)cc1 Chemical compound Oc1ccc(CCCOc2nc(Br)cnc2NS(c2cccc(Cl)c2Cl)(=O)=O)cc1 HUNHGMOTJKCXTA-UHFFFAOYSA-N 0.000 description 1
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- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200119A SE0200119D0 (sv) | 2002-01-16 | 2002-01-16 | Novel compounds |
| SE0201857A SE0201857D0 (sv) | 2002-06-17 | 2002-06-17 | Novel compounds |
| PCT/SE2003/000041 WO2003059893A1 (en) | 2002-01-16 | 2003-01-14 | N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005521650A JP2005521650A (ja) | 2005-07-21 |
| JP2005521650A5 JP2005521650A5 (https=) | 2006-03-02 |
| JP4504021B2 true JP4504021B2 (ja) | 2010-07-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559997A Expired - Fee Related JP4504021B2 (ja) | 2002-01-16 | 2003-01-14 | N−ピラジニル−フェニルスルホンアミド、およびケモカイン介在疾患の処置におけるそれらの使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7662825B2 (https=) |
| EP (1) | EP1467976B1 (https=) |
| JP (1) | JP4504021B2 (https=) |
| KR (1) | KR20040073566A (https=) |
| CN (1) | CN100357275C (https=) |
| AR (1) | AR038179A1 (https=) |
| AT (1) | ATE534635T1 (https=) |
| AU (1) | AU2003201802A1 (https=) |
| BR (1) | BR0306922A (https=) |
| CA (1) | CA2472204A1 (https=) |
| CO (1) | CO5640137A2 (https=) |
| ES (1) | ES2375107T3 (https=) |
| IL (1) | IL162678A0 (https=) |
| IS (1) | IS7348A (https=) |
| MX (1) | MXPA04006806A (https=) |
| NO (1) | NO20043370L (https=) |
| NZ (1) | NZ533750A (https=) |
| PL (1) | PL371432A1 (https=) |
| RU (1) | RU2312105C9 (https=) |
| TW (1) | TWI328007B (https=) |
| WO (1) | WO2003059893A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004010A1 (en) * | 2002-07-10 | 2006-01-05 | Hiromu Habashita | Ccr4 antagonist and medical use thereof |
| GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| US7482355B2 (en) | 2002-08-24 | 2009-01-27 | Astrazeneca Ab | Pyrimidine derivatives as modulators of chemokine receptor activity |
| SE0301653D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| SE0302304D0 (sv) * | 2003-08-27 | 2003-08-27 | Astrazeneca Ab | Novel compounds |
| EP1661889A4 (en) * | 2003-09-05 | 2009-08-05 | Ono Pharmaceutical Co | ANTAGONIST OF THE CHEMOKINE RECEPTOR AND ITS USE FOR MEDICAL PURPOSES |
| GB0401269D0 (en) * | 2004-01-21 | 2004-02-25 | Astrazeneca Ab | Compounds |
| WO2006020830A2 (en) * | 2004-08-12 | 2006-02-23 | Amgen Inc. | Bisaryl-sulfonamides |
| KR101280095B1 (ko) | 2004-08-28 | 2013-09-09 | 아스트라제네카 아베 | 케모킨 수용체 조절제로서의 피리미딘 술폰아미드 유도체 |
| TW200800921A (en) * | 2005-09-19 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| WO2007063934A1 (ja) * | 2005-12-02 | 2007-06-07 | Mitsubishi Tanabe Pharma Corporation | 脂環式複素環化合物 |
| US20090182142A1 (en) * | 2005-12-02 | 2009-07-16 | Shigeru Furukubo | Aromatic Compound |
| TW200730512A (en) * | 2005-12-12 | 2007-08-16 | Astrazeneca Ab | Novel compounds |
| GB0526255D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| EP2170848B1 (en) | 2007-06-27 | 2014-10-22 | AstraZeneca AB | Pyrazinone derivatives and their use in the treatment of lung diseases |
| EP2276731A1 (en) * | 2008-04-09 | 2011-01-26 | Boehringer Ingelheim International GmbH | 2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10 |
| WO2010053182A1 (ja) | 2008-11-10 | 2010-05-14 | 協和発酵キリン株式会社 | キヌレニン産生抑制剤 |
| EP2727908A3 (en) * | 2009-04-22 | 2014-08-20 | Axikin Pharmaceuticals, Inc. | 2,5-disubstituted arylsulfonamide CCR3 antagonists |
| TWI535442B (zh) | 2010-05-10 | 2016-06-01 | Kyowa Hakko Kirin Co Ltd | A nitrogen-containing heterocyclic compound having an action of inhibiting the production of canine erythritine |
| ES2552100T3 (es) * | 2010-12-16 | 2015-11-25 | Allergan, Inc. | Nuevos derivados de 1,2-bis-sulfonamida como moduladores de receptores de quimiocinas |
| JP6047497B2 (ja) | 2011-11-09 | 2016-12-21 | 協和発酵キリン株式会社 | 含窒素複素環化合物 |
| JP6327803B2 (ja) * | 2013-07-09 | 2018-05-23 | 久慶 ▲ふく▼楊 | 大出力高効率単相多極発電機 |
| CN106008418A (zh) * | 2016-05-20 | 2016-10-12 | 厦门大学 | 一种5-氨甲基-2-呋喃甲醇的合成方法 |
| CN111971279B (zh) * | 2018-01-26 | 2025-09-09 | 拉普特医疗公司 | 趋化因子受体调节剂及其用途 |
| CN113069446B (zh) * | 2021-03-01 | 2022-12-02 | 中山亿维迪科技有限公司 | El102在制备治疗新型冠状病毒所致疾病的药物中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US143024A (en) * | 1873-09-23 | Improvement in clothes-pins | ||
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| CA2162630C (en) | 1994-11-25 | 2007-05-01 | Volker Breu | Sulfonamides |
| GB2295616A (en) | 1994-12-01 | 1996-06-05 | Zeneca Ltd | N-Diazine-benzenesulphonamide derivatives as endothelin receptor antagonists |
| GB9512697D0 (en) | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
| US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| WO2000001389A1 (en) | 1998-07-06 | 2000-01-13 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| DE60030764T2 (de) | 1999-12-15 | 2007-09-13 | Bristol-Myers Squibb Co. | Biphenyl - sulfonamide als duale angiotensin - endothelin - rezeptor - antagonisten |
| AU2002358390A1 (en) | 2001-12-18 | 2003-06-30 | Astrazeneca Ab | Novel compounds |
| US20060004010A1 (en) | 2002-07-10 | 2006-01-05 | Hiromu Habashita | Ccr4 antagonist and medical use thereof |
| SE0301650D0 (sv) | 2003-06-04 | 2003-06-04 | Astrazeneca Ab | Novel compounds |
| SE0301653D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| SE0301654D0 (sv) | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| SE0302304D0 (sv) * | 2003-08-27 | 2003-08-27 | Astrazeneca Ab | Novel compounds |
| TW200800921A (en) | 2005-09-19 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| TW200730512A (en) * | 2005-12-12 | 2007-08-16 | Astrazeneca Ab | Novel compounds |
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2003
- 2003-01-07 TW TW092100237A patent/TWI328007B/zh active
- 2003-01-14 AU AU2003201802A patent/AU2003201802A1/en not_active Abandoned
- 2003-01-14 PL PL03371432A patent/PL371432A1/xx not_active Application Discontinuation
- 2003-01-14 IL IL16267803A patent/IL162678A0/xx unknown
- 2003-01-14 KR KR10-2004-7010982A patent/KR20040073566A/ko not_active Ceased
- 2003-01-14 CN CNB038044811A patent/CN100357275C/zh not_active Expired - Fee Related
- 2003-01-14 CA CA002472204A patent/CA2472204A1/en not_active Abandoned
- 2003-01-14 EP EP03700655A patent/EP1467976B1/en not_active Expired - Lifetime
- 2003-01-14 AT AT03700655T patent/ATE534635T1/de active
- 2003-01-14 NZ NZ533750A patent/NZ533750A/xx unknown
- 2003-01-14 BR BR0306922-2A patent/BR0306922A/pt not_active IP Right Cessation
- 2003-01-14 US US10/501,510 patent/US7662825B2/en not_active Expired - Fee Related
- 2003-01-14 MX MXPA04006806A patent/MXPA04006806A/es active IP Right Grant
- 2003-01-14 RU RU2004119966/04A patent/RU2312105C9/ru not_active IP Right Cessation
- 2003-01-14 WO PCT/SE2003/000041 patent/WO2003059893A1/en not_active Ceased
- 2003-01-14 JP JP2003559997A patent/JP4504021B2/ja not_active Expired - Fee Related
- 2003-01-14 ES ES03700655T patent/ES2375107T3/es not_active Expired - Lifetime
- 2003-01-16 AR ARP030100126A patent/AR038179A1/es unknown
-
2004
- 2004-07-08 IS IS7348A patent/IS7348A/is unknown
- 2004-07-15 CO CO04067437A patent/CO5640137A2/es not_active Application Discontinuation
- 2004-08-13 NO NO20043370A patent/NO20043370L/no not_active Application Discontinuation
-
2009
- 2009-05-05 US US12/435,864 patent/US20100081670A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IS7348A (is) | 2004-07-08 |
| AR038179A1 (es) | 2005-01-05 |
| RU2004119966A (ru) | 2005-06-10 |
| TW200303308A (en) | 2003-09-01 |
| EP1467976A1 (en) | 2004-10-20 |
| BR0306922A (pt) | 2004-11-09 |
| KR20040073566A (ko) | 2004-08-19 |
| ES2375107T3 (es) | 2012-02-24 |
| WO2003059893A1 (en) | 2003-07-24 |
| RU2312105C9 (ru) | 2008-06-10 |
| HK1068885A1 (en) | 2005-05-06 |
| CN100357275C (zh) | 2007-12-26 |
| RU2312105C2 (ru) | 2007-12-10 |
| CN1639132A (zh) | 2005-07-13 |
| NZ533750A (en) | 2006-03-31 |
| AU2003201802A1 (en) | 2003-07-30 |
| PL371432A1 (en) | 2005-06-13 |
| US20060025423A1 (en) | 2006-02-02 |
| MXPA04006806A (es) | 2004-12-06 |
| US20100081670A1 (en) | 2010-04-01 |
| EP1467976B1 (en) | 2011-11-23 |
| TWI328007B (en) | 2010-08-01 |
| CA2472204A1 (en) | 2003-07-24 |
| CO5640137A2 (es) | 2006-05-31 |
| NO20043370L (no) | 2004-09-28 |
| JP2005521650A (ja) | 2005-07-21 |
| IL162678A0 (en) | 2005-11-20 |
| US7662825B2 (en) | 2010-02-16 |
| ATE534635T1 (de) | 2011-12-15 |
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