JP4476570B2 - Full-injection aerosol-type disinfectant - Google Patents
Full-injection aerosol-type disinfectant Download PDFInfo
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- JP4476570B2 JP4476570B2 JP2003173575A JP2003173575A JP4476570B2 JP 4476570 B2 JP4476570 B2 JP 4476570B2 JP 2003173575 A JP2003173575 A JP 2003173575A JP 2003173575 A JP2003173575 A JP 2003173575A JP 4476570 B2 JP4476570 B2 JP 4476570B2
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- 238000002347 injection Methods 0.000 title claims description 30
- 239000007924 injection Substances 0.000 title claims description 30
- 239000000645 desinfectant Substances 0.000 title claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 49
- 239000000443 aerosol Substances 0.000 claims description 45
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 20
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 1
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- 239000003350 kerosene Substances 0.000 description 1
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Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
【０００１】
【産業上の利用分野】
本発明は、除菌剤の改良、具体的には全量噴射エアゾール型除菌剤に関するものである。
【０００２】
【従来の技術】
従来より、食品の腐敗及びそれに起因する食中毒の発生予防や、台所・調理台等の除菌などを目的として、様々な殺菌・消毒剤ならびに除菌剤が使用されてきた。このうち、公衆衛生用の殺菌・消毒剤は、殺菌効力の高い成分（ポピドンヨード、グルタルアルデヒドなど）を使用し医薬品に該当するため、一般家庭で簡単に取り扱えない。一方、食品用エタノールの除菌性を利用したアルコールスプレーが台所用などで広く用いられているが、その除菌効果は低く持続時間も短い。そこで、例えば、特開２００２−３６９８７３号公報には、水系ウレタン樹脂及び低級アルコールと、消臭剤及び／又は除菌剤を含有する消臭及び／又は除菌用組成物が開示され、消臭剤及び／又は除菌剤の一例としてグルコン酸クロルヘキシジンがあげられているが、あくまでソファー、カーペットなどの繊維の表面への噴霧を目的とし、部屋全体を効率的に除菌しようとするものではない。これに対し、特開２００２−２０２０２号公報は、有効成分が害虫防除成分、消臭成分、防菌成分、防黴成分から選択された２種以上の異種成分からなる室内処理用の全量噴射型エアゾールを開示するが、害虫防除を主体にしているため、除菌効果の観点から十分に検討されているとは言いがたい。
【０００３】
【特許文献１】
特開２００２−３６９８７３号公報
【特許文献２】
特開２００２−２０２０２号公報
【０００４】
【発明が解決しようとする課題】
本発明は、除菌効果とその持続性にすぐれ、しかも部屋全体を効率的に除菌できる全量噴射エアゾール型除菌剤を提供することを目的とする。
【０００５】
（１）エアゾール内容物全体量に対してグルコン酸クロルヘキシジンを０．０３〜３．０ｗ／ｖ％、エタノールを１０〜３０容量％及び水を１０〜３７容量％、更に、植物性ポリフェノールを０．０２〜１．０ｗ／ｖ％含有し、かつ水／エタノールの容量比が０．４／１．０〜３．２／１．０であるエアゾール原液と、ジメチルエーテルを含む噴射剤からなるエアゾール内容物を、容器内圧として０．３〜０．６ＭＰａでエアゾール容器に充填し、かつ噴射ボタン作動後５〜６０秒のタイムラグを設けて噴射を開始する遅延噴射機構を装填した全量噴射エアゾール型除菌剤。
（２）植物性ポリフェノールが、茶抽出物、柿抽出物、グレープフルーツ種子抽出物から選ばれた一種又は二種であることを特徴とする（１）の全量噴射エアゾール型除菌剤。
【０００６】
【発明の実施の形態】
本発明で用いる除菌成分・グルコン酸クロルヘキシジンは、ビスジグアナイド系殺菌剤で、グラム陽性及び陰性菌などの各種細菌に対して高い殺菌力を示すとともに持続性にもすぐれ、手指消毒液として用いられているものである。
本発明では、このグルコン酸クロルヘキシジンをエアゾール内容物全体量に対して０．０３〜３．０ｗ／ｖ％、エタノールを１０〜３０容量％及び水を１０〜３７容量％含有し、かつ水／エタノールの容量比が０．４／1．０〜３．２／1．０であるエアゾール原液を用いたことに特徴を有する。すなわち、エアゾール原液と後記ジメチルエーテル主体の噴射剤とを組み合わせて除菌用エアゾール内容物を調製するにあたり、グルコン酸クロルヘキシジン、エタノール及び水をこの特定の比率で配合したエアゾール原液を用いることによって、最もすぐれた除菌効果を奏することを見出し、本発明を完成したものである。
【０００７】
グルコン酸クロルヘキシジンの配合量が、エアゾール内容物全体量に対して０．０３ｗ／ｖ％未満であると十分な除菌効果が得られず、一方３．０ｗ／ｖ％を超えた場合、除菌効果が飽和するばかりか、エアゾール内容物の液性に影響を及ぼす恐れがある。
また、エタノールの配合量については、グルコン酸クロルヘキシジンとの相乗的な除菌効果ならびに製剤物性や噴射性能の点から１０〜３０容量％に特定される。すなわち、１０容量％に満たないと、グルコン酸クロルヘキシジンの除菌効果を引き出せず、製剤の安定性でも好ましくない。一方３０容量％を越えると、水を加えたエアゾール原液の比率が上がり、噴射されたエアゾール内容物の拡散性に問題を生じる。
水はグルコン酸クロルヘキシジンの除菌効果を持続させるために必要で、エタノールや後記ジメチルエーテルとの配合比率を検討した結果、エアゾール内容物全体量に対して１０〜３７容量％で、かつ水／エタノールの容量比を０．４／1．０〜３．２／1．０に設定するのが最適であることが認められた。
【０００８】
本発明で用いるエアゾール原液には、除菌効果を増強するために、植物性ポリフェノールをエアゾール内容物全体量に対して０．０２〜１．０ｗ／ｖ％配合するのが好ましい。植物性ポリフェノールは、植物内で二次代謝物として広く分布するものであり、例えばフラボノイド類、イソフラボノイド類、ネオフラボノイド類、カテコール及びその誘導体類、フェノール性酸及びその誘導体類などの単一もしくは混合物で代表される。それらは、茶、柿、グレープフルーツ、ヨモギ、ホオノキ、レンギョウなどの植物からの抽出物であってもよく、特に、茶抽出物、柿抽出物、グレープフルーツ種子抽出物から選ばれた一種又は二種が本発明に好適である。
かかる植物性ポリフェノールを配合することによって、除菌効果を増強することはもちろん、消臭効果を付与したり、「シックハウス症候群」で問題となっているホルムアルデヒド等の有害揮散性化合物の除去も期待しえるものである。
【０００９】
また、本発明のエアゾール原液には、本発明の趣旨に支障を来たさない限りにおいて、有機溶剤（エタノール以外のアルコール類、グリコール類、グリコールエーテル類、ケトン類、エステル類、灯油等の炭化水素類など）、界面活性剤（ポリオキシエチレンアルキルエーテル類、ポリオキシエチレンソルビタン脂肪酸エステル類、グリセリン脂肪酸エステル類など）、分散剤、香料、安定剤（ＢＨＴ、ＢＨＡなど）、防錆剤（安息香酸ナトリウム、クエン酸アンモニウムなど）、賦形剤などを必要に応じて添加してもよい。
更に、本発明では、例えば塩化ベンザルコニウムやε−ポリリジンなどの他のタイプの殺菌・消毒剤、ヒノキチオールやイソプロピルメチルフェノールなどの抗菌・防黴成分、ピレスロイド剤で代表される殺虫成分、殺ダニ成分、忌避成分などを適宜添加して多目的組成物とすることもできる。
【００１０】
本発明の全量噴射エアゾール型除菌剤を構成する噴射剤としては、ジメチルエーテル（ＤＭＥ）を主体に用いる。もちろん、噴射性能の調整のために、液化石油ガス（ＬＰＧ）、弗化炭化水素ガス（フロンガス）や圧縮ガス（窒素ガスや炭酸ガス等）を若干配合しうるが、液化石油ガスや弗化炭化水素ガスをベースにすると、エアゾール原液との相溶性に問題を生じるだけでなく、その除菌効果にも支障をきたす。
また、本発明では、エアゾール内容物の噴霧粒子の平均粒子径を３０μｍ以下に抑えるのが好ましく、エアゾール原液と噴射剤の比率を、２５／７５〜５０／５０(容量比)、更に好ましくは３０／７０〜４５／５５(容量比)の範囲に設定するとよい。
【００１１】
本発明の全量噴射エアゾール型除菌剤を噴射させるためのエアゾール噴射は、エアゾール内容物を充填したエアゾール容器、バルブ、該バルブのステム部分に装着されるアクチュエーターなどから構成され、アクチュエーターには、噴口を含む噴射ボタン、遅延噴射機構部、これをカバーするスリーブなどが装填される。なお、エアゾール内容物を充填するに際しては、噴霧粒子の拡散性を考慮して容器内圧を０．３〜０．６ＭＰａに設定する必要がある。
【００１２】
本発明では人体に対する安全性の高い除菌成分・グルコン酸クロルヘキシジンが使用されるが、使用者に対する安全性を一層確保するために、噴射ボタン作動後５〜６０秒のタイムラグを設けて噴射する遅延噴射機構を備えることを必須とする。
遅延噴射機構としては、例えば、▲１▼その本体空間部に流入する内容物の圧力で弁部材が所定長だけ上方向に移動した時に、それまでの閉状態から開状態へと切り替わって内容物が噴出するタイプ（特開２００１−８９２号公報）や、▲２▼エアゾール内容物の噴出路に、エアゾール内容物との接触によって少なくとも一部を溶解し噴出路を開放する遮蔽体を配置したタイプ（特開平９−３０１４５８号公報）や、▲３▼シリンダを構成する密閉容器内部に流体が充填されており、作動時、その密閉容器の底に位置するピストンがエアゾール内圧により流体内を上方へ押し上げられる時、ピストンに形成された透孔を通ってその流体が前記シリンダ内をピストンの上から下に移動するように構成して噴射を調整するタイプ（特開平１０−２１６５７７号公報）などを例示できるが、これら以外にも様々なタイプが開示されている。本発明にはいずれも適用可能であるが、▲１▼のタイプが噴射性能上よりすぐれている。
【００１３】
こうして得られた本発明の全量噴射エアゾール型除菌剤、例えば１００ｍＬ容量缶のものは、５分以内で火災の心配なく６〜１０畳の部屋を簡便に処理できるうえ、大腸菌、枯草菌、乳酸球菌などの各種細菌に対して高い除菌効果を示し、効果の持続性にもすぐれている。また、遅延噴射機構を備えているので、使用者がエアゾール噴射物に触れたり吸入することなく部屋から退出する時間的猶予があり安全性の点でもより優れている。
【００１４】
【実施例】
次に、具体的実施例に基づいて、本発明の全量噴射エアゾール型除菌剤を更に詳細に説明するが、本発明はこれに限定されるものではない。
【００１５】
実施例
グルコン酸クロルヘキシジン０．５ｇ（エアゾール内容物全体量に対して０．５ｗ／ｖ％）、グレープフルーツ種子抽出物０．２ｇ（エアゾール内容物全体量に対して０．２ｗ／ｖ％）、エタノール１５ｍＬ（エアゾール内容物全体量に対して１５容量％）及び水２０ｍＬ（エアゾール内容物全体量に対して２０容量％）を含有するエアゾール原液３７ｍＬをエアゾール容器に入れ、該容器にバルブ部分を取り付け、該バルブ部分を通じて噴射剤としてのジメチルエーテル６３ｍＬを加圧充填した後、アクチュエーター（上面の外径が１２ｍｍの噴射ボタン１個と前述の▲１▼のタイプの遅延噴射機構を含む）を装填した。なお、容器内圧は０．４ＭＰａであった。
かかる本発明の全量噴射エアゾール型除菌剤を２５ｍ3の部屋の中央に置き、噴射ボタンを押して部屋を退出した。噴射ボタン作動約１０秒後に内容物が噴出し、部屋全体にくまなく拡散した。この除菌処理は極めて効率的で、各種細菌に対する高い除菌効果は数日間にわたり持続した。
【００１６】
試験例
実施例に準じて表１に示す各種全量噴射エアゾール型除菌剤（１００ｍＬ缶）を調製した。２５ｍ3の部屋の中央に置いて噴射し、以下の試験を実施した。なお、除菌剤Ａはグルコン酸クロルヘキシジンを示す。
（１）除菌効果：寒天培地表面に菌液（大腸菌）を塗布した培地入りシャーレ（内径９ｃｍ）を部屋の中央、四隅に配置し、噴射２４時間後、コロニーの形成の有無で除菌効果を評価した。表中、○：菌の抑制効果大、 △：菌の抑制効果わずかにあり、 ×：菌の抑制効果なし、で示した。
（２）噴霧粒子の拡散性能：上記部屋の中央又は四隅の除菌効果に基づいて評価した。表中、○：拡散性良好、 △：普通程度、 ×：不良、で示した。
【００１７】
【表１】
試験の結果、特定の比率でグルコン酸クロルヘキシジン、エタノール及び水を組み合わせたエアゾール原液と、ジメチルエーテル（ＤＭＥ）を主体とする噴射剤を用いてなる本発明の全量噴射エアゾール型除菌剤は、高い除菌効果を奏し噴霧粒子の拡散性能も優れた。
これに対し、比較例１や比較例２のように、グルコン酸クロルヘキシジンを配合しない一般的なアルコール製剤や、配合しても０．０３ｗ／ｖ％に満たない除菌剤は、除菌効果が劣った。一方、グルコン酸クロルヘキシジンの配合量が３．０ｗ／ｖ％を超えると（比較例３）、除菌効果が飽和するばかりか、エアゾールの噴射性能に悪影響を及ぼしメリットがなかった。
また、比較例４の如く、エタノールの配合量が所定量に比べて低すぎた場合、噴射剤が分離しエアゾールとして不適当で、グルコン酸クロルヘキシジンの除菌効果を活かすことができなかった。更に、水／エタノールの容量比を０．４未満にして水の配合量を減らした比較例５でも除菌効果が劣り、水の配合が特にグルコン酸クロルヘキシジンの除菌効果を持続させるうえで有用なことが認められた。なお、本発明１の噴射剤をＤＭＥからＬＰＧ主体に替えた比較例６は、除菌効果の低下を招いただけでなく、エアゾール内容物の相溶性にも問題があった。
【００１９】
【発明の効果】
本発明の全量噴射エアゾール型除菌剤は、部屋全体を簡便に処理できるうえ、大腸菌、枯草菌、乳酸球菌などの各種細菌に対して高い除菌効果を示し、効果の持続性にもすぐれている。また、遅延噴射機構を備えているので、使用者がエアゾール噴射物に触れたり吸入することなく部屋から退出する時間的猶予があり安全性の点でもより優れている。[0001]
[Industrial application fields]
The present invention relates to an improvement of a disinfectant, specifically, a total-injection aerosol-type disinfectant.
[0002]
[Prior art]
Conventionally, various disinfecting / disinfecting agents and disinfecting agents have been used for the purpose of preventing the occurrence of food spoilage and food poisoning resulting therefrom, and disinfecting kitchens and kitchen tables. Of these, disinfectants for public health use ingredients with high bactericidal efficacy (popidone iodine, glutaraldehyde, etc.) and fall under the category of pharmaceuticals, and therefore cannot be easily handled at home. On the other hand, alcohol sprays utilizing the sterilizing properties of ethanol for foods are widely used in kitchens and the like, but their sterilizing effect is low and their duration is short. Thus, for example, JP-A-2002-369873 discloses a deodorizing and / or disinfecting composition containing a water-based urethane resin and a lower alcohol, a deodorizing agent and / or a disinfecting agent. Although chlorhexidine gluconate is mentioned as an example of an agent and / or disinfectant, it is not intended to efficiently disinfect the entire room only for the purpose of spraying on the surface of fibers such as sofas and carpets. . On the other hand, Japanese Patent Application Laid-Open No. 2002-20202 discloses a total amount injection type for indoor treatment in which an active ingredient is composed of two or more kinds of different components selected from a pest control component, a deodorant component, a fungicide component, and a fungus component. Although the aerosol is disclosed, it is difficult to say that it has been sufficiently studied from the viewpoint of the sterilizing effect because it mainly controls pests.
[0003]
[Patent Document 1]
JP 2002-369873 A [Patent Document 2]
Japanese Patent Laid-Open No. 2002-20202
[Problems to be solved by the invention]
An object of the present invention is to provide a whole-volume spray aerosol-type disinfectant that is excellent in disinfecting effect and its sustainability and that can efficiently disinfect the entire room.
[0005]
(1) 0.03-3.0 w / v% of chlorhexidine gluconate, 10-30% by volume of ethanol and 10-37% by volume of water, and 0.1% of vegetable polyphenol with respect to the total amount of aerosol content . Aerosol content comprising an aerosol stock solution containing 02 to 1.0 w / v% and having a water / ethanol volume ratio of 0.4 / 1.0 to 3.2 / 1.0, and a propellant containing dimethyl ether Full-injection aerosol-type disinfectant loaded with a delay injection mechanism that starts injection by providing a time lag of 5 to 60 seconds after operation of the injection button .
( 2 ) The total amount spray aerosol-type disinfectant according to (1), wherein the plant polyphenol is one or two selected from tea extract, koji extract, and grapefruit seed extract.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
The sterilizing ingredient chlorhexidine gluconate used in the present invention is a bisdiguanide fungicide and exhibits high bactericidal activity against various bacteria such as gram-positive and negative bacteria, and has excellent durability, and is used as a hand sanitizer. It is what.
In the present invention, this chlorhexidine gluconate contains 0.03-3.0 w / v%, 10-30% ethanol and 10-37% water by volume, and water / ethanol. This is characterized in that an aerosol stock solution having a volume ratio of 0.4 / 1.0 to 3.2 / 1.0 was used. That is, in preparing an aerosol content for sterilization by combining an aerosol stock solution and a dimethyl ether-based propellant described later, it is best to use an aerosol stock solution containing chlorhexidine gluconate, ethanol and water in this specific ratio. The present invention has been completed by finding that it has a sterilizing effect.
[0007]
If the amount of chlorhexidine gluconate is less than 0.03 w / v% with respect to the total amount of the aerosol content, a sufficient sterilizing effect cannot be obtained. Not only is the effect saturated, it may affect the liquid properties of the aerosol contents.
In addition, the blending amount of ethanol is specified to be 10 to 30% by volume from the viewpoint of synergistic sterilization effect with chlorhexidine gluconate, pharmaceutical properties and jetting performance. That is, if it is less than 10% by volume, the sterilizing effect of chlorhexidine gluconate cannot be brought out, and the stability of the preparation is not preferable. On the other hand, if it exceeds 30% by volume, the ratio of the aerosol stock solution to which water is added increases, which causes a problem in the diffusibility of the injected aerosol contents.
Water is necessary to maintain the sterilization effect of chlorhexidine gluconate. As a result of examining the blending ratio with ethanol and dimethyl ether described later, it is 10 to 37% by volume with respect to the total amount of the aerosol content, and water / ethanol It has been found that it is optimal to set the volume ratio to 0.4 / 1.0 to 3.2 / 1.0.
[0008]
In order to enhance the sterilization effect, the aerosol stock solution used in the present invention preferably contains 0.02-1.0 w / v% of plant polyphenol with respect to the total amount of the aerosol content. Plant polyphenols are widely distributed as secondary metabolites in plants, such as flavonoids, isoflavonoids, neoflavonoids, catechol and derivatives thereof, single or a phenolic acid and derivatives thereof, etc. Represented by the mixture. They may be extracts from plants such as tea, rice cake, grapefruit, mugwort, honoki, forsythia, and in particular one or two selected from tea extract, koji extract, grapefruit seed extract. Suitable for the present invention.
In addition to enhancing the sterilization effect by blending such a plant polyphenol, it is also expected to provide a deodorizing effect and remove harmful volatile compounds such as formaldehyde that are a problem in "sick house syndrome". It is what
[0009]
In addition, the aerosol stock solution of the present invention contains carbon dioxide such as organic solvents (alcohols other than ethanol, glycols, glycol ethers, ketones, esters, kerosene, etc.) as long as the gist of the present invention is not impaired. Hydrogen), surfactants (polyoxyethylene alkyl ethers, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, etc.), dispersants, fragrances, stabilizers (BHT, BHA, etc.), rust preventives (benzoic incense) Sodium acid, ammonium citrate, etc.), excipients and the like may be added as necessary.
Furthermore, in the present invention, for example, other types of bactericidal / disinfecting agents such as benzalkonium chloride and ε-polylysine, antibacterial / antifungal components such as hinokitiol and isopropylmethylphenol, insecticidal components typified by pyrethroid agents, Ingredients, repellent ingredients and the like can be added as appropriate to make a multipurpose composition.
[0010]
Dimethyl ether (DME) is mainly used as a propellant constituting the total injection aerosol type disinfectant of the present invention. Of course, liquefied petroleum gas (LPG), fluorinated hydrocarbon gas (Freon gas) and compressed gas (nitrogen gas, carbon dioxide gas, etc.) may be mixed slightly to adjust the injection performance. When hydrogen gas is used as a base, it not only causes a problem in compatibility with the aerosol stock solution, but also has a problem in its sterilization effect.
In the present invention, the average particle diameter of the spray particles of the aerosol content is preferably suppressed to 30 μm or less, and the ratio of the aerosol stock solution to the propellant is 25/75 to 50/50 (volume ratio), more preferably 30. It may be set in the range of / 70 to 45/55 (capacity ratio).
[0011]
The aerosol injection for injecting the full-amount aerosol-type disinfectant of the present invention is composed of an aerosol container filled with an aerosol content, a valve, an actuator mounted on the stem portion of the valve, and the like. Are loaded with an injection button, a delay injection mechanism, a sleeve covering the injection button, and the like. When filling the aerosol contents, it is necessary to set the internal pressure of the container to 0.3 to 0.6 MPa in consideration of the diffusibility of the spray particles.
[0012]
In the present invention, a highly sterilizing component, chlorhexidine gluconate, which is highly safe for the human body is used, but in order to further secure the safety for the user, a delay of 5-60 seconds after the injection button is activated for injection It is essential to provide an injection mechanism.
Examples of the delay injection mechanism include: (1) When the valve member moves upward by a predetermined length due to the pressure of the contents flowing into the main body space, the contents are switched from the closed state until then to the open state. Type (JP-A-2001-892), or (2) type in which a shield that melts at least a part by contact with the aerosol contents and opens the ejection path is disposed in the aerosol content ejection path (3) Japanese Patent Laid-Open Publication No. 9-301458 and (3) The inside of the sealed container constituting the cylinder is filled with fluid, and during operation, the piston located at the bottom of the sealed container moves upward in the fluid by the aerosol internal pressure. A type in which, when pushed up, the fluid moves through the through hole formed in the piston so that the fluid moves in the cylinder from above to below the piston (JP-A-10-2). And which may or may not be 6577 JP), but various types are disclosed besides these. Any of the present invention can be applied, but the type {circle around (1)} is superior in jetting performance.
[0013]
The thus-obtained total amount sprayed aerosol-type disinfectant of the present invention, for example, a 100 mL capacity can, can easily treat a 6-10 tatami room within 5 minutes without fear of a fire, and can also be used for Escherichia coli, Bacillus subtilis, lactic acid. It shows high sterilization effect against various bacteria such as cocci and has excellent sustainability. In addition, since the delay injection mechanism is provided, the user has time to leave the room without touching or inhaling the aerosol spray, which is superior in terms of safety.
[0014]
【Example】
Next, based on specific examples, the full-injection aerosol-type disinfectant of the present invention will be described in more detail, but the present invention is not limited thereto.
[0015]
Example Chlorhexidine gluconate 0.5 g (0.5 w / v% based on the total amount of aerosol contents), 0.2 g of grapefruit seed extract (0.2 w / v% based on the total amount of aerosol contents), ethanol Place 37 mL of an aerosol stock solution containing 15 mL (15% by volume with respect to the total amount of aerosol contents) and 20 mL of water (20% by volume with respect to the total amount of aerosol contents) in an aerosol container, and attach a valve portion to the container. After pressurizing and filling 63 mL of dimethyl ether as a propellant through the valve portion, an actuator (including one injection button with an outer diameter of 12 mm on the upper surface and the delay injection mechanism of the type {circle around (1)} above) was loaded. The container internal pressure was 0.4 MPa.
The total amount spray aerosol-type disinfectant of the present invention was placed in the center of a 25 m 3 room, and the spray button was pushed to leave the room. About 10 seconds after the injection button was activated, the contents erupted and diffused throughout the room. This sterilization treatment was extremely efficient, and the high sterilization effect against various bacteria lasted for several days.
[0016]
Test Examples Various types of sprayed aerosol-type disinfectants (100 mL cans) shown in Table 1 were prepared according to Examples. The following test was carried out by spraying in the center of a 25 m 3 room. In addition, disinfectant A shows chlorhexidine gluconate.
(1) Bactericidal effect: A petri dish containing medium (9 cm inner diameter) coated with a bacterial solution (E. coli) on the surface of an agar medium is placed in the center and at the four corners of the room. Evaluated. In the table, ◯: The effect of suppressing the fungus is large, Δ: The effect of suppressing the fungus is slightly, and ×: The effect of suppressing the fungus is not shown.
(2) Diffusion performance of spray particles: Evaluated based on the sterilization effect at the center or four corners of the room. In the table, ◯: good diffusibility, Δ: normal degree, ×: poor.
[0017]
[Table 1]
As a result of the test, the total amount injection aerosol-type disinfectant of the present invention using an aerosol stock solution combining chlorhexidine gluconate, ethanol and water at a specific ratio and a propellant mainly composed of dimethyl ether (DME) Excellent fungus effect and spray particle diffusion performance.
On the other hand, as in Comparative Example 1 and Comparative Example 2, a general alcohol preparation that does not contain chlorhexidine gluconate or a disinfectant that is less than 0.03 w / v even if added, has a disinfecting effect. inferior. On the other hand, when the blending amount of chlorhexidine gluconate exceeded 3.0 w / v% (Comparative Example 3), not only the disinfection effect was saturated, but also the aerosol injection performance was adversely affected and there was no merit.
Further, as in Comparative Example 4, when the blending amount of ethanol was too low as compared with the predetermined amount, the propellant was separated and unsuitable as an aerosol, and the sterilizing effect of chlorhexidine gluconate could not be utilized. Furthermore, even in Comparative Example 5 in which the water / ethanol volume ratio was less than 0.4 and the amount of water was reduced, the sterilization effect was inferior, and the water formulation was particularly useful for maintaining the sterilization effect of chlorhexidine gluconate. That was recognized. Note that Comparative Example 6 in which the propellant of the present invention 1 was changed from DME to LPG mainly had a problem in the compatibility of the aerosol contents as well as a decrease in the sterilization effect.
[0019]
【The invention's effect】
The total injection aerosol type disinfectant of the present invention can easily treat the entire room, shows a high disinfecting effect against various bacteria such as Escherichia coli, Bacillus subtilis, and lactic acid cocci, and has excellent sustainability. Yes. In addition, since the delay injection mechanism is provided, the user has time to leave the room without touching or inhaling the aerosol spray, which is superior in terms of safety.
Claims (2)
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