JP2006028147A - Spray type room space sterilizing agent and spray type room space sterilizing method using the agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a spray type room space sterilizing agent and to provide a spray type room space sterilizing method that can effectively and efficiently sterilize the whole space in rooms of a hospital or a food plant. <P>SOLUTION: In the spray type room space sterilizing method, the spray type room space sterilizing agent containing 0.5 to 2 %wt. of 2,4,4'-trichloro-2'-hydroxy diphenyl ether represented by formula (1), 5 to 15 %wt. of an alcoholic solvent or acetone, and 83 to 94.5 %wt. of liquefied carbon dioxide is sprayed with a spray gun in the room till every corners. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a disinfectant and a disinfecting method for disinfecting indoors and the like over a wide area.

  As a conventional method of sterilizing a room or the like, there is a method of heating a sterilizing agent to vaporize an active ingredient (for example, see Patent Document 1). There is also a method of spraying a sterilizing component as an aerosol. (For example, see Patent Document 2)

In this method of heating the bactericide to vaporize the active ingredient, the application amount is changed depending on the preparation form, application time, application place, etc., but the drug in the space 1 m ³ varies widely and usually 0.001 to 10 g. It has become. Moreover, the method of spraying a sterilizing component as an aerosol is a method in which clothing or the like is placed in an application place after being sprayed in a narrow place such as a chiffon, a closet, or a clothes box.
JP2003-40712 JP2003-238321

  As a problem to be solved, in the case of a method in which an active ingredient is vaporized by heating a bactericide, there is a large variation in the dose of the space. In the case of the aerosol spraying method, only a narrow space is targeted. As described above, the medicine reaches every corner of a wide space in the room, and there is nothing that can sterilize and disinfect the room sufficiently effectively and efficiently.

で示される２，４，４’−トリクロロ−２’−ヒドロキシジフェニルエ−テル化合物（以下、本化合物と記す。）と付着面への展着効果があるアルコール系溶媒またはアセトン（以下、本展着成分と記す。）と、これらの成分を溶解してなる液化二酸化炭素（以下、本噴霧成分と記す。）がサイホン管付き耐圧容器中に含有されてなることを特徴とする空間噴霧殺菌剤（以下、本殺菌剤と記す。）及び本殺菌剤を投薬ガンより室内に噴霧処理することを特徴とする室内の空間噴霧殺菌方法に関するものである。In order to achieve the above-mentioned object, the present invention has the formula (1)

2,4,4′-trichloro-2′-hydroxydiphenyl ether compound (hereinafter referred to as the present compound) and an alcohol solvent or acetone (hereinafter referred to as the present exhibition) having a spreading effect on the adhesion surface. And a liquefied carbon dioxide obtained by dissolving these components (hereinafter referred to as the present spray component) in a pressure-resistant container with a siphon tube. (Hereinafter referred to as the present bactericidal agent) and an indoor space spray sterilizing method characterized in that the bactericidal agent is sprayed indoors from a dosing gun.

  The present compound (generic name: trictosan) used in the present invention has a wide sterilization range and exhibits strong sterilization and antibacterial activity against many types of bacteria and fungi.

  The present spreading component increases the adhesion rate of the present compound to the floor surface, wall surface, ceiling surface, object, etc., and increases the sterilizing and disinfecting effect.

  The spray component is mainly composed of the compound, the spreading component, and liquefied carbon dioxide. In the spray component, as long as the effect of the present invention is not impaired, plant essential oil, synthetic fragrance, antioxidant, Furthermore, other bactericidal compounds and insecticidal compounds may be contained.

This disinfectant is filled with the spray component in a pressure vessel with a siphon tube, and is usually in a pressurized state of about 65 to 75 kg / cm ² at 20 ° C. Under such pressure, carbon dioxide is liquefied. The present compound and the present spreading component are dissolved in the liquefied carbon dioxide. In addition, when it becomes about 31 degreeC or more, a carbon dioxide will be in a supercritical state and this compound and this spreading component will be isolate | separated.

  The pressure vessel is not particularly limited as long as the spray component can be stably held in the pressure range, and examples of the material include iron, stainless steel, aluminum, and the like. The thing of the shape used in the high pressure gas container for carbon dioxide etc. can be used. The pressure vessel may be of any structure that can take out the spray components as a liquid.

  As a specific example of such a pressure vessel, for example, the one shown in FIG. 1 can be cited. The outer pressure vessel is composed of a pressure vessel body 1 and a siphon tube 2. Examples of the material of the siphon tube include copper, a copper alloy, and stainless steel, and the tube is a single tube that reaches the bottom of the pressure vessel main body. The inner diameter is about 3 to 5 mm. As the spray gun attached to the pressure vessel main body, one having a nozzle diameter of 0.3 to 1.0 mm, preferably 0.5 mm is usually used.

  The present bactericidal agent can be prepared by placing the present compound and the present spreading component in a pressure-resistant container, attaching a valve with a siphon tube, and then pressurizing and filling a predetermined amount of liquefied carbon dioxide. The total amount of the drug filled in the pressure vessel is usually about 700 g per 1 L of the pressure vessel.

  Specific examples of plant essential oils and synthetic fragrances that can be contained in the spray component and have bactericidal and insect repellent effects include peppermint oil, peppermint oil, cypress oil, hiba oil, pine oil, lavender oil, eucalyptus oil, citronella oil, lime Oil, hyssop oil, rosemary oil, tea tree oil, rose oil, ylang ylang oil, clove oil, bay oil, geranium oil, sage oil, patchouli oil, winter grease oil, etc. Ionone, phenoxyethanol, linalool, dihydrolinalol, cineol, citronol, eugenol, menthol, menthone, etc. are raised, and vitamin Es such as α, β, γ, and δ-tocopherol as antioxidants, γ-oryzanol, dibutylhydroxyanisole (BHA), dibutylhydroxytolue (BHT).

  Examples of the bactericidal and antibacterial compounds include aldehyde-based, alcohol-based, peroxide-based, iodine compounds, chlorine compounds, hyguanite-based, ionic surfactants, etc. in addition to phenolic bactericidal and antibacterial agents other than triclosan. .

  Examples of insecticidal and insecticidal compounds include pyrethroids, organophosphorus compounds and carbamate compounds.

  Pest repellent compounds include N-cyanoamidine compounds, chlorine compounds, thiourea compounds, phenylpyrazole compounds, and the like.

By spraying the disinfectant toward the floor, wall, ceiling, space and object to be sterilized with a spray gun, the entire application chamber can be sterilized. This treatment is particularly effective for sterilizing bacteria, fungi and the like. The spray amount is usually 1 to 50 g / m ³ , preferably ³ to 20 g / m ³ .

  For example, when the disinfectant is sprayed with an injection gun toward the upper space of a room, carbon dioxide is vaporized, and the present compound and spreading component are accompanied by the vaporized carbon dioxide to form a fine particle state (particle size of several to several tens of particles). μm), drifting into the applicable space and arriving throughout the room. Further, the spreading component is integrated with the present compound, and the present compound strongly adheres to the object when it adheres to the indoor object, so that the bactericidal effect can be enhanced.

  This disinfectant can be used in various rooms that require cleanliness, such as hospitals, food factories, offices, cafeterias, houses, hotel accommodations, museums, etc., and can be sterilized effectively and efficiently. Is.

  As an effect of the present invention, since the present compound having a wide sterilization range and strong sterilization and antibacterial activity against various types of bacteria is sprayed as ultrafine particles, it can spread to every corner of the whole space by self-diffusion. it can. Moreover, a specific space can also be processed efficiently and effectively by processing with a spray gun the place where medicines are difficult to enter, such as a gap between an object and a wall under a desk.

In addition, when a specific object is desired to be sterilized or disinfected, the spreading component increases the adhesion rate of the present compound and increases the sterilizing / disinfecting effect by directly treating it with a spray gun.
As described above, it is possible to sterilize every corner of the indoor space that you want to sterilize, and when there is an object or space that you want to sterilize intensively, it is more efficient by intensively spraying the spray gun toward the place And a sterilizing method that can be effectively sterilized.

  This space spray disinfectant and the space spray disinfecting method using this agent are particularly intended for hospitals, food factories and the like that require disinfection in the room.

  In hospitals, etc., the infection prevention that has recently become a problem, especially MRSA (methicillin-resistant Staphylococcus aureus), etc. are effective in spraying this disinfectant into the room, thereby disinfecting the whole room, and in particular the bed to be disinfected. It is a space spray sterilization agent and a space spray sterilization method that sterilizes and sterilizes a room efficiently and effectively by spraying an instrument material toward a spray gun.

  Similarly, in food factories and the like, spraying this fungicide effective for the prevention of food poisoning bacteria, especially Salmonella, etc., indoors will sterilize the whole room, and spray guns especially for machinery and equipment to be sterilized. It is a space spray sterilizing agent and a space spray sterilization method that sterilizes and disinfects the whole factory efficiently and effectively.

EXAMPLES Next, although an Example is given and this invention is demonstrated in detail, this invention is not limited only to the following examples.
Formulation Example 1
The compound (2,4,4 ') having an internal volume of 3.6 liters and a pressure resistant vessel with a valve (made of Cr-Mo steel, a siphon tube reaching the lower part connected to the valve is provided in the pressure resistant vessel). After adding 24 g of trichloro-2′-hydroxydiphenyl ether compound) and 240 g of spreading component (ethanol), 2.15 kg of liquefied carbon dioxide gas was charged under pressure, and then a spray nozzle with a pressure hose (nozzle diameter) 0.5 mm) was attached, and the space spray disinfectant 1 was obtained.

^＊初発菌数は菌液中の生菌数と噴霧量から求めた推定値
^＊＊測定限界値３００ｃｅｌｌｓ／１００ｃｍ^{２
＊＊＊}薬剤を噴霧せずに同様の操作を行い、対象区回収率を次の式から求めた。

Test example 1
In a 6 m ³ (1.7 m × 1.7 m × 2.1 m) peat grade chamber, the following test bacteria (bacteria for normal agar medium and fungus for PDA medium for 48 hours, respectively, were plated at 35 ° C. for 48 hours, The bacteria were suspended in 50 ml of washing solution to obtain a bacterial solution) and sprayed uniformly into the peat grade chamber using a small spray. This room was sprayed with 60 g (10 g / m ³ ) of the space spray fungicide uniformly and kept for 4 hours, and then the number of viable bacteria was confirmed.
Test bacteria (Staphylococcus aureus IFO13276)
(Escherichia coli: Escherichia coli IFO3301)
(Bacillus subtilis IFO3134)
(Pseudomonas aeruginosa IFO13275)
(Black Koji Mold: Aspergillus niger IFO 9455)
To check the number of viable bacteria, use a wipe inspection set “Easy Wipe Check” manufactured by Eiken Equipment Co., Ltd., and perform a wipe inspection on an arbitrary place 100 cm ² in the Pete Grady Chamber. The number of viable bacteria was confirmed by serial dilution method. In addition, the following inactivation treatment was performed in consideration of the effect of the drug transferred into the medium by the wiping test.
The inactivation treatment was selected based on materials from the manufacturer, and the sodium thiosulfate was added to the wiping inspection set “Fukifuki check” (liquid volume 10 ml) manufactured by Eiken Equipment Co., Ltd. to a concentration of 0.5%. After wiping in a normal procedure, the stock solution was diluted once 10-fold.
Regarding the effectiveness of the inactivator, wipe off from the smooth surface to which 5 times the standard dosage amount is attached to the inspection kit that wiped the wall surface to which a certain number of bacteria have adhered, and the bacteria recovery rate The effectiveness was confirmed by observing the decrease in.
For the measurement of the amount of the disinfectant, the filter paper for measuring the amount of adhesion was placed on the floor during the treatment, and after the treatment, the sample was extracted with ethanol and measured with a capillary chromatograph.
Table 1 shows the results of measurement of the number of viable bacteria after the treatment against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Aspergillus niger and the adhesion rate of this fungicide.

^{* The} initial number of bacteria is an estimated value obtained from the number of viable bacteria in the bacterial solution and the spray amount.
^** Measurement limit value 300cells / 100cm ^2
*** The same operation was performed without spraying the drug, and the target area recovery rate was obtained from the following formula.

It is explanatory drawing which shows an example of the state by which the space spray antibacterial agent of this invention was filled in the pressure-resistant container, and the injection gun was attached.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Pressure-resistant container main body 2 ... Siphon tube 3 ... Injection gun 4 ... Pressure-resistant hose 5 ... Nozzle

Claims (4)

Formula (1)

A space spray disinfectant comprising: 2,4,4′-trichloro-2′-hydroxydiphenyl ether compound represented by the formula: alcohol solvent or acetone, and liquefied carbon dioxide.   0.5 to 2% by weight of 2,4,4′-trichloro-2′-hydroxydiphenyl ether compound, 5 to 15% by weight of alcohol solvent or acetone, and 83 to 94.5% by weight of liquefied carbon dioxide The space spray disinfectant according to claim 1, comprising:   The space spray disinfectant according to claim 1 or 2, wherein the alcohol solvent is one kind selected from the group consisting of ethanol, propanol, glycerin and propylene glycol, or a mixed solvent of two or more kinds.   A space spray sterilization method comprising spraying the space spray antibacterial agent according to claim 1, 2 or 3 in a spray form with a spray gun having a nozzle diameter of 0.3 to 1.0 mm.

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