JP4454228B2 - 注入装置のための駆動機構 - Google Patents
注入装置のための駆動機構 Download PDFInfo
- Publication number
- JP4454228B2 JP4454228B2 JP2002575041A JP2002575041A JP4454228B2 JP 4454228 B2 JP4454228 B2 JP 4454228B2 JP 2002575041 A JP2002575041 A JP 2002575041A JP 2002575041 A JP2002575041 A JP 2002575041A JP 4454228 B2 JP4454228 B2 JP 4454228B2
- Authority
- JP
- Japan
- Prior art keywords
- drive mechanism
- piston member
- cartridge
- piston
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Fuel-Injection Apparatus (AREA)
- Knitting Machines (AREA)
- Percussion Or Vibration Massage (AREA)
- Means For Warming Up And Starting Carburetors (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Manufacturing Of Electric Cables (AREA)
Description
好ましくは、注入装置は、移動可能な押しボタンを具備し、押しボタンが移動すると、用量設定スピンドルが移動させられる。
伝動手段10は、ケーブル手段12を引き出すことができるスプール24を具備する。スプール24は、その周囲表面に複数個の歯が付けられている。
Claims (8)
- 入れ子式の複数個のピストン部材を具備するピストンが、薬剤を含む薬剤カートリッジの第一の端に対して逐次的に運動して、選択的に、前記薬剤カートリッジの第一の端を封鎖する押子を前記薬剤カートリッジの中に駆動して、前記薬剤カートリッジの第二の端に配置される送液部材を介して薬剤を排出する携帯用注入装置のための駆動機構であって、さらに、用量ダイヤル手段を具備し、前記駆動機構は、さらに、移動可能な用量設定スピンドル、ケーブル手段、および移動可能な伝動手段を具備し、前記移動可能な伝動手段の移動により、前記ケーブル手段が入れ子式の複数個のピストン部材の少なくとも一つを動かすことにより、前記押子を駆動し、前記伝動手段は、前記ケーブル手段を巻き付けるスプールを具備し、前記スプールは、移動可能な前記用量設定スピンドル上に設けられたねじ付き部と係合する歯を具備することを特徴とする特徴とする携帯用注入装置のための駆動機構。
- 前記ケーブル手段は、第一の端を前記伝動手段に連結され、そして第二の端を前記ピストン部材の一つに連結されることを特徴とする請求項1に記載の駆動機構。
- 前記ケーブル手段の前記第二の端は、内部ピストン部材に連結されることと、前記ケーブル手段の第一の端と第二の端との間の前記ケーブル手段の中間部が、入れ子式の前記ピストン部材の別の部材に配置された案内手段の上方を通ることを特徴とする請求項1又は2に記載の駆動機構。
- 入れ子式の前記ピストン部材を後退位置に戻すための復帰手段が具備されることを特徴とする請求項1〜3の何れか1項に記載の駆動機構。
- 前記復帰手段は、ばね手段を具備することを特徴とする請求項4に記載の駆動機構。
- 前記ケーブル手段は、第一の端で外部ピストン部材に連結され、そして第二の端で中間ピストン部材に連結され、前記伝動手段は、移動可能な前記用量設定スピンドル上に設けられたねじ付き部に沿って摂動するように適合されていることを特徴とする請求項1に記載の駆動機構。
- 請求項1〜6の何れか1項に記載の駆動機構を具備する携帯用注入装置。
- 前記注入装置は、さらに、移動可能な押しボタンを具備し、前記押しボタンが移動することによって、前記用量設定スピンドルを移動させることを特徴とする請求項7に記載の携帯用注入装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0107604.1A GB0107604D0 (en) | 2001-03-27 | 2001-03-27 | Improvements in and relating to injection device |
PCT/GB2002/001435 WO2002076531A1 (en) | 2001-03-27 | 2002-03-26 | Drive mechanism for an injection device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009243933A Division JP5054750B2 (ja) | 2001-03-27 | 2009-10-23 | 携帯用注入装置 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004533285A JP2004533285A (ja) | 2004-11-04 |
JP2004533285A5 JP2004533285A5 (ja) | 2005-12-22 |
JP4454228B2 true JP4454228B2 (ja) | 2010-04-21 |
Family
ID=9911629
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002575041A Expired - Lifetime JP4454228B2 (ja) | 2001-03-27 | 2002-03-26 | 注入装置のための駆動機構 |
JP2009243933A Expired - Lifetime JP5054750B2 (ja) | 2001-03-27 | 2009-10-23 | 携帯用注入装置 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009243933A Expired - Lifetime JP5054750B2 (ja) | 2001-03-27 | 2009-10-23 | 携帯用注入装置 |
Country Status (16)
Country | Link |
---|---|
US (1) | US7008405B2 (ja) |
EP (1) | EP1372762B1 (ja) |
JP (2) | JP4454228B2 (ja) |
KR (1) | KR100854450B1 (ja) |
CN (1) | CN1247272C (ja) |
AT (1) | ATE354388T1 (ja) |
AU (1) | AU2002247843B2 (ja) |
BR (1) | BR0208015B1 (ja) |
CA (1) | CA2439902C (ja) |
DE (1) | DE60218291T2 (ja) |
DK (1) | DK1372762T3 (ja) |
GB (1) | GB0107604D0 (ja) |
HK (1) | HK1061814A1 (ja) |
IL (2) | IL157604A0 (ja) |
MX (1) | MXPA03008685A (ja) |
WO (1) | WO2002076531A1 (ja) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
BR0307589A (pt) | 2002-02-11 | 2005-02-01 | Antares Pharma Inc | Dispositivo de injeção intradérmica |
CN100569307C (zh) * | 2004-02-18 | 2009-12-16 | 阿瑞斯贸易股份公司 | 用于注射液态药物的手持式电控注射装置 |
ATE444090T1 (de) | 2004-10-21 | 2009-10-15 | Novo Nordisk As | Wählmechanismus für einen drehstift |
FI1850892T4 (fi) | 2005-01-24 | 2023-08-31 | Neula-avusteinen esitäytetyn ruiskun omaava suihkuinjektori | |
US8361036B2 (en) | 2006-03-10 | 2013-01-29 | Novo Nordisk A/S | Injection device having a gearing arrangement |
WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
AU2007253481B2 (en) | 2006-05-18 | 2013-01-17 | Novo Nordisk A/S | An injection device with mode locking means |
WO2009044401A2 (en) | 2007-10-02 | 2009-04-09 | Yossi Gross | External drug pump |
US8814834B2 (en) | 2008-03-10 | 2014-08-26 | Antares Pharma, Inc. | Injector safety device |
AU2009279719B2 (en) | 2008-08-05 | 2015-07-23 | Antares Pharma, Inc. | Multiple dosage injector |
US8579865B2 (en) | 2009-03-20 | 2013-11-12 | Antares Pharma, Inc. | Hazardous agent injection system |
US9339607B2 (en) | 2009-03-31 | 2016-05-17 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery devices |
KR101016417B1 (ko) * | 2010-04-14 | 2011-02-21 | 김현호 | 물의 마찰열을 이용한 저탄소 저비용의 농업용 난방 유지장치 |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
CA2861706A1 (en) | 2011-12-29 | 2013-07-04 | Novo Nordisk A/S | Dial-up/dial-down mechanism for wind-up pen |
DK2822618T3 (da) | 2012-03-06 | 2024-01-22 | Antares Pharma Inc | Forfyldt nål med brudkraftfunktion |
WO2013152323A1 (en) | 2012-04-06 | 2013-10-10 | Wotton Paul K | Needle assisted jet injection administration of testosterone compositions |
US9364611B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
FI3659647T3 (fi) | 2013-02-11 | 2024-03-28 | Antares Pharma Inc | Neula-avusteinen suihkuinjektiolaite, jolla on pienennetty liipaisinvoima |
WO2014164786A1 (en) | 2013-03-11 | 2014-10-09 | Madsen Patrick | Dosage injector with pinion system |
WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
WO2016091960A1 (en) * | 2014-12-10 | 2016-06-16 | Sanofi | Space saving drug injection device |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
CN112972833B (zh) | 2015-10-09 | 2024-01-09 | 西医药服务以色列分公司 | 注射器针帽脱离器 |
CN109310816B (zh) | 2016-01-21 | 2020-04-21 | 西医药服务以色列有限公司 | 针插入和缩回机构 |
JP6885960B2 (ja) | 2016-01-21 | 2021-06-16 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 視覚的インジケータを有する薬剤デリバリデバイス |
EP3711793B1 (en) | 2016-01-21 | 2021-12-01 | West Pharma Services IL, Ltd. | A method of connecting a cartridge to an automatic injector |
WO2017161076A1 (en) | 2016-03-16 | 2017-09-21 | Medimop Medical Projects Ltd. | Staged telescopic screw assembly having different visual indicators |
CN109562229B (zh) | 2016-08-01 | 2021-07-13 | 西医药服务以色列有限公司 | 抗旋转药筒销 |
CN113855913A (zh) | 2017-05-30 | 2021-12-31 | 西部制药服务有限公司(以色列) | 用于穿戴式注射器的模块化驱动机构 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US604297A (en) * | 1898-05-17 | Tilvlepiece | ||
FR2437216A1 (fr) * | 1978-09-26 | 1980-04-25 | Arion Henri | Dispositif de pousse-seringue mecanique a entrainement chronometrique |
US4659327A (en) * | 1985-11-26 | 1987-04-21 | Dentsply Research & Development Corp. | Multiple dosage syringe |
US5858000A (en) * | 1988-12-14 | 1999-01-12 | Inviro Medical Devices Ltd. | Safety syringe needle device with interchangeable and retractable needle platform |
US5032117A (en) | 1989-01-30 | 1991-07-16 | Motta Louis J | Tandem syringe |
US5271527A (en) * | 1992-04-02 | 1993-12-21 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
JP2529819B2 (ja) * | 1994-01-27 | 1996-09-04 | 日本イーライリリー株式会社 | 注射装置 |
DE19717107B4 (de) * | 1997-04-23 | 2005-06-23 | Disetronic Licensing Ag | System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist |
US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
US5957896A (en) | 1997-08-11 | 1999-09-28 | Becton, Dickinson And Company | Medication delivery pen |
IL135255A0 (en) | 1998-01-30 | 2001-05-20 | Novo Nordisk As | An injection syringe |
ATE386563T1 (de) * | 2000-07-14 | 2008-03-15 | Novo Nordisk As | Flüssigkeitsabgabevorrichtung und verfahren zum vermindern des tröpfelns |
US6508788B2 (en) * | 2000-10-27 | 2003-01-21 | Novo Nordisk A/S | Medication delivery device with telescopic piston rod |
-
2001
- 2001-03-27 GB GBGB0107604.1A patent/GB0107604D0/en not_active Ceased
-
2002
- 2002-03-26 CA CA2439902A patent/CA2439902C/en not_active Expired - Fee Related
- 2002-03-26 AU AU2002247843A patent/AU2002247843B2/en not_active Ceased
- 2002-03-26 DK DK02716924T patent/DK1372762T3/da active
- 2002-03-26 JP JP2002575041A patent/JP4454228B2/ja not_active Expired - Lifetime
- 2002-03-26 MX MXPA03008685A patent/MXPA03008685A/es active IP Right Grant
- 2002-03-26 BR BRPI0208015-0A patent/BR0208015B1/pt not_active IP Right Cessation
- 2002-03-26 WO PCT/GB2002/001435 patent/WO2002076531A1/en active IP Right Grant
- 2002-03-26 IL IL15760402A patent/IL157604A0/xx active IP Right Grant
- 2002-03-26 CN CNB028070607A patent/CN1247272C/zh not_active Expired - Lifetime
- 2002-03-26 DE DE60218291T patent/DE60218291T2/de not_active Expired - Lifetime
- 2002-03-26 EP EP02716924A patent/EP1372762B1/en not_active Expired - Lifetime
- 2002-03-26 AT AT02716924T patent/ATE354388T1/de not_active IP Right Cessation
- 2002-03-26 US US10/471,717 patent/US7008405B2/en not_active Expired - Lifetime
- 2002-03-26 KR KR1020037012483A patent/KR100854450B1/ko not_active IP Right Cessation
-
2003
- 2003-08-26 IL IL157604A patent/IL157604A/en not_active IP Right Cessation
-
2004
- 2004-07-02 HK HK04104752A patent/HK1061814A1/xx not_active IP Right Cessation
-
2009
- 2009-10-23 JP JP2009243933A patent/JP5054750B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2010046507A (ja) | 2010-03-04 |
EP1372762A1 (en) | 2004-01-02 |
CA2439902A1 (en) | 2002-10-03 |
ATE354388T1 (de) | 2007-03-15 |
KR100854450B1 (ko) | 2008-08-27 |
CN1498120A (zh) | 2004-05-19 |
CA2439902C (en) | 2010-02-23 |
BR0208015A (pt) | 2004-03-02 |
CN1247272C (zh) | 2006-03-29 |
JP2004533285A (ja) | 2004-11-04 |
EP1372762B1 (en) | 2007-02-21 |
JP5054750B2 (ja) | 2012-10-24 |
MXPA03008685A (es) | 2004-05-17 |
DK1372762T3 (da) | 2007-06-11 |
US7008405B2 (en) | 2006-03-07 |
US20040092876A1 (en) | 2004-05-13 |
AU2002247843B2 (en) | 2005-11-24 |
IL157604A (en) | 2008-04-13 |
DE60218291T2 (de) | 2007-10-31 |
KR20030093281A (ko) | 2003-12-06 |
GB0107604D0 (en) | 2001-05-16 |
WO2002076531A1 (en) | 2002-10-03 |
BR0208015B1 (pt) | 2012-06-12 |
DE60218291D1 (de) | 2007-04-05 |
IL157604A0 (en) | 2004-03-28 |
HK1061814A1 (en) | 2004-10-08 |
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