IL157604A - Drive mechanism for an injection device - Google Patents

Drive mechanism for an injection device

Info

Publication number
IL157604A
IL157604A IL157604A IL15760403A IL157604A IL 157604 A IL157604 A IL 157604A IL 157604 A IL157604 A IL 157604A IL 15760403 A IL15760403 A IL 15760403A IL 157604 A IL157604 A IL 157604A
Authority
IL
Israel
Prior art keywords
drive mechanism
cartridge
cable
injection device
piston
Prior art date
Application number
IL157604A
Other languages
Hebrew (he)
Original Assignee
Dca Design Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dca Design Int Ltd filed Critical Dca Design Int Ltd
Publication of IL157604A publication Critical patent/IL157604A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Fuel-Injection Apparatus (AREA)
  • Knitting Machines (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Manufacturing Of Electric Cables (AREA)
  • Means For Warming Up And Starting Carburetors (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

Injection devices are known for the self administration of medicament by patients. The medicament is typically contained within a cartridge located within the injection device. It is a problem that injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Also, the injection device must be of a size that enables a piston or similar used to drive the Cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge. A drive mechanism for an injecting device is disclosed in which the drive mechanism comprises a displaceable dosing spindle 6 , a dial dose means 8 , a transmission means 10 , and a cable means 12 , a piston comprising a plurality of nested piston members 30, 32, 34 , displacement of the transmission means 10 causing the cable means 12 to move at least one of one of the nested piston members to drive a cartridge bung 18.

Description

DRIVE MECHANISM FOR AN INJECTION DEVICE DCA DESIGN INTERNATIONAL LIMITED C: 49570 DRIVE MECHANISM FOR AN INJECTION DEVICE · The present invention relates to improvements in an injection device, and in particular to improvements to a drive mechanism for a portable injection device for dispensing controlled quantities of a medicament.
Injection devices are known for the self adrninislrationofmedicarnentbypatients. Forexample, those suffering from diabetes may require regular injections ofinsulin. Injection devices allow the patient to select a dose and to administer that dose. It is known to automate this process so that a user need only press a button and the injection device will dispense a selected dose of medicament. This relieves the patient of the task of controlling the amount dispensed while rnanually expelling the medicament fromthe injection device. This is aparticularproblemforthe elderly, the infirm, those suffering fromvision difficulties and others suffering from diabetes related problems which impair their faculties.
The medicament is typically contained within a cartridge lo cated within the injection device. The cartridge has abungorpistonat one end whichis driven towards asecond end ofthe cartridge to expelthemedicamentfromtheinjection device. Itis aproblemthat injection devices shouldbe small enough to fit into ajacket pocket or ahand bag without difficulty. At the same time, the injection device must be of a size that enables apiston or the like used to drive the cartridge bung witliinthe cartridge to be moved both to a aximumdispenseposition within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge.
It is an advantage of thepresent invention that it seeks to provide asolutionto these conflicting requirements.
According to a first aspect of thepresent invention, a drive mechanismfor an injection device in which apistonis successively moved in relation to afirst endofamedicamentcailridge containing a medicament selectively to drive a bung closing a first end of the medicament cartridge into the medicament cartridge to expelmedicament through a delivery member located at a second end of the medicament cartridge, is disclosed in which the drive mechanism further comprises a displaceable dosing spindle, a dial dose means, a transmission means, and a cable means, thepistoncorrjpraingaplm-aliryofnestedpistonmerri means causing the cable means to move at least one of one of the nested pistonmembers to drive the bung.
In a first embodiment, the cable is connected at a first end to the transmission means and at a second endto one ofthe piston members. Preferably the transmissionmeans comprises aspool onto which the cable means is wound, the spool being provided with teeth which engage a threaded portion provided on the displaceable dosing spindle. More preferablythe second endofthe cable means is connected to an inner piston member and that an intermediate part ofthe cable means between the first and second ends of the cable means runs over guide means located on other of the nested piston members.
Alternatively the cable maybe connected at a first endto an outer pistonmember and at asecond endto aninteimediatepistonmember, the transmissionmeans being adapted to precess along a threaded portion provided on the displaceable dosing spindle. Preferably the transmissionmeans comprises a claw member connected to an inner piston member and that an intermediate part ofthe cable means between the first and second ends ofthe cable means runs over a guide means located on the inner piston member.
According to a second aspect ofthe present invention, an injection device incorporates a drive mechanism according to the first aspect of the invention.
Preferably, the injection device further comprises adisplaceable button, displacement ofthe button causing displacement of the dosing spindle.
The invention willnowbe described, by way of example only, with reference to the accompanying drawings in which: - Figure 1 shows in side s ection a first embodiment of an injection device having a delivery device according to the present invention; Figure 2 shows a side section similar to Figure 1 with a path of the cable means shown more deafly, Figure 3 shows a similar view to Figure 2 with the injection device in a ready position; Figure 4 shows a view similar to Figure 3 after dialling of a required dosage; Figure 5 shows a view sirnilar to Figure 4 after delivery of the required dosage; , Figure 6 shows in side section a second embodiment of aninjection device having adelivery device according to the present invention; Figure 7 shows a similar view to Figure 6 with the injection device in a ready position; Figure 8 shows a view similar to Figure 7 after dialling of a required dosage; Figure 9 shows a view sirnilar to Figure 8 after delivery of the required dosage; and Figure 10 shows a side section of amechanismfor use with the injection device of Figures 6 to 9.
Like reference numerals will be used to refer to like parts of the injection device.
Refeiring first to Figures 1 to 5, there may be seen aportableinjection device incoφoratingad^ive mechanism in accordance with the first aspect of the present invention.
The injection device 2 comprises amainhousing 4 in which the drive mechanismis located and a button 20. The drive mechanism comprises a displaceable dosing spindle 6, a dial dose means 8, . a trai-smission means 10, a cable means 12 and a piston. A needle unit 14 including a delivery member in the formahollow needle is secured to afirst end of the main housing 4. Amedicament cartridge 16 havkg afii-stendandasecondendmaybestoredinmemainhousing4. "Whenthe needle unit 14 is in place, the needle unit 14 pierces a flexible membrane at the first end of the medicament cartridge 16. A displaceable bung 18 islocatedatthesecondendofthemedicament cartridge 16. A cover (not shown) may be provided over the first end of the main housing 4 to protect the needle unit 14 from damage and a user from inadvertent pricking by the needle.
The button 20, as shown in the illustrated embodiment, is preferably in the formof a cap or cup adapted for slidable movement within the main housing 4 as shown in the illustrated embodiment. T¾ernainhousing4 ndthebutton20 are preferably provided with acatch (not shown) releasably to retain the button 20 in a closed or ' off position. The button 20 is provided with a stop member 22 onaninner side ofthe button20. Inthe illustrated embodiment, the stop member 22 is formed as a shoulder to one side of the button 20.
The dial dosemeans 8 is located to the side ofthe main housing 4. The dial dosemeans 8 is used by auser to select adosage of medicament to be dispensed from the injection device 2 in amanner to be described.
Thetransmissionmeans i0comprisesaspool24fromwhichthecablemeans 12 can be deployed. The spool 24 is provided with a plurality of teeth about a peripheral surface thereof.
The dosing spindle 6 is provided along at least apart of its lengthwith athreadedportion26. The teeth ofthe spool24 engage with the threadedportion26 ofthe dosing spindle 6. A first end of the dosing spindle 6 is connected to the dose dial means 8 such that dialling of a dose causes rotation ofthe dosing spindle 6. A second end ofthe dosing spindle 6 is provided with an abutment surface 28.
The piston comprises a plurality of nested piston members. Inthe illustrated enibodirnent, the piston comprises an outer pistonmember34, anintermediatepistonmember 32 and aninner piston member 30. The outer piston member 34 is fixed in relation to the main housing 4. The intermediate pistonmember 32 is nested for relative movement withrespect to andwithinthe outer member 34. Theinnerpistonmember 30 isnestedforrelativemovementwithrespectto andwithin the intermediate pistonmember 32. A first end ofthe inner piston member 30 extends beyond the intermediate pistonmember 32 and the outer pistonmember 34. The first end of the inner piston member 30 is adaptedinuse to selectively drive the bung 18 into the medicament cartridge 16 to expel medicament through the delivery member. 157604/2 llieintermedktepistonmember 32 and the outapistonmernber 34 are each provided with, guide means about which the cable means 12 is adapted to run. The cable means 12 is secured at a first end to the spool 24 and at a second end to. the inner piston member 30. In the illustrated embodiment, the cable means 12 runs from the spool 24 o er a first guide means 36 pro vided on the outer piston member 34, over a second guide means 38 provided at a second end of the inteimediate piston member 32, over a third guide means 40 provided at a first end of the iniemiediatepistonmemrjer32to IntheuTusttal^enix)dimerit,1hje cable means 12 is secured at a second end of the inner piston member 30 (Figure 2) .
A return means 42 is located between thesecond endofmeirinerpj-stoniriember 30 andmemain housing 4. The return means 42 may take any suitable form, for example spring means such as a helical spring.
In use, a user releases thebutton20 to ready the injection device 2 (Figure 3). A user then dials arequired dose using the dial dosemeans 8. This causes the dosingspindle 6 to rotate andprecess along its axis towards a second end of the housing 4. FromPigure 4, if can be seen that a dose has been dialled and that the abutment surface 28 at the second end of the dosing spindle 6 has been moved into contact with the stop member 22 on the inside of the button 20.
The button 20 may now be pressed to deliver thedialled dosage of medicament As 1ne button 20 is driven towards the first end of the housing 4, the stop member 22 oh the button20 pushes the abutment surface 28 of me dosing spindle 6 such that the dosing spindle 6 is abodriven towards the first end of the housing 4. Since the dosing spindle 6 is not rotated, the spool 24 is rotated to draw the cable means onto the spool, thereby shortening the effective length of the cable means between the spool and the inner piston member 30.
This causes the inner piston member 30 and the intermediate pistonmember 32 to be drawn out of the nested position and the inner piston member 30 to be advanced towards the medicament (partridge bung 18todrrvetherriedicarrierit^ the medicament cartridge 16 (Figure 5).
This process may be repeated until the medicament cartridge 16 is empty, the medicament cartridge contains insufficient medicament to deliver the dialled dose or some other condition is met. The piston may then be withdrawn by allowing the dosing spindle 6 to rotate freely such that the inner pistonmember 30 can be drawnbackto anestedposition under the action of the retummeans 42. Innormal us e, the dosing spindle 6 may only be rotated under the action of the dial dose means 8.
A second embodiment of the invention is shown in Figures 6 to 10. The injection device comprises a main housing 4' in which the drive mechanism is located and a button 20'. The drive mechanism comprises adisplaceable dosing spindle 6', a dial dose means 8', atransmissionmeans 10', acable meansl2' andapiston. Aneedleunit W'mclucimgadeUveiymemberinmeformahollowneedle issecuredto afirstendofmemainhousing4'. Amedicament cartridge 16' having a first end and asecondendmaybestoredinthemainhousing4'. When the needle unit 14'isinplace, theneedle unit 14' pierces a flexible membrane at the first end of the medicament cartridge 16'. A displaceable bung 18' is located at the second endofthemedicament cartridge 16'. A cover (not shown) maybeprovidedoverthe &stendofthernamhousing4'topOtectu¾eneedeunit 14'fi.Om damage and a user from inadvertent pricking by the needle.
The button 20', as shown in the illustrated embodiment, is preferably in the fonnof a cup adapted • forsh^blemovementwithfomernah^ The main housing 4' and the button20' are preferably provided with a catch (not shown) releasably to retain thebutton20'inaclosedo 'off position. Thebutton20' isprovidedwithastopmember22'on an inner side of the button 20'. In the illustrated embodiment, the stop member 22' is formed as a extension formed on an inner surface of the button 20'.
The dial dose means 8' is located to one side ofmernainhousing4'. The dial dose means 8'is used by auser to select adosage of medicament to be dispensed from the injection device 2' in amanner to be described.
The dosing spindle 6' comprises aradially extending flange about aportionintennediate between a first end of the dosing spindle 6' and a second end of the dosing spindle 6'. A spline 44 is provided about the first end of the dosing spindle 6' whereby the dosing spindle 6' is connected to the dial dose means 8' such that dialling of a dose causes rotation of the dosing spindle 6'. A second end of the dosing spindle 6' is provided with an abutment suiface 28'. The second end of the dosing spindle 6' is provided with a threaded portion 26' along at least a part thereof.
The piston comprises a plurality of nested piston members. In the illustrated embodiment, the piston comprises an outer piston member 34', an mterrnediate piston member 32' and an inner piston member 30'. The outer piston member 34' is fixed in relation to the main housing 4' and receives the inner piston member 30' and the intermediate piston member 32' therein. The intermediate pistonmember32'is nested forrelativemovementwithrespect to and within the outer piston member 34'. The inner piston member 30 ' is nested for relative movement with respect to arid within the intermediate pistonmember 32'. A first end of the intermediate piston member 32' extends beyond the inner pistonmember 30' and the outer pistonmember 34'. The first end of the intermediate piston member 32' is adapted in use to selectively drive the bung 18' into the medicament cartridge 16' to expel medicament through the delivery member.
The inner piston member 30' is provided with guide means 36' about which the cable means 12' is adapted to run. The cable means 12' is secured at a first end to the outer pistonmember 34' and at a second end to the intermediate piston member 32'. In the illustrated embodiment, the cable means 12' runs from the outer piston member 34' over the guide means 36* provided on the inner pistonmember 30' to where the cable meansl2' is securedto the intermediate pistonmember 32', The transmission means 10' comprises a claw 46. Theclaw46ismountedonthesecondendof the dosing spindle 6' such that the dosing spindle 6' may precess therethrough. The claw 46 is connected to a second end of the inner piston member 30'.
In use, auseiu¾leasesthebutton20'toreadytheinjectiondevice2'(Figure7). Auser then dials a required dose using the dial dose means 8'. This causes the dosing spindle 6' to rotate and precess along its axis through the claw 46 towards a second end of the housing 4'. From Figure 8, it can be seen that a dose has been dialled and that the abutment surface 28' at the second end of the dosing spindle 6' has been moved towards the stop member 22' on the inside of the button 20'.
The button 20' may now be pressed to deliver the dialled dosage of medicament. As the button 20' is driven towards the first end of the housing 4', the stop member 22' on the button 20' meets the abutment surface 28' of the dosing spindle 6' such that the dosing spindle 6' is also driven towards the first end of the housing 4'. Since the dosing spindle 6' is not rotated, the claw 46 is moved towards the first end of the housing 4' together with the inner piston member 30' attached thereto . This pushes the inner piston member 30' away from the outer piston member 34'. This has the effect of causing the cable means 12' to draw the intermediate piston member 32 ' out o f the outer pistonmember 34' and be advanced towards the medicament cartridge bung 18' to drive the medicament cartridge bung 18' forwards to expelrr-edcamentfi mmemedicamentcartiidge 16' (Figure 9).
This process maybe repeateduntilthe cartridge 16' is empty, the medicament cartridge contains insufficient medicament to deliver the dialled dose or some other condition is met (Figure 10).
The relative aiTangement of the drive mechanism and the medicament cartridge means that the main housing provides a elatively large flat face where arelatively large dose display, such as aliquid crystal display may be located. This in turn enables the dose display to use relatively large figures or other characters. This is an advantage for those with impaired vision.

Claims (5)

1. A drive mechanism for an injection device in which a piston is successively moved in relation to a first end of amedicament cartridge containing amedicament selectively to drive abung closing afirst end of the medicament cartridge into the medicament cartridge to expelmedicament through a delivery member lo cated at a s econd end of the medicament cartridge, in which the drive mechanism farther comprises a displaceable dosing spindle, a dial dose means, a transmission means, and a cable means, the piston comprising aplurality of nestedpistonmembers, displacement of the transmission means causing the cable means to move at least one of one of the nested piston members to drive the bung.
2. A drive mechanism according to claim 1 , characteris ed in that the cable is connected at a first end to the ttansmission means and at a second end to one of the piston members.
3. A drive mechanism according to claiml orclaim2, characterisedinthatthetransmission means comprises aspool onto which the cable means is wound, the spoolbeingprovidedwithteeth which engage a threaded portion provided on the displaceable dosing spindle.
4. Adiivemechanismaccordingto claim3 chai'acterisedinthatthesecondendofthecable means is connected to an inner piston member and that an intermediate part of the cable means between the first and second ends of the cable means runs over guide means located on other of the nested piston members.
5. Aarivemechanismaccordingto anyprevious claim, charactei'isedrnthatretumrneans are provided to return the nested piston members to a retracted position. k 6 A drive mechanism according to claim 5, characterised in that return means comprises spring means. 1576G4/2 10 7 A drive mechanism according to claim 1 , characteris ed in that the cable is connected at a first end to an outer piston member and at a second end to an intermediate piston member, the fransmissionmeans being adapted to precess along athreadedportionprovided on the displaceable dosing spindle. 8 AaViven echanismaccordingto claim 1 or clam means comprises a claw member connected to aninnerpistonmember and that an intermediate part of the cable means between the first and second ends of the cable means runs over a guide means located on the inner piston member. 9 An injection device incorporating a drive mechanism according to any previous claim . 10 An injection device according to claim93 ctiaracterisedk that the injection device further comprises a displaceable button, displacement of the button causing displacement of the dosing spindle.
IL157604A 2001-03-27 2003-08-26 Drive mechanism for an injection device IL157604A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0107604.1A GB0107604D0 (en) 2001-03-27 2001-03-27 Improvements in and relating to injection device
PCT/GB2002/001435 WO2002076531A1 (en) 2001-03-27 2002-03-26 Drive mechanism for an injection device

Publications (1)

Publication Number Publication Date
IL157604A true IL157604A (en) 2008-04-13

Family

ID=9911629

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15760402A IL157604A0 (en) 2001-03-27 2002-03-26 Drive mechanism for an injection device
IL157604A IL157604A (en) 2001-03-27 2003-08-26 Drive mechanism for an injection device

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL15760402A IL157604A0 (en) 2001-03-27 2002-03-26 Drive mechanism for an injection device

Country Status (15)

Country Link
US (1) US7008405B2 (en)
EP (1) EP1372762B1 (en)
JP (2) JP4454228B2 (en)
KR (1) KR100854450B1 (en)
CN (1) CN1247272C (en)
AT (1) ATE354388T1 (en)
AU (1) AU2002247843B2 (en)
BR (1) BR0208015B1 (en)
CA (1) CA2439902C (en)
DE (1) DE60218291T2 (en)
DK (1) DK1372762T3 (en)
GB (1) GB0107604D0 (en)
IL (2) IL157604A0 (en)
MX (1) MXPA03008685A (en)
WO (1) WO2002076531A1 (en)

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PT2298391E (en) * 2004-02-18 2012-05-02 Ares Trading Sa Portable electronic injection device for injecting liquid medication
DK1804865T3 (en) 2004-10-21 2010-02-01 Novo Nordisk As Down-turning adjustment mechanism for a pen with spring pull-up
FI1850892T4 (en) 2005-01-24 2023-08-31 Prefilled needle assisted syringe jet injector
JP5183499B2 (en) * 2006-03-10 2013-04-17 ノボ・ノルデイスク・エー／エス Injection device
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AU2002247843B2 (en) 2005-11-24
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JP4454228B2 (en) 2010-04-21
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US20040092876A1 (en) 2004-05-13
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CN1498120A (en) 2004-05-19
HK1061814A1 (en) 2004-10-08

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