JP4444377B2 - 磁性細胞分離装置 - Google Patents

磁性細胞分離装置 Download PDF

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Publication number
JP4444377B2
JP4444377B2 JP50303499A JP50303499A JP4444377B2 JP 4444377 B2 JP4444377 B2 JP 4444377B2 JP 50303499 A JP50303499 A JP 50303499A JP 50303499 A JP50303499 A JP 50303499A JP 4444377 B2 JP4444377 B2 JP 4444377B2
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Japan
Prior art keywords
magnet
pole
magnets
interpole
magnetic device
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Expired - Lifetime
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JP50303499A
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Japanese (ja)
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JP2002504852A (ja
JP2002504852A5 (cg-RX-API-DMAC7.html
Inventor
スターマン,マーティン・ディ
リトゥリ,ポール
ステルター,リチャード・イー
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デクスター・マグネティック・テクノロジーズ・インコーポレイテッド
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Publication of JP2002504852A5 publication Critical patent/JP2002504852A5/ja
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/035Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • B03C1/288Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00Magnets
    • H01F7/02Permanent magnets [PM]
    • H01F7/0273Magnetic circuits with PM for magnetic field generation
    • H01F7/0278Magnetic circuits with PM for magnetic field generation for generating uniform fields, focusing, deflecting electrically charged particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/22Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/26Details of magnetic or electrostatic separation for use in medical or biological applications

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  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Centrifugal Separators (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP50303499A 1997-06-04 1998-06-04 磁性細胞分離装置 Expired - Lifetime JP4444377B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/868,598 US6451207B1 (en) 1997-06-04 1997-06-04 Magnetic cell separation device
US08/868,598 1997-06-04
PCT/US1998/011816 WO1998055236A1 (en) 1997-06-04 1998-06-04 Magnetic cell separation device

Publications (3)

Publication Number Publication Date
JP2002504852A JP2002504852A (ja) 2002-02-12
JP2002504852A5 JP2002504852A5 (cg-RX-API-DMAC7.html) 2005-12-22
JP4444377B2 true JP4444377B2 (ja) 2010-03-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP50303499A Expired - Lifetime JP4444377B2 (ja) 1997-06-04 1998-06-04 磁性細胞分離装置

Country Status (8)

Country Link
US (2) US6451207B1 (cg-RX-API-DMAC7.html)
EP (1) EP0986436B1 (cg-RX-API-DMAC7.html)
JP (1) JP4444377B2 (cg-RX-API-DMAC7.html)
AT (1) ATE274376T1 (cg-RX-API-DMAC7.html)
AU (1) AU753848B2 (cg-RX-API-DMAC7.html)
CA (1) CA2292631C (cg-RX-API-DMAC7.html)
DE (1) DE69825890T2 (cg-RX-API-DMAC7.html)
WO (1) WO1998055236A1 (cg-RX-API-DMAC7.html)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413420B1 (en) * 2000-03-17 2002-07-02 Dexter Magnetic Technologies, Inc. Magnetic separation device
FR2826592B1 (fr) 2001-06-27 2003-08-15 Bio Merieux Procede, dispositif, et equipement de separation par voie humide de micro particules magnetiques
DE10136060A1 (de) * 2001-07-25 2003-02-13 Roche Diagnostics Gmbh System zur Separation von magnetisch anziehbaren Partikeln
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
BR0214772A (pt) 2001-12-07 2007-01-09 Macropore Biosurgery Inc sistemas e métodos para o tratamento de pacientes com células lipoaspiradas processadas
US6846985B2 (en) 2002-01-22 2005-01-25 Nanoset, Llc Magnetically shielded assembly
US7162302B2 (en) 2002-03-04 2007-01-09 Nanoset Llc Magnetically shielded assembly
US20040225213A1 (en) 2002-01-22 2004-11-11 Xingwu Wang Magnetic resonance imaging coated assembly
US7091412B2 (en) 2002-03-04 2006-08-15 Nanoset, Llc Magnetically shielded assembly
US7011758B2 (en) * 2002-02-11 2006-03-14 The Board Of Trustees Of The University Of Illinois Methods and systems for membrane testing
CA2481545A1 (en) 2002-04-12 2003-10-23 Instrumentation Laboratory Company Immunoassay probe
CN1665790A (zh) * 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
US20040140875A1 (en) * 2003-01-22 2004-07-22 Strom Carl H. Unipolar magnetic system
JP4971787B2 (ja) 2003-02-20 2012-07-11 サイトリ セラピューティクス インコーポレイテッド 心臓血管疾患の治療における脂肪組織由来細胞の使用方法
EP1664282A4 (en) * 2003-09-19 2008-04-09 Newsouth Innovations Pty Ltd METHOD FOR ISOLATING HEPATOCYTES
JP2005128771A (ja) * 2003-10-23 2005-05-19 Fujitsu Ltd データファイルシステム、データアクセスサーバ、およびデータアクセスプログラム
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
NL1028845C2 (nl) * 2005-04-22 2006-10-24 Rail Road Systems B V Inrichting voor het creeren van een substantieel magneetveld vrij gebied omgeven door een gebied met een magneetveld gradient.
JP5763875B2 (ja) * 2005-06-24 2015-08-12 セプマグ、システムズ、ソシエダッド、リミターダSepmag Systems,S.L. 磁性粒子を分離するためのデバイス及び方法
US20070018764A1 (en) * 2005-07-19 2007-01-25 Analisi Tecnologica Innovadora Per A Processos Device and method for separating magnetic particles
NL1030761C2 (nl) * 2005-12-23 2007-06-29 Bakker Holding Son Bv Werkwijze en inrichting voor het scheiden van vaste deeltjes op basis van dichtheidsverschil.
WO2007079149A2 (en) * 2005-12-28 2007-07-12 The General Hospital Corporation Blood cell sorting methods and systems
US20090304644A1 (en) * 2006-05-30 2009-12-10 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue
US20100015104A1 (en) * 2006-07-26 2010-01-21 Cytori Therapeutics, Inc Generation of adipose tissue and adipocytes
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
WO2010006328A2 (en) * 2008-07-11 2010-01-14 The General Hospital Corporation Magnetic apparatus for blood separation
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US20100099076A1 (en) * 2008-10-16 2010-04-22 Kent State University Sensitive and rapid detection of viral particles in early viral infection by laser tweezers
KR101644534B1 (ko) * 2009-05-01 2016-08-01 비미니 테크놀로지스 엘엘씨 조직 및 세포 부유화 이식편의 최적화 시스템, 방법 및 조성물
US8845812B2 (en) * 2009-06-12 2014-09-30 Micron Technology, Inc. Method for contamination removal using magnetic particles
IN2012DN03194A (cg-RX-API-DMAC7.html) 2009-10-28 2015-10-09 Magnetation Inc
TWI362964B (en) * 2009-12-23 2012-05-01 Ind Tech Res Inst Magnetic separation device and method for separating magnetic substances in bio-samples
WO2011123477A1 (en) * 2010-03-29 2011-10-06 Glenn Lane Spatial segregation of plasma components
US20140083948A1 (en) 2011-03-11 2014-03-27 Guisheng Yang Magnetic particle scavenging device and method
US20120262260A1 (en) * 2011-04-18 2012-10-18 Exact Sciences Corporation Magnetic microparticle localization device
BR112013026824B1 (pt) 2011-04-20 2021-06-29 Magglobal Llc Dispositivo e sistema de separação magnética de alta intensidade
US9401260B2 (en) 2013-03-15 2016-07-26 Glenn Lane Family Limited Liability Limited Partnership Adjustable mass resolving aperture
MX2016003127A (es) 2013-09-19 2016-10-28 Cytori Therapeutics Inc Metodos de uso de células derivadas de tejido adiposo en la modulación de dolor y/o fibrosis.
JP6289638B2 (ja) * 2014-07-03 2018-03-07 三菱電機株式会社 渦電流選別装置および渦電流選別方法
US9387486B2 (en) * 2014-09-30 2016-07-12 Ut-Battelle, Llc High-gradient permanent magnet apparatus and its use in particle collection
EP3609993A1 (en) 2017-04-13 2020-02-19 Universiteit Antwerpen Micro algae harvesting methods and devices
US10449553B2 (en) * 2018-03-03 2019-10-22 Yuchen Zhou Magnetic biological entity separation device and method of use
US11278915B1 (en) 2018-07-20 2022-03-22 NeoGeneStar LLC Device for capturing and releasing magnetic particles
WO2020174005A1 (en) 2019-02-28 2020-09-03 The Regenerative Group Ltd. Regenerative combination of plasma and adipose tissue
CN110004062B (zh) * 2019-04-18 2022-07-01 中国人民解放军第四军医大学 分选富集数量极稀少循环肿瘤细胞的装置和方法
EP4344786A1 (en) 2022-09-27 2024-04-03 Sepmag Systems, S.L. Biomagnetic separation system with double ring profile
WO2025145622A1 (zh) * 2024-01-04 2025-07-10 北京麦戈龙生物科技有限公司 磁性粒子分离装置
CN117884254B (zh) * 2024-01-04 2025-02-25 北京麦戈龙科技有限公司 磁性粒子分离装置
CN117839863B (zh) * 2024-01-04 2025-02-25 北京麦戈龙科技有限公司 磁性粒子分离装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365599A (en) 1965-03-17 1968-01-23 Wehr Corp Magnetic circuit
GB1202100A (en) 1967-10-18 1970-08-12 Bethlehem Steel Corp Magnetic separator method and apparatus
US5622831A (en) 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
US5269915A (en) 1993-04-08 1993-12-14 Colonel Clair Magnetic source and condenser for producing flux perpendicular to gas and liquid flow in ferrous and nonferrous pipes
JP2788861B2 (ja) * 1994-11-30 1998-08-20 株式会社チップトン 磁気選別装置及びそれに用いられる払拭ブラシ

Also Published As

Publication number Publication date
US6572778B2 (en) 2003-06-03
DE69825890T2 (de) 2005-09-08
EP0986436A1 (en) 2000-03-22
ATE274376T1 (de) 2004-09-15
DE69825890D1 (de) 2004-09-30
WO1998055236A1 (en) 1998-12-10
EP0986436B1 (en) 2004-08-25
CA2292631C (en) 2008-01-15
JP2002504852A (ja) 2002-02-12
US6451207B1 (en) 2002-09-17
CA2292631A1 (en) 1998-12-10
US20030015474A1 (en) 2003-01-23
AU753848B2 (en) 2002-10-31
AU8061698A (en) 1998-12-21

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