JP4434899B2 - Scalp application composition and scalp irritation mitigation method - Google Patents

Description

  The present invention relates to a scalp coating composition for reducing irritation to the scalp by chemical treatment, for example, before and after chemical treatment such as hair coloring and perm, preferably before chemical treatment, and a method for alleviating scalp irritation.

  In recent years, with the diversification of hairstyles, there has been an increasing opportunity for hair to be chemically treated with hair dyes, bleaches, permanent wave agents, hair straighteners, and the like. These chemical treatments can cause irritation and inflammation of the scalp.

Conventionally, as a stimulant mitigating agent for alleviating irritation to skin, hair, mucous membrane and the like by cosmetic raw materials, Tochu extract (see Patent Document 1), cardamom, Clara, button bow fu, gadget, chamomile, guarana, Pueraria, rice field The use of extracts of ginseng, tartary buckwheat, nutmeg, pepper, myoga, and peach seed (see Patent Document 2) has been proposed. Moreover, the use of rice germ oil and azulene has been proposed as a stimulus inhibitor for hair dyes (see Patent Document 3).
JP 2001-302437 A JP 2003-155246 A JP 2002-363053 A

  However, the above-mentioned stimulant-relieving agent or stimulus-suppressing agent for cosmetic raw materials has not been able to obtain a sufficient stimulus-relaxing effect against irritation to the scalp by chemical treatment such as hair color and perm.

  The present invention has been made in view of the above points, and provides a scalp coating composition and a scalp irritation mitigation method capable of alleviating primary irritation and inflammation to the scalp by chemical treatment such as hair coloring and perm. For the purpose.

(1) The invention of claim 1
And Saccharomyces yeast extract, containing an inorganic salt is an alkali metal or alkaline earth metal salts, as the inorganic salts, see containing sodium chloride and potassium chloride, the amount of the inorganic salt is 0.1 The gist of the composition for scalp coating is in the range of ˜5% by weight .

The composition for coating the scalp of the present invention contains a Saccharomyces genus yeast extract, and thus has a high effect of reducing primary irritation and inflammation to the scalp by chemical treatment such as hair coloring and perm.
Examples of Saccharomyces genus yeast extract include red wine yeast extract, white wine yeast extract, beer yeast extract, baker's yeast extract, sake yeast extract and the like. In particular, red wine yeast extract is preferred.
In addition, since the composition for coating the scalp of the present invention contains an inorganic salt that is an alkali metal salt or an alkaline earth metal salt, the effect of alleviating primary irritation and inflammation to the scalp by chemical treatment such as hair color and perm Is even higher.
Moreover, even if there is little compounding quantity of Saccharomyces genus yeast extract compared with the case where an inorganic salt is not contained, there can exist the same effect.
Moreover, the composition for scalp application | coating of this invention contains a sodium chloride and potassium chloride as an inorganic salt, and the effect which relieves the primary irritation | stimulation and inflammation to the scalp by chemical treatments, such as a hair color and a permanent, is still higher.
In addition, the composition for coating the scalp according to the present invention has a hair color that contains an inorganic salt in an amount of 0.1% by weight or more (preferably 0.5% by weight or more, more preferably 1% by weight or more). The effect of alleviating primary irritation and inflammation to the scalp by chemical treatment such as perm.
In addition, the composition for coating the scalp of the present invention has an inorganic salt content of 5 wt% or less (preferably 3 wt% or less). And the effect of alleviating inflammation is even higher.
(2) The invention of claim 2
The gist of the composition for coating the scalp according to claim 1, wherein the composition is used to relieve irritation to the scalp by chemical treatment of hair color or perm.
(3) The invention of claim 3
The Saccharomyces yeast extract is a Saccharomyces yeast, a dry powder of the Saccharomyces yeast, a product obtained by treating the Saccharomyces yeast by ultraviolet irradiation or self-digestion, or a degradation obtained by decomposing the Saccharomyces yeast with an acid or a protease It is extracted from a product using a solvent comprising at least one selected from water, ethanol, propylene glycol, 1.3-butylene glycol, and an aqueous glycerin solution. The composition for scalp application described in 1 above is summarized.

The composition for scalp coating of the present invention contains a Saccharomyces genus yeast extract produced as described above.
The Saccharomyces yeast used in the present invention is used to ferment grapes (fruit, pericarp, seeds, etc.) to produce red wine. After fermentation, Saccharomyces yeasts are separated from red wine by a centrifuge or the like. At this time, Saccharomyces genus yeast is separated while adsorbing polyphenols, and dried to obtain Saccharomyces genus yeast.

  Moreover, when utilizing the decomposition product by yeast self-digestion, 10-100 times the amount of purified water was added to the wet cells after washing, and self-digestion was performed at 35-45 ° C. for about 24-72 hours. Thereafter, a yeast degradation product obtained by filtration, lyophilization, or concentration under reduced pressure can be used as necessary.

  When using a degradation product of yeast proteolytic enzyme, 10 to 100 times the amount of purified water is added to the wet cells after washing, and 200 to 500,000 units of proteolytic enzyme is added to 1 kg of wet cells. Add approximately and react for 12 to 48 hours near the enzyme activity temperature. Next, after inactivating the enzyme, if necessary, an appropriate amount of an aqueous solvent can be added, and after performing operations such as centrifugation, filtration, lyophilization, or concentration under reduced pressure, a yeast degradation product can be used.

  When using an acid hydrolyzate of yeast, an acid such as hydrochloric acid is added to the washed wet cells and hydrolyzed at 40 to 60 ° C. for 3 to 8 hours with occasional stirring. Thereafter, the yeast degradation product obtained by neutralizing with an alkali such as sodium hydroxide, filtering as necessary, and then freeze-drying or concentration under reduced pressure can be used.

  These yeast degradation products may be used as they are as a yeast extract, or a yeast degradation product extract obtained by extraction from a yeast degradation product by the method described below may be used as a yeast extract.

In obtaining an extract from yeast, the cultured cells are collected, washed with purified water to obtain wet cells, and the wet cells are used as they are or after breaking the cells with high frequency or the like. .
Monohydric alcohols such as water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octyl alcohol, glycerin, ethylene glycol Polyhydric alcohols such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1.3-butylene glycol, hexylene glycol or derivatives thereof One type or two or more types are selected from aqueous solvents and added as an extraction solvent for extraction. The extraction solvent is not particularly limited as long as it is an aqueous solvent as described above, but from the viewpoint of safety and stability when blended into a skin external preparation, purified water, ethanol, 1.3-butylene glycol, glycerin, propylene It is preferable to use glycol alone or in combination of two or more.

  Examples of the extraction method include a method of extraction by immersion in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, etc., and these methods are used alone or in combination of two or more. To extract.

The ratio of the wet microbial cells and the solvent during the extraction is not particularly limited, but the solvent is 0.5 to 1000 times the weight of the wet microbial cells 1, particularly 0.5 to 500 in terms of extraction operation and efficiency. 100 times by weight is preferable. The extraction temperature is conveniently in the range from room temperature to the boiling point of the solvent under normal pressure, and the extraction time varies depending on the extraction temperature and the like, but is preferably in the range of 2 hours to 2 weeks.
(4) The invention of claim 4
The gist of the composition for scalp application according to any one of claims 1 to 3, wherein the Saccharomyces yeast extract is a red wine yeast extract.

The composition for coating the scalp of the present invention contains red wine yeast extract as a yeast extract of the genus Saccharomyces, so that the effect of alleviating the primary irritation and inflammation to the scalp by chemical treatment such as hair color and perm.
(5) The invention of claim 5
The content of the Saccharomyces genus yeast extract is in the range of 0.01 to 10% by weight, and the composition for scalp coating according to any one of claims 1 to 4 is summarized.

  The composition for coating the scalp of the present invention is such that the blending amount of Saccharomyces yeast extract is 0.01% by weight or more (preferably 0.05% by weight or more, particularly preferably 0.1% by weight or more). The effect of alleviating primary irritation and inflammation to the scalp by chemical treatment such as color and perm.

  In addition, the composition for coating the scalp of the present invention increases the effect of alleviating primary irritation and inflammation to the scalp as the amount of Saccharomyces genus yeast extract increases, but the increase in the effect is 5% by weight. If it exceeds 10% by weight, it becomes more peaked. If it exceeds 10% by weight, it becomes more peaked. The composition for coating the scalp of the present invention contains 10% by weight or less (preferably 8% by weight or less, more preferably 5% by weight or less) of the Saccharomyces yeast extract. Since the amount of the Saccharomyces spp.

(6 ) The invention of claim 6
The scalp coating according to any one of claims 1 to 5 , wherein the weight ratio of the blended amount of the inorganic salt and the blended amount of the Saccharomyces yeast extract is in the range of 1: 0.05 to 3. The gist of the composition is as follows.

In the scalp coating composition of the present invention, the weight ratio of the inorganic salt and the Saccharomyces yeast extract is 1: 0.05 to 3 (preferably 1: 0.1 to 2, more preferably 1: 0.3-1.5), the effect of alleviating primary irritation and inflammation to the scalp by chemical treatment such as hair color and perm is even higher.
( 7 ) The invention of claim 7
Before and / or after chemical treatment of hair color or perm on hair, scalp irritation alleviation using the composition for scalp application according to any one of claims 1 to 6 to alleviate irritation to the scalp by the chemical treatment The method is summarized.

ADVANTAGE OF THE INVENTION According to this invention, the primary irritation | stimulation and inflammation to a scalp by chemical treatments, such as a hair color and a permanent, can be relieved.
The composition for coating scalp of the present invention comprises generally used oils and fats, polyhydric alcohols, lower alcohols, thickeners, ultraviolet absorbers, preservatives, antioxidants, chelating agents, pH adjusters, surfactants, and fragrances. , A pigment, water, and the like can be appropriately blended.

  Hereinafter, examples (examples) of embodiments of the composition for coating the scalp and the method for alleviating scalp irritation according to the present invention will be described.

a) First, the manufacturing method of the composition for scalp application of a present Example is demonstrated. As shown in Tables 1 to 4, Reference Examples 1 to 8 by mixing the components in a predetermined ratio, 12 to 20 were prepared scalp coating compositions of Examples 9-1 1.

上記表１〜表４において、参考例１〜８、１２〜２０、実施例９〜１１の頭皮塗布用組成物のいずれかに含まれる赤ワイン酵母抽出液、白ワイン酵母抽出液、及びビール酵母抽出液は、サッカロミセス属酵母エキスである。特に、赤ワイン酵母抽出液は、赤ワイン酵母エキスである。

In Table 1 to Table 4, Reference Examples 1 to 8, 12 to 20, red wine yeast extract to be contained in any of the scalp coating compositions of Examples 9 to 1, white wine yeast extract, and brewer's yeast The extract is a Saccharomyces yeast extract. In particular, the red wine yeast extract is a red wine yeast extract.

  The red wine yeast extract is a water-soluble red wine yeast extract (FAOII) manufactured by Kyowa Hakko Co., Ltd. The white wine yeast extract is a wine yeast extract (trade name) manufactured by Kyowa Hakko. The beer yeast extract is a yeast extract (trade name) manufactured by Maruzen Pharmaceutical Co., Ltd.

Example 9-1 1, scalp coating composition of Example 1 2-20 as inorganic salt is an alkali metal salt include sodium chloride, potassium chloride, or both.
In Tables 1 to 4, the unit of the blending amount is parts by weight, and the “suitable amount” that is the blending amount of purified water is an amount that makes the total amount of the scalp coating composition 100 parts by weight.

  Moreover, as shown in the said Table 2 and Table 4, the composition for scalp application of Comparative Examples 1-4 was manufactured by mixing each component by a predetermined | prescribed ratio. Since these comparative examples 1-4 do not contain Saccharomyces yeast extract, it is outside the scope of the present invention.

b) Next, the scalp irritation mitigation method using the composition for scalp application of the present Example will be described.
Before chemical treatment such as hair color or perm is applied to the hair, the scalp coating composition of this example is applied to the scalp.

  In addition, after the chemical treatment, the scalp coating composition of the present embodiment may be applied to the scalp, or both before and after the chemical treatment. The composition may be applied to the scalp.

c) Next, the experiment conducted in order to confirm the effect of the composition for scalp application of a present Example is demonstrated.
i) Experimental method for evaluating primary skin irritation Japanese white rabbits were used in the experiments. Its shaved was 1 inch square range test substance back (Reference Example 1～8,1 2-20, one of the scalp coating compositions of Examples 9-1 1 and Comparative Examples 1 to 4) 0 Pretreatment was performed by applying 5 ml. In addition, a site where no pretreatment was performed was also set as an untreated control part.

  30 minutes after the pretreatment, 0.5 ml of the hair dye composition was applied on the pretreated site and the untreated control site. Here, the hair dye composition was used by mixing the first agent and the second agent having the composition shown in Table 5. The test substance was removed 24 hours after the hair dye composition was applied.

被験物質塗布から２４時間経過時に、前処置部位と未処置対照部位のそれぞれについて、Ｄｒａｉｚｅの方法に従い、皮膚反応を紅斑と浮腫に分けて判定し、評価点を定めた。具体的には、表６に示す基準に従って、紅斑形成の評価点と、浮腫形成の評価点とを定め、それらをそれぞれＸ２４、Ｙ２４とした。また、被験物質塗布から７２時間経過時にも、同様に、紅斑形成の評価点と、浮腫形成の評価点とを定め、それらをＸ７２、Ｙ７２とした。そして、前処置部位と未処置部位のそれぞれについて、Ｘ２４、Ｙ２４、Ｘ７２、及びＹ７２の合計を３で割った数値を算出した。この数値を実験に用いた各動物ごとに求めて全体の平均値を出し、これを一次刺激性インデックス（Ｐ．Ｉ．Ｉ）とした。

After 24 hours from the application of the test substance, the skin reaction was divided into erythema and edema according to the Draize method for each of the pretreated site and the untreated control site, and an evaluation score was determined. Specifically, according to the criteria shown in Table 6, an erythema formation evaluation point and an edema formation evaluation point were determined, which were designated as X24 and Y24, respectively. Similarly, when 72 hours have passed since the test substance application, evaluation points for erythema formation and evaluation points for edema formation were determined, and these were designated as X72 and Y72. And the numerical value which divided the sum total of X24, Y24, X72, and Y72 by 3 about each of the pre-treatment site | part and the non-treatment site | part was calculated. This value was obtained for each animal used in the experiment, and the overall average value was calculated. This was used as the primary irritation index (PI).

そして、次式（１）に従い、被験物質によるＰ．Ｉ．Ｉ抑制率を算出した。

Then, according to the following formula (1), P.I. I. I inhibition rate was calculated.

Formula (1) C = {(A−B) / A} × 100
A: P. at an untreated control site. I. I
B: P. at the site pretreated with the test substance. I. I
C: P.I. I. I suppression rate (%)
This P.I. I. According to the value of the I inhibition rate, the evaluation of the test substance was determined as follows.
(Evaluation)
A: P.I. I. I suppression rate is 25% or more. I. I suppression rate is 15% or more and less than 25%. I. I suppression rate is 5% or more and less than 15%. I. I suppression rate is less than 5%
ii) Experimental results The experimental results are shown in Tables 1 to 4 above.

Reference Example 1-8, 12-20, scalp coating compositions of Examples 9 to 1 are all evaluated △ above, it was superior in the effect of alleviating the primary irritation or inflammation of the scalp. In contrast, the scalp coating compositions of Comparative Examples 1 to 4 were all evaluated as x.

  Reference Example 1 contains red wine yeast extract as a Saccharomyces genus yeast extract, so that P. P. is more effective than Reference Example 2 including white wine yeast extract and Reference Example 3 including beer yeast extract. I. The I suppression rate was further excellent.

  In addition, Reference Example 1 has a P.P. value higher than that of Reference Example 4 in which the blending amount is 0.01% by weight because the blending amount of the red wine yeast extract exceeds 0.01% by weight. I. The I suppression rate was further excellent. In addition, Reference Example 1 has a P.P. value higher than that of Reference Example 5 in which the compounding amount of the red wine yeast extract exceeds 0.1% by weight, so that the compounding amount is 0.1% by weight. I. The I suppression rate was further excellent.

In Examples 9 to 1, Reference Example 1 2-20 is because it contains sodium chloride or potassium chloride is an alkali metal salt, was more excellent in the effect of relieving the primary irritation or inflammation of the scalp. In particular, since Example 9 contains both sodium chloride and potassium chloride, P.P. 13 is better than Reference Example 13 containing only sodium chloride and Reference Example 14 containing only potassium chloride. I. The I suppression rate was further excellent.

In Example 9, Reference Example by the amount of the inorganic salt (sodium chloride and potassium chloride) is in the range of 0.1 to 10 wt%, the amount of the same type of inorganic salt is out of the range Than P.12. I. The I suppression rate was further excellent. Furthermore, in Example 9, since the blending amount of the inorganic salt is in the range of 1 to 3% by weight, the P.I. I. The I suppression rate was further excellent.

  Similarly, in Reference Example 13, the blending amount of the inorganic salt (sodium chloride) is in the range of 0.1 to 10% by weight, so that the blending amount of the same kind of inorganic salt is outside the above range. P. I. The I suppression rate was further excellent. Furthermore, in Reference Example 13, the blending amount of the inorganic salt is in the range of 1 to 3% by weight, so that the blending amount of the same kind of inorganic salt is more than that of Reference Examples 16, 18, and 19 outside the above range. I. The I suppression rate was further excellent.

  Further, in Reference Example 13, the ratio of the blending amount of the red wine yeast extract to the blending amount of the inorganic salt is in the range of 1: 0.05 to 3, so that the above ratio is outside this range. Than P. I. The I suppression rate was further excellent. Further, in Reference Example 13, the ratio of the red wine yeast extract to the inorganic salt is in the range of 1: 0.3 to 1.5, so that the above ratio is outside this range. , 19, 20 I. The I suppression rate was further excellent.

  Needless to say, the present invention is not limited to the above-described embodiments, and can be implemented in various modes without departing from the scope of the present invention.

Claims (7)

Saccharomyces yeast extract,
An inorganic salt which is an alkali metal salt or an alkaline earth metal salt;
Containing
As the inorganic salts, see containing sodium chloride and potassium chloride,
The composition for scalp coating, wherein the amount of the inorganic salt is in the range of 0.1 to 5% by weight .   The composition for scalp coating according to claim 1, wherein the composition is used for alleviating irritation to the scalp by chemical treatment of hair color or perm.   The Saccharomyces yeast extract is a Saccharomyces yeast, a dry powder of the Saccharomyces yeast, a product obtained by treating the Saccharomyces yeast by ultraviolet irradiation or self-digestion, or a degradation obtained by decomposing the Saccharomyces yeast with an acid or a protease It is extracted from a product using a solvent comprising at least one selected from water, ethanol, propylene glycol, 1.3-butylene glycol, and an aqueous glycerin solution. A composition for scalp application according to 1.   The composition for scalp coating according to any one of claims 1 to 3, wherein the Saccharomyces yeast extract is a red wine yeast extract.   The composition for coating the scalp according to any one of claims 1 to 4, wherein the amount of the Saccharomyces yeast extract is in the range of 0.01 to 10% by weight. The scalp coating according to any one of claims 1 to 5 , wherein the weight ratio of the blended amount of the inorganic salt and the blended amount of the Saccharomyces yeast extract is in the range of 1: 0.05 to 3. Composition. Before and / or after chemical treatment of hair color or perm on hair, scalp irritation alleviation using the composition for scalp application according to any one of claims 1 to 6 to alleviate irritation to the scalp by the chemical treatment Method.