JP4422897B2 - 核酸を検出するためのプライマ伸長法 - Google Patents
核酸を検出するためのプライマ伸長法 Download PDFInfo
- Publication number
- JP4422897B2 JP4422897B2 JP2000546055A JP2000546055A JP4422897B2 JP 4422897 B2 JP4422897 B2 JP 4422897B2 JP 2000546055 A JP2000546055 A JP 2000546055A JP 2000546055 A JP2000546055 A JP 2000546055A JP 4422897 B2 JP4422897 B2 JP 4422897B2
- Authority
- JP
- Japan
- Prior art keywords
- primer
- probe
- nucleic acid
- sample
- probes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/067,212 US6566101B1 (en) | 1997-06-16 | 1998-04-27 | Primer extension methods for detecting nucleic acids |
| US09/067,212 | 1998-04-27 | ||
| PCT/US1999/008849 WO1999055912A1 (en) | 1998-04-27 | 1999-04-23 | Primer extension methods for detecting nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009119325A Division JP2009232850A (ja) | 1998-04-27 | 2009-05-15 | 核酸を検出するためのプライマ伸長法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512814A JP2002512814A (ja) | 2002-05-08 |
| JP2002512814A5 JP2002512814A5 (enExample) | 2006-07-13 |
| JP4422897B2 true JP4422897B2 (ja) | 2010-02-24 |
Family
ID=22074469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000546055A Expired - Fee Related JP4422897B2 (ja) | 1998-04-27 | 1999-04-23 | 核酸を検出するためのプライマ伸長法 |
| JP2009119325A Withdrawn JP2009232850A (ja) | 1998-04-27 | 2009-05-15 | 核酸を検出するためのプライマ伸長法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009119325A Withdrawn JP2009232850A (ja) | 1998-04-27 | 2009-05-15 | 核酸を検出するためのプライマ伸長法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6566101B1 (enExample) |
| EP (1) | EP1073769A1 (enExample) |
| JP (2) | JP4422897B2 (enExample) |
| AU (1) | AU771294B2 (enExample) |
| CA (1) | CA2326697A1 (enExample) |
| WO (1) | WO1999055912A1 (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566101B1 (en) * | 1997-06-16 | 2003-05-20 | Anthony P. Shuber | Primer extension methods for detecting nucleic acids |
| AU1479200A (en) * | 1998-11-23 | 2000-06-13 | Exact Laboratories, Inc. | Methods for detecting lower-frequency molecules |
| CA2366778C (en) | 1999-04-09 | 2008-07-22 | Exact Sciences Corporation | Methods for detecting nucleic acids indicative of cancer |
| US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
| US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| US6692918B2 (en) | 1999-09-13 | 2004-02-17 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| EP1238113B1 (en) | 1999-12-07 | 2010-02-24 | EXACT Sciences Corporation | Detection of lung neoplasms in stool |
| US6919174B1 (en) | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
| US7229756B1 (en) * | 2000-10-19 | 2007-06-12 | University Of Cincinnati | Alpha-2B-adrenergic receptor polymorphisms |
| DE60141087D1 (de) | 2000-06-26 | 2010-03-04 | Nugen Technologies Inc | Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren |
| US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| CA2430329A1 (en) | 2000-12-13 | 2002-06-20 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
| US7078168B2 (en) * | 2001-02-27 | 2006-07-18 | Biotage Ab | Method for determining allele frequencies |
| GB0105330D0 (en) | 2001-03-02 | 2001-04-18 | Renovo Ltd | Genetic testing |
| WO2002072772A2 (en) | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| CA2439074A1 (en) | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| CA2457527A1 (en) * | 2001-08-31 | 2003-03-13 | Gen-Probe Incorporated | Affinity-shifted probes for quantifying analyte polynucleotides |
| WO2003071252A2 (en) | 2002-02-15 | 2003-08-28 | Exact Sciences Corporation | Methods for analysis of molecular events |
| JP2006523465A (ja) | 2003-04-14 | 2006-10-19 | ニューゲン テクノロジーズ, インコーポレイテッド | ランダムにプライミングされる複合プライマーを用いる大規模増幅 |
| US20100216153A1 (en) * | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US20080241827A1 (en) * | 2004-05-10 | 2008-10-02 | Exact Sciences Corporation | Methods For Detecting A Mutant Nucleic Acid |
| US7476734B2 (en) | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
| WO2006026654A2 (en) * | 2004-08-27 | 2006-03-09 | Exact Sciences Corporation | Method for detecting a recombinant event |
| WO2006031955A2 (en) | 2004-09-14 | 2006-03-23 | The Regents Of The University Of Colorado, A Body Corporate | Method for treatment with bucindolol based on genetic targeting |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US8669052B2 (en) | 2008-06-10 | 2014-03-11 | Rapid Pathogen Screening, Inc. | Lateral flow nucleic acid detector |
| US9777314B2 (en) * | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
| JP2008539742A (ja) * | 2005-05-11 | 2008-11-20 | サノフィ−アベンティス | Gipプロモーター多型の使用 |
| US7939258B2 (en) | 2005-09-07 | 2011-05-10 | Nugen Technologies, Inc. | Nucleic acid amplification procedure using RNA and DNA composite primers |
| TR201910868T4 (tr) * | 2006-02-02 | 2019-08-21 | Univ Leland Stanford Junior | Dijital analizle invazif olmayan fetal genetik tarama. |
| AU2012201607B2 (en) * | 2006-05-01 | 2013-09-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Methods and agents for detecting Parechovirus |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| EP2029779A4 (en) * | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| US20090047694A1 (en) * | 2007-08-17 | 2009-02-19 | Shuber Anthony P | Clinical Intervention Directed Diagnostic Methods |
| US20090029372A1 (en) * | 2007-05-14 | 2009-01-29 | Kobenhavns Universitet | Adam12 as a biomarker for bladder cancer |
| GB2450356A (en) * | 2007-06-20 | 2008-12-24 | Secretary Trade Ind Brit | Method of Determining the Genotype of a Polymorphism using labelled nucleotides |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| US20090075266A1 (en) * | 2007-09-14 | 2009-03-19 | Predictive Biosciences Corporation | Multiple analyte diagnostic readout |
| US8431367B2 (en) | 2007-09-14 | 2013-04-30 | Predictive Biosciences Corporation | Detection of nucleic acids and proteins |
| US8852893B2 (en) | 2007-09-14 | 2014-10-07 | Physicians Choice Laboratory Services, Llc | Detection of nucleic acids and proteins |
| US20100267041A1 (en) * | 2007-09-14 | 2010-10-21 | Predictive Biosciences, Inc. | Serial analysis of biomarkers for disease diagnosis |
| US7955822B2 (en) * | 2007-09-14 | 2011-06-07 | Predictive Biosciences Corp. | Detection of nucleic acids and proteins |
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| US8609433B2 (en) | 2009-12-04 | 2013-12-17 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with sample compressor |
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| HUE031848T2 (en) | 2008-09-20 | 2017-08-28 | Univ Leland Stanford Junior | Non-invasive diagnosis of fetal aneuploidy by sequencing |
| JP5575239B2 (ja) | 2009-07-21 | 2014-08-20 | ジェン−プローブ・インコーポレーテッド | 拡張されたダイナミックレンジにわたる核酸配列の定量的検出のための方法および組成物 |
| KR20120100938A (ko) | 2009-09-23 | 2012-09-12 | 셀매틱스, 인크. | 불임 및/또는 난자 품질을 평가하기 위한 방법 및 장치 |
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| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
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| EP3495496B1 (en) | 2013-10-07 | 2020-11-25 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
| KR20170063519A (ko) | 2014-07-17 | 2017-06-08 | 셀매틱스, 인크. | 불임 및 관련 병리상태를 평가하기 위한 방법 및 시스템 |
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| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US10808287B2 (en) | 2015-10-23 | 2020-10-20 | Rapid Pathogen Screening, Inc. | Methods and devices for accurate diagnosis of infections |
| WO2017176864A1 (en) * | 2016-04-05 | 2017-10-12 | Lariat Biosciences, Inc. | Compositions for and methods of enriching genetic mutants for detecting, diagnosing, and prognosing cancer |
| ITUA20163413A1 (it) * | 2016-05-13 | 2017-11-13 | Fondazione St Italiano Tecnologia | Reazione di amplificazione di acidi nucleici con primer cooperativi. |
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| CA3207879A1 (en) | 2017-01-24 | 2018-08-02 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
| EP3596233B1 (en) | 2017-03-17 | 2022-05-18 | Sequenom, Inc. | Methods and processes for assessment of genetic mosaicism |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5591582A (en) | 1985-07-23 | 1997-01-07 | The Board Of Rijks Universiteit Leiden | Methods for detecting activated RAS oncogenes |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| DE68916671T2 (de) | 1988-03-18 | 1995-03-02 | Baylor College Medicine | Mutationsnachweis durch kompetitiven Oligonukleotid-Priming. |
| JP3021036B2 (ja) | 1989-02-13 | 2000-03-15 | ジェネコ・ピーティーワイ・リミテッド | 核酸配列又はその中の変化の検出 |
| JP2802125B2 (ja) | 1989-06-23 | 1998-09-24 | キヤノン株式会社 | 核酸の検出方法 |
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-
1998
- 1998-04-27 US US09/067,212 patent/US6566101B1/en not_active Expired - Lifetime
-
1999
- 1999-04-23 WO PCT/US1999/008849 patent/WO1999055912A1/en not_active Ceased
- 1999-04-23 JP JP2000546055A patent/JP4422897B2/ja not_active Expired - Fee Related
- 1999-04-23 AU AU38654/99A patent/AU771294B2/en not_active Ceased
- 1999-04-23 CA CA002326697A patent/CA2326697A1/en not_active Abandoned
- 1999-04-23 EP EP99921441A patent/EP1073769A1/en not_active Withdrawn
-
2003
- 2003-02-05 US US10/358,989 patent/US20040110162A1/en not_active Abandoned
-
2009
- 2009-05-15 JP JP2009119325A patent/JP2009232850A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999055912A1 (en) | 1999-11-04 |
| EP1073769A1 (en) | 2001-02-07 |
| AU3865499A (en) | 1999-11-16 |
| CA2326697A1 (en) | 1999-11-04 |
| US20040110162A1 (en) | 2004-06-10 |
| AU771294B2 (en) | 2004-03-18 |
| JP2002512814A (ja) | 2002-05-08 |
| JP2009232850A (ja) | 2009-10-15 |
| US6566101B1 (en) | 2003-05-20 |
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