JP4357902B2 - 液体分離装置及び液体分離方法 - Google Patents
液体分離装置及び液体分離方法 Download PDFInfo
- Publication number
- JP4357902B2 JP4357902B2 JP2003307482A JP2003307482A JP4357902B2 JP 4357902 B2 JP4357902 B2 JP 4357902B2 JP 2003307482 A JP2003307482 A JP 2003307482A JP 2003307482 A JP2003307482 A JP 2003307482A JP 4357902 B2 JP4357902 B2 JP 4357902B2
- Authority
- JP
- Japan
- Prior art keywords
- flow path
- flow
- separation
- component
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000926 separation method Methods 0.000 title claims description 186
- 239000007788 liquid Substances 0.000 title claims description 116
- 210000004369 blood Anatomy 0.000 claims description 32
- 239000008280 blood Substances 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 24
- 210000000601 blood cell Anatomy 0.000 claims description 12
- 235000004252 protein component Nutrition 0.000 claims description 7
- 239000011873 medical mixture Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 2
- 239000000306 component Substances 0.000 description 171
- 108020004414 DNA Proteins 0.000 description 22
- 210000003743 erythrocyte Anatomy 0.000 description 21
- 235000018102 proteins Nutrition 0.000 description 19
- 102000004169 proteins and genes Human genes 0.000 description 19
- 108090000623 proteins and genes Proteins 0.000 description 19
- 239000012141 concentrate Substances 0.000 description 12
- 210000000265 leukocyte Anatomy 0.000 description 12
- 239000008155 medical solution Substances 0.000 description 12
- 238000010586 diagram Methods 0.000 description 11
- 239000004205 dimethyl polysiloxane Substances 0.000 description 9
- 239000011521 glass Substances 0.000 description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 9
- 229920002050 silicone resin Polymers 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000001914 filtration Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 238000002523 gelfiltration Methods 0.000 description 5
- 210000004180 plasmocyte Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000012503 blood component Substances 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- -1 Polydimethylsiloxane Polymers 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000004401 flow injection analysis Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000002061 nanopillar Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Images
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003307482A JP4357902B2 (ja) | 2003-08-29 | 2003-08-29 | 液体分離装置及び液体分離方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003307482A JP4357902B2 (ja) | 2003-08-29 | 2003-08-29 | 液体分離装置及び液体分離方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005074309A JP2005074309A (ja) | 2005-03-24 |
| JP2005074309A5 JP2005074309A5 (enExample) | 2006-07-27 |
| JP4357902B2 true JP4357902B2 (ja) | 2009-11-04 |
Family
ID=34410259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003307482A Expired - Fee Related JP4357902B2 (ja) | 2003-08-29 | 2003-08-29 | 液体分離装置及び液体分離方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4357902B2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4509632B2 (ja) * | 2004-04-05 | 2010-07-21 | 株式会社アドバンス | 血球分離構造物 |
| JP4587215B2 (ja) * | 2005-02-16 | 2010-11-24 | セイコーインスツル株式会社 | 成分分離機構と成分分離方法 |
| JP4673197B2 (ja) * | 2005-11-24 | 2011-04-20 | 日立Geニュークリア・エナジー株式会社 | 液体試料のモニタリング方法及び液体試料分析装置 |
| JP5084188B2 (ja) * | 2006-07-04 | 2012-11-28 | 日本電子株式会社 | 試料保持体、試料検査方法及び試料検査装置並びに試料検査システム |
| JP4857094B2 (ja) * | 2006-12-01 | 2012-01-18 | 前澤工業株式会社 | 沈砂分離設備 |
| JP2009273556A (ja) * | 2008-05-13 | 2009-11-26 | Ritsumeikan | 血漿又は血清分離装置 |
| KR101690550B1 (ko) * | 2015-05-14 | 2017-01-09 | 케이씨코트렐 주식회사 | 분진부하 저감장치를 포함하는 집진설비 |
-
2003
- 2003-08-29 JP JP2003307482A patent/JP4357902B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005074309A (ja) | 2005-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10144009B2 (en) | Microfluidics sorter for cell detection and isolation | |
| JP4991688B2 (ja) | 流体分離装置 | |
| CA2966603C (en) | Combined sorting and concentrating particles in a microfluidic device | |
| EP2378267A1 (en) | Particle separation and concentration system | |
| Patil et al. | Isolation of circulating tumour cells by physical means in a microfluidic device: a review | |
| CN107262171A (zh) | 一种血液分离预处理芯片及血液分离装置 | |
| US20110303586A1 (en) | Target particles-separating device and method using multi-orifice flow fractionation channel | |
| EP3060342B1 (en) | Fluid filtering device and assembly | |
| JP4357902B2 (ja) | 液体分離装置及び液体分離方法 | |
| EP2999778B1 (en) | Common port emulsion generation article, system and method | |
| EP3684507B1 (en) | Particle sorting in a microfluidic system | |
| US20050029190A1 (en) | Method and separating module for the separation of particles from a dispersion, in particular of blood corpuscles from blood | |
| WO2017149164A1 (en) | Device and method for refining particles | |
| Balyan et al. | Flow induced particle separation and collection through linear array pillar microfluidics device | |
| US20160184822A1 (en) | Microfluidic device for particle enumeration | |
| JP2005074309A5 (enExample) | ||
| JP4587215B2 (ja) | 成分分離機構と成分分離方法 | |
| KR20110135330A (ko) | Moff 채널을 이용한 표적 입자 분리 장치 및 분리 방법 | |
| Indhu et al. | Design of a filter using array of pillar for particle separation | |
| Wang et al. | Blood plasma self-separation technologies during the self-driven flow in microfluidic platforms. Bioengineering 2021, 8, 94 | |
| US20210387191A1 (en) | Fluid refining device | |
| Blattert et al. | Fabrication and testing of novel blood separation devices based on microchannel bend structures | |
| Ramya et al. | MEMS based Chip for Blood Cell Sorting using Microfluidic Channel | |
| KR20180110772A (ko) | 혈액 내 암세포 검출 장치 | |
| Zheng et al. | Streamline based design of a MEMS device for continuous blood cell separation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060607 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060607 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090602 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090702 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20090804 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20090805 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120814 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4357902 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| RD01 | Notification of change of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7421 Effective date: 20091105 |
|
| RD01 | Notification of change of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7421 Effective date: 20091112 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120814 Year of fee payment: 3 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D03 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120814 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130814 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |