JP4354403B2 - マロンジアルデヒドを検出するための試薬、その製造方法及びそれを使用するための検査キット - Google Patents
マロンジアルデヒドを検出するための試薬、その製造方法及びそれを使用するための検査キット Download PDFInfo
- Publication number
- JP4354403B2 JP4354403B2 JP2004524194A JP2004524194A JP4354403B2 JP 4354403 B2 JP4354403 B2 JP 4354403B2 JP 2004524194 A JP2004524194 A JP 2004524194A JP 2004524194 A JP2004524194 A JP 2004524194A JP 4354403 B2 JP4354403 B2 JP 4354403B2
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- JP
- Japan
- Prior art keywords
- reagent
- urine
- present
- phosphoric acid
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
- Y10T436/202499—Formaldehyde or acetone
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Description
Claims (14)
- 尿に含まれるマロンジアルデヒドの存在を検出するために個人で使用するための検査キットであって、
規定量の試薬であって、およそ1リットルあたり、約8−12gのピロ亜硫酸ナトリウム、約995から1005mlの脱イオン水、10mlのリン酸、約4.8から5.2gの塩基性フクシンを含み、pHは1.75から1.93の間である試薬が入っている密封コンテナと、
尿の標本を集めるための容器と、
前記容器から前記尿を規定量取り出し、前記コンテナの密封を破った後、前記コンテナにそれを入れるためのディスペンサーと、
2−5分間の待ち時間の後の試薬と尿との混合物の色と、尿に含まれるアルデヒドの存在があるか否かを示している試薬と尿との混合物の色とを比較するためのカラーチャートとを含むことを特徴とする検査キット。 - 前記密封コンテナは、1mlの体積容量を有し、その中に含まれた前記規定量の試薬は0.1mlである請求項1記載の検査キット。
- 前記ピロ亜硫酸ナトリウムは10gの量で存在している請求項1記載の検査キット。
- 前記塩基性フクシンが5.0gの量で存在している請求項1記載の検査キット。
- 前記試薬のpHが1.88である請求項1記載の検査キット。
- 尿に含まれるアルデヒドの存在を検出するために使用される試薬であって、約8−12gのピロ亜硫酸ナトリウムと、約999−1005mlの脱イオン水と、10mlのリン酸と、約4.8−5.2gの塩基性フクシンとを含み、pHは1.75から1.93の間であることを特徴とする試薬。
- ピロ亜硫酸ナトリウムが10g存在している請求項6記載の試薬。
- 塩基性フクシンが5g存在している請求項7記載の試薬。
- pHが1.88である請求項8記載の試薬。
- 尿に含まれるアルデヒドの存在を検出するのに使用するための試薬のおよそ1リットルあたりの製造方法であって、
約995−1005mlの脱イオン水に約8−12gのピロ亜硫酸ナトリウムを溶かし、10mlのリン酸を加え、約4.8−5.2gの塩基性フクシンを加え、上記の成分を少なくとも10分間混合し、約28−32gの動物骨炭を加え、その骨炭がよく分配されるまで混合し、混合した結果物を24時間から36時間置いたままにし、骨炭を取り除き、そして、pHが1.75−1.93の間に達するまでリン酸を加えることによって混合物のpHを調整するステップを含むことを特徴とする製造方法。 - 前記ピロ亜硫酸ナトリウムが10g存在している請求項10記載の方法。
- 前記塩基性フクシンが5g存在している請求項10記載の方法。
- 前記動物骨炭が30g存在している請求項10記載の方法。
- リン酸をゆっくり加え、よく撹拌することによって、前記pHレベルが1.88に調整される請求項10記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/209,540 US6689617B1 (en) | 2002-07-30 | 2002-07-30 | Agent for detecting malondialdehyde, method of making the same, and test kit for use thereof |
PCT/US2003/023811 WO2004011910A2 (en) | 2002-07-30 | 2003-07-29 | Agent for detecting malondialdehyde, method of making the same, and test kit for use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005534902A JP2005534902A (ja) | 2005-11-17 |
JP4354403B2 true JP4354403B2 (ja) | 2009-10-28 |
Family
ID=30770593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004524194A Expired - Fee Related JP4354403B2 (ja) | 2002-07-30 | 2003-07-29 | マロンジアルデヒドを検出するための試薬、その製造方法及びそれを使用するための検査キット |
Country Status (11)
Country | Link |
---|---|
US (1) | US6689617B1 (ja) |
EP (1) | EP1525471B1 (ja) |
JP (1) | JP4354403B2 (ja) |
KR (1) | KR101034993B1 (ja) |
CN (1) | CN100338463C (ja) |
AT (1) | ATE479894T1 (ja) |
AU (1) | AU2003259303A1 (ja) |
CA (1) | CA2494022C (ja) |
DE (1) | DE60334003D1 (ja) |
HK (1) | HK1073359A1 (ja) |
WO (1) | WO2004011910A2 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7514265B2 (en) * | 2004-10-05 | 2009-04-07 | Marine Products Tech | Aldehyde detection kit and method thereof |
US8012761B2 (en) * | 2006-12-14 | 2011-09-06 | Kimberly-Clark Worldwide, Inc. | Detection of formaldehyde in urine samples |
US7846383B2 (en) * | 2006-12-15 | 2010-12-07 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device and absorbent article containing same |
CA2710904A1 (en) * | 2010-07-23 | 2012-01-23 | Norgen Biotek Corp. | Methods and devices for rapid urine concentration |
KR101370613B1 (ko) * | 2012-01-31 | 2014-03-26 | 주식회사 디에프아이 | 인체 내 활성산소 검출수단 |
JP6174309B2 (ja) * | 2012-09-28 | 2017-08-02 | 有限会社アサクサ錠剤研究所 | 試験液製品 |
KR101334265B1 (ko) | 2013-04-08 | 2013-12-12 | 경북대학교병원 | 결절맥락막혈관병증 진단용 조성물 |
CN103901029B (zh) * | 2014-03-27 | 2016-05-25 | 华中科技大学 | 一种氧化损伤体外检测方法及检测试剂盒 |
CN105699371A (zh) * | 2016-01-28 | 2016-06-22 | 湖北雅仕达生物技术有限公司 | 一种检测液体中含有醛的试剂及制备方法 |
KR101822417B1 (ko) * | 2017-06-14 | 2018-01-29 | 주식회사 청도제약 | 인간의 체액에서 산화 스트레스를 측정하기 위한 방법 |
CN108287159A (zh) * | 2018-02-08 | 2018-07-17 | 朱佳琪 | 一种用于食品中甲醛检测的化学试剂及其制备方法 |
KR102221289B1 (ko) * | 2019-04-12 | 2021-03-02 | 가천대학교 산학협력단 | 폴더블 타입의 등온 증폭 마이크로 디바이스 및 이를 이용한 병원균 검출방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4201693A (en) * | 1978-05-02 | 1980-05-06 | American Hospital Supply Corporation | Stable schiff reagent |
US4753891A (en) | 1985-05-24 | 1988-06-28 | Akzo N.V. | Schiff test for rapid detection of low levels of aldehydes |
US5985665A (en) | 1996-06-19 | 1999-11-16 | Research Development Foundation | Biochemical analysis of antioxidant function of lymphocytes in culture |
JP3381053B2 (ja) | 1996-11-29 | 2003-02-24 | 日研フード株式会社 | 酸化的ストレス判断解析表 |
US6004821A (en) * | 1998-03-07 | 1999-12-21 | Levine; Robert A. | Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample |
JP3867880B2 (ja) * | 1998-04-08 | 2007-01-17 | シスメックス株式会社 | 尿中赤血球の鑑別装置および方法 |
US6165797A (en) | 1999-02-19 | 2000-12-26 | Bio-Defense Nutritionals, Inc. | Methods for testing oxidative stress |
-
2002
- 2002-07-30 US US10/209,540 patent/US6689617B1/en not_active Expired - Lifetime
-
2003
- 2003-07-29 KR KR1020057001788A patent/KR101034993B1/ko active IP Right Grant
- 2003-07-29 DE DE60334003T patent/DE60334003D1/de not_active Expired - Lifetime
- 2003-07-29 EP EP03772087A patent/EP1525471B1/en not_active Expired - Lifetime
- 2003-07-29 AU AU2003259303A patent/AU2003259303A1/en not_active Abandoned
- 2003-07-29 CA CA2494022A patent/CA2494022C/en not_active Expired - Fee Related
- 2003-07-29 AT AT03772087T patent/ATE479894T1/de not_active IP Right Cessation
- 2003-07-29 JP JP2004524194A patent/JP4354403B2/ja not_active Expired - Fee Related
- 2003-07-29 CN CNB038180367A patent/CN100338463C/zh not_active Expired - Fee Related
- 2003-07-29 WO PCT/US2003/023811 patent/WO2004011910A2/en active Application Filing
-
2005
- 2005-08-11 HK HK05106905.6A patent/HK1073359A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE479894T1 (de) | 2010-09-15 |
US20040023402A1 (en) | 2004-02-05 |
EP1525471A2 (en) | 2005-04-27 |
CN100338463C (zh) | 2007-09-19 |
WO2004011910A2 (en) | 2004-02-05 |
JP2005534902A (ja) | 2005-11-17 |
CA2494022A1 (en) | 2004-02-05 |
CN1672045A (zh) | 2005-09-21 |
KR101034993B1 (ko) | 2011-05-17 |
CA2494022C (en) | 2011-09-27 |
WO2004011910A3 (en) | 2004-12-23 |
US6689617B1 (en) | 2004-02-10 |
KR20050024512A (ko) | 2005-03-10 |
EP1525471A4 (en) | 2007-07-11 |
HK1073359A1 (en) | 2005-09-30 |
AU2003259303A1 (en) | 2004-02-16 |
DE60334003D1 (de) | 2010-10-14 |
EP1525471B1 (en) | 2010-09-01 |
AU2003259303A8 (en) | 2004-02-16 |
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