JP4321966B2 - 適合性抗微生物剤を含有する電気輸送式デバイス - Google Patents
適合性抗微生物剤を含有する電気輸送式デバイス Download PDFInfo
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- JP4321966B2 JP4321966B2 JP2000579294A JP2000579294A JP4321966B2 JP 4321966 B2 JP4321966 B2 JP 4321966B2 JP 2000579294 A JP2000579294 A JP 2000579294A JP 2000579294 A JP2000579294 A JP 2000579294A JP 4321966 B2 JP4321966 B2 JP 4321966B2
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
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- Electrotherapy Devices (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2297895T5 (es) * | 1997-10-10 | 2012-07-03 | Pure Bioscience | Desinfectante y método de preparación |
| US7261905B2 (en) * | 1999-04-07 | 2007-08-28 | Pure Bioscience | Disinfectant and method of making |
| US6890953B2 (en) * | 2000-04-06 | 2005-05-10 | Innovative Medical Services | Process for treating water |
| US6488828B1 (en) * | 2000-07-20 | 2002-12-03 | Roche Diagnostics Corporation | Recloseable biosensor |
| US20020156415A1 (en) * | 2000-08-24 | 2002-10-24 | Redding Bruce K. | Ultrasonically enhanced substance delivery system and device |
| ATE293475T1 (de) * | 2000-09-11 | 2005-05-15 | Alza Corp | Vorrichtung zur transdermalen verabreichung von medikamenten und entsprechendes herstellungsverfahren |
| MXPA03009121A (es) * | 2001-04-04 | 2004-11-22 | Johnson & Johnson | Dispositivo de suministro de electrotransporte transdermico que incluye una composicion de reserva compatible antimicrobiana. |
| US6631294B2 (en) * | 2001-06-01 | 2003-10-07 | Biofisica, Llc | Apparatus and methods for facilitating wound healing |
| US6908448B2 (en) * | 2001-08-24 | 2005-06-21 | Dermisonics, Inc. | Substance delivery device |
| DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US6663615B1 (en) | 2001-09-04 | 2003-12-16 | The Ohio State University | Dual stage microvalve and method of use |
| WO2003053514A1 (en) * | 2001-12-19 | 2003-07-03 | Alza Corporation | Reservoir housing having a conductive region integrally formed therein |
| WO2003061726A2 (en) * | 2002-01-16 | 2003-07-31 | Encapsulation Systems, Inc. | Substance delivery device |
| US20040044073A1 (en) * | 2002-08-31 | 2004-03-04 | Innovative Medical Services | Composition and process for treating acne |
| US7435438B1 (en) * | 2003-05-16 | 2008-10-14 | Pure Bioscience | Disinfectant and method of use |
| AU2004267997B2 (en) * | 2003-08-28 | 2010-06-03 | Pure Bioscience | Silver dihydrogen citrate compositions comprising a second antimicrobial agent |
| JP2007513706A (ja) * | 2003-12-12 | 2007-05-31 | メドトロニック・インコーポレーテッド | 埋め込み可能な医療機器のための抗菌保護 |
| US7457667B2 (en) * | 2004-02-19 | 2008-11-25 | Silverleaf Medical Products, Inc. | Current producing surface for a wound dressing |
| US7662176B2 (en) * | 2004-02-19 | 2010-02-16 | Vomaris Innovations, Inc. | Footwear apparatus and methods of manufacture and use |
| WO2006004595A2 (en) * | 2004-05-28 | 2006-01-12 | Georgia Tech Research Corporation | Methods and devices for thermal treatment |
| US20090318846A1 (en) * | 2004-05-28 | 2009-12-24 | Georgia Tech Research Corporation | Methods and apparatus for surface ablation |
| US20060015052A1 (en) * | 2004-07-15 | 2006-01-19 | Crisp William E | Wound dressing |
| US20090227930A1 (en) * | 2004-07-15 | 2009-09-10 | Crisp William E | Hygiene materials and absorbents |
| US20100069813A1 (en) * | 2004-07-15 | 2010-03-18 | Crisp William E | Wound dressings |
| US7495146B2 (en) * | 2004-07-15 | 2009-02-24 | Vivo Ltd. Partnership | Wound dressing |
| US20060051430A1 (en) * | 2004-09-07 | 2006-03-09 | Arata Andrew B | Silver dihydrogen citrate compositions |
| US20060062854A1 (en) * | 2004-09-22 | 2006-03-23 | Noble Fiber Technologies, Llc | Hydrogel having anti-microbial properties |
| WO2007011987A2 (en) * | 2005-07-18 | 2007-01-25 | Alza Corporation | Device and method for increasing the throughput of irritation testing of transdermal formulations |
| CA2621234A1 (en) | 2005-08-31 | 2007-03-08 | Alza Corporation | Cathode for electrotransport delivery of anionic drug |
| WO2007109274A2 (en) * | 2006-03-21 | 2007-09-27 | Alza Corporation | Hydratable polymeric ester matrix for drug electrotransport |
| RU2465812C2 (ru) * | 2006-05-08 | 2012-11-10 | БАЙЕР ХЕЛТКЭА ЭлЭлСи | Система детектирования аномального выходного сигнала для биосенсора |
| JP2010502270A (ja) * | 2006-08-29 | 2010-01-28 | アルザ・コーポレーシヨン | 水和可能な貯蔵器の水和測定付きの薬品電気輸送 |
| US20080122582A1 (en) * | 2006-11-29 | 2008-05-29 | Texas Instruments Incorporated | Location Based Portable Device Feature Disabler |
| WO2008082558A2 (en) * | 2006-12-20 | 2008-07-10 | Alza Corporation | Anode for electrotransport of cationic drug |
| WO2008116105A1 (en) * | 2007-03-22 | 2008-09-25 | Alza Corporation | Pivotally engaged multiple part electrotransport drug delivery device |
| US8197844B2 (en) * | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
| ES2319054B1 (es) * | 2007-08-06 | 2010-02-12 | Gp Pharm S.A. | Composicion farmaceutica oral de desmopresina. |
| US20090043244A1 (en) * | 2007-08-08 | 2009-02-12 | Inan Omer T | Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change |
| WO2009036316A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Energy management, tracking and security for adherent patient monitor |
| US9186089B2 (en) | 2007-09-14 | 2015-11-17 | Medtronic Monitoring, Inc. | Injectable physiological monitoring system |
| US20090076345A1 (en) * | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Device with Multiple Physiological Sensors |
| US8591430B2 (en) * | 2007-09-14 | 2013-11-26 | Corventis, Inc. | Adherent device for respiratory monitoring |
| EP2194858B1 (en) * | 2007-09-14 | 2017-11-22 | Corventis, Inc. | Medical device automatic start-up upon contact to patient tissue |
| US20090076350A1 (en) * | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Data Collection in a Multi-Sensor Patient Monitor |
| WO2009036329A1 (en) * | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Multi-sensor patient monitor to detect impending cardiac decompensation |
| US8460189B2 (en) * | 2007-09-14 | 2013-06-11 | Corventis, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
| US20090076342A1 (en) * | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Multi-Sensor Device with Empathic Monitoring |
| US20090105634A1 (en) * | 2007-10-17 | 2009-04-23 | Alza Corporation | Anodic Reservoir for Electrotransport of Cationic Drug |
| US20090105632A1 (en) * | 2007-10-18 | 2009-04-23 | Padmanabhan Rama V | Electrotransport Of Lisuride |
| US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
| USD588274S1 (en) | 2008-02-12 | 2009-03-10 | Alza Corporation | Skin-adhering drug delivery patch |
| JP5405500B2 (ja) * | 2008-03-12 | 2014-02-05 | コーヴェンティス，インク． | 心調律に基づく心代償不全予測 |
| WO2009123970A2 (en) * | 2008-04-01 | 2009-10-08 | Alza Corporation | Electrotransport fentanyl delivery device with consistent delivery |
| WO2009146214A1 (en) | 2008-04-18 | 2009-12-03 | Corventis, Inc. | Method and apparatus to measure bioelectric impedance of patient tissue |
| US20090312689A1 (en) * | 2008-06-05 | 2009-12-17 | Alza Corporation | Adjustable Current Electrotransport Fentanyl Delivery Device |
| WO2011050283A2 (en) | 2009-10-22 | 2011-04-28 | Corventis, Inc. | Remote detection and monitoring of functional chronotropic incompetence |
| US9451897B2 (en) * | 2009-12-14 | 2016-09-27 | Medtronic Monitoring, Inc. | Body adherent patch with electronics for physiologic monitoring |
| US8965498B2 (en) | 2010-04-05 | 2015-02-24 | Corventis, Inc. | Method and apparatus for personalized physiologic parameters |
| JP5927506B2 (ja) | 2010-04-13 | 2016-06-01 | レルマダ セラピューティクス、インク． | １−メチル−２’，６’−ピペコロキシリダイドの皮膚医薬組成物および使用方法 |
| US8428709B1 (en) * | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
| US8428708B1 (en) | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
| US8301238B2 (en) | 2011-03-31 | 2012-10-30 | Incline Therapeutics, Inc. | Two-part electrotransport device |
| USD699855S1 (en) | 2012-11-12 | 2014-02-18 | Incline Therapeutics, Inc. | Iontophoretic drug delivery device |
| JP6081156B2 (ja) * | 2012-11-15 | 2017-02-15 | アルケア株式会社 | ハイドロゲル |
| RU2534521C2 (ru) * | 2012-11-27 | 2014-11-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский государственный университет" (ТГУ) | Способ трансдермального введения инсулина и устройство для его осуществления |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4585652A (en) | 1984-11-19 | 1986-04-29 | Regents Of The University Of Minnesota | Electrochemical controlled release drug delivery system |
| US5496266A (en) * | 1990-04-30 | 1996-03-05 | Alza Corporation | Device and method of iontophoretic drug delivery |
| US5023085A (en) | 1989-11-29 | 1991-06-11 | Pfizer Inc. | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals |
| US5047007A (en) | 1989-12-22 | 1991-09-10 | Medtronic, Inc. | Method and apparatus for pulsed iontophoretic drug delivery |
| US5169384A (en) | 1991-08-16 | 1992-12-08 | Bosniak Stephen L | Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue |
| US5310404A (en) * | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| US5434144A (en) | 1994-03-04 | 1995-07-18 | The Procter & Gamble Company | Methods of using cyclic polyanionic polyol derivatives for regulating skin wrinkles |
| AU2286995A (en) | 1994-04-08 | 1995-10-30 | Alza Corporation | Electrotransport system with ion exchange competitive ion capture |
| JPH09511927A (ja) | 1994-04-18 | 1997-12-02 | ザ、プロクター、エンド、ギャンブル、カンパニー | 歯槽骨へのビスホスホネート類のイオン導入デリバリー |
| US5624415A (en) * | 1995-04-24 | 1997-04-29 | Alza Corporation | Reduction of skin irritation and resistance during electrotransport |
| US6881208B1 (en) | 1995-06-05 | 2005-04-19 | Joseph B. Phipps | Method and device for transdermal electrotransport delivery of fentanyl and sufentanil |
| AU699774B2 (en) * | 1995-06-05 | 1998-12-17 | Alza Corporation | Device for transdermal electrotransport delivery of fentanyl and sufentanil |
| ZA964320B (en) | 1995-06-05 | 1997-01-13 | Alza Corp | Device for transdermal electrotransport delivery of fentanyl and sufentanil |
| US5788666A (en) | 1995-06-15 | 1998-08-04 | Empi, Inc. | Iontophoresis electrode |
| JP2001505197A (ja) * | 1996-11-14 | 2001-04-17 | アルザ・コーポレーション | リドカイン及びエピネフリンの電気的補助投与のための製剤 |
| US9030418B2 (en) * | 2008-06-24 | 2015-05-12 | Lg Electronics Inc. | Mobile terminal capable of sensing proximity touch |
-
1999
- 1999-10-29 DK DK99956789T patent/DK1135188T3/da active
- 1999-10-29 RU RU2001111889/14A patent/RU2232608C2/ru not_active IP Right Cessation
- 1999-10-29 HU HU0104383A patent/HUP0104383A3/hu unknown
- 1999-10-29 DE DE69937647T patent/DE69937647T2/de not_active Expired - Lifetime
- 1999-10-29 HK HK02100999.9A patent/HK1039462B/en not_active IP Right Cessation
- 1999-10-29 EP EP99956789A patent/EP1135188B1/en not_active Expired - Lifetime
- 1999-10-29 NZ NZ511464A patent/NZ511464A/en not_active IP Right Cessation
- 1999-10-29 AU AU13321/00A patent/AU766913B2/en not_active Expired
- 1999-10-29 PT PT99956789T patent/PT1135188E/pt unknown
- 1999-10-29 CN CNB998127345A patent/CN1170604C/zh not_active Expired - Lifetime
- 1999-10-29 IL IL14280899A patent/IL142808A0/xx active IP Right Grant
- 1999-10-29 JP JP2000579294A patent/JP4321966B2/ja not_active Expired - Lifetime
- 1999-10-29 WO PCT/US1999/025486 patent/WO2000025858A1/en not_active Ceased
- 1999-10-29 CA CA2349715A patent/CA2349715C/en not_active Expired - Lifetime
- 1999-10-29 ES ES99956789T patent/ES2297941T3/es not_active Expired - Lifetime
- 1999-10-29 KR KR1020017005541A patent/KR100649380B1/ko not_active Expired - Lifetime
- 1999-11-02 US US09/433,615 patent/US6181963B1/en not_active Expired - Lifetime
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2001
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- 2001-05-02 ZA ZA200103523A patent/ZA200103523B/en unknown
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2008
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Also Published As
| Publication number | Publication date |
|---|---|
| DE69937647T2 (de) | 2008-10-30 |
| WO2000025858A1 (en) | 2000-05-11 |
| CN1324259A (zh) | 2001-11-28 |
| CY1107290T1 (el) | 2012-11-21 |
| KR100649380B1 (ko) | 2006-11-24 |
| KR20010075678A (ko) | 2001-08-09 |
| HUP0104383A3 (en) | 2002-12-28 |
| DE69937647D1 (de) | 2008-01-10 |
| RU2232608C2 (ru) | 2004-07-20 |
| EP1135188B1 (en) | 2007-11-28 |
| HK1039462B (en) | 2008-07-18 |
| EP1135188A1 (en) | 2001-09-26 |
| AU1332100A (en) | 2000-05-22 |
| DK1135188T3 (da) | 2008-03-31 |
| JP2002528236A (ja) | 2002-09-03 |
| CA2349715A1 (en) | 2000-05-11 |
| NO20012167L (no) | 2001-06-22 |
| CN1170604C (zh) | 2004-10-13 |
| HK1039462A1 (en) | 2002-04-26 |
| ZA200103523B (en) | 2002-05-09 |
| IL142808A (en) | 2007-06-17 |
| AU766913B2 (en) | 2003-10-23 |
| ES2297941T3 (es) | 2008-05-01 |
| HUP0104383A2 (hu) | 2002-03-28 |
| NO20012167D0 (no) | 2001-05-02 |
| NZ511464A (en) | 2003-07-25 |
| CA2349715C (en) | 2010-02-09 |
| IL142808A0 (en) | 2002-03-10 |
| US6181963B1 (en) | 2001-01-30 |
| PT1135188E (pt) | 2008-03-19 |
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