JP4309931B2 - 神経系障害のスクリーニング装置 - Google Patents
神経系障害のスクリーニング装置 Download PDFInfo
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- JP4309931B2 JP4309931B2 JP2007102591A JP2007102591A JP4309931B2 JP 4309931 B2 JP4309931 B2 JP 4309931B2 JP 2007102591 A JP2007102591 A JP 2007102591A JP 2007102591 A JP2007102591 A JP 2007102591A JP 4309931 B2 JP4309931 B2 JP 4309931B2
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Images
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
- G16Z99/00—Subject matter not provided for in other main groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
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- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Data Mining & Analysis (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Databases & Information Systems (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Primary Health Care (AREA)
- Nuclear Medicine (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Description
図2は、図1の装置の他の実施態様であり、
図3は、本発明に従う方法のフローチャートであり、
図3Aは、図3の詳細を示したフローチャートであり、 図4は、本発明の方法の追加の側面のフローチャートであり、
図5は、データー処理前の、脳の範囲及びそれと関連づけられた数値を表し、
図6は、データー処理後の脳の範囲とそれと関連づけられた単一の数値を表す。
[数1]
ΣPi ・Mi
i
N
に従い行われ、ここでPi は関心のある各領域の予備的処理(preprocessed)された値、Mi はその関心のある領域に対応するマーカー値であり、ここで、
ΣMi =0
であり、Nは関心のある領域の合計数である。このマーカーとの相互相関は、ステップ104において各マーカーについて単一の共分散値をもたらし、そのデーター配列のマーカー表示を提示する。ポストプロセッサー6は相互相関器で得られた値を取り込み、ステップ105において生データーをリスケール(rescale)し、患者もしくは被検者のスコアであるところの0〜1の間の値を作成する。
ZはAc−Pc線(腹部と背部の交連を連結し、定位 (脳)固定座標の標準基準線である)からのスライスの水平面距離、
Xe、Yeは楕円原点座標、
R1、R2は主軸半径、
AngはR1又はR2とのいずれかとY軸とのなす鋭角であり、それは反時計方向に測定され、
LHは左大脳半球、
RHは右大脳半球である。
ΣPi ・Mi
の値35.215に帰結する。スライスの他の部分に対応する表及び他のスライスが合わされると、それは全共分散0.114を帰結する。共分散統計は、各人が彼又は彼女の機能的イメージにおいて、標準化された配列に対して与えられたマーカーを表示する程度の指標である。この分析において、各患者がマーカーを表示する程度は、正常な被検者の多くの試料にわたって得られた平均配列により決定されたベースラインと対照される。
Claims (4)
- 神経系障害についての患者のスクリーニングにおいて使用するためのマーカーと、該マーカーに作用する相互相関器と、相互相関された患者プロファイルを作成するための患者プロファイルと、該相互相関された患者プロファイルに作用して患者における神経系障害のスクリーニングを行うためのポストプロセッサーとを含み、該マーカーが、所定の脳形態の予め定められた座標の複数のセットの各々での、機能障害のある脳の機能的活動に対応して関連づけられた数値を該脳のスキャニングデータに基づいてコンピュータにより得ること、および得られた数値をコンピュータのメモリーに記憶して、患者から得られる対応する数値と比較されるところのマーカーとすることを含む方法により製造されるところの、患者における神経系障害のスクリーニング装置。
- 該機能的活動に対応して関連づけられた数値が単一の数値である、請求項1に従う装置。
- 該予め定められた座標の複数のセットの各々が患者の脳の関心のある領域に対応する、請求項1に従う装置。
- 該機能的活動が、パーキンソン病、アルツハイマー病、変形性筋緊張異常、小脳変性、うつ病、早老症、または神経AIDSを有する患者の集団においてプロファイルされる、請求項1に従う装置。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/379,056 US5632276A (en) | 1995-01-27 | 1995-01-27 | Markers for use in screening patients for nervous system dysfunction and a method and apparatus for using same |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8522908A Division JPH10512784A (ja) | 1995-01-27 | 1996-01-11 | 患者スクリーニング用マーカー |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007307360A JP2007307360A (ja) | 2007-11-29 |
JP4309931B2 true JP4309931B2 (ja) | 2009-08-05 |
Family
ID=23495638
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8522908A Pending JPH10512784A (ja) | 1995-01-27 | 1996-01-11 | 患者スクリーニング用マーカー |
JP2006221155A Pending JP2007018524A (ja) | 1995-01-27 | 2006-08-14 | 患者スクリーニング用マーカー |
JP2007102591A Expired - Fee Related JP4309931B2 (ja) | 1995-01-27 | 2007-04-10 | 神経系障害のスクリーニング装置 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8522908A Pending JPH10512784A (ja) | 1995-01-27 | 1996-01-11 | 患者スクリーニング用マーカー |
JP2006221155A Pending JP2007018524A (ja) | 1995-01-27 | 2006-08-14 | 患者スクリーニング用マーカー |
Country Status (7)
Country | Link |
---|---|
US (2) | US5632276A (ja) |
EP (1) | EP0869736A4 (ja) |
JP (3) | JPH10512784A (ja) |
AU (1) | AU4898796A (ja) |
CA (1) | CA2211537C (ja) |
IL (1) | IL116866A (ja) |
WO (1) | WO1996022729A1 (ja) |
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1995
- 1995-01-27 US US08/379,056 patent/US5632276A/en not_active Expired - Lifetime
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1996
- 1996-01-11 WO PCT/US1996/000568 patent/WO1996022729A1/en active Application Filing
- 1996-01-11 CA CA2211537A patent/CA2211537C/en not_active Expired - Fee Related
- 1996-01-11 EP EP96905154A patent/EP0869736A4/en not_active Withdrawn
- 1996-01-11 JP JP8522908A patent/JPH10512784A/ja active Pending
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- 1996-01-23 IL IL11686696A patent/IL116866A/xx not_active IP Right Cessation
- 1996-09-04 US US08/706,478 patent/US5873823A/en not_active Expired - Lifetime
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2006
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JPH10512784A (ja) | 1998-12-08 |
CA2211537A1 (en) | 1996-08-01 |
EP0869736A1 (en) | 1998-10-14 |
AU4898796A (en) | 1996-08-14 |
JP2007307360A (ja) | 2007-11-29 |
WO1996022729A1 (en) | 1996-08-01 |
JP2007018524A (ja) | 2007-01-25 |
US5632276A (en) | 1997-05-27 |
CA2211537C (en) | 2012-03-20 |
IL116866A0 (en) | 1996-07-23 |
EP0869736A4 (en) | 2004-03-31 |
US5873823A (en) | 1999-02-23 |
IL116866A (en) | 2000-02-29 |
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