JP4299837B2 - 呼気凝縮液の採取のための使い捨てハンドヘルド装置 - Google Patents
呼気凝縮液の採取のための使い捨てハンドヘルド装置 Download PDFInfo
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- JP4299837B2 JP4299837B2 JP2005510061A JP2005510061A JP4299837B2 JP 4299837 B2 JP4299837 B2 JP 4299837B2 JP 2005510061 A JP2005510061 A JP 2005510061A JP 2005510061 A JP2005510061 A JP 2005510061A JP 4299837 B2 JP4299837 B2 JP 4299837B2
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- central chamber
- condensate collection
- breath
- collection device
- wall
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- Expired - Fee Related
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B2010/0083—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements for taking gas samples
- A61B2010/0087—Breath samples
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43491602P | 2002-12-20 | 2002-12-20 | |
| US44758103P | 2003-02-14 | 2003-02-14 | |
| PCT/US2003/041209 WO2004058125A2 (en) | 2002-12-20 | 2003-12-19 | Disposable hand-held device for collection of exhaled breath condensate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006511824A JP2006511824A (ja) | 2006-04-06 |
| JP2006511824A5 JP2006511824A5 (https=) | 2006-08-10 |
| JP4299837B2 true JP4299837B2 (ja) | 2009-07-22 |
Family
ID=32685345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005510061A Expired - Fee Related JP4299837B2 (ja) | 2002-12-20 | 2003-12-19 | 呼気凝縮液の採取のための使い捨てハンドヘルド装置 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20040138577A1 (https=) |
| EP (1) | EP1571985B1 (https=) |
| JP (1) | JP4299837B2 (https=) |
| AT (1) | ATE427068T1 (https=) |
| AU (1) | AU2003300356A1 (https=) |
| BR (1) | BR0316872B1 (https=) |
| CA (1) | CA2511218C (https=) |
| DE (1) | DE60326988D1 (https=) |
| WO (1) | WO2004058125A2 (https=) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7828741B2 (en) * | 2002-12-20 | 2010-11-09 | The Charlotte-Mecklenburg Hospital Authority | Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia |
| AU2003300356A1 (en) * | 2002-12-20 | 2004-07-22 | The Charlotte-Mecklenburg Hospital Authority | Disposable hand-held device for collection of exhaled breath condensate |
| US7547285B2 (en) * | 2003-02-14 | 2009-06-16 | The Charlotte-Mecklenburg Hospital Authority | Device and method for collection of exhaled alveolar breath condensate |
| US20130190639A1 (en) * | 2002-12-20 | 2013-07-25 | The Charlotte-Mecklenburg Hospital Authority | Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia |
| FR2858236B1 (fr) | 2003-07-29 | 2006-04-28 | Airox | Dispositif et procede de fourniture de gaz respiratoire en pression ou en volume |
| WO2005085870A1 (en) * | 2004-03-03 | 2005-09-15 | The Charlotte-Mecklenburg Hospital Authority | The use of free hemoglobin and its surrogate markers to detect and monitor pulmonary hypertension |
| GB2427686A (en) * | 2005-06-24 | 2007-01-03 | Equine Healthcare Ltd | Breath condensate collector |
| US8240187B2 (en) * | 2005-08-16 | 2012-08-14 | Oridion Medical (1987) Ltd. | Breath sampling device and method for using same |
| US9498150B2 (en) * | 2005-08-16 | 2016-11-22 | Oridion Medical 1987 Ltd. | Breath sampling device |
| US8002712B2 (en) * | 2006-01-26 | 2011-08-23 | Meka Vikas V | Breath and breath condensate analysis system and associated methods |
| US7779840B2 (en) * | 2006-06-21 | 2010-08-24 | General Electric Company | Ventilator breath condensate sampler and method of collecting a breath condensate sample |
| US7914460B2 (en) * | 2006-08-15 | 2011-03-29 | University Of Florida Research Foundation, Inc. | Condensate glucose analyzer |
| WO2008099003A2 (en) * | 2007-02-16 | 2008-08-21 | Universiteit Maastricht | Apparatus for and method of condensing exhaled breath |
| US8857429B2 (en) * | 2007-06-15 | 2014-10-14 | Idtx Systems, Inc. | Drug delivery and monitoring system for a ventilator |
| GB2451249A (en) * | 2007-07-24 | 2009-01-28 | Equine Healthcare Ltd | A breath condensate collector |
| JP5167753B2 (ja) * | 2007-09-17 | 2013-03-21 | 有限会社ピコデバイス | 微量化学物質の測定方法およびその装置 |
| EP2194867B1 (en) * | 2007-10-02 | 2021-06-02 | Anna-Carin Olin | Collection and measurement of exhaled particles |
| EP2276396A1 (en) * | 2008-04-14 | 2011-01-26 | Deka Products Limited Partnership | Devices, systems, and methods for aiding in the detection of a physiological abnormality |
| US8457706B2 (en) | 2008-05-16 | 2013-06-04 | Covidien Lp | Estimation of a physiological parameter using a neural network |
| US8302602B2 (en) | 2008-09-30 | 2012-11-06 | Nellcor Puritan Bennett Llc | Breathing assistance system with multiple pressure sensors |
| CN102264404A (zh) * | 2008-12-23 | 2011-11-30 | 美国政府卫生和公众服务部疾病预防和控制中心 | 肺部浮质收集装置 |
| US8434479B2 (en) | 2009-02-27 | 2013-05-07 | Covidien Lp | Flow rate compensation for transient thermal response of hot-wire anemometers |
| US8469031B2 (en) | 2009-12-01 | 2013-06-25 | Covidien Lp | Exhalation valve assembly with integrated filter |
| US8469030B2 (en) | 2009-12-01 | 2013-06-25 | Covidien Lp | Exhalation valve assembly with selectable contagious/non-contagious latch |
| US8439036B2 (en) | 2009-12-01 | 2013-05-14 | Covidien Lp | Exhalation valve assembly with integral flow sensor |
| US8439037B2 (en) | 2009-12-01 | 2013-05-14 | Covidien Lp | Exhalation valve assembly with integrated filter and flow sensor |
| JP5206997B2 (ja) * | 2010-01-28 | 2013-06-12 | 日本光電工業株式会社 | ガス分析装置 |
| USD653749S1 (en) | 2010-04-27 | 2012-02-07 | Nellcor Puritan Bennett Llc | Exhalation module filter body |
| USD655405S1 (en) | 2010-04-27 | 2012-03-06 | Nellcor Puritan Bennett Llc | Filter and valve body for an exhalation module |
| USD655809S1 (en) | 2010-04-27 | 2012-03-13 | Nellcor Puritan Bennett Llc | Valve body with integral flow meter for an exhalation module |
| US8869793B1 (en) | 2010-05-18 | 2014-10-28 | Idtx Systems, Inc. | Compact self-contained automated MDI adapters or units for ventilators |
| CN103168233B (zh) * | 2010-12-01 | 2014-12-31 | 浙江大学 | 同时检测人体呼出气体中EBCs和VOCs的一体化分析装置 |
| US9629971B2 (en) | 2011-04-29 | 2017-04-25 | Covidien Lp | Methods and systems for exhalation control and trajectory optimization |
| WO2013006391A1 (en) * | 2011-07-01 | 2013-01-10 | 3M Innovative Properties Company | A method and apparatus for screening drug offenders |
| US9364624B2 (en) | 2011-12-07 | 2016-06-14 | Covidien Lp | Methods and systems for adaptive base flow |
| US9498589B2 (en) | 2011-12-31 | 2016-11-22 | Covidien Lp | Methods and systems for adaptive base flow and leak compensation |
| US20130255095A1 (en) * | 2012-03-27 | 2013-10-03 | Bsh Bosch Und Siemens Hausgerate Gmbh | Clothes treatment appliance with condenser and cleaning device |
| US20130255097A1 (en) * | 2012-03-27 | 2013-10-03 | Bsh Bosch Und Siemens Hausgerate Gmbh | Clothes treatment appliance with condenser and cleaning device |
| US9144658B2 (en) | 2012-04-30 | 2015-09-29 | Covidien Lp | Minimizing imposed expiratory resistance of mechanical ventilator by optimizing exhalation valve control |
| US9617582B2 (en) | 2012-09-04 | 2017-04-11 | University Of Maryland College Park | Human exhaled aerosol droplet biomarker system and method |
| USD731049S1 (en) | 2013-03-05 | 2015-06-02 | Covidien Lp | EVQ housing of an exhalation module |
| USD731048S1 (en) | 2013-03-08 | 2015-06-02 | Covidien Lp | EVQ diaphragm of an exhalation module |
| USD736905S1 (en) | 2013-03-08 | 2015-08-18 | Covidien Lp | Exhalation module EVQ housing |
| USD692556S1 (en) | 2013-03-08 | 2013-10-29 | Covidien Lp | Expiratory filter body of an exhalation module |
| USD701601S1 (en) | 2013-03-08 | 2014-03-25 | Covidien Lp | Condensate vial of an exhalation module |
| USD744095S1 (en) | 2013-03-08 | 2015-11-24 | Covidien Lp | Exhalation module EVQ internal flow sensor |
| USD731065S1 (en) | 2013-03-08 | 2015-06-02 | Covidien Lp | EVQ pressure sensor filter of an exhalation module |
| USD693001S1 (en) | 2013-03-08 | 2013-11-05 | Covidien Lp | Neonate expiratory filter assembly of an exhalation module |
| US9950135B2 (en) | 2013-03-15 | 2018-04-24 | Covidien Lp | Maintaining an exhalation valve sensor assembly |
| GB201313817D0 (en) | 2013-08-01 | 2013-09-18 | Maddison Product Design Ltd | Exhaled breath condensate collector |
| DE102013215640A1 (de) * | 2013-08-08 | 2015-02-12 | Siemens Aktiengesellschaft | Anordnung zur Entnahme von Atemgasproben |
| AU2014312293B2 (en) | 2013-08-28 | 2020-04-30 | University Of Louisville Research Foundation, Inc. | Noninvasive detection of lung cancer using exhaled breath |
| US10173025B2 (en) | 2014-04-21 | 2019-01-08 | Idtx Systems, Inc. | Automated drug delivery systems |
| US10561814B2 (en) | 2014-11-19 | 2020-02-18 | Idtx Systems, Inc. | Automated drug dispensing systems with automated HME bypass for ventilator circuits |
| USD775345S1 (en) | 2015-04-10 | 2016-12-27 | Covidien Lp | Ventilator console |
| CA3032583C (en) | 2015-07-31 | 2026-03-31 | University Of Louisville Research Foundation, Inc. | Noninvasive detection of cancer originating in tissue outside of the lung using exhaled breath |
| CN111426822B (zh) * | 2015-09-14 | 2022-12-13 | 艾森利克斯公司 | 采集分析蒸汽凝析,特别是呼出气凝析的装置与系统,以及使用方法 |
| DE102016200816A1 (de) * | 2016-01-21 | 2017-07-27 | Robert Bosch Gmbh | Vorrichtung und Verfahren zur Gewinnung von Atemgaskondensat |
| GB2548122B (en) * | 2016-03-08 | 2018-09-12 | Univ Of Northumbria At Newcastle | Exhaled breath condensate collection device and a kit of parts therefor |
| KR101927446B1 (ko) | 2016-03-18 | 2018-12-10 | 주식회사 센시스 | 일산화탄소 측정을 위한 호기 필터 장치 |
| KR101766218B1 (ko) | 2016-04-08 | 2017-08-08 | 선문대학교 산학협력단 | 한손으로 사용가능한 수동식 인공호흡기용 악력장치 |
| US10502665B2 (en) * | 2016-04-18 | 2019-12-10 | University Of Maryland, College Park | Aerosol collection system and method |
| WO2018126119A1 (en) * | 2016-12-30 | 2018-07-05 | Lee Luke P | Aerosol capture and processing device |
| WO2019178247A1 (en) * | 2018-03-15 | 2019-09-19 | Biolum Sciences Llc | Sensor devices and systems for monitoring markers in breath |
| NL2021637B1 (en) * | 2018-09-14 | 2020-05-07 | Stichting Katholieke Univ | Breath sampler |
| CN110123382B (zh) * | 2019-05-07 | 2021-08-24 | 雄安绿研检验认证有限公司 | 一种人体呼出气体离线采集装置及方法 |
| CN211927449U (zh) | 2019-06-14 | 2020-11-13 | 切尔卡斯亚有限公司 | 一种水分捕获设备 |
| US11896767B2 (en) | 2020-03-20 | 2024-02-13 | Covidien Lp | Model-driven system integration in medical ventilators |
| CN111436974A (zh) * | 2020-05-12 | 2020-07-24 | 江苏一米生物科技有限公司 | 收集呼吸道气体的装置及其方法 |
| US20230366041A1 (en) * | 2020-09-16 | 2023-11-16 | Northwestern University | Determination of the presence of sars-cov-2 or other respiratory pathogen in a person |
| CN112729898B (zh) * | 2020-12-22 | 2023-01-06 | 自然资源部第一海洋研究所 | 一种便于样本回收的重力振动复合型深海柱状取样器 |
| JP2024536778A (ja) * | 2021-09-20 | 2024-10-08 | ヴォスビオ,インコーポレーテッド | 生物学的試料の捕捉および処理のためのデバイス、方法およびキット |
| WO2023086823A1 (en) * | 2021-11-09 | 2023-05-19 | Quintron Instrument Company, Inc. | Apparatus and methods for viral and bacterial breath collection |
| CN114235518B (zh) * | 2021-11-23 | 2024-09-06 | 重庆医科大学 | 一种用于血迹模型制作的前处理装置 |
| GB2644537A (en) * | 2023-04-21 | 2026-04-15 | Vosbio Inc | Method and device for breath pathogen detection |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3000379A (en) * | 1960-01-04 | 1961-09-19 | John J Viers | Oxygen tent apparatus |
| US3509771A (en) * | 1964-03-04 | 1970-05-05 | Aerojet General Co | Breath sampling apparatus |
| US3420224A (en) * | 1967-06-13 | 1969-01-07 | Bioconsultants Inc | Apparatus for analysis of respired gas |
| US3622278A (en) * | 1969-04-21 | 1971-11-23 | Hittman Associates Inc | Method and means for breath analysis |
| US3622178A (en) * | 1969-07-09 | 1971-11-23 | Fruehauf Corp | Longitudinally movable landing gear for trailers and the like |
| US3613665A (en) * | 1969-08-08 | 1971-10-19 | Reynolds G Gorsuch | Sampling means for exhaled air |
| US3830630A (en) * | 1972-06-21 | 1974-08-20 | Triangle Environment Corp | Apparatus and method for alcoholic breath and other gas analysis |
| US3799149A (en) * | 1972-12-26 | 1974-03-26 | Nasa | Metabolic analyzer |
| US3891508A (en) * | 1973-06-01 | 1975-06-24 | Joseph M Merrick | Method of rapid identification of gram-negative bacteria |
| DE2816499C2 (de) * | 1978-04-15 | 1981-02-19 | Draegerwerk Ag, 2400 Luebeck | Verfahren und Anordnung zur Erkennung und Abtrennung des Alveolarluftanteiles aus der Atemluft |
| US4259951A (en) * | 1979-07-30 | 1981-04-07 | Chesebrough-Pond's Inc. | Dual valve for respiratory device |
| US4491660A (en) * | 1980-01-10 | 1985-01-01 | Abbott Laboratories | Matrix polymers for binding endotoxins |
| IL59383A (en) * | 1980-02-14 | 1983-03-31 | Technion Res & Dev Foundation | Micromethod for the determination of endotoxins with limulus amebocyte lysate |
| US4322217A (en) * | 1980-06-27 | 1982-03-30 | Mallinckrodt, Inc. | Process for preparing Limulus lysate |
| US4349626A (en) * | 1980-10-28 | 1982-09-14 | The Monell Chemical Senses Center | Method of detecting Pseudomonas aeruginosa infections utilizing selected ketone and/or sulfur metabolites |
| US4438209A (en) * | 1981-07-17 | 1984-03-20 | Mallinckrodt, Inc. | Radioimmunoassay for fibrinopeptide A |
| US4510241A (en) * | 1981-09-03 | 1985-04-09 | Mallinckrodt, Inc. | Peptide-type substrates useful in the quantitative determination of endotoxin |
| DE3323720A1 (de) * | 1983-07-01 | 1985-01-03 | Bodenseewerk Perkin-Elmer & Co GmbH, 7770 Überlingen | Verfahren und vorrichtung zur probenahme von atemluft an einem arbeitsplatz |
| US4717658A (en) * | 1985-12-03 | 1988-01-05 | Miles Inc. | Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) |
| US4870158A (en) * | 1987-01-05 | 1989-09-26 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Polymyxin lipopolysaccharide antigen and associated method |
| US4784486A (en) * | 1987-10-06 | 1988-11-15 | Albion Instruments | Multi-channel molecular gas analysis by laser-activated Raman light scattering |
| US5541057A (en) * | 1989-09-18 | 1996-07-30 | Biostar, Inc. | Methods for detection of an analyte |
| ATE148230T1 (de) * | 1989-10-30 | 1997-02-15 | Biowhittaker Inc | Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat |
| US5186242A (en) * | 1990-03-09 | 1993-02-16 | Calsonic Corporation | Condenser provided with forced cooling means |
| US5042501A (en) * | 1990-05-01 | 1991-08-27 | Battelle Memorial Institute | Apparatus and method for analysis of expired breath |
| US5198339A (en) * | 1990-07-13 | 1993-03-30 | Board Of Regents, The University Of Texas System | Method for detection of gram-negative bacterial lipopolysaccharides in biological fluids |
| US5211181A (en) * | 1991-05-17 | 1993-05-18 | Martek Corporation | Apparatus and method for collecting human breath samples |
| SE502780C2 (sv) * | 1991-09-25 | 1996-01-08 | Siemens Elema Ab | Avfuktningsanordning |
| US5383469A (en) * | 1992-01-31 | 1995-01-24 | Board Of Trustees Of The Leland Stanford Junior University | Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus |
| EP0556906B1 (en) * | 1992-02-17 | 1996-05-22 | Akzo Nobel N.V. | Calibrator and use thereof in an immuno-assay |
| US5285794A (en) * | 1992-12-14 | 1994-02-15 | Temple University Of The Commonwealth System Of Higher Education | Respiratory gas monitor |
| US5380295A (en) * | 1992-12-14 | 1995-01-10 | Mallinckrodt Medical, Inc. | Delivery apparatus with mechanism preventing rearward movement of a piston disposed therein |
| US5625189A (en) * | 1993-04-16 | 1997-04-29 | Bruce W. McCaul | Gas spectroscopy |
| IT1264461B1 (it) * | 1993-05-14 | 1996-09-23 | Dar Spa | Filtro antibatterico monouso applicabile particolarmente su linee di collegamento ad apparecchi spirometrici |
| CA2146667A1 (en) * | 1993-08-18 | 1995-02-23 | Adolf Hoess | Lipopolysaccharide-binding and neutralizing peptides |
| JP3429036B2 (ja) * | 1993-09-30 | 2003-07-22 | 生化学工業株式会社 | エンドトキシンの特異的測定剤 |
| US5487380A (en) * | 1993-10-19 | 1996-01-30 | Abbott Laboratories | Exhaled gas filter and cooler |
| US5465728A (en) * | 1994-01-11 | 1995-11-14 | Phillips; Michael | Breath collection |
| SE9400253L (sv) * | 1994-01-27 | 1995-07-28 | Siemens Elema Ab | Anordning avsedd att minska den relativa fuktigheten i en strömmande gas |
| US5479815A (en) * | 1994-02-24 | 1996-01-02 | Kraft Foods, Inc. | Method and apparatus for measuring volatiles released from food products |
| US5376555A (en) * | 1994-02-25 | 1994-12-27 | Intoximeters, Inc. | Method for testing breath alcohol with discrimination between alveolar and upper respiratory tract alcohol |
| SE501880C2 (sv) * | 1994-03-24 | 1995-06-12 | Siemens Elema Ab | Anordning för att minska den relativa fuktigheten i en strömmande gas |
| AU2444195A (en) | 1994-05-13 | 1995-12-05 | Filt Forschungsgesellschaft Fur Lungen-Und Thoraxerkrankungen MbH | Process and device for collecting expired breath condensate |
| JP3571378B2 (ja) * | 1994-09-30 | 2004-09-29 | 扶桑薬品工業株式会社 | 感染症診断用プローブ |
| US5787885A (en) * | 1994-10-13 | 1998-08-04 | Lemelson; Jerome H. | Body fluid analysis system |
| US6033368A (en) * | 1996-03-28 | 2000-03-07 | Nitromed, Inc. | Condensate colorimetric nitrogen oxide analyzer |
| AU719940B2 (en) * | 1996-04-09 | 2000-05-18 | Aerocrine Ab | Method and apparatus for the measurement of components of exhaled breath in humans |
| US5795787A (en) * | 1996-04-09 | 1998-08-18 | Silkoff; Philip | Method and apparatus for the measurement of exhaled nitric oxide in humans |
| US6148657A (en) * | 1996-08-13 | 2000-11-21 | Suzuki Motor Corporation | Method and apparatus for analyzing a breath sample |
| JP4046378B2 (ja) * | 1996-09-19 | 2008-02-13 | 株式会社カネカ | エンドトキシン吸着システム |
| US6186958B1 (en) * | 1997-02-26 | 2001-02-13 | Oridion Medical | Breath test analyzer |
| US5826575A (en) * | 1997-03-13 | 1998-10-27 | Nellcor Puritan Bennett, Incorporated | Exhalation condensate collection system for a patient ventilator |
| US5938637A (en) * | 1997-03-14 | 1999-08-17 | Path | Single-use medicine delivery unit for needleless hypodermic injector |
| US5996586A (en) * | 1997-03-26 | 1999-12-07 | Phillips; Michael | Breath test for detection of lung cancer |
| US5876947A (en) * | 1997-07-25 | 1999-03-02 | The New York Blood Center, Inc. | Monospecific antibody reactive with Fibrinogen and fibrinopeptide B |
| US6645724B1 (en) * | 1997-09-19 | 2003-11-11 | National University Of Singapore | Assays for endotoxin |
| US6099481A (en) * | 1997-11-03 | 2000-08-08 | Ntc Technology, Inc. | Respiratory profile parameter determination method and apparatus |
| SE9704329D0 (sv) | 1997-11-25 | 1997-11-25 | Siemens Elema Ab | Gasmätare |
| US5998389A (en) * | 1998-05-20 | 1999-12-07 | Biowhitaker Technologies | Endotoxin-specific assay |
| WO1999065386A1 (en) * | 1998-06-15 | 1999-12-23 | The Trustees Of The University Of Pennsylvania | Diagnosing intrapulmonary infection and analyzing nasal sample |
| WO1999066304A1 (en) * | 1998-06-19 | 1999-12-23 | California Institute Of Technology | Trace level detection of analytes using artificial olfactometry |
| US6106783A (en) * | 1998-06-30 | 2000-08-22 | Microliter Analytical Supplies, Inc. | Microplate assembly and closure |
| US6585661B1 (en) * | 1998-12-18 | 2003-07-01 | University Of Virginia Patent Foundation | Device and method for monitoring asthma |
| US6221026B1 (en) * | 1999-01-12 | 2001-04-24 | Michael Phillips | Breath test for the detection of various diseases |
| US6139506A (en) * | 1999-01-29 | 2000-10-31 | Instrumentarium Oy | Method for measuring pulmonary functional residual capacity |
| US6283122B1 (en) * | 1999-03-10 | 2001-09-04 | Flight Medical Ltd. | Exhalation valve for respirator |
| US6149603A (en) * | 1999-05-14 | 2000-11-21 | Ventrex, Inc. | Method and apparatus for determining whether an intubated patient has been properly intubated |
| US6656127B1 (en) * | 1999-06-08 | 2003-12-02 | Oridion Breathid Ltd. | Breath test apparatus and methods |
| US6612306B1 (en) * | 1999-10-13 | 2003-09-02 | Healthetech, Inc. | Respiratory nitric oxide meter |
| US6363772B1 (en) * | 1999-12-10 | 2002-04-02 | Quadrivium, L.L.C. | System and method for detection of a biological condition |
| AU2001261091A1 (en) * | 2000-05-01 | 2001-11-12 | Respiratory Research, Inc. | Method and device for collecting and analyzing exhaled breath |
| US20040234971A1 (en) * | 2001-02-01 | 2004-11-25 | Joany Jackman | Diagnosis of pathogen infections using mass spectral analysis of immune system modulators in post-exposure biological samples |
| AU2002309803A1 (en) | 2001-04-17 | 2002-10-28 | University Of Virginia Patent Foundation | Breath test for assessing diseases, particularly asthma |
| US7118537B2 (en) * | 2001-04-30 | 2006-10-10 | Respiratory Research, Inc. | Method and device for collecting and analyzing exhaled breath |
| GB0120027D0 (en) * | 2001-08-16 | 2001-10-10 | Isis Innovation | Spectroscopic breath analysis |
| US6582376B2 (en) * | 2001-09-13 | 2003-06-24 | Pranalytica, Inc. | Alveolar breath collection device and method |
| US6824520B2 (en) * | 2001-09-21 | 2004-11-30 | Pulmonary Data Services, Inc. | Method and apparatus for tracking usage of a respiratory measurement device |
| US6575918B2 (en) * | 2001-09-27 | 2003-06-10 | Charlotte-Mecklenburg Hospital | Non-invasive device and method for the diagnosis of pulmonary vascular occlusions |
| US6726637B2 (en) * | 2001-12-06 | 2004-04-27 | Michael Phillips | Breath collection apparatus |
| US7473229B2 (en) * | 2001-12-10 | 2009-01-06 | Pranalytica, Inc. | Method of analyzing components of alveolar breath |
| US7828741B2 (en) | 2002-12-20 | 2010-11-09 | The Charlotte-Mecklenburg Hospital Authority | Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia |
| AU2003300356A1 (en) | 2002-12-20 | 2004-07-22 | The Charlotte-Mecklenburg Hospital Authority | Disposable hand-held device for collection of exhaled breath condensate |
| US7547285B2 (en) | 2003-02-14 | 2009-06-16 | The Charlotte-Mecklenburg Hospital Authority | Device and method for collection of exhaled alveolar breath condensate |
| WO2005085870A1 (en) | 2004-03-03 | 2005-09-15 | The Charlotte-Mecklenburg Hospital Authority | The use of free hemoglobin and its surrogate markers to detect and monitor pulmonary hypertension |
| CA2566804A1 (en) | 2004-06-07 | 2006-01-19 | The Charlotte-Mecklenburg Hospital Authority | Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia |
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- 2003-12-19 AT AT03814375T patent/ATE427068T1/de not_active IP Right Cessation
- 2003-12-19 WO PCT/US2003/041209 patent/WO2004058125A2/en not_active Ceased
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- 2003-12-19 US US10/742,721 patent/US20040138577A1/en not_active Abandoned
- 2003-12-19 BR BRPI0316872-7A patent/BR0316872B1/pt not_active IP Right Cessation
- 2003-12-19 DE DE60326988T patent/DE60326988D1/de not_active Expired - Lifetime
- 2003-12-19 JP JP2005510061A patent/JP4299837B2/ja not_active Expired - Fee Related
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| JP2006511824A (ja) | 2006-04-06 |
| US20040138577A1 (en) | 2004-07-15 |
| BR0316872B1 (pt) | 2014-02-18 |
| HK1083733A1 (en) | 2006-07-14 |
| BR0316872A (pt) | 2005-10-25 |
| EP1571985B1 (en) | 2009-04-01 |
| US8491494B2 (en) | 2013-07-23 |
| AU2003300356A8 (en) | 2004-07-22 |
| DE60326988D1 (de) | 2009-05-14 |
| WO2004058125A2 (en) | 2004-07-15 |
| ATE427068T1 (de) | 2009-04-15 |
| US20130197388A1 (en) | 2013-08-01 |
| CA2511218C (en) | 2012-06-05 |
| WO2004058125A3 (en) | 2004-08-26 |
| EP1571985A4 (en) | 2008-02-27 |
| CA2511218A1 (en) | 2004-07-15 |
| US20070203424A1 (en) | 2007-08-30 |
| AU2003300356A1 (en) | 2004-07-22 |
| EP1571985A2 (en) | 2005-09-14 |
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