JP4289687B2 - 血友病の治療のための遺伝子治療で使用する方法と組成物 - Google Patents

血友病の治療のための遺伝子治療で使用する方法と組成物 Download PDF

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JP4289687B2
JP4289687B2 JP54061098A JP54061098A JP4289687B2 JP 4289687 B2 JP4289687 B2 JP 4289687B2 JP 54061098 A JP54061098 A JP 54061098A JP 54061098 A JP54061098 A JP 54061098A JP 4289687 B2 JP4289687 B2 JP 4289687B2
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ハイ，キャサリン，エー．
ハーゾグ，ローランド，ダブリュ．
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ザ チルドレンズ ホスピタル オブ フィラデルフィア
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    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material

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JP54061098A 1997-03-14 1998-03-12 血友病の治療のための遺伝子治療で使用する方法と組成物 Expired - Lifetime JP4289687B2 (ja)

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US4071197P 1997-03-14 1997-03-14
US60/040,711 1997-03-14
PCT/US1998/004790 WO1998041240A1 (en) 1997-03-14 1998-03-12 Methods and compositions for use in gene therapy for treatment of hemophilia

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JP2001517221A JP2001517221A (ja) 2001-10-02
JP2001517221A5 JP2001517221A5 (enExample) 2005-11-10
JP4289687B2 true JP4289687B2 (ja) 2009-07-01

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US (3) US6093392A (enExample)
EP (1) EP1005376B1 (enExample)
JP (1) JP4289687B2 (enExample)
AT (1) ATE486614T1 (enExample)
AU (1) AU745386B2 (enExample)
CA (1) CA2283639A1 (enExample)
DE (1) DE69841982D1 (enExample)
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US6984517B1 (en) 1998-05-28 2006-01-10 The United States Of America As Represented By The Department Of Health And Human Services AAV5 vector and uses thereof
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EP1005376B1 (en) 2010-11-03
US20110263690A1 (en) 2011-10-27
US6093392A (en) 2000-07-25
WO1998041240A1 (en) 1998-09-24
ES2355588T3 (es) 2011-03-29
AU745386B2 (en) 2002-03-21
DE69841982D1 (de) 2010-12-16
JP2001517221A (ja) 2001-10-02
EP1005376A4 (en) 2004-11-24
EP1005376A1 (en) 2000-06-07
CA2283639A1 (en) 1998-09-24
US7998734B2 (en) 2011-08-16
US20080213222A1 (en) 2008-09-04
ATE486614T1 (de) 2010-11-15
AU6458698A (en) 1998-10-12

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