JP4271735B2 - 新規のｌｄｌ−レセプター - Google Patents
新規のｌｄｌ−レセプター Download PDFInfo
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- JP4271735B2 JP4271735B2 JP54363598A JP54363598A JP4271735B2 JP 4271735 B2 JP4271735 B2 JP 4271735B2 JP 54363598 A JP54363598 A JP 54363598A JP 54363598 A JP54363598 A JP 54363598A JP 4271735 B2 JP4271735 B2 JP 4271735B2
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- lrp5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4355397P | 1997-04-15 | 1997-04-15 | |
| US60/043,553 | 1997-04-15 | ||
| US4874097P | 1997-06-05 | 1997-06-05 | |
| US60/048,740 | 1997-06-05 | ||
| PCT/GB1998/001102 WO1998046743A1 (en) | 1997-04-15 | 1998-04-15 | Novel ldl-receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002501376A JP2002501376A (ja) | 2002-01-15 |
| JP2002501376A5 JP2002501376A5 (OSRAM) | 2005-11-24 |
| JP4271735B2 true JP4271735B2 (ja) | 2009-06-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP54363598A Expired - Lifetime JP4271735B2 (ja) | 1997-04-15 | 1998-04-15 | 新規のｌｄｌ−レセプター |
Country Status (9)
| Country | Link |
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| US (1) | US6545137B1 (OSRAM) |
| EP (1) | EP0988379B1 (OSRAM) |
| JP (1) | JP4271735B2 (OSRAM) |
| AT (1) | ATE359367T1 (OSRAM) |
| AU (1) | AU733722B2 (OSRAM) |
| CA (1) | CA2286313C (OSRAM) |
| DE (1) | DE69837542T2 (OSRAM) |
| ES (1) | ES2285767T3 (OSRAM) |
| WO (1) | WO1998046743A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7244577B2 (en) * | 1997-04-15 | 2007-07-17 | Merck & Co., Inc. | Method of screening for modulator of LRP5 activity |
| US6780609B1 (en) | 1998-10-23 | 2004-08-24 | Genome Therapeutics Corporation | High bone mass gene of 1.1q13.3 |
| US6770461B1 (en) | 1998-10-23 | 2004-08-03 | Genome Therapeutics Corporation | High bone mass gene of 11q13.3 |
| US6699466B1 (en) * | 1999-08-05 | 2004-03-02 | Research Corporation Technologies, Inc. | IL-16 antagonist peptides and DNA encoding the peptides |
| FR2798138B1 (fr) * | 1999-09-03 | 2004-05-21 | Centre Nat Rech Scient | Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante |
| CN1454256A (zh) * | 2000-04-05 | 2003-11-05 | 基因组治疗公司 | 11q13.3的高骨量基因 |
| EP1285002B1 (en) * | 2000-05-26 | 2007-07-18 | Oscient Pharmaceuticals Corporation | Regulating lipid levels via the zmax1 or hbm gene |
| US7186515B1 (en) | 2000-06-02 | 2007-03-06 | University Of Connecticut Health Center | Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof |
| AU6669401A (en) | 2000-06-02 | 2001-12-11 | Univ Connecticut Health Ct | Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy |
| US7179462B2 (en) | 2000-06-02 | 2007-02-20 | University Of Connecticut Health Center | α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof |
| EP1313753A4 (en) * | 2000-08-18 | 2004-09-15 | Proskelia | REGULATORY GENE AND SYSTEM FOR USE IN THE DIAGNOSIS AND TREATMENT OF OSTEOPOROSIS |
| WO2002074906A2 (en) * | 2001-03-16 | 2002-09-26 | Eli Lilly And Company | Lp mammalian proteins; related reagents |
| US7416849B2 (en) * | 2001-05-11 | 2008-08-26 | Oscient Pharmaceuticals Corporation | HBM variants that modulate bone mass and lipid levels |
| US20040221326A1 (en) * | 2001-05-11 | 2004-11-04 | Philip Babij | Transgenic animal model of bone mass modulation |
| US7514594B2 (en) | 2001-05-11 | 2009-04-07 | Wyeth | Transgenic animal model of bone mass modulation |
| EP1395285A4 (en) * | 2001-05-17 | 2005-06-01 | Genome Therapeutics Corp | REAGENTS AND METHODS FOR MODULATING DKK-MEDIATED INTERACTIONS |
| US20040038860A1 (en) | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
| PL375043A1 (en) | 2001-08-20 | 2005-11-14 | University Of Connecticut Health Center | Methods for preparing compositions comprising heat shock proteins or alpha-2-macroglobulin, useful for the treatment of cancer and infectious disease |
| GB2381790A (en) * | 2001-09-26 | 2003-05-14 | Glaxo Group Ltd | LDL-receptor polypeptides |
| JP2005220022A (ja) * | 2002-03-08 | 2005-08-18 | Anges Mg Inc | Ｗｎｔの新規作用、及び、疾患治療への応用 |
| US7169559B2 (en) * | 2002-05-13 | 2007-01-30 | Fonterra Corporate Research and Development Ltd. | LDL receptor-related proteins 1 and 2 and treatment of bone or cartilage conditions |
| US20030219793A1 (en) * | 2002-10-04 | 2003-11-27 | Carulli John P. | High bone mass gene of 11q13.3 |
| WO2005049640A2 (en) | 2003-11-17 | 2005-06-02 | Merck & Co., Inc. | Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof |
| US7473770B2 (en) | 2003-11-17 | 2009-01-06 | Merck & Co., Inc. | Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof |
| EP1692167A2 (en) * | 2003-11-24 | 2006-08-23 | Gunnar Westin | Mutant lrp5/6 wnt-signaling receptors in cancer diagnosis, prognosis and treatment |
| CA2798432A1 (en) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies |
| EA201291181A1 (ru) | 2010-05-06 | 2013-05-30 | Новартис Аг | Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) |
| KR20140091031A (ko) | 2011-11-04 | 2014-07-18 | 노파르티스 아게 | 저밀도 지단백질-관련 단백질 6 (lrp6) - 반감기 연장제 구축물 |
| TWI887192B (zh) | 2017-05-31 | 2025-06-21 | 比利時商艾伯林克斯公司 | 拮抗腫瘤細胞中wnt訊息傳導之多肽 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5635177A (en) * | 1992-01-22 | 1997-06-03 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
| WO1995013373A1 (en) * | 1993-11-10 | 1995-05-18 | Arch Development Corporation | Ubiquitous nuclear receptor: compositions and methods |
| WO1995030774A1 (en) * | 1994-05-05 | 1995-11-16 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
| AU716849B2 (en) * | 1995-06-23 | 2000-03-09 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Depigmenting activity of agouti signal protein and peptides thereof |
| CN1454256A (zh) | 2000-04-05 | 2003-11-05 | 基因组治疗公司 | 11q13.3的高骨量基因 |
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1998
- 1998-04-15 EP EP98917374A patent/EP0988379B1/en not_active Expired - Lifetime
- 1998-04-15 DE DE69837542T patent/DE69837542T2/de not_active Expired - Lifetime
- 1998-04-15 US US09/060,299 patent/US6545137B1/en not_active Expired - Lifetime
- 1998-04-15 ES ES98917374T patent/ES2285767T3/es not_active Expired - Lifetime
- 1998-04-15 JP JP54363598A patent/JP4271735B2/ja not_active Expired - Lifetime
- 1998-04-15 WO PCT/GB1998/001102 patent/WO1998046743A1/en not_active Ceased
- 1998-04-15 AT AT98917374T patent/ATE359367T1/de not_active IP Right Cessation
- 1998-04-15 CA CA2286313A patent/CA2286313C/en not_active Expired - Lifetime
- 1998-04-15 AU AU70614/98A patent/AU733722B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0988379A1 (en) | 2000-03-29 |
| DE69837542T2 (de) | 2008-01-31 |
| US6545137B1 (en) | 2003-04-08 |
| CA2286313A1 (en) | 1998-10-22 |
| JP2002501376A (ja) | 2002-01-15 |
| CA2286313C (en) | 2011-01-11 |
| AU7061498A (en) | 1998-11-11 |
| ATE359367T1 (de) | 2007-05-15 |
| EP0988379B1 (en) | 2007-04-11 |
| DE69837542D1 (de) | 2007-05-24 |
| ES2285767T3 (es) | 2007-11-16 |
| AU733722B2 (en) | 2001-05-24 |
| WO1998046743A1 (en) | 1998-10-22 |
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