JP4215827B2 - 閉鎖帯毒素レセプター - Google Patents

閉鎖帯毒素レセプター Download PDF

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Publication number
JP4215827B2
JP4215827B2 JP53667698A JP53667698A JP4215827B2 JP 4215827 B2 JP4215827 B2 JP 4215827B2 JP 53667698 A JP53667698 A JP 53667698A JP 53667698 A JP53667698 A JP 53667698A JP 4215827 B2 JP4215827 B2 JP 4215827B2
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JP
Japan
Prior art keywords
zot
cells
seq
sequence
actin
Prior art date
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Expired - Fee Related
Application number
JP53667698A
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English (en)
Japanese (ja)
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JP2001518077A5 (enExample
JP2001518077A (ja
Inventor
ファサノ,アレシオ
Original Assignee
ユニバーシティ オブ メリーランド,ボルチモア
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Priority claimed from US08/803,364 external-priority patent/US5864014A/en
Application filed by ユニバーシティ オブ メリーランド,ボルチモア filed Critical ユニバーシティ オブ メリーランド,ボルチモア
Publication of JP2001518077A publication Critical patent/JP2001518077A/ja
Publication of JP2001518077A5 publication Critical patent/JP2001518077A5/ja
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Publication of JP4215827B2 publication Critical patent/JP4215827B2/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/909Vibrio
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP53667698A 1997-02-20 1998-02-18 閉鎖帯毒素レセプター Expired - Fee Related JP4215827B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/803,364 US5864014A (en) 1997-02-20 1997-02-20 Zonula occludens toxin receptor
US09/024,198 US5912323A (en) 1997-02-20 1998-02-17 Zonula occludens toxin receptors
US09/024,198 1998-02-17
US08/803,364 1998-02-17
PCT/US1998/002257 WO1998037096A1 (en) 1997-02-20 1998-02-18 Zonula occludens toxin receptors

Publications (3)

Publication Number Publication Date
JP2001518077A JP2001518077A (ja) 2001-10-09
JP2001518077A5 JP2001518077A5 (enExample) 2005-10-06
JP4215827B2 true JP4215827B2 (ja) 2009-01-28

Family

ID=26698164

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53667698A Expired - Fee Related JP4215827B2 (ja) 1997-02-20 1998-02-18 閉鎖帯毒素レセプター

Country Status (9)

Country Link
US (2) US5912323A (enExample)
EP (1) EP1007553B1 (enExample)
JP (1) JP4215827B2 (enExample)
AT (1) ATE359294T1 (enExample)
AU (1) AU6270298A (enExample)
CA (1) CA2281617A1 (enExample)
DE (1) DE69837546T2 (enExample)
ES (1) ES2285762T3 (enExample)
WO (1) WO1998037096A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
EP1249244A1 (en) 2001-04-13 2002-10-16 Universiteit Gent Therapeutic compositions for the treatment of a disease modulated by the G-actin / F-actin equilibrium, especially a respiratory tract disease
JP2005526772A (ja) * 2002-03-15 2005-09-08 リテック 消化機能病理を処置するための組成物
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
DE60334923D1 (de) 2002-09-06 2010-12-23 Promega Corp Tät
US7741067B2 (en) 2002-12-23 2010-06-22 Promega Corporation Luciferase-based assays
JP2007534621A (ja) * 2003-07-15 2007-11-29 ユニバーシティ オブ メリーランド, ボルチモア Zotおよびゾニューリンに対するレセプターのアゴニストペプチド
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
CA2614068A1 (en) * 2004-06-29 2006-08-24 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
AR053661A1 (es) * 2005-01-14 2007-05-16 Univ Maryland Peptido para entregar vacunas via mucosas
AR057058A1 (es) * 2005-06-09 2007-11-14 Alba Therapeutics Corp Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas
BRPI0707616A2 (pt) * 2006-02-09 2011-05-10 Alba Therapuetics Corp formulaÇÕes para um efetor de junÇço oclusiva
US20090069247A1 (en) * 2006-10-06 2009-03-12 Blake Paterson Use of tight junction antagonists to treat inflammatory bowel disease
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
WO2008073627A2 (en) 2006-11-03 2008-06-19 Alba Therapeutics Corporation Method of diagnosing and treating asthma
US8728491B2 (en) * 2007-05-07 2014-05-20 Alba Therapeutics Corporation Transcutaneous delivery of therapeutic agents
US20110201543A1 (en) * 2007-06-29 2011-08-18 Blake Paterson Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress
WO2009015382A2 (en) 2007-07-26 2009-01-29 Alba Therapeutics Corporation Novel peptides that enhance tight junction permeability

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
US5665389A (en) * 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes

Also Published As

Publication number Publication date
EP1007553B1 (en) 2007-04-11
US5948629A (en) 1999-09-07
US5912323A (en) 1999-06-15
WO1998037096A1 (en) 1998-08-27
CA2281617A1 (en) 1998-08-27
ATE359294T1 (de) 2007-05-15
DE69837546D1 (de) 2007-05-24
DE69837546T2 (de) 2007-12-27
ES2285762T3 (es) 2007-11-16
EP1007553A1 (en) 2000-06-14
JP2001518077A (ja) 2001-10-09
EP1007553A4 (en) 2004-09-22
AU6270298A (en) 1998-09-09

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AU702385B2 (en) Oral dosage composition for intestinal delivery and method of use of the same
US5827534A (en) Oral dosage composition comprising zonnula occludens toxin and a therapeutic agent for intestinal delivery
Fasano et al. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
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