CA2281617A1 - Zonula occludens toxin receptors - Google Patents

Zonula occludens toxin receptors Download PDF

Info

Publication number
CA2281617A1
CA2281617A1 CA002281617A CA2281617A CA2281617A1 CA 2281617 A1 CA2281617 A1 CA 2281617A1 CA 002281617 A CA002281617 A CA 002281617A CA 2281617 A CA2281617 A CA 2281617A CA 2281617 A1 CA2281617 A1 CA 2281617A1
Authority
CA
Canada
Prior art keywords
zot
seq
cells
receptor
test compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002281617A
Other languages
English (en)
French (fr)
Inventor
Alessio Fasano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland Baltimore
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/803,364 external-priority patent/US5864014A/en
Application filed by Individual filed Critical Individual
Publication of CA2281617A1 publication Critical patent/CA2281617A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/909Vibrio
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002281617A 1997-02-20 1998-02-18 Zonula occludens toxin receptors Abandoned CA2281617A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/803,364 US5864014A (en) 1997-02-20 1997-02-20 Zonula occludens toxin receptor
US09/024,198 US5912323A (en) 1997-02-20 1998-02-17 Zonula occludens toxin receptors
US09/024,198 1998-02-17
US08/803,364 1998-02-17
PCT/US1998/002257 WO1998037096A1 (en) 1997-02-20 1998-02-18 Zonula occludens toxin receptors

Publications (1)

Publication Number Publication Date
CA2281617A1 true CA2281617A1 (en) 1998-08-27

Family

ID=26698164

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002281617A Abandoned CA2281617A1 (en) 1997-02-20 1998-02-18 Zonula occludens toxin receptors

Country Status (9)

Country Link
US (2) US5912323A (enExample)
EP (1) EP1007553B1 (enExample)
JP (1) JP4215827B2 (enExample)
AT (1) ATE359294T1 (enExample)
AU (1) AU6270298A (enExample)
CA (1) CA2281617A1 (enExample)
DE (1) DE69837546T2 (enExample)
ES (1) ES2285762T3 (enExample)
WO (1) WO1998037096A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
EP1249244A1 (en) 2001-04-13 2002-10-16 Universiteit Gent Therapeutic compositions for the treatment of a disease modulated by the G-actin / F-actin equilibrium, especially a respiratory tract disease
JP2005526772A (ja) * 2002-03-15 2005-09-08 リテック 消化機能病理を処置するための組成物
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
DE60334923D1 (de) 2002-09-06 2010-12-23 Promega Corp Tät
US7741067B2 (en) 2002-12-23 2010-06-22 Promega Corporation Luciferase-based assays
JP2007534621A (ja) * 2003-07-15 2007-11-29 ユニバーシティ オブ メリーランド, ボルチモア Zotおよびゾニューリンに対するレセプターのアゴニストペプチド
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
CA2614068A1 (en) * 2004-06-29 2006-08-24 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
AR053661A1 (es) * 2005-01-14 2007-05-16 Univ Maryland Peptido para entregar vacunas via mucosas
AR057058A1 (es) * 2005-06-09 2007-11-14 Alba Therapeutics Corp Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas
BRPI0707616A2 (pt) * 2006-02-09 2011-05-10 Alba Therapuetics Corp formulaÇÕes para um efetor de junÇço oclusiva
US20090069247A1 (en) * 2006-10-06 2009-03-12 Blake Paterson Use of tight junction antagonists to treat inflammatory bowel disease
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
WO2008073627A2 (en) 2006-11-03 2008-06-19 Alba Therapeutics Corporation Method of diagnosing and treating asthma
US8728491B2 (en) * 2007-05-07 2014-05-20 Alba Therapeutics Corporation Transcutaneous delivery of therapeutic agents
US20110201543A1 (en) * 2007-06-29 2011-08-18 Blake Paterson Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress
WO2009015382A2 (en) 2007-07-26 2009-01-29 Alba Therapeutics Corporation Novel peptides that enhance tight junction permeability

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
US5665389A (en) * 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes

Also Published As

Publication number Publication date
EP1007553B1 (en) 2007-04-11
US5948629A (en) 1999-09-07
US5912323A (en) 1999-06-15
WO1998037096A1 (en) 1998-08-27
ATE359294T1 (de) 2007-05-15
DE69837546D1 (de) 2007-05-24
DE69837546T2 (de) 2007-12-27
ES2285762T3 (es) 2007-11-16
EP1007553A1 (en) 2000-06-14
JP4215827B2 (ja) 2009-01-28
JP2001518077A (ja) 2001-10-09
EP1007553A4 (en) 2004-09-22
AU6270298A (en) 1998-09-09

Similar Documents

Publication Publication Date Title
AU702385B2 (en) Oral dosage composition for intestinal delivery and method of use of the same
EP1007553B1 (en) Zonula occludens toxin receptors
US5827534A (en) Oral dosage composition comprising zonnula occludens toxin and a therapeutic agent for intestinal delivery
Fasano et al. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
EP1698345B1 (en) Peptide antagonist of zonulin and its use
US5864014A (en) Zonula occludens toxin receptor
JP2001527572A (ja) 実質的に純粋なゾヌリン(zonulin)、哺乳動物密着結合の生理学的な調節因子
MXPA01001321A (en) Peptide antagonists of zonulin and methods for use of the same

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued