DE69837546T2 - Rezeptoren für Zonula Occludens-Toxin - Google Patents

Rezeptoren für Zonula Occludens-Toxin Download PDF

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Publication number
DE69837546T2
DE69837546T2 DE69837546T DE69837546T DE69837546T2 DE 69837546 T2 DE69837546 T2 DE 69837546T2 DE 69837546 T DE69837546 T DE 69837546T DE 69837546 T DE69837546 T DE 69837546T DE 69837546 T2 DE69837546 T2 DE 69837546T2
Authority
DE
Germany
Prior art keywords
zot
vibrio cholera
amino acid
acid sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69837546T
Other languages
German (de)
English (en)
Other versions
DE69837546D1 (de
Inventor
Alessio Ellicott City FASANO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland Baltimore
University of Maryland College Park
Original Assignee
University of Maryland Baltimore
University of Maryland College Park
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/803,364 external-priority patent/US5864014A/en
Application filed by University of Maryland Baltimore, University of Maryland College Park filed Critical University of Maryland Baltimore
Publication of DE69837546D1 publication Critical patent/DE69837546D1/de
Application granted granted Critical
Publication of DE69837546T2 publication Critical patent/DE69837546T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/909Vibrio
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69837546T 1997-02-20 1998-02-18 Rezeptoren für Zonula Occludens-Toxin Expired - Fee Related DE69837546T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US803364 1985-12-02
US08/803,364 US5864014A (en) 1997-02-20 1997-02-20 Zonula occludens toxin receptor
US24198 1998-02-17
US09/024,198 US5912323A (en) 1997-02-20 1998-02-17 Zonula occludens toxin receptors
PCT/US1998/002257 WO1998037096A1 (en) 1997-02-20 1998-02-18 Zonula occludens toxin receptors

Publications (2)

Publication Number Publication Date
DE69837546D1 DE69837546D1 (de) 2007-05-24
DE69837546T2 true DE69837546T2 (de) 2007-12-27

Family

ID=26698164

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69837546T Expired - Fee Related DE69837546T2 (de) 1997-02-20 1998-02-18 Rezeptoren für Zonula Occludens-Toxin

Country Status (9)

Country Link
US (2) US5912323A (enExample)
EP (1) EP1007553B1 (enExample)
JP (1) JP4215827B2 (enExample)
AT (1) ATE359294T1 (enExample)
AU (1) AU6270298A (enExample)
CA (1) CA2281617A1 (enExample)
DE (1) DE69837546T2 (enExample)
ES (1) ES2285762T3 (enExample)
WO (1) WO1998037096A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
EP1249244A1 (en) 2001-04-13 2002-10-16 Universiteit Gent Therapeutic compositions for the treatment of a disease modulated by the G-actin / F-actin equilibrium, especially a respiratory tract disease
JP2005526772A (ja) * 2002-03-15 2005-09-08 リテック 消化機能病理を処置するための組成物
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
DE60334923D1 (de) 2002-09-06 2010-12-23 Promega Corp Tät
US7741067B2 (en) 2002-12-23 2010-06-22 Promega Corporation Luciferase-based assays
JP2007534621A (ja) * 2003-07-15 2007-11-29 ユニバーシティ オブ メリーランド, ボルチモア Zotおよびゾニューリンに対するレセプターのアゴニストペプチド
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
CA2614068A1 (en) * 2004-06-29 2006-08-24 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
AR053661A1 (es) * 2005-01-14 2007-05-16 Univ Maryland Peptido para entregar vacunas via mucosas
AR057058A1 (es) * 2005-06-09 2007-11-14 Alba Therapeutics Corp Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas
BRPI0707616A2 (pt) * 2006-02-09 2011-05-10 Alba Therapuetics Corp formulaÇÕes para um efetor de junÇço oclusiva
US20090069247A1 (en) * 2006-10-06 2009-03-12 Blake Paterson Use of tight junction antagonists to treat inflammatory bowel disease
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
WO2008073627A2 (en) 2006-11-03 2008-06-19 Alba Therapeutics Corporation Method of diagnosing and treating asthma
US8728491B2 (en) * 2007-05-07 2014-05-20 Alba Therapeutics Corporation Transcutaneous delivery of therapeutic agents
US20110201543A1 (en) * 2007-06-29 2011-08-18 Blake Paterson Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress
WO2009015382A2 (en) 2007-07-26 2009-01-29 Alba Therapeutics Corporation Novel peptides that enhance tight junction permeability

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
US5665389A (en) * 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes

Also Published As

Publication number Publication date
EP1007553B1 (en) 2007-04-11
US5948629A (en) 1999-09-07
US5912323A (en) 1999-06-15
WO1998037096A1 (en) 1998-08-27
CA2281617A1 (en) 1998-08-27
ATE359294T1 (de) 2007-05-15
DE69837546D1 (de) 2007-05-24
ES2285762T3 (es) 2007-11-16
EP1007553A1 (en) 2000-06-14
JP4215827B2 (ja) 2009-01-28
JP2001518077A (ja) 2001-10-09
EP1007553A4 (en) 2004-09-22
AU6270298A (en) 1998-09-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee