JP4076587B2 - 希釈された単核細胞を収集するシステムおよび方法 - Google Patents

希釈された単核細胞を収集するシステムおよび方法 Download PDF

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Publication number
JP4076587B2
JP4076587B2 JP50717199A JP50717199A JP4076587B2 JP 4076587 B2 JP4076587 B2 JP 4076587B2 JP 50717199 A JP50717199 A JP 50717199A JP 50717199 A JP50717199 A JP 50717199A JP 4076587 B2 JP4076587 B2 JP 4076587B2
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chamber
container
interface
mnc
tube
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JP2002509534A5 (enExample
JP2002509534A (ja
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ミン，キュンギョーン
アイ． ブラウン，リチャード
ジェイ． カントゥ，ロバート
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バクスター インターナショナル インコーポレイテッド
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/302—Active control mechanisms with external energy, e.g. with solenoid valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36222—Details related to the interface between cassette and machine
    • A61M1/362227—Details related to the interface between cassette and machine the interface providing means for actuating on functional elements of the cassette, e.g. plungers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362261—Constructional details of cassettes, e.g. specific details on material or shape at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362265—Details of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362266—Means for adding solutions or substances to the blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP50717199A 1997-07-01 1998-06-22 希釈された単核細胞を収集するシステムおよび方法 Expired - Fee Related JP4076587B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/886,732 US6027657A (en) 1997-07-01 1997-07-01 Systems and methods for collecting diluted mononuclear cells
US08/886,732 1997-07-01
PCT/US1998/012166 WO1999001197A1 (en) 1997-07-01 1998-06-22 Systems and methods for collecting diluted mononuclear cells

Publications (3)

Publication Number Publication Date
JP2002509534A JP2002509534A (ja) 2002-03-26
JP2002509534A5 JP2002509534A5 (enExample) 2005-12-22
JP4076587B2 true JP4076587B2 (ja) 2008-04-16

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JP50717199A Expired - Fee Related JP4076587B2 (ja) 1997-07-01 1998-06-22 希釈された単核細胞を収集するシステムおよび方法

Country Status (7)

Country Link
US (1) US6027657A (enExample)
EP (2) EP1468713A3 (enExample)
JP (1) JP4076587B2 (enExample)
CN (1) CN1261815A (enExample)
BR (1) BR9810661A (enExample)
CA (1) CA2294395A1 (enExample)
WO (1) WO1999001197A1 (enExample)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312607B1 (en) 1995-06-07 2001-11-06 Baxter International Inc. Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent
US5958250A (en) * 1995-06-07 1999-09-28 Baxter International Inc. Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent
US20020077241A1 (en) * 1999-09-03 2002-06-20 Baxter International Inc. Blood processing systems and methods with quick attachment of a blood separation chamber to a centrifuge rotor
US6294094B1 (en) 1999-09-03 2001-09-25 Baxter International Inc. Systems and methods for sensing red blood cell hematocrit
US6322488B1 (en) 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing
US6284142B1 (en) 1999-09-03 2001-09-04 Baxter International Inc. Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing
US7011761B2 (en) * 1999-09-03 2006-03-14 Baxter International Inc. Red blood cell processing systems and methods which control red blood cell hematocrit
US6524231B1 (en) * 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US6348156B1 (en) 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US6860846B2 (en) * 1999-09-03 2005-03-01 Baxter International Inc. Blood processing systems and methods with umbilicus-driven blood processing chambers
US6315707B1 (en) 1999-09-03 2001-11-13 Baxter International Inc. Systems and methods for seperating blood in a rotating field
US7430478B2 (en) 2000-03-01 2008-09-30 Caridian Bct, Inc. Blood processing information system with blood loss equivalency tracking
EP1238361A1 (en) * 2000-03-01 2002-09-11 Gambro, Inc. Extracorporeal blood processing information management system
US6890291B2 (en) * 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US6878105B2 (en) * 2001-08-16 2005-04-12 Baxter International Inc. Red blood cell processing systems and methods with deliberate under spill of red blood cells
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7186230B2 (en) * 2002-03-04 2007-03-06 Therakos, Inc Method and apparatus for the continuous separation of biological fluids into components
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
WO2003089926A2 (en) * 2002-04-19 2003-10-30 Mission Medical, Inc. Integrated automatic blood processing unit
US7297272B2 (en) * 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
US6849039B2 (en) * 2002-10-24 2005-02-01 Baxter International Inc. Blood processing systems and methods for collecting plasma free or essentially free of cellular blood components
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
US7708710B2 (en) * 2003-12-23 2010-05-04 Fenwal, Inc. Method and apparatus for collecting and processing blood
US7476209B2 (en) * 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
US8685258B2 (en) * 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
US8075468B2 (en) * 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
US8394006B2 (en) 2010-11-19 2013-03-12 Kensey Nash Corporation Centrifuge
US8317672B2 (en) 2010-11-19 2012-11-27 Kensey Nash Corporation Centrifuge method and apparatus
US20220031925A1 (en) 2010-11-19 2022-02-03 Dsm Ip Assets B.V. Centrifuge
US8870733B2 (en) 2010-11-19 2014-10-28 Kensey Nash Corporation Centrifuge
US8469871B2 (en) 2010-11-19 2013-06-25 Kensey Nash Corporation Centrifuge
US8556794B2 (en) 2010-11-19 2013-10-15 Kensey Nash Corporation Centrifuge
US9744498B2 (en) 2011-03-11 2017-08-29 Fenwal, Inc. Disposable fluid circuits and methods for cell washing with on-line dilution of cell feed
EP2694131B1 (en) 2011-04-07 2019-08-28 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
US9089479B2 (en) 2011-05-03 2015-07-28 Fenwal, Inc. Medium, solutions and methods for the washing, culturing and storage of white blood cells
US9334927B2 (en) * 2011-09-22 2016-05-10 Fenwal, Inc. Drive system for centrifuge with planetary gear and flexible shaft
US9717842B2 (en) 2011-09-22 2017-08-01 Fenwal, Inc. Disposable fluid circuits and methods for cell washing
EP2731724B1 (en) * 2011-09-22 2015-01-14 Fenwal, Inc. Drive system for centrifuge
US9399093B2 (en) 2012-01-27 2016-07-26 Fenwal, Inc. Systems and methods for performing online extracorporeal photopheresis
US20190224494A1 (en) * 2012-03-20 2019-07-25 Fenwal, Inc. Apparatus and method for batch photoactivation of mononuclear cells with cryopreservation
US11571504B2 (en) 2019-03-21 2023-02-07 Fenwal, Inc. Apparatus and method for batch photoactivation of mononuclear cells
US20130252227A1 (en) 2012-03-20 2013-09-26 Fenwal, Inc. Apparatus and Method for Providing Cryopreserved ECP-Treated Mononuclear Cells
US9393359B2 (en) 2012-04-10 2016-07-19 Fenwal, Inc. Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution
US9733805B2 (en) 2012-06-26 2017-08-15 Terumo Bct, Inc. Generating procedures for entering data prior to separating a liquid into components
CN102755770B (zh) * 2012-07-30 2014-12-03 博雅干细胞科技有限公司 富血小板血浆的提取方法和提取的富血小板血浆
US10172995B2 (en) 2013-02-06 2019-01-08 Fenwal, Inc. System and method for determining irradiation exposure time with irradiation sensors during extracorporeal photopheresis
US9974899B2 (en) 2013-02-06 2018-05-22 Fenwal, Inc. Method for delivering desired light dose to cells in a light attenuating medium
US10213544B2 (en) 2013-06-13 2019-02-26 Fenwal, Inc. Methods for treating a suspension of mononuclear cells to facilitate extracorporeal photopheresis
JP2017511748A (ja) 2014-01-31 2017-04-27 ディーエスエム アイピー アセッツ ビー．ブイ． 脂肪組織遠心分離機および使用方法
US9597444B2 (en) 2014-05-12 2017-03-21 Fenwal, Inc. Systems and methods for determining replacement fluid and plasma flow rates for red blood cell exchange procedures
US20160114095A1 (en) * 2014-10-27 2016-04-28 Fenwal, Inc. Methods and systems for collecting mononuclear cells
US9833557B2 (en) 2014-12-19 2017-12-05 Fenwal, Inc. Systems and methods for determining free plasma hemoglobin
JP6632359B2 (ja) 2015-01-05 2020-01-22 フェンウォール、インコーポレイテッド 体外フォトフェレーシスにおいて照射受光部を用いて最小ヘマトクリットを検出するためのシステムと方法
EP3552637B1 (en) 2015-02-06 2022-09-28 Fenwal, Inc. System for determining irradiation exposure time with light sensors during extracorporeal photopheresis
US9816073B2 (en) 2015-07-27 2017-11-14 Fenwal, Inc. Systems and methods for detecting fluid leaks using a non-contact sensor
US20170028121A1 (en) 2015-07-31 2017-02-02 Fenwal, Inc. Irradiation device for biological fluids
US10434240B2 (en) * 2015-08-17 2019-10-08 Fenwal, Inc. Methods and systems for processing and washing a photopheresis mononuclear cell product
US11383015B2 (en) * 2016-01-11 2022-07-12 Fenwal, Inc. System and method for plasma purification prior to mononuclear cell collection
US11793720B2 (en) * 2016-01-29 2023-10-24 Terumo Kabushiki Kaisha Medical bag hanger and blood collection device package
EP3299049B1 (en) 2016-09-21 2022-11-02 Fenwal, Inc. System for maintaining patient fluid balance during an extracorporeal therapeutic cell treatment
US10363355B2 (en) 2016-09-21 2019-07-30 Fenwal, Inc. System and method for platelet removal during mononuclear cell collection
EP3300748B1 (en) 2016-09-21 2021-11-03 Fenwal, Inc. Disposable fluid circuits for extracorporeal photopheresis with integrated source of photoactive agent
US10556053B2 (en) 2017-01-30 2020-02-11 Fenwal, Inc. System for collecting mononuclear cells having a suitable hematocrit for extracorporeal photopheresis
EP3372259B1 (en) * 2017-03-07 2022-11-23 Fenwal, Inc. System and methods for separating blood under conditions of reduced plasma clarity
CN107189975B (zh) * 2017-05-26 2020-12-25 奥凯（苏州）生物技术有限公司 一种封闭式细胞扩增系统的细胞收集方法
EP3422354B1 (en) 2017-06-29 2025-09-17 Fenwal, Inc. System and method for authenticating medical device disposable components
EP4112093A1 (en) 2017-10-02 2023-01-04 Fenwal, Inc. Systems and methods for monitoring and controlling fluid balance during a biological fluid procedure
EP3461510B1 (en) 2017-10-02 2022-04-27 Fenwal, Inc. Systems and methods for returning treated mononuclear cells to a blooo source
US11679193B2 (en) 2017-12-20 2023-06-20 Fenwal, Inc. System and method of collecting and infusing an apoptotic white blood cell component and a transplant component
ES3047108T3 (en) 2018-01-22 2025-12-03 Scinogy Products Pty Ltd System, method and controller for recovery of concentrated particles suspended in fluid
EP3533482B1 (en) 2018-03-01 2024-08-07 Fenwal, Inc. Systems and methods for performing online extracorporeal photopheresis
AU2019266347B2 (en) * 2018-05-11 2024-05-02 Lupagen, Inc. Systems and methods for closed loop, real-time modifications of patient cells
US10886022B2 (en) 2018-05-18 2021-01-05 Fenwal, Inc. System and method for authenticating disposable components in extracorporeal photopheresis
US11678825B2 (en) * 2018-10-04 2023-06-20 Fenwal, Inc. Methods and systems for collecting samples in a photopheresis procedure
US12097383B2 (en) 2018-12-13 2024-09-24 Fenwal, Inc. Systems and methods for treating a biological fluid with light in the event of a bulb outage
US11504463B2 (en) 2019-01-10 2022-11-22 Fenwal, Inc. Systems and methods for verifying that a biological product is ready for treatment
EP3705147B1 (en) 2019-03-05 2024-11-06 Fenwal, Inc. Collection, genome editing, and washing of t-cell lymphocytes
US11311823B2 (en) 2019-03-05 2022-04-26 Fenwal, Inc. Collection of mononuclear cells and peripheral blood stem cells
US11883543B2 (en) 2019-04-16 2024-01-30 Fenwal, Inc. Systems and methods for photoactivation of a biological fluid
US11517919B2 (en) 2019-06-06 2022-12-06 Fenwal, Inc. Systems and methods for harvesting MNCs as part of a plasma collection procedure
US12390573B2 (en) 2019-08-20 2025-08-19 Fenwal, Inc. System and methods for automatic dilution of whole blood to increase plasma clarity
EP3868477A1 (en) * 2020-02-18 2021-08-25 Alfa Laval Corporate AB Centrifugal separator for separating a liquid mixture
US12318530B2 (en) 2021-04-13 2025-06-03 Fenwal, Inc. Systems and methods for performing extracorporeal photopheresis
US20230043534A1 (en) 2021-08-06 2023-02-09 Fenwal, Inc. Systems and Methods for Converting an Apheresis Fluid Processing Circuit to Single or Double Needle Mode
JP2023024955A (ja) * 2021-08-06 2023-02-21 フェンウォール、インコーポレイテッド 血液からの血小板の分離および単核細胞の返還のためのシステムおよび方法
US20240024559A1 (en) 2022-07-22 2024-01-25 Fenwal, Inc. Blood processing and treatment systems and methods with procedure estimator

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145713A (en) * 1963-09-12 1964-08-25 Protein Foundation Inc Method and apparatus for processing blood
US3655123A (en) * 1966-08-08 1972-04-11 Us Health Education & Welfare Continuous flow blood separator
US3519201A (en) * 1968-05-07 1970-07-07 Us Health Education & Welfare Seal means for blood separator and the like
BE794220A (fr) * 1972-01-28 1973-05-16 Ibm Reservoir destine notamment au traitement du sang
US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
US4113173A (en) * 1975-03-27 1978-09-12 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus
US3957197A (en) * 1975-04-25 1976-05-18 The United States Of America As Represented By The United States Energy Research And Development Administration Centrifuge apparatus
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4007871A (en) * 1975-11-13 1977-02-15 International Business Machines Corporation Centrifuge fluid container
US4425112A (en) * 1976-02-25 1984-01-10 The United States Of America As Represented By The Department Of Health And Human Services Flow-through centrifuge
US4636193A (en) * 1976-05-14 1987-01-13 Baxter Travenol Laboratories, Inc. Disposable centrifugal blood processing system
US4430072A (en) * 1977-06-03 1984-02-07 International Business Machines Corporation Centrifuge assembly
US4094461A (en) * 1977-06-27 1978-06-13 International Business Machines Corporation Centrifuge collecting chamber
US4419089A (en) * 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US5006103A (en) * 1977-08-12 1991-04-09 Baxter International Inc. Disposable container for a centrifuge
US4114802A (en) * 1977-08-29 1978-09-19 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with biaxial connector
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4387848A (en) * 1977-10-03 1983-06-14 International Business Machines Corporation Centrifuge assembly
US4164318A (en) * 1977-10-12 1979-08-14 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus with reduced-load tubing
US4146172A (en) * 1977-10-18 1979-03-27 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing system
US4386730A (en) * 1978-07-21 1983-06-07 International Business Machines Corporation Centrifuge assembly
SE412528B (sv) * 1978-07-25 1980-03-10 Separex Sa Centrifugrotor och kollaberbar separationsbehallare
US4283004A (en) * 1979-08-15 1981-08-11 Baxter Travenol Laboratories, Inc. Vibration attenuation support assembly for a centrifugal liquid processing apparatus
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
US4447221A (en) * 1982-06-15 1984-05-08 International Business Machines Corporation Continuous flow centrifuge assembly
SE8302215D0 (sv) * 1983-04-20 1983-04-20 Alfa Laval Marine Power Eng Centrifugalseparator
US4605503A (en) * 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
FR2548541B1 (fr) * 1983-07-07 1986-09-12 Rhone Poulenc Sa Procede de plasmapherese et appareillage utilisable notamment pour ce procede
FR2548907B1 (fr) * 1983-07-13 1985-11-08 Rhone Poulenc Sa Procede de plasmapherese et appareillage utilisable notamment pour ce procede
US4530691A (en) * 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4776964A (en) * 1984-08-24 1988-10-11 William F. McLaughlin Closed hemapheresis system and method
JPS61245855A (ja) * 1985-04-22 1986-11-01 Green Cross Corp:The 連続式血液分離装置
US4647279A (en) * 1985-10-18 1987-03-03 Cobe Laboratories, Inc. Centrifugal separator
US4724317A (en) * 1985-12-05 1988-02-09 Baxter Travenol Laboratories, Inc. Optical data collection apparatus and method used with moving members
US4670002A (en) * 1985-12-09 1987-06-02 Hitachi Koki Company, Ltd. Centrifugal elutriator rotor
US4708712A (en) * 1986-03-28 1987-11-24 Cobe Laboratories, Inc. Continuous-loop centrifugal separator
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5076911A (en) * 1987-01-30 1991-12-31 Baxter International Inc. Centrifugation chamber having an interface detection surface
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US4834890A (en) * 1987-01-30 1989-05-30 Baxter International Inc. Centrifugation pheresis system
US5104526A (en) * 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system
US4806252A (en) * 1987-01-30 1989-02-21 Baxter International Inc. Plasma collection set and method
US4936820A (en) * 1988-10-07 1990-06-26 Baxter International Inc. High volume centrifugal fluid processing system and method for cultured cell suspensions and the like
US5078671A (en) * 1988-10-07 1992-01-07 Baxter International Inc. Centrifugal fluid processing system and method
US5316667A (en) * 1989-05-26 1994-05-31 Baxter International Inc. Time based interface detection systems for blood processing apparatus
JP4065927B2 (ja) * 1991-12-23 2008-03-26 バクスター、インターナショナル、インコーポレイテッド 分離チャンバーへのアクセスを提供する分離可能なボウル及びスプール要素を有する遠心機
US5437624A (en) * 1993-08-23 1995-08-01 Cobe Laboratories, Inc. Single needle recirculation system for harvesting blood components
SE9302369D0 (sv) * 1993-07-08 1993-07-08 Omega Medicinteknik Ab Paassystem avsett foer centrifugalseparationsamt an vaendning av detta paassystem
US5704888A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5704889A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus

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EP1468713A2 (en) 2004-10-20
BR9810661A (pt) 2000-10-03
US6027657A (en) 2000-02-22
EP1468713A3 (en) 2004-10-27
EP1024872A1 (en) 2000-08-09
CA2294395A1 (en) 1999-01-14
EP1024872B1 (en) 2011-08-10
JP2002509534A (ja) 2002-03-26
EP1024872A4 (en) 2001-03-14
CN1261815A (zh) 2000-08-02
WO1999001197A1 (en) 1999-01-14

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