JP4060366B2 - リポキシン化合物及び細胞増殖性疾患の治療におけるそれらの利用 - Google Patents
リポキシン化合物及び細胞増殖性疾患の治療におけるそれらの利用 Download PDFInfo
- Publication number
- JP4060366B2 JP4060366B2 JP51396298A JP51396298A JP4060366B2 JP 4060366 B2 JP4060366 B2 JP 4060366B2 JP 51396298 A JP51396298 A JP 51396298A JP 51396298 A JP51396298 A JP 51396298A JP 4060366 B2 JP4060366 B2 JP 4060366B2
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- JP
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- Prior art keywords
- cells
- lxa4
- lipoxin
- carbon atoms
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 C*c1c(*)c(I)c(C)c(*)c1* Chemical compound C*c1c(*)c(I)c(C)c(*)c1* 0.000 description 4
- RYYROWQSGRKERM-UHFFFAOYSA-N CNc(c(N)cc([NH+](NC)[O-])c1)c1N Chemical compound CNc(c(N)cc([NH+](NC)[O-])c1)c1N RYYROWQSGRKERM-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/712,610 US6048897A (en) | 1993-06-15 | 1996-09-13 | Lipoxin compounds and their use in treating cell proliferative disorders |
US08/712,610 | 1996-09-13 | ||
PCT/US1997/016342 WO1998011049A1 (en) | 1996-09-13 | 1997-09-15 | Lipoxin compounds and their use in treating cell proliferative disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001500866A JP2001500866A (ja) | 2001-01-23 |
JP4060366B2 true JP4060366B2 (ja) | 2008-03-12 |
Family
ID=24862848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51396298A Expired - Fee Related JP4060366B2 (ja) | 1996-09-13 | 1997-09-15 | リポキシン化合物及び細胞増殖性疾患の治療におけるそれらの利用 |
Country Status (11)
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6887901B1 (en) | 1993-06-15 | 2005-05-03 | Brigham & Women's Hospital, Inc. | Lipoxin compounds and their use in treating cell proliferative disorders |
US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
PL199236B1 (pl) | 1998-07-08 | 2008-08-29 | Sanofi Aventis Deutschland | N-Aryloamidy kwasów sulfonyloaminokarboksylowych podstawionych siarką, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie N-aryloamidów kwasów sulfonyloaminokarboksylowych podstawionych siarką |
AU776271B2 (en) * | 1999-03-18 | 2004-09-02 | Brigham And Women's Hospital | Lipoxin compounds and their use |
CA2747376A1 (en) | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
EP1616566A1 (en) * | 1999-03-18 | 2006-01-18 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds for treating TNF-alpha initiated inflammation |
AU2004235617B2 (en) * | 1999-03-18 | 2008-06-05 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
EP1586550A1 (en) * | 1999-03-18 | 2005-10-19 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
US6645978B1 (en) | 1999-11-09 | 2003-11-11 | Alcon, Inc. | Lipoxin A4 and its analogs for the treatment of dry eye |
WO2001060778A2 (en) | 2000-02-16 | 2001-08-23 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
WO2001070664A2 (en) * | 2000-03-20 | 2001-09-27 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
ES2344814T3 (es) * | 2001-03-02 | 2010-09-07 | The Brigham And Women's Hospital | Analogos de lipoxina como nuevos inhibidores de la angiogenesis. |
ATE412448T1 (de) * | 2001-03-02 | 2008-11-15 | Brigham & Womens Hospital | Lipoxin analoge als neue inhibitoren der angiogenese |
GB0119583D0 (en) * | 2001-08-10 | 2001-10-03 | Unilever Plc | Cosmetic composition and method of treating skin |
EP1441715B1 (en) * | 2001-11-06 | 2013-02-27 | The Brigham And Women's Hospital, Inc. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
EP1911448B1 (en) * | 2001-11-06 | 2013-01-02 | The Brigham and Women's Hospital, Inc. | Lipoxins and Aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
WO2003053423A2 (en) * | 2001-12-18 | 2003-07-03 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
EP2361622A1 (en) | 2001-12-18 | 2011-08-31 | The Brigham and Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
EP1941875B1 (en) * | 2001-12-18 | 2012-09-12 | The Brigham and Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
CA2495260C (en) * | 2002-08-12 | 2012-05-29 | Brigham And Women's Hospital | Resolvins: biotemplates for novel therapeutic interventions |
WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
GB0313259D0 (en) * | 2003-06-09 | 2003-07-16 | Consejo Superior Investigacion | Magnetic nanoparticles |
US20050250694A1 (en) * | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
US20050130897A1 (en) * | 2003-12-11 | 2005-06-16 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
US20050238589A1 (en) * | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
CA2584286C (en) * | 2004-11-09 | 2014-01-14 | Alcon, Inc. | 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses |
US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
US8245230B2 (en) * | 2005-03-14 | 2012-08-14 | Qnx Software Systems Limited | Adaptive partitioning scheduler for multiprocessing system |
WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
US20100029504A1 (en) | 2007-01-16 | 2010-02-04 | Phigenix, Inc. | Detecting pax2 for the diagnosis of breast cancer |
WO2007061783A1 (en) | 2005-11-18 | 2007-05-31 | Trustees Of Boston University | Treatment and prevention of bone loss using resolvins |
US20070254897A1 (en) * | 2006-04-28 | 2007-11-01 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
UY30755A1 (es) | 2006-12-04 | 2008-07-31 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4 |
US20080287341A1 (en) * | 2007-05-18 | 2008-11-20 | Danyang Chen | Treatment of vascular abnormalities using nanoparticles |
JP2009026126A (ja) * | 2007-07-20 | 2009-02-05 | Nec Electronics Corp | 半導体装置 |
CN101843622B (zh) * | 2010-04-27 | 2011-09-14 | 黄波 | 脂氧素在制备女性避孕药物中的应用 |
US9439966B2 (en) | 2011-10-12 | 2016-09-13 | Case Western Reserve University | Multi-component nanochains |
WO2014072537A1 (de) | 2012-11-12 | 2014-05-15 | Biocrates Life Sciences Ag | Verwendung von qualitätsindikatoren zum nachweis von auftauprozessen in gefrorenen gewebeproben |
CN105439813B (zh) * | 2014-08-08 | 2017-10-27 | 广州丹康医药生物有限公司 | 化合物的合成方法 |
EP3454907B1 (en) | 2016-06-03 | 2020-07-22 | Thetis Pharmaceuticals LLC | Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation |
EP3544684A4 (en) | 2016-11-22 | 2020-07-15 | The Brigham and Women's Hospital, Inc. | PERSONALIZED METABOLOLIPIDOMIC PROFILING OF SPECIALIZED PRO-RESOLUTION MEDIATORS |
WO2018161175A1 (en) | 2017-03-09 | 2018-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
Family Cites Families (19)
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US4560514A (en) * | 1984-05-04 | 1985-12-24 | Bengt Samuelsson | Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds |
US4576758A (en) * | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
US4780281A (en) | 1985-06-14 | 1988-10-25 | Wayne State University | Method for assay of peroxidase enzyme or reducing substrate activity |
JPS62198677A (ja) | 1986-02-26 | 1987-09-02 | Nissan Chem Ind Ltd | テトラオ−ル誘導体 |
JPH0739368B2 (ja) | 1986-10-01 | 1995-05-01 | 旭硝子株式会社 | 20,20,20−トリフルオロアラキドン酸誘導体およびその製造法 |
CA1329809C (en) * | 1987-07-08 | 1994-05-24 | Nissan Chemical Industries, Ltd. | Optically active allyl alcohol and process for producing leucotriene b_ using thereof |
JPH01228994A (ja) | 1988-03-10 | 1989-09-12 | Fumie Satou | γ−シリルアリルアルコール及びその製造法 |
US5079261A (en) * | 1989-04-28 | 1992-01-07 | Brigham And Women's Hospital | Use of lipoxin a4 and its derivatives as antagonists for slow-reacting substances of anaphylaxis |
JP2834512B2 (ja) | 1990-01-30 | 1998-12-09 | 帝人株式会社 | リポキシン誘導体を有効成分とする疾患治療剤 |
US5322699A (en) | 1991-02-04 | 1994-06-21 | The Rockefeller University | Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1) |
US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
JP3227922B2 (ja) | 1993-01-20 | 2001-11-12 | 富士電機株式会社 | 自動販売機 |
DE69435125D1 (de) * | 1993-06-15 | 2008-10-02 | Brigham & Womens Hospital | Lipoxinverbindungen mit verlängerter halbwertszeit |
US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
WO1995001179A1 (en) | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
US5998487A (en) | 1998-04-08 | 1999-12-07 | Colgate-Palmolive Company | Anti-inflammatory and antibacterial benzyl phenol agents and their use in oral compositions |
CA2339049C (en) | 1998-09-08 | 2010-02-23 | Cornell Research Foundation, Inc. | Treating inflammatory diseases of the head and neck with cyclooxygenase-2 inhibitors |
WO2001070664A2 (en) | 2000-03-20 | 2001-09-27 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
-
1996
- 1996-09-13 US US08/712,610 patent/US6048897A/en not_active Expired - Lifetime
-
1997
- 1997-09-15 AT AT02001564T patent/ATE404522T1/de active
- 1997-09-15 AU AU42710/97A patent/AU723321B2/en not_active Ceased
- 1997-09-15 WO PCT/US1997/016342 patent/WO1998011049A1/en active IP Right Grant
- 1997-09-15 ES ES97941078T patent/ES2175460T3/es not_active Expired - Lifetime
- 1997-09-15 DK DK97941078T patent/DK0927150T3/da active
- 1997-09-15 DE DE69738918T patent/DE69738918D1/de not_active Expired - Lifetime
- 1997-09-15 DK DK02001564T patent/DK1201639T3/da active
- 1997-09-15 EP EP08014341A patent/EP2058293A1/en not_active Withdrawn
- 1997-09-15 AT AT97941078T patent/ATE215924T1/de active
- 1997-09-15 DE DE69711894T patent/DE69711894T2/de not_active Expired - Lifetime
- 1997-09-15 PT PT97941078T patent/PT927150E/pt unknown
- 1997-09-15 EP EP02001564A patent/EP1201639B1/en not_active Expired - Lifetime
- 1997-09-15 JP JP51396298A patent/JP4060366B2/ja not_active Expired - Fee Related
- 1997-09-15 PT PT02001564T patent/PT1201639E/pt unknown
- 1997-09-15 EP EP97941078A patent/EP0927150B1/en not_active Expired - Lifetime
- 1997-09-15 ES ES02001564T patent/ES2312499T3/es not_active Expired - Lifetime
- 1997-09-15 CA CA002265708A patent/CA2265708C/en not_active Expired - Fee Related
-
1999
- 1999-05-11 US US09/309,423 patent/US6316648B1/en not_active Expired - Fee Related
-
2001
- 2001-03-09 US US09/803,347 patent/US6750360B2/en not_active Expired - Fee Related
- 2001-03-09 US US09/803,549 patent/US6653493B2/en not_active Expired - Fee Related
- 2001-03-09 US US09/803,402 patent/US20020091279A1/en not_active Abandoned
- 2001-03-09 US US09/803,552 patent/US20010031882A1/en not_active Abandoned
- 2001-10-01 US US09/968,445 patent/US6569075B2/en not_active Expired - Fee Related
-
2002
- 2002-06-19 US US10/175,268 patent/US6620919B2/en not_active Expired - Fee Related
- 2002-12-02 US US10/307,811 patent/US6635776B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4060366B2 (ja) | リポキシン化合物及び細胞増殖性疾患の治療におけるそれらの利用 | |
US7294728B2 (en) | Lipoxin compounds and their use in treating cell proliferative disorders | |
JP4819847B2 (ja) | リポキシン化合物 | |
AU2007231814B2 (en) | Lipoxin compounds and their use in treating cell proliferative disorders |
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