JP4037905B2 - 半減期の長いｏｂタンパク質誘導体 - Google Patents
半減期の長いｏｂタンパク質誘導体 Download PDFInfo
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- JP4037905B2 JP4037905B2 JP52455197A JP52455197A JP4037905B2 JP 4037905 B2 JP4037905 B2 JP 4037905B2 JP 52455197 A JP52455197 A JP 52455197A JP 52455197 A JP52455197 A JP 52455197A JP 4037905 B2 JP4037905 B2 JP 4037905B2
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
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- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
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- 239000007858 starting material Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Emergency Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57949495A | 1995-12-27 | 1995-12-27 | |
| US08/579,494 | 1995-12-27 | ||
| US66718496A | 1996-06-20 | 1996-06-20 | |
| US08/667,184 | 1996-06-20 | ||
| PCT/US1996/020718 WO1997024440A1 (en) | 1995-12-27 | 1996-12-19 | Ob protein derivatives having prolonged half-life |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000504210A JP2000504210A (ja) | 2000-04-11 |
| JP2000504210A5 JP2000504210A5 (cg-RX-API-DMAC7.html) | 2004-11-11 |
| JP4037905B2 true JP4037905B2 (ja) | 2008-01-23 |
Family
ID=27077779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52455197A Expired - Lifetime JP4037905B2 (ja) | 1995-12-27 | 1996-12-19 | 半減期の長いｏｂタンパク質誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0870026B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4037905B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1154726C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE267255T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU1520097A (cg-RX-API-DMAC7.html) |
| BR (1) | BR9612359A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2238307A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ9802013A3 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69632546T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL124831A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX9804687A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ326592A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2178307C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997024440A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
| ES2093593T1 (es) * | 1995-05-05 | 1997-01-01 | Hoffmann La Roche | Proteinas obesas (ob) recombinantes. |
| CA2236163A1 (en) * | 1995-11-22 | 1997-05-29 | Amgen Inc. | Methods of increasing lean tissue mass using ob protein compositions |
| US6936439B2 (en) | 1995-11-22 | 2005-08-30 | Amgen Inc. | OB fusion protein compositions and methods |
| US20030040467A1 (en) | 1998-06-15 | 2003-02-27 | Mary Ann Pelleymounter | Ig/ob fusions and uses thereof. |
| US6025324A (en) * | 1996-05-15 | 2000-02-15 | Hoffmann-La Roche Inc. | Pegylated obese (ob) protein compositions |
| EP1835030A1 (en) * | 1996-12-20 | 2007-09-19 | Amgen, Inc. | OB fusion protein compositions and methods |
| AU770897B2 (en) * | 1996-12-20 | 2004-03-04 | Amgen, Inc. | OB fusion protein compositions and methods |
| AU7132798A (en) * | 1997-04-17 | 1998-11-11 | Amgen, Inc. | Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods |
| AU2002300605B8 (en) * | 1997-04-17 | 2006-02-09 | Amgen Inc. | Compositions Comprising Conjugates of Stable, Active, Human OB Protein with Antibody FC Chain and Methods |
| US6017876A (en) * | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| EP1489100B1 (en) | 1997-12-08 | 2016-06-15 | Merck Patent GmbH | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| ATE417068T1 (de) | 1998-04-23 | 2008-12-15 | Ajinomoto Kk | Stoff mit antithrombotischer aktivität und verfahren zur bestimmung von glycokallidin |
| US6492138B1 (en) | 1998-05-21 | 2002-12-10 | Amgen Canada Inc. | Polynucleotides encoding a novel SHC-binding protein |
| US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| WO2001010912A1 (en) | 1999-08-09 | 2001-02-15 | Lexigen Pharmaceuticals Corp. | Multiple cytokine-antibody complexes |
| AU2154401A (en) | 1999-11-12 | 2001-05-30 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
| US7091321B2 (en) | 2000-02-11 | 2006-08-15 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of antibody-based fusion proteins |
| EP1294401B1 (en) | 2000-06-29 | 2007-08-01 | EMD Lexigen Research Center Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
| US7635676B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
| US7635680B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
| AU2002252035A1 (en) | 2001-02-21 | 2002-09-12 | Surromed, Inc. | Modified annexin proteins and methods for preventing thrombosis |
| US7645739B2 (en) | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
| CN1330664C (zh) | 2001-03-07 | 2007-08-08 | 默克专利有限公司 | 用于含杂合同种型抗体部分的蛋白质的表达技术 |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| CA2446087C (en) | 2001-05-03 | 2013-06-18 | Stephen D. Gillies | Recombinant tumor specific antibody and use thereof |
| EP1454138B1 (en) | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
| MXPA05006384A (es) | 2002-12-17 | 2005-08-29 | Merck Patent Gmbh | Anticuerpo humanizado (h14.18) del anticuerpo 14.18 de raton enlazado a gd2 y su fusion con il-2. |
| KR20050086948A (ko) | 2002-12-27 | 2005-08-30 | 디오벡스, 인코포레이티드 | 인슐린으로 인한 저혈당증을 예방하고 조절하기 위한조성물 및 방법 |
| US7655618B2 (en) | 2002-12-27 | 2010-02-02 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
| US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| EP1682584B1 (en) * | 2003-11-13 | 2013-04-17 | Hanmi Science Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
| PT1699822E (pt) | 2003-12-30 | 2008-07-30 | Merck Patent Gmbh | Proteínas de fusão de il-7 |
| BRPI0417916A (pt) | 2003-12-31 | 2007-04-10 | Merck Patent Gmbh | proteìna de fusão de fc-eritropoietina com farmacocinética melhorada |
| US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| KR100639397B1 (ko) * | 2004-03-18 | 2006-10-26 | (주)에스제이바이오메드 | 항비만용 면역원성 하이브리드 폴리펩타이드 및 이를포함하는 항비만 백신 조성물 |
| US7589179B2 (en) | 2004-12-09 | 2009-09-15 | Merck Patent Gmbh | IL-7 variants with reduced immunogenicity |
| US8227408B2 (en) | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
| EP1972349A1 (en) * | 2007-03-21 | 2008-09-24 | Biocompatibles UK Limited | GLP-1 fusion peptides conjugated to polymer(s), their production and use |
| JP5622720B2 (ja) | 2008-05-21 | 2014-11-12 | ニューロテスインコーポレイテッド | 神経原繊維変化に関連する進行性認知障害の治療方法 |
| JP2012508242A (ja) | 2008-11-04 | 2012-04-05 | ニコラオス テザプシディス | 神経原線維のもつれ及びアミロイドβの蓄積に起因する進行性認知機能障害を治療するためのレプチン組成物及び方法 |
| CN102405230A (zh) | 2009-04-22 | 2012-04-04 | 默克专利有限公司 | 具有修饰的FcRn结合位点的抗体融合蛋白 |
| CN104147596A (zh) * | 2013-05-14 | 2014-11-19 | 李荣秀 | 生物药非共价结合聚合物延长治疗浓度的方法及用途 |
| CN104524568B (zh) * | 2015-01-08 | 2018-04-20 | 中国人民解放军第二军医大学 | 一种治疗肥胖症的药物组合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| ES2093593T1 (es) * | 1995-05-05 | 1997-01-01 | Hoffmann La Roche | Proteinas obesas (ob) recombinantes. |
| GB9511935D0 (en) * | 1995-06-13 | 1995-08-09 | Smithkline Beecham Plc | Novel compound |
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1996
- 1996-12-19 CA CA002238307A patent/CA2238307A1/en not_active Abandoned
- 1996-12-19 CN CNB961992654A patent/CN1154726C/zh not_active Expired - Lifetime
- 1996-12-19 RU RU98113706/14A patent/RU2178307C2/ru active
- 1996-12-19 AU AU15200/97A patent/AU1520097A/en not_active Abandoned
- 1996-12-19 EP EP96945295A patent/EP0870026B1/en not_active Expired - Lifetime
- 1996-12-19 AT AT96945295T patent/ATE267255T1/de active
- 1996-12-19 JP JP52455197A patent/JP4037905B2/ja not_active Expired - Lifetime
- 1996-12-19 BR BR9612359A patent/BR9612359A/pt not_active Application Discontinuation
- 1996-12-19 DE DE69632546T patent/DE69632546T2/de not_active Expired - Lifetime
- 1996-12-19 CZ CZ982013A patent/CZ9802013A3/cs unknown
- 1996-12-19 IL IL12483196A patent/IL124831A0/xx unknown
- 1996-12-19 WO PCT/US1996/020718 patent/WO1997024440A1/en not_active Ceased
- 1996-12-19 NZ NZ326592A patent/NZ326592A/en not_active IP Right Cessation
-
1998
- 1998-06-11 MX MX9804687A patent/MX9804687A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BR9612359A (pt) | 1999-07-13 |
| CN1154726C (zh) | 2004-06-23 |
| NZ326592A (en) | 2001-05-25 |
| ATE267255T1 (de) | 2004-06-15 |
| JP2000504210A (ja) | 2000-04-11 |
| IL124831A0 (en) | 1999-01-26 |
| CN1205738A (zh) | 1999-01-20 |
| EP0870026B1 (en) | 2004-05-19 |
| CZ9802013A3 (cs) | 1998-09-16 |
| RU2178307C2 (ru) | 2002-01-20 |
| WO1997024440A1 (en) | 1997-07-10 |
| AU1520097A (en) | 1997-07-28 |
| EP0870026A1 (en) | 1998-10-14 |
| CA2238307A1 (en) | 1997-07-10 |
| DE69632546D1 (de) | 2004-06-24 |
| DE69632546T2 (de) | 2005-06-30 |
| MX9804687A (es) | 1998-10-31 |
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