JP4031805B2 - 血液捕集および分離システム - Google Patents
血液捕集および分離システム Download PDFInfo
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- JP4031805B2 JP4031805B2 JP2006035025A JP2006035025A JP4031805B2 JP 4031805 B2 JP4031805 B2 JP 4031805B2 JP 2006035025 A JP2006035025 A JP 2006035025A JP 2006035025 A JP2006035025 A JP 2006035025A JP 4031805 B2 JP4031805 B2 JP 4031805B2
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
- B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3692—Washing or rinsing blood or blood constituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/60—Containers for suction drainage, adapted to be used with an external suction source
- A61M1/62—Containers comprising a bag in a rigid low-pressure chamber, with suction applied to the outside surface of the bag
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/64—Containers with integrated suction means
- A61M1/67—Containers incorporating a piston-type member to create suction, e.g. syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
- A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Description
本発明は供血者から血液を捕集して処理するシステムを与え、このシステムは供血者の椅子の傍らに全体を配置させるに充分なくらいに小型化し得る。しかも、血液が供血された後、供血者が依然として椅子に留まっているうちに血液を処理し得る。従って、分離された血液成分(血漿および赤血球)は、全血が抽出された直後に各々の成分に最適な環境に貯蔵し得るので、血液をその処理のための分離実験室へ輸送する必要がない。
本発明の開示する分離器は模式的に図1に示されており、この分離器は、血液が捕集されて処理される無菌の閉止システム使い捨てセットと、この使い捨てセットに介入して捕集及び処理工程を制御する制御ユニット6とからなる。使い捨てセットの一実施例は、供血者70から血液を抽出する針72と、ACD,CPDまたは三ナトリウムくえん酸塩のような抗凝固薬を保持するバッグ92とを有する。このバッグ92は、システムによる血液処理の後の血漿または血小板富化血漿(Platelet-rich plasma)のための貯蔵容器としての役割を果たす。この使い捨てセットは第二のバッグ91をも含み、この第二バッグは赤血球保存溶液を保持し得るので、この中へは分離の後に赤血球を指向させて貯留する。このセットは更に可変容量ローター2aを含む。これらシステムの主要な要素は、四本の配管73により連結されており、そのうちの二本の配管は、針72が取り付けられる継手71に接続され、三本の配管は弁81により接続されている。幾多の異なる形式の弁も本発明に使用し得るが、本発明の一つの好適実施例は、所望の方式で流体を指向させる停止コック形式の弁を使用する。他の使い捨てセットを図4に示す。この実施例においては、四本の配管の各々は、弁手段82を使い捨てセットの他の要素の一つ、即ち針72、ローター2a、第1と第2の容器91,92へ接続する。
Claims (10)
- 全血供給源から静脈アクセス手段を介して捕集された多量の全血を処理し、遠心分離により血液をその成分に分離する捕集システムを作動させる方法であって、
前記捕集システムが、血液を当該捕集システムの可変容量ローター内で捕集し処理するように作動され、
前記捕集システムがさらにインターロックデバイスを備え、前記静脈アクセス手段が当該インターロックデバイスに挿入されるまでは、前記捕集システムが前記ローターからの処理された血液成分の送り出しを行わないようにすることからなる方法。 - 血液を捕集して処理する捕集システムを作動させる方法であって、
静脈アクセス手段を介して、全血供給源から多量の全血を抽出し、可変容量ローターとインターロックデバイスとを備えている前記捕集システムへ向かわせ、前記静脈アクセス手段が当該インターロックデバイスに挿入されるまでは、前記捕集システムが前記ローターからの処理された血液成分の送り出しを行わないようにする段階と、
前記ローターを回転させて、全血を成分に分離する段階と、
前記成分を前記ローターから第一の容器へ向かわせる段階とを含む方法。 - 請求項2記載の方法において、血液が血漿と赤血球とに分離されていて、
血漿を前記ローターから前記第一の容器へ導く段階と
赤血球を前記ローターから第二の容器へ導く段階とを更に含む方法。 - 前記第一の容器から全血へ抗凝固薬を添加する段階を更に含む請求項3記載の方法。
- 赤血球保存溶液が前記第二の容器に包含されている請求項4記載の方法。
- 請求項3記載の方法において、
血漿が前記ローターから導かれた後であって、赤血球が前記ローターから導かれる前に、前記ローターへ洗浄液を添加する段階と、
洗浄液と赤血球とを混合するように前記ローターを揺動させる段階と、
洗浄液と赤血球とが混合された後に、洗浄液と赤血球とを分離するように前記ローターを回転させる段階と、
分離された洗浄液を前記ローターから導く段階とを更に含む方法。 - 血液を捕集し処理する捕集システムを作動させる方法であって、
静脈アクセス手段を介して全血供給源から全血を抽出する段階と、
第一の容器から全血へ抗凝固薬を添加する段階と、
全血を、可変容量ローターとインターロックデバイスとを備える前記捕集システムへ導き、前記静脈アクセス手段が当該インターロックデバイスに挿入されるまでは、当該捕集システムが前記ローターからの処理された血液成分の送り出しを行わないようにする段階と、
全血を血漿と赤血球に分離するように前記ローターを回転させる段階と、
血漿を前記ローターから前記第一の容器へ導く段階と、
赤血球を前記ローターから第二の容器へ導く段階とを含む方法。 - 前記ローターが可変容量ローターである請求項7記載の方法。
- 赤血球保存溶液が前記第二の容器に包含されている請求項7記載の方法。
- 多量の全血を捕集し処理する捕集システムを作動させる方法であって、
血液を収容する遠心分離ローターと、インターロックデバイスとを有する前記捕集システムを設け、静脈アクセス手段が当該インターロックデバイスに挿入されるまでは、当該捕集システムが前記ローターからの処理された血液成分の送り出しを行わないようにする段階と、
全血供給源を前記静脈アクセス手段を介して前記捕集システムへ接続する段階と、
血液成分を前記全血供給源へ帰還させることなく、当該全血供給源から前記捕集システムへ血液を抽出する段階と、
血液が前記全血供給源から抽出された後、前記静脈アクセス手段を前記インターロックデバイスに挿入する段階と、
前記捕集システムを用いて、遠心分離により血液を第一と第二の成分に分離する段階と、
前記第一の成分を前記ローターから貯留容器へ移動させる段階とを含む方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/482,617 US5651766A (en) | 1995-06-07 | 1995-06-07 | Blood collection and separation system |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50043297A Division JP3958364B2 (ja) | 1995-06-07 | 1996-03-05 | 血液捕集および分離システム |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006212439A JP2006212439A (ja) | 2006-08-17 |
JP4031805B2 true JP4031805B2 (ja) | 2008-01-09 |
Family
ID=23916756
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50043297A Expired - Lifetime JP3958364B2 (ja) | 1995-06-07 | 1996-03-05 | 血液捕集および分離システム |
JP2006035025A Expired - Lifetime JP4031805B2 (ja) | 1995-06-07 | 2006-02-13 | 血液捕集および分離システム |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50043297A Expired - Lifetime JP3958364B2 (ja) | 1995-06-07 | 1996-03-05 | 血液捕集および分離システム |
Country Status (8)
Country | Link |
---|---|
US (8) | US5651766A (ja) |
EP (1) | EP0830157B1 (ja) |
JP (2) | JP3958364B2 (ja) |
AT (1) | ATE269116T1 (ja) |
AU (1) | AU710558B2 (ja) |
CA (1) | CA2220295C (ja) |
DE (1) | DE69632731T2 (ja) |
WO (1) | WO1996040319A1 (ja) |
Families Citing this family (132)
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AU710558B2 (en) | 1999-09-23 |
JP3958364B2 (ja) | 2007-08-15 |
JP2006212439A (ja) | 2006-08-17 |
JPH11506030A (ja) | 1999-06-02 |
EP0830157A1 (en) | 1998-03-25 |
US5853382A (en) | 1998-12-29 |
ATE269116T1 (de) | 2004-07-15 |
US6007509A (en) | 1999-12-28 |
US5651766A (en) | 1997-07-29 |
WO1996040319A1 (en) | 1996-12-19 |
DE69632731T2 (de) | 2005-07-14 |
CA2220295C (en) | 2008-11-04 |
DE69632731D1 (de) | 2004-07-22 |
EP0830157B1 (en) | 2004-06-16 |
CA2220295A1 (en) | 1996-12-19 |
US6102883A (en) | 2000-08-15 |
US5779660A (en) | 1998-07-14 |
US6379322B1 (en) | 2002-04-30 |
AU5302696A (en) | 1996-12-30 |
US5728060A (en) | 1998-03-17 |
US6641552B1 (en) | 2003-11-04 |
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