JP3996396B2 - 18fフッ化物の生産のためのシステムと方法 - Google Patents
18fフッ化物の生産のためのシステムと方法 Download PDFInfo
- Publication number
- JP3996396B2 JP3996396B2 JP2001562717A JP2001562717A JP3996396B2 JP 3996396 B2 JP3996396 B2 JP 3996396B2 JP 2001562717 A JP2001562717 A JP 2001562717A JP 2001562717 A JP2001562717 A JP 2001562717A JP 3996396 B2 JP3996396 B2 JP 3996396B2
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- JP
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- Prior art keywords
- fluoride
- solvent
- reaction chamber
- separator
- gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 27
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title claims description 92
- 239000002904 solvent Substances 0.000 claims abstract description 48
- 238000006243 chemical reaction Methods 0.000 claims description 93
- 239000007789 gas Substances 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 229910001868 water Inorganic materials 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 19
- 238000001816 cooling Methods 0.000 claims description 17
- 239000003480 eluent Substances 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 5
- 150000001450 anions Chemical class 0.000 claims description 4
- 239000011261 inert gas Substances 0.000 claims description 3
- 238000005342 ion exchange Methods 0.000 claims description 3
- 230000001678 irradiating effect Effects 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 description 15
- 238000013459 approach Methods 0.000 description 14
- 239000000463 material Substances 0.000 description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- 239000007858 starting material Substances 0.000 description 9
- 239000001307 helium Substances 0.000 description 8
- 229910052734 helium Inorganic materials 0.000 description 8
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 8
- 230000005855 radiation Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 229910052754 neon Inorganic materials 0.000 description 5
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
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- VRYALKFFQXWPIH-PBXRRBTRSA-N (3r,4s,5r)-3,4,5,6-tetrahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)CC=O VRYALKFFQXWPIH-PBXRRBTRSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
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- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
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- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
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- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- NVIVJPRCKQTWLY-UHFFFAOYSA-N cobalt nickel Chemical compound [Co][Ni][Co] NVIVJPRCKQTWLY-UHFFFAOYSA-N 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
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- 235000014113 dietary fatty acids Nutrition 0.000 description 1
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- 229930195729 fatty acid Natural products 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- -1 huber Chemical compound 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- HKVLOZLUWWLDFP-UHFFFAOYSA-M hydron;tetrabutylazanium;carbonate Chemical compound OC([O-])=O.CCCC[N+](CCCC)(CCCC)CCCC HKVLOZLUWWLDFP-UHFFFAOYSA-M 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052758 niobium Inorganic materials 0.000 description 1
- 239000010955 niobium Substances 0.000 description 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
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- 239000012466 permeate Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
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Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0015—Fluorine
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Glass Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Fertilizers (AREA)
- Noodles (AREA)
- Saccharide Compounds (AREA)
- Physical Water Treatments (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18435200P | 2000-02-23 | 2000-02-23 | |
US60/184,352 | 2000-02-23 | ||
PCT/US2001/005608 WO2001063623A1 (fr) | 2000-02-23 | 2001-02-23 | Systeme et procede de production de fluorure 18f |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2003524787A JP2003524787A (ja) | 2003-08-19 |
JP2003524787A5 JP2003524787A5 (fr) | 2005-08-04 |
JP3996396B2 true JP3996396B2 (ja) | 2007-10-24 |
Family
ID=22676532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001562717A Expired - Fee Related JP3996396B2 (ja) | 2000-02-23 | 2001-02-23 | 18fフッ化物の生産のためのシステムと方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US6845137B2 (fr) |
EP (1) | EP1258010B1 (fr) |
JP (1) | JP3996396B2 (fr) |
AT (1) | ATE430368T1 (fr) |
AU (2) | AU3981601A (fr) |
CA (1) | CA2401066C (fr) |
DE (1) | DE60138526D1 (fr) |
MX (1) | MXPA02008280A (fr) |
WO (1) | WO2001063623A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6599484B1 (en) * | 2000-05-12 | 2003-07-29 | Cti, Inc. | Apparatus for processing radionuclides |
AU2001274843A1 (en) * | 2000-05-17 | 2001-11-26 | The Regents Of The University Of California | Method for producing(18f)fluoride ion |
US6567492B2 (en) * | 2001-06-11 | 2003-05-20 | Eastern Isotopes, Inc. | Process and apparatus for production of F-18 fluoride |
JP3989897B2 (ja) * | 2001-06-13 | 2007-10-10 | ザ ユニバーシティ オブ アルバータ,ザ ユニバーシティ オブ ブリティッシュ コロンビア,カールトン ユニバーシティ,サイモン フレイザー ユニバーシティ アンド ザ ユニバーシティ オブ ビクトリ | イオンビームによる18f−フッ化物の製造のための装置と方法 |
US7018614B2 (en) * | 2002-11-05 | 2006-03-28 | Eastern Isotopes, Inc. | Stabilization of radiopharmaceuticals labeled with 18-F |
US20050201505A1 (en) * | 2003-08-08 | 2005-09-15 | Welch Michael J. | Enhanced separation process for (76Br, 77Br and 124I) preparation and recovery of each |
US7831009B2 (en) * | 2003-09-25 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Tantalum water target body for production of radioisotopes |
DE102005026253A1 (de) * | 2004-06-18 | 2006-01-05 | General Electric Co. | Erzeugung von 18F(F2) Fluor aus 18O(O2) Sauerstoff mit hoher Ausbeute |
US20050279130A1 (en) * | 2004-06-18 | 2005-12-22 | General Electric Company | 18O[O2] oxygen refilling technique for the production of 18[F2] fluorine |
US20060023829A1 (en) * | 2004-08-02 | 2006-02-02 | Battelle Memorial Institute | Medical radioisotopes and methods for producing the same |
US20060039522A1 (en) * | 2004-08-18 | 2006-02-23 | Research Foundation Of The State University Of New York | Cyclotron target, apparatus for handling fluids with respect thereto and for recovering irradiated fluids, and methods of operating same |
GB0506041D0 (en) * | 2005-03-24 | 2005-04-27 | Ge Healthcare Ltd | Stripping method |
GB2426862B (en) * | 2005-06-04 | 2007-04-11 | Alan Charles Sturt | Thermonuclear power generation |
JP4099187B2 (ja) * | 2005-09-30 | 2008-06-11 | 株式会社日立製作所 | 放射性同位元素製造装置、及びターゲットのリサイクル方法 |
JP4885809B2 (ja) * | 2007-08-14 | 2012-02-29 | 住友重機械工業株式会社 | Oガス回収装置及びoガス回収方法 |
US20100243082A1 (en) * | 2007-10-31 | 2010-09-30 | Atomic Energy Council - Institute Of Nuclear Energy Research | Liquid isotope delivery system |
KR100967359B1 (ko) * | 2008-04-30 | 2010-07-05 | 한국원자력연구원 | 내부 핀구조를 가지는 동위원소 생산 기체표적 |
KR20160072846A (ko) | 2008-05-02 | 2016-06-23 | 샤인 메디컬 테크놀로지스, 인크. | 의료용 동위원소를 생산하는 디바이스 및 방법 |
WO2012003009A2 (fr) | 2010-01-28 | 2012-01-05 | Shine Medical Technologies, Inc. | Chambre de réaction segmentée pour production de radio-isotope |
US9177679B2 (en) * | 2010-02-11 | 2015-11-03 | Uchicago Argonne, Llc | Accelerator-based method of producing isotopes |
US9336916B2 (en) | 2010-05-14 | 2016-05-10 | Tcnet, Llc | Tc-99m produced by proton irradiation of a fluid target system |
WO2012039036A1 (fr) * | 2010-09-22 | 2012-03-29 | 独立行政法人放射線医学総合研究所 | Processus et dispositif pour la production d'un radionucléide à l'aide d'un accélérateur |
WO2012092394A1 (fr) | 2010-12-29 | 2012-07-05 | Cardinal Health 414, Llc | Système fermé de remplissage de flacon pour distribution aseptique |
US10734126B2 (en) | 2011-04-28 | 2020-08-04 | SHINE Medical Technologies, LLC | Methods of separating medical isotopes from uranium solutions |
US9269467B2 (en) | 2011-06-02 | 2016-02-23 | Nigel Raymond Stevenson | General radioisotope production method employing PET-style target systems |
US20130102772A1 (en) | 2011-07-15 | 2013-04-25 | Cardinal Health 414, Llc | Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals-full |
US9417332B2 (en) | 2011-07-15 | 2016-08-16 | Cardinal Health 414, Llc | Radiopharmaceutical CZT sensor and apparatus |
US20130020727A1 (en) | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc. | Modular cassette synthesis unit |
CA2869559C (fr) | 2012-04-05 | 2022-03-29 | Shine Medical Technologies, Inc. | Ensemble aqueux et methode de controle |
US10849994B2 (en) * | 2016-06-28 | 2020-12-01 | Asociación Centro De Investigación Cooperativa En Biomateriales — Cic Biomagune | Pharmaceutical composition comprising fluorine-18 labelled gases |
JP6274689B1 (ja) * | 2016-11-16 | 2018-02-07 | 株式会社京都メディカルテクノロジー | Ri標識化合物製造装置及びri標識化合物製造方法 |
US10109383B1 (en) * | 2017-08-15 | 2018-10-23 | General Electric Company | Target assembly and nuclide production system |
JP6873381B1 (ja) * | 2020-12-19 | 2021-05-19 | 株式会社京都メディカルテクノロジー | 18f標識化合物製造装置及び18f標識化合物製造方法 |
CN113955771A (zh) * | 2021-10-29 | 2022-01-21 | 北京善为正子医药技术有限公司 | 一种快速制备18f氟化钠pet药物的自动合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1201222A (fr) * | 1982-06-01 | 1986-02-25 | Robert Robertson | Obtention d'iode-123 par la methode du gaz-cible |
DE3424525A1 (de) | 1984-07-04 | 1986-01-16 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch |
JPH0778558B2 (ja) * | 1990-07-20 | 1995-08-23 | 日本鋼管株式会社 | ▲上13▼nh▲上+▼▲下4▼,▲上18▼f−同時製造用ターゲット箱 |
US5280505A (en) * | 1991-05-03 | 1994-01-18 | Science Research Laboratory, Inc. | Method and apparatus for generating isotopes |
US5425063A (en) * | 1993-04-05 | 1995-06-13 | Associated Universities, Inc. | Method for selective recovery of PET-usable quantities of [18 F] fluoride and [13 N] nitrate/nitrite from a single irradiation of low-enriched [18 O] water |
US5468355A (en) * | 1993-06-04 | 1995-11-21 | Science Research Laboratory | Method for producing radioisotopes |
US5917874A (en) * | 1998-01-20 | 1999-06-29 | Brookhaven Science Associates | Accelerator target |
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2001
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- 2001-02-23 WO PCT/US2001/005608 patent/WO2001063623A1/fr active IP Right Grant
- 2001-02-23 DE DE60138526T patent/DE60138526D1/de not_active Expired - Lifetime
- 2001-02-23 CA CA2401066A patent/CA2401066C/fr not_active Expired - Fee Related
- 2001-02-23 EP EP01914426A patent/EP1258010B1/fr not_active Expired - Lifetime
- 2001-02-23 AU AU3981601A patent/AU3981601A/xx active Pending
- 2001-02-23 US US09/790,572 patent/US6845137B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
EP1258010A1 (fr) | 2002-11-20 |
DE60138526D1 (de) | 2009-06-10 |
WO2001063623A1 (fr) | 2001-08-30 |
AU2001239816B2 (en) | 2005-01-27 |
JP2003524787A (ja) | 2003-08-19 |
AU3981601A (en) | 2001-09-03 |
US6845137B2 (en) | 2005-01-18 |
US20010043663A1 (en) | 2001-11-22 |
US20050129162A1 (en) | 2005-06-16 |
EP1258010B1 (fr) | 2009-04-29 |
ATE430368T1 (de) | 2009-05-15 |
MXPA02008280A (es) | 2004-04-05 |
CA2401066A1 (fr) | 2001-08-30 |
CA2401066C (fr) | 2010-08-10 |
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