JP3977553B2 - Liquid oral composition - Google Patents
Liquid oral composition Download PDFInfo
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- JP3977553B2 JP3977553B2 JP24868599A JP24868599A JP3977553B2 JP 3977553 B2 JP3977553 B2 JP 3977553B2 JP 24868599 A JP24868599 A JP 24868599A JP 24868599 A JP24868599 A JP 24868599A JP 3977553 B2 JP3977553 B2 JP 3977553B2
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- Prior art keywords
- component
- oil
- liquid oral
- oral composition
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Description
【0001】
【発明の属する技術分野】
本発明は保存安定性の良好な液状口腔用組成物に関する。
【0002】
【従来の技術及び発明が解決しようとする課題】
液状歯磨き、洗口剤等の液状口腔用組成物には、油溶性成分の可溶化剤としてポリオキシエチレン硬化ヒマシ油に代表される非イオン界面活性剤が配合されている(特開昭59−122417号、同59−122418号)。ポリオキシエチレン硬化ヒマシ油は、可溶化能が高く、広く使用されているが、大量に使用すると粘膜を刺激するおそれがあり、また風味も損なわれる傾向にあった。
一方、ポリグリセリン脂肪酸エステルやショ糖脂肪酸エステルも口腔用組成物の可溶化剤として使用されているが、その可溶化能は充分でなく、特に室温以下の保存時に沈澱物が生じるという問題があった。
従って本発明の目的は、保存安定性が良好で、かつ風味がよく、刺激性の少ない液状口腔用組成物を提供することにある。
【0003】
【課題を解決するための手段】
そこで本発明者らは、油溶性成分に対して一定量のポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル又はアルキルグリコシドを配合し、さらにこれに少量の陰イオン界面活性剤を配合すれば、低温保存下でも沈澱が生じず安定であり、かつ風味が良好で、刺激等もない液状口腔用組成物が得られることを見出した。
【0004】
すなわち、本発明は、次の成分(A)、(B)及び(C)、
(A)油溶性成分、
(B)成分(A)に対して2〜7重量倍の、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル及びアルキルグリコシドから選ばれる1種以上の非イオン界面活性剤、
(C)成分(B)100重量部に対して1重量部以上、10重量部未満の陰イオン界面活性剤
を含有する液状口腔用組成物を提供するものである。
【0005】
【発明の実施の形態】
本発明の液状口腔用組成物に用いられる(A)油溶性成分としては、香料成分、油溶性薬効剤及び油剤が挙げられる。ここで香料成分としては、メントール、カルボン、アネトール、ペパーミントオイル、メンチルラクテート等が挙げられる。また油溶性薬効剤としては、非水溶性ビタミン(A,D,E,F,K,P等)及びその誘導体、グリチルレチン酸、アズレン誘導体、ステロイド、抗プラスミン剤、非水溶性殺菌剤、フタライド類、ニコチン酸誘導体、マロニエ、バーチ、カミツレ、オトギリソウ、センブリ、ヒバマタ等の生薬の有機溶剤抽出物等が挙げられる。さらに油剤としては、スクワラン、パラフィン、シリコーン、各種脂肪酸、エステル油、エーテル油、動植物油等が挙げられる。これらの油溶性成分は1種以上を組み合せて配合することができ、合計で全組成物中に0.01〜2重量%(以下、単に%で示す)、特に0.1〜1%配合するのが好ましい。
【0006】
ポリグリセリン脂肪酸エステルとしては、グリセリンが2〜20個縮合したポリグリセリンに炭素数8〜24の脂肪酸が1〜4個エステル結合したものが挙げられ、特に5〜10個縮合したポリグリセリンと炭素数12〜14の脂肪酸のモノエステルが好ましい。またショ糖脂肪酸エステルとしては、ショ糖に炭素数8〜24の脂肪酸がエステル結合したものが挙げられ、特に炭素数16〜18の脂肪酸のショ糖エステルが好ましい。アルキルグリコシドとしては、炭素数8〜24のアルキル基が単糖又はオリゴ糖にエーテル結合したものが好ましく、特にアルキル基の炭素数8〜16のものが好ましい。これらの成分(B)の成分は1種以上を組み合せて配合することができ、合計で成分(A)に対して2〜7重量倍配合すると、成分(A)を安定に可溶化できる。また成分(B)の好ましい配合量は成分(A)に対して2〜5重量倍である。
【0007】
本発明に用いられる(C)陰イオン界面活性剤としては、アルキルリン酸エステル、ポリオキシアルキレン化アルキルリン酸エステル、アルキル硫酸エステル、ポリオキシアルキレン化アルキル硫酸エステル、アシルアミノ酸、ポリオキシアルキレン化アシルアミノ酸及びこれらの塩から選ばれる1種以上が挙げられる。ここで、アルキルリン酸エステルとしては、炭素数8〜24のアルキル又はアルケニル基を1個又は2個有するリン酸エステルが挙げられ、このうちモノC8−C24アルキルリン酸エステル、ジC8−C24アルキルリン酸エステルが好ましい。また、ポリオキシアルキレン化アルキルリン酸エステルとしては、モノ−又はジ−(ポリオキシエチレン化C8−C24アルキル)リン酸エステルが好ましい。
【0008】
アルキル硫酸エステルとしては、C8−C24アルキル硫酸エステルが好ましく、ポリオキシアルキレン化アルキル硫酸エステルとしては、ポリオキシエチレン化C8−C24アルキル硫酸エステルが好ましい。アシルアミノ酸としては、サルコシン、グリシン、タウリン、グルタミン酸等のアミノ酸のアミノ基が炭素数8〜24の脂肪酸でアシル化されたものが好ましく、特にN−C8−C24長鎖アシルサルコシン、N−C8−C24長鎖アシルグルタミン酸、N−C8−C24長鎖アシルメチルタウリン等が好ましい。ポリオキシアルキレン化アシルアミノ酸としては、上記のアシルアミノ酸がポリオキシエチレン化されたものが好ましい。
【0009】
また、これらの陰イオン界面活性剤の塩としては、ナトリウム塩、カリウム塩などのアルカリ金属塩、アルギニン、リジン、ヒスチジン等の塩基性アミノ酸塩、アンモニウム塩、アルカノールアミン塩等が好ましい。
【0010】
これらの陰イオン界面活性剤は、成分(B)100重量部に対して1重量部以上10重量部未満配合すると、成分(B)による油溶性成分の可溶化能を向上させることができるため、成分(B)を大量に配合することなく、低温保存条件でも長期間安定な液状口腔用組成物が得られる。また成分(B)の配合を大量必要としないため刺激や風味の点でも改善される。より好ましい陰イオン界面活性剤の配合量は成分(B)に対し3〜9.5%である。
【0011】
本発明の液状口腔用組成物は、水性液状であり、好ましくは水性の透明又は均一なマイクロエマルション系であり、液状歯磨、洗口剤、口中清涼剤、含嗽剤等として使用することができる。
【0012】
本発明液状口腔用組成物には、さらに水、グリセリン、ソルビトール、キシリトール、トレハロース、プロピレングリコールなどの湿潤剤、甘味剤、モノフルオロリン酸ナトリウム、フッ化ナトリウム、フッ化スズ等の歯質強化剤、抗炎症剤、殺菌剤、塩化亜鉛等の収斂剤、保存料、pH調整剤、キレート剤、エタノール等の水溶性成分を配合することができる。
【0013】
【実施例】
実施例1〜6及び比較例1〜3
表1記載の処方で液状歯磨剤を調製し、製造直後に外観を観察し、次いで室温、5℃及び−5℃条件下に1ケ月保存後に安定性を評価した。結果を表1に示す。
【0014】
【表1】
【0015】
表1から明らかなように、油溶性成分に対して2〜7重量倍の成分(B)(ポリグリセリン脂肪酸エステル)と、成分(B)100重量部に対して1重量部以上10重量部未満の陰イオン界面活性剤を配合すれば、室温〜低温下で長期間安定な液状口腔用組成物が得られることがわかる。また、実施例1〜6の液状歯磨剤は、風味も良好で、かつ口腔内への刺激もなかった。
【0016】
【0017】
【0018】
【0019】
【0020】
【発明の効果】
本発明の液状口腔用組成物は、室温〜低温条件下での長期安定性に優れる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a liquid oral composition having good storage stability.
[0002]
[Prior art and problems to be solved by the invention]
Liquid oral compositions such as liquid toothpastes and mouthwashes are blended with nonionic surfactants typified by polyoxyethylene hydrogenated castor oil as solubilizers for oil-soluble components (Japanese Patent Laid-Open No. Sho 59-). 122417, 59-122418). Polyoxyethylene hydrogenated castor oil has a high solubilizing ability and is widely used. However, when used in a large amount, the mucous membrane may be irritated and the flavor tends to be impaired.
On the other hand, polyglycerin fatty acid esters and sucrose fatty acid esters are also used as solubilizers for oral compositions, but their solubilizing ability is not sufficient, and there is a problem that precipitates are generated particularly during storage at room temperature or lower. It was.
Accordingly, an object of the present invention is to provide a liquid oral composition having good storage stability, good flavor and less irritation.
[0003]
[Means for Solving the Problems]
Therefore, the present inventors blended a certain amount of polyglycerin fatty acid ester, sucrose fatty acid ester or alkylglycoside with the oil-soluble component, and further blended with a small amount of an anionic surfactant to preserve it at low temperature. However, the present inventors have found that a liquid oral composition that is stable without precipitation and has a good flavor and no irritation can be obtained.
[0004]
That is, the present invention includes the following components (A), (B) and (C),
(A) oil-soluble component,
(B) one or more nonionic surfactants selected from polyglycerin fatty acid ester, sucrose fatty acid ester, and alkyl glycoside, 2 to 7 times by weight with respect to component (A),
(C) A liquid oral composition containing 1 part by weight or more and less than 10 parts by weight of an anionic surfactant with respect to 100 parts by weight of the component (B).
[0005]
DETAILED DESCRIPTION OF THE INVENTION
Examples of the (A) oil-soluble component used in the liquid oral composition of the present invention include a fragrance component, an oil-soluble medicinal agent and an oil agent. Here, examples of the fragrance component include menthol, carvone, anethole, peppermint oil, menthyl lactate and the like. Oil-soluble medicinal agents include water-insoluble vitamins (A, D, E, F, K, P, etc.) and their derivatives, glycyrrhetinic acid, azulene derivatives, steroids, antiplasmin agents, water-insoluble fungicides, phthalides And organic solvent extracts of herbal medicines such as nicotinic acid derivatives, maronier, birch, chamomile, hypericum, assembly, and hibamata. Furthermore, examples of the oil agent include squalane, paraffin, silicone, various fatty acids, ester oil, ether oil, animal and vegetable oils. These oil-soluble components can be blended in combination of one or more, and the total amount is 0.01 to 2% by weight (hereinafter simply indicated by%), especially 0.1 to 1%. Is preferred.
[0006]
Examples of the polyglycerol fatty acid ester include those obtained by condensing 1 to 4 fatty acids having 8 to 24 carbon atoms with polyglycerol condensed with 2 to 20 glycerol, and particularly those having 5 to 10 condensed polyglycerol and carbon number. Monoesters of 12-14 fatty acids are preferred. Examples of the sucrose fatty acid ester include sucrose in which a fatty acid having 8 to 24 carbon atoms is ester-bonded, and a sucrose ester of a fatty acid having 16 to 18 carbon atoms is particularly preferable. As the alkyl glycoside, an alkyl group having 8 to 24 carbon atoms in which an ether group is bonded to a monosaccharide or oligosaccharide is preferable, and an alkyl group having 8 to 16 carbon atoms is particularly preferable. These components (B) can be blended in combination of one or more. When blended in total 2 to 7 times by weight with respect to component (A), component (A) can be stably solubilized. Moreover, the preferable compounding quantity of a component (B) is 2-5 weight times with respect to a component (A).
[0007]
Examples of the (C) anionic surfactant used in the present invention include alkyl phosphate ester, polyoxyalkylenated alkyl phosphate ester, alkyl sulfate ester, polyoxyalkylenated alkyl sulfate ester, acylamino acid, and polyoxyalkylenated acyl. 1 or more types chosen from an amino acid and these salts are mentioned. Here, examples of the alkyl phosphate ester include phosphate esters having one or two alkyl or alkenyl groups having 8 to 24 carbon atoms. Among them, mono C 8 -C 24 alkyl phosphate ester, di-C 8 -C 24 alkyl phosphoric acid ester is preferred. The polyoxyalkylenated alkyl phosphate ester is preferably a mono- or di- (polyoxyethylenated C 8 -C 24 alkyl) phosphate ester.
[0008]
The alkyl sulfates, preferably C 8 -C 24 alkyl sulfates, polyoxyalkylene alkyl sulfates, polyoxyethylenated C 8 -C 24 alkyl sulfates are preferred. The acylamino acid is preferably one in which the amino group of an amino acid such as sarcosine, glycine, taurine, glutamic acid is acylated with a fatty acid having 8 to 24 carbon atoms, and particularly N—C 8 -C 24 long chain acyl sarcosine, N— C 8 -C 24 long chain acyl glutamic acid, N—C 8 -C 24 long chain acylmethyl taurine and the like are preferred. As the polyoxyalkylenated acylamino acid, those in which the acylamino acid is polyoxyethylenated are preferable.
[0009]
Further, as salts of these anionic surfactants, alkali metal salts such as sodium salt and potassium salt, basic amino acid salts such as arginine, lysine and histidine, ammonium salts and alkanolamine salts are preferable.
[0010]
When these anionic surfactants are blended in an amount of 1 part by weight or more and less than 10 parts by weight with respect to 100 parts by weight of the component (B), the solubilizing ability of the oil-soluble component by the component (B) can be improved. Without blending a large amount of the component (B), a liquid oral composition that is stable for a long time even under low-temperature storage conditions can be obtained. Further, since a large amount of the component (B) is not required, it is improved in terms of irritation and flavor. A more preferable amount of the anionic surfactant is 3 to 9.5% based on the component (B).
[0011]
The liquid oral composition of the present invention is an aqueous liquid, preferably an aqueous transparent or uniform microemulsion system, and can be used as a liquid dentifrice, mouthwash, mouth freshener, mouthwash, and the like.
[0012]
The liquid oral composition of the present invention further includes a wetting agent such as water, glycerin, sorbitol, xylitol, trehalose and propylene glycol, a sweetener, a tooth enhancer such as sodium monofluorophosphate, sodium fluoride and tin fluoride. , Anti-inflammatory agents, bactericides, astringents such as zinc chloride, preservatives, pH adjusters, chelating agents, ethanol and other water-soluble components can be blended.
[0013]
【Example】
Examples 1-6 and Comparative Examples 1-3
A liquid dentifrice was prepared according to the formulation shown in Table 1, the appearance was observed immediately after production, and then the stability was evaluated after storage for 1 month at room temperature, 5 ° C and -5 ° C. The results are shown in Table 1.
[0014]
[Table 1]
[0015]
As apparent from Table 1, 2 to 7 times by weight of component (B) (polyglycerin fatty acid ester) with respect to the oil-soluble component, and 1 part by weight or more and less than 10 parts by weight with respect to 100 parts by weight of component (B) It can be seen that a liquid oral composition that is stable for a long period of time at room temperature to low temperature can be obtained by adding an anionic surfactant. Moreover, the liquid dentifrice of Examples 1-6 also had favorable flavor, and there was no irritation | stimulation in an intraoral area.
[0016]
[0017]
[0018]
[0019]
[0020]
【The invention's effect】
The liquid oral composition of the present invention is excellent in long-term stability under room temperature to low temperature conditions.
Claims (3)
(A)油溶性成分、
(B)成分(A)に対して2〜7重量倍の、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル及びアルキルグリコシドから選ばれる1種以上の非イオン界面活性剤、
(C)成分(B)100重量部に対して1重量部以上、10重量部未満の陰イオン界面活性剤
を含有する液状口腔用組成物。The following components (A), (B) and (C),
(A) oil-soluble component,
(B) one or more nonionic surfactants selected from polyglycerin fatty acid ester, sucrose fatty acid ester, and alkyl glycoside, 2 to 7 times by weight with respect to component (A),
(C) Liquid oral cavity composition containing 1 weight part or more and less than 10 weight part anionic surfactant with respect to 100 weight part of component (B).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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JP24868599A JP3977553B2 (en) | 1999-09-02 | 1999-09-02 | Liquid oral composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24868599A JP3977553B2 (en) | 1999-09-02 | 1999-09-02 | Liquid oral composition |
Publications (2)
Publication Number | Publication Date |
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JP2001072559A JP2001072559A (en) | 2001-03-21 |
JP3977553B2 true JP3977553B2 (en) | 2007-09-19 |
Family
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JP24868599A Expired - Fee Related JP3977553B2 (en) | 1999-09-02 | 1999-09-02 | Liquid oral composition |
Country Status (1)
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JP (1) | JP3977553B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20210244636A1 (en) * | 2018-10-24 | 2021-08-12 | Sunstar Inc. | Composition for oral cavity |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005029513A (en) * | 2003-07-07 | 2005-02-03 | Kobayashi Pharmaceut Co Ltd | Breath cool-refreshing preparation and method for producing the same |
JP4918973B2 (en) * | 2005-08-12 | 2012-04-18 | ライオン株式会社 | Dentifrice composition |
JP5043588B2 (en) * | 2007-10-12 | 2012-10-10 | 花王株式会社 | Liquid oral composition |
BRPI0906453A2 (en) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Oral Care Composition and Method for Improving Oral Health |
RU2471475C2 (en) * | 2008-02-08 | 2013-01-10 | Колгейт-Палмолив Компани | Oral care product and method for using it |
JP5930953B2 (en) * | 2011-12-14 | 2016-06-08 | 花王株式会社 | Method for producing antibacterial agent composition |
JP6800936B2 (en) * | 2018-10-24 | 2020-12-16 | サンスター株式会社 | Oral composition |
-
1999
- 1999-09-02 JP JP24868599A patent/JP3977553B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210244636A1 (en) * | 2018-10-24 | 2021-08-12 | Sunstar Inc. | Composition for oral cavity |
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