JP3412872B2 - Oral composition - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to an oral composition, and more particularly to an oral composition containing a specific glucose-1-phosphate salt as a wetting agent.

[0002]

2. Description of the Related Art Oral compositions such as dentifrice contain a humectant for preventing dehydration in the air to delay the drying or to give moisture to maintain the dentifrice in a paste form. . In general, as the wetting agent, sorbitol, glycerin, propylene glycol, ethylene glycol, polypropylene glycol, polyethylene glycol, xylit, maltite, lactit, etc. are used.

[0003]

[Problems to be Solved by the Invention]
The above-mentioned moisturizers generally used have excellent moisturizing action, but on the other hand, since many of them have a polyol skeleton, they have a strong sweetness and are used in oral compositions such as toothpaste and water toothpaste. When combined with, it exhibits a strong sweetness. However, many people dislike this sweetness, and in order to impart the desired taste, it is necessary to devise such as masking the sweetness with a flavoring agent, etc., but from the characteristics of this humectant, prepare a light oral composition. It was difficult.

[0004]

Under such circumstances, the present inventors have conducted earnest research to find a tasteless wetting agent having a wettability equivalent to that of a conventional wetting agent, and as a result, a specific wetting agent was found. The present invention has been completed by finding that glucose-1-phosphate has a wettability equivalent to that of a conventional wetting agent and is tasteless.

That is, the present invention relates to glucose-1-phosphate sodium salt, potassium salt or calcium salt 1-8.
It is intended to provide an oral composition containing 0% by weight as a wetting agent and containing no water-soluble zinc salt.

The glucose-1-phosphate used in the present invention is a sodium salt, potassium salt or calcium salt.

Regarding the incorporation of glucose-1-phosphate into the oral composition for use in the present invention, it is necessary to promote the colloidation of the reaction product of hydrofluoric acid or a salt thereof with a water-soluble calcium salt. And the same amount as hydrofluoric acid, 0.00
It is known to add from 01 to 10% by weight (Japanese Patent Laid-Open No. 4-217618), but nothing is known about its use as a wetting agent.

In the present invention, the glucose-1-phosphate salt may be used either individually or in combination of two or more. The amount of the glucose-1-phosphate salt to be incorporated into the oral composition is 1-80 with respect to the total composition. % By weight, preferably more than 10% by weight and 5
0% by weight or less, particularly preferably 11 to 30% by weight
Is.

In the oral composition of the present invention, known ingredients such as carboxymethyl cellulose and salts thereof, methyl cellulose, hydroxyethyl cellulose, carrageenan, sodium polyacrylate, sodium alginate, hydroxypropyl cellulose, carboxymethyl hydroxy are known depending on its form. Caking agents such as sodium ethyl cellulose, propylene glycol alginate, xanthan gum, tragacanth gum, karaya gum, arabia gum, polyvinyl alcohol, polyvinylpyrrolidone, bee gum and lavonite; chlorhexidine salts, cetylpyridinium chloride bactericides; pH adjustment of sodium phosphate etc. Agents; enzymes such as dextranase, amylase, protease, lysozyme, mutanase; sodium chloride, cypress All, ε- aminocaproic acid,
Tranexamic acid, allantoins, tocopherols,
Dihydrocholesterol, glycyrrhetinic acid, glycyrrhizic acid and salts thereof; chlorophyll, azulene, chamomile, toki, Kawayumi, anti-inflammatory agents such as crude drugs and blood circulation promoters;
Lauryl sulfate, myristyl sulfate, α-olefin sulfonate, N-acyl amino acid salt, acyl monoglyceride sulfate, soap, fatty acid monoglyceride, fatty acid monoalkanolamide, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, Surfactants such as alkyl glucoside, imidazolium betaine, alkyl betaine, alkylamido betaine, sulfobetaine, amine oxide; sweeteners such as sodium saccharin, stevioside, thaumatin, asparatylphenylalanine methyl ester; parahydroxybenzoic acid, parahydroxybenzoic acid. Preservatives such as ethyl, propyl parahydroxybenzoate, butyl parahydroxybenzoate and sodium parahydroxybenzoate; coloring agents such as titanium dioxide Dyes; peppermint oil, spearmint oil, menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n
-Decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineol, linalool, ethyl linalool, vanillin, thymol, anise oil, lemon oil,
Fragrances such as orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil and the like can be appropriately added.

In the present invention, it is preferable not to include a fluorine compound, but when the compounding amount of glucose-1-phosphate exceeds 10% by weight with respect to the total composition, a fluorine compound is contained. Good.

The dosage form of the composition for oral cavity of the present invention is not particularly limited, and various dosage forms such as dentifrice, tooth coating agent, chewing gum and the like can be prepared, and these are manufactured by a conventional method according to the dosage form. can do.

Glucose-1-phosphate has a moisturizing action equal to or higher than that of conventionally used moisturizers and has no taste. Therefore, the oral composition of the present invention contains the moisturizer at the time of its preparation. A desired taste can be imparted without considering taste, particularly sweetness. Further, glucose-1-phosphate has a buffering action because it has a phosphate group, and also acts as a pH adjuster.

[0013]

The present invention will be described below with reference to examples, but the present invention is not limited to these examples.

Glucose-1-phosphate sodium salt,
Glucose-1-phosphate calcium salt was used and dissolved in ion-exchanged water to prepare a solution having a concentration of 1.0% by weight. 50 g of this solution was stored in an electric dryer at 50 ° C. for 12 hours, the weight change was measured, and the water reduction rate was calculated, which was used as a measure of wettability. Further, as a comparison, sorbitol and glycerin, which are widely used as a dentifrice wetting agent, were used and the water reduction rate was calculated in the same manner as in Example 1. The results are shown in Table 1.

[0015]

[Table 1]

From these results, it is clear that glucose-1-phosphate has a moisturizing action equivalent to or higher than that of sorbitol and glycerin which are generally used moisturizers.

Example 2 Glucose-1-phosphate calcium salt or sorbitol was included in the oral cavity in an amount of 0.1 g, and sensory evaluation of taste was conducted by panelists A to G. The results are shown in Table 2.

[0018]

[Table 2]

From these results, it was found that glucose-1-phosphate calcium salt has no sweetness as compared with the conventional humectant sorbitol.

Example 3 Glucose-1-phosphate calcium salt or sorbitol was used as a wetting agent to prepare a dentifrice having the composition shown in Table 3, and 10 g of this dentifrice was stored in an electric dryer at 40 ° C. for 12 hours and weighed. The change was measured and the water loss rate was calculated. As a result, the water loss rate of the dentifrice containing glucose-1-phosphate calcium salt as a wetting agent was 27.2%, and the water loss rate of the dentifrice containing sorbitol as a wetting agent was 30.3%. It was From this, it was found that glucose-1-phosphate calcium salt has a wettability equal to or higher than that of sorbitol.

[0021]

[Table 3]

Example 4 Using the toothpaste prepared in Example 3, sensory evaluation of taste was carried out by 7 panelists in the same manner as in Example 2. For the evaluation, 1 g of toothpaste was placed on a toothbrush and brushed for 1 minute by a usual method, and then the taste was evaluated in 3 grades (not sweet, slightly sweet, sweet). As a result, all the seven panelists answered that the toothpaste containing glucose-1-calcium phosphate salt was "not sweet", and the toothpaste containing sorbitol had 3 panelists "slightly sweet" among the 7 panelists, and the remaining 4 panelists were "sweet". I answered. From this result, it was found that glucose-1-phosphate calcium salt has no sweetness as compared with the conventional humectant sorbitol.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yasuki Eguchi 3-32-5-203 Akatsuka Shinmachi, Itabashi-ku, Tokyo (56) References JP-A-5-117157 (JP, A) JP-A-5-117153 ( JP, A) JP 4-173727 (JP, A) JP 2-292211 (JP, A) JP 2-292210 (JP, A) JP 62-96408 (JP, A) JP 3-151849 (JP, A) JP 48-58152 (JP, A) JP 3-7214 (JP, A) JP 41-2200 (JP, B1) (58) Fields investigated (Int .Cl. ⁷ , DB name) A61K ^7/ 16-7/30

Claims (2)

(57) [Claims] 1. An oral composition comprising 1 to 80% by weight of a sodium salt, a potassium salt or a calcium salt of glucose-1-phosphate as a wetting agent and containing no water-soluble zinc salt. 2. The compounding amount of sodium salt, potassium salt or calcium salt of glucose-1-phosphate is 10% by weight.
The oral composition according to claim 1, which is more than 50 wt% and less than 50 wt%.