JP3919123B1 - Liquid skin external preparation containing stable glutathione and liquid skin external preparation for whitening and skin containing the same - Google Patents
Liquid skin external preparation containing stable glutathione and liquid skin external preparation for whitening and skin containing the same Download PDFInfo
- Publication number
- JP3919123B1 JP3919123B1 JP2005373497A JP2005373497A JP3919123B1 JP 3919123 B1 JP3919123 B1 JP 3919123B1 JP 2005373497 A JP2005373497 A JP 2005373497A JP 2005373497 A JP2005373497 A JP 2005373497A JP 3919123 B1 JP3919123 B1 JP 3919123B1
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- Prior art keywords
- extract
- acid
- external preparation
- glutathione
- salts
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Abstract
【課題】グルタチオンを溶液状態で安定化させる安定化剤及びそれを含有するグルタチオン安定化組成物を提供するとともに、前記グルタチオン安定化組成物に美白成分及び美肌成分を配合した皮膚外用剤を提供することにある。
【解決手段】乳清分画物及び糖蜜分画物からなるグルタチオン安定化剤、該グルタチオン安定化剤とグルタチオンとが配合されてなるグルタチオン安定化組成物、並びに前記グルタチオン安定化組成物に美白成分及び／又は美肌成分が配合されてなる美白用皮膚外用剤及び美肌用皮膚外用剤とする。
Provided are a stabilizer for stabilizing glutathione in a solution state and a glutathione stabilizing composition containing the same, and a skin external preparation containing a whitening component and a skin beautifying component in the glutathione stabilizing composition. There is.
A glutathione stabilizer comprising a whey fraction and a molasses fraction, a glutathione stabilizing composition comprising the glutathione stabilizer and glutathione, and a whitening ingredient in the glutathione stabilizing composition. And / or a whitening skin external preparation and a skin beautifying skin external preparation, which are formulated with skin beautifying ingredients.
Description
本発明は、還元型グルタチオンを安定化させることができるグルタチオン安定化剤、及びそれを含有するグルタチオン安定化組成物に関する。更に、この安定化組成物に美白成分、美肌成分を配合した、より有用な皮膚外用剤に関する。 The present invention relates to a glutathione stabilizer capable of stabilizing reduced glutathione, and a glutathione stabilizing composition containing the same. Furthermore, it is related with the more useful skin external preparation which mix | blended the whitening component and the skin beautifying component with this stabilization composition.
グルタチオンは、グルタミン・システイン・グリシンの３種のアミノ酸より構成されるペプチドで、抗酸化作用、活性酵素捕捉作用、抗アレルギー作用、解毒作用、メラニン生成抑制作用など非常に有用な効果を多数有しており、食品、医薬品、化粧品等の各分野で注目を集めている。 Glutathione is a peptide composed of three amino acids, glutamine, cysteine, and glycine, and has many very useful effects such as antioxidant action, active enzyme capture action, antiallergic action, detoxification action, and melanin production inhibitory action. It attracts attention in various fields such as food, pharmaceuticals and cosmetics.
健康食品分野において、グルタチオンが粉末状、錠剤状、カプセル状などで含有された食品が多数存在する。これは、グルタチオンが溶液状態において非常に不安定なため、このような乾燥状態で提供される必要があるからである。 In the health food field, there are many foods containing glutathione in powder form, tablet form, capsule form or the like. This is because glutathione is very unstable in solution and needs to be provided in such a dry state.
一方、化粧品分野において、例えば、特許文献１〜４にはグルタチオンを任意に含有する抗酸化剤が、特許文献５〜８にはグルタチオンを任意に含有する美白剤が開示されている。しかしながら、グルタチオンは溶液状態において非常に安定性が悪いため、その効果が十分に得られないという問題を有していた。また、市場でもグルタチオンが配合された化粧品等は見当たらない。 On the other hand, in the cosmetics field, for example, Patent Documents 1 to 4 disclose antioxidants optionally containing glutathione, and Patent Documents 5 to 8 disclose whitening agents optionally containing glutathione. However, glutathione has a problem that its stability cannot be obtained sufficiently because it is very unstable in a solution state. In addition, there are no cosmetics with glutathione in the market.
さらに、特許文献８及び９には、グルタチオンと糖蜜抽出エキス、あるいは黒砂糖抽出エキスが任意に選択され含有されてなる化粧品が開示され、この化粧品は、グルタチオンと糖蜜抽出エキス、あるいは黒砂糖抽出エキスにより、美白効果が得られるというものである。しかしながら、この発明もやはり、グルタチオンの安定性に劣り、効果が十分に得られないという問題を有していた。 Further, Patent Documents 8 and 9 disclose cosmetics comprising glutathione and molasses extract or brown sugar extract, which are arbitrarily selected and contained. This cosmetic contains glutathione and molasses extract or brown sugar extract. Therefore, a whitening effect can be obtained. However, this invention also has the problem that the stability of glutathione is inferior and the effect cannot be sufficiently obtained.
即ち、グルタチオンを溶液状態において有効量を安定に配合できれば、その効果を生かした皮膚外用剤が開発できるだけでなく、他の有効成分との相乗効果が期待できる。しかしながら、開発が望まれているものの、そのような発明が未だ創出されていないのが現状である。 That is, if an effective amount of glutathione can be stably blended in a solution state, not only a skin external preparation utilizing the effect can be developed, but also a synergistic effect with other active ingredients can be expected. However, although development is desired, such an invention has not yet been created.
本発明者らは、グルタチオンが溶液状態において非常に安定性が悪いことに鑑み、グルタチオンの溶液状態における安定性、特に化粧品等で汎用される水溶液系における安定性確保について鋭意検討を行った。その結果、グルタチオンに乳清分画物及び糖蜜分画物を配合することにより、水溶液系におけるグルタチオンの安定性が著しく改善されることを見出した。 In view of the fact that glutathione is very poor in a solution state, the present inventors have conducted intensive studies on securing the stability of glutathione in a solution state, particularly in an aqueous solution system widely used in cosmetics and the like. As a result, it was found that the stability of glutathione in an aqueous solution system was remarkably improved by adding a whey fraction and a molasses fraction to glutathione.
また、この乳清分画物及び糖蜜分画物からなるグルタチオン安定化剤とともにグルタチオンを配合したグルタチオン安定化組成物に、更に美白成分、美肌成分を配合することにより、優れた美白用皮膚外用剤及び美肌用皮膚外用剤となることを見出し、本発明を完成するに至った。 In addition, an excellent skin external preparation for whitening by blending a glutathione stabilizing composition comprising glutathione together with a glutathione stabilizer comprising the whey fraction and molasses fraction, and further blending a whitening component and a skin beautifying component. And it discovered that it became a skin external preparation for beautiful skin, and came to complete this invention.
即ち、本発明の課題は、グルタチオンを溶液状態で安定化させる安定化剤及びそれを含有するグルタチオン安定化組成物を提供するとともに、グルタチオン安定化組成物に美白成分及び美肌成分を配合した皮膚外用剤を提供することにある。 That is, an object of the present invention is to provide a stabilizer that stabilizes glutathione in a solution state and a glutathione-stabilizing composition containing the same, and for skin external use that contains a whitening component and a skin-beautifying component in the glutathione-stabilizing composition. It is to provide an agent.
請求項１に係る発明は、乳清分画物及び糖蜜分画物と、グルタチオンを含有する液状皮膚外用剤であって、前記糖蜜分画物が、アルコールまたはアルコールと水の混液での抽出によって得られたものであり、かつ着色成分が除去されたものであることを特徴とする液状皮膚外用剤に関する。
請求項２に係る発明は、前記乳清分画物が、ヒト、ウシ、ヤギ、ヒツジ、ブタの乳清より選ばれた一種または二種以上であることを特徴とする請求項１記載の液状皮膚外用剤に関する。
請求項３に係る発明は、前記乳清分画物が、分娩後５日以内の初乳清であることを特徴とする請求項１または２に記載の液状皮膚外用剤に関する。
請求項４に係る発明は、前記乳清分画物が、酸・アルコール可溶分画物であることを特徴とする請求項１乃至３いずれかに記載の液状皮膚外用剤に関する。
請求項５に係る発明は、前記酸・アルコール可溶分画物が、ｐＨ１〜５、アルコール濃度１０〜５０％（ｖ／ｖ）の条件下で処理し、不溶物を除去したものであることを特徴とする請求項４記載の液状皮膚外用剤に関する。
請求項６に係る発明は、前記グルタチオンが、還元型グルタチオンであることを特徴とする請求項１乃至５いずれかに記載の液状皮膚外用剤に関する。
請求項７に係る発明は、更に、有機酸とその塩を含有する請求項１乃至６いずれかに記載の液状皮膚外用剤に関する。
The invention according to claim 1 is a liquid skin external preparation containing whey fraction and molasses fraction, and glutathione , wherein the molasses fraction is extracted by extraction with alcohol or a mixture of alcohol and water. The present invention relates to a liquid skin external preparation characterized by being obtained and from which coloring components have been removed .
The invention according to claim 2 is the liquid according to claim 1, wherein the whey fraction is one or more selected from whey of humans, cows, goats, sheep and pigs. It relates to an external preparation for skin.
The invention according to claim 3 relates to the external preparation for liquid skin according to claim 1 or 2, wherein the whey fraction is colostrum within 5 days after delivery.
The invention according to claim 4 relates to the liquid skin external preparation according to any one of claims 1 to 3, wherein the whey fraction is an acid / alcohol soluble fraction.
In the invention according to claim 5, the acid / alcohol soluble fraction is treated under conditions of pH 1 to 5 and alcohol concentration 10 to 50% (v / v) to remove insoluble matters. The liquid skin external preparation of Claim 4 characterized by these.
The invention according to claim 6 relates to the liquid skin external preparation according to any one of claims 1 to 5, wherein the glutathione is reduced glutathione.
The invention according to claim 7 further relates to the liquid skin external preparation according to any one of claims 1 to 6, further comprising an organic acid and a salt thereof.
請求項８に係る発明は、請求項１乃至７いずれかに記載の液状皮膚外用剤に美白成分を配合してなる美白用液状皮膚外用剤に関する。
請求項９に係る発明は、前記美白成分が、システイン及びその誘導体、Ｌ-アスコルビン酸及びＬ-アスコルビン酸アルキルエステル、Ｌ-アスコルビン酸リン酸エステル、Ｌ-アスコルビン酸硫酸エステルの誘導体、これらナトリウム塩、カリウム塩のアルカリ金属塩、カルシウム塩、マグネシウム塩のアルカリ土類金属塩から選ばれる一種以上のアスコルビン酸及びその誘導体、グラブリジン、グラブレン、リクイリチン、イソリクイリチン、胎盤抽出物、アルブチン、ハイドロキノン及びその誘導体、レゾルシン及びその誘導体、フェルラ酸及びその誘導体、カフェー酸及びそれらの誘導体、蝉退抽出物、プラセンタ抽出物、カンゾウ抽出物、カミツレ抽出物、カロテノイド類、アスパラガス抽出物、エンドウ豆抽出物、エイジツ抽出物、ウワウルシ抽出物、オウゴン抽出物、オノニス抽出物、海藻抽出物、キイチゴ抽出物、クジン抽出物、クララ抽出物、ケイケットウ抽出物、ゴカヒ抽出物、コーヒー抽出物、コメヌカ抽出物、小麦胚芽抽出物、サイシン抽出物、サンザシ抽出物、サンペンズ抽出物、シラユリ抽出物、シャクヤク抽出物、センプクカ抽出物、大豆抽出物、茶抽出物、トマト抽出物、ノイバラ抽出物、ビャクレン抽出物、ブナの芽抽出物、ブドウ抽出物、フローデマニータ抽出物、ホップ抽出物、マイカイカ抽出物、モッカ抽出物、ユキノシタ抽出物、ユーカリ抽出物、ヨクイニン抽出物、グァバ抽出物、愛玉子抽出物、ラカンカ抽出物から選ばれる一種または二種以上である請求項８記載の美白用液状皮膚外用剤に関する。
The invention according to claim 8 relates to a liquid skin external preparation for whitening comprising the liquid skin external preparation according to any one of claims 1 to 7 and a whitening component.
The invention according to claim 9 is characterized in that the whitening component is cysteine or a derivative thereof, L-ascorbic acid and an alkyl ester of L-ascorbic acid, an L-ascorbic acid phosphate, a derivative of L-ascorbic acid sulfate, or a sodium salt thereof. One or more ascorbic acids selected from alkali metal salts of potassium salts, calcium salts, alkaline earth metal salts of magnesium salts and derivatives thereof, grabrizine, grabrene, liquiritin, isoliquiritin, placenta extract, arbutin, hydroquinone and derivatives thereof, Resorcin and its derivatives, ferulic acid and its derivatives, caffeic acid and their derivatives, wiping extract, placenta extract, licorice extract, chamomile extract, carotenoids, asparagus extract, pea extract, age extract object, Walnut extract, Ogon extract, Ononis extract, Seaweed extract, Raspberry extract, Kudin extract, Clara extract, Caiquet extract, Gokahi extract, Coffee extract, Rice bran extract, Wheat germ extract, Saisin Extract, hawthorn extract, sunpens extract, shirayuri extract, peony extract, Sempukuka extract, soy extract, tea extract, tomato extract, Neubara extract, beechlen extract, beech bud extract, grape One type selected from an extract, a flow demanita extract, a hop extract, a mica squid extract, a mokka extract, a yukinoshita extract, a eucalyptus extract, a yokuinin extract, a guava extract, a love egg extract, and a rakanka extract It is related with the liquid skin external preparation for whitening of Claim 8 which is 2 or more types.
請求項１０に係る発明は、請求項１乃至７いずれかに記載の液状皮膚外用剤と美肌成分を配合してなる美肌用液状皮膚外用剤に関する。
請求項１１に係る発明は、前記美肌成分が、デオキシリボ核酸及びその塩、アデノシン三リン酸及びその塩、アデノシン一リン酸及びその塩から選ばれる一種以上のアデニル酸誘導体及びその塩、リボ核酸及びその塩、グアニン及びその誘導体、キサンチン及びその誘導体から選ばれる一種以上の核酸関連物質、血清除蛋白抽出物、脾臓抽出物、胎盤抽出物、鶏冠抽出物、ローヤルゼリーから選ばれる一種以上の動物由来の抽出物、酵母抽出物、乳酸菌抽出物、ビフィズス菌抽出物から選ばれる一種以上の微生物由来の抽出物、ニンジン抽出物、センブリ抽出物、イチョウ抽出物、ローズマリー抽出物、オウバク抽出物、オウゴン抽出物、ニンニク抽出物、レイシ抽出物、セファランチンから選ばれる一種以上の植物由来の抽出物、α-またはγ-リノレン酸及びそれらの誘導体、エイコサペンタエン酸及びそれらの誘導体、コハク酸及びその塩、グリコール酸及びその塩、乳酸及びその塩、リンゴ酸及びその塩、サリチル酸及びその塩から選ばれる一種以上のα-ヒドロキシ酸及びそれらの誘導体から選ばれる一種または二種以上である請求項１０記載の美肌用液状皮膚外用剤に関する。
The invention according to claim 10 relates to a liquid skin external preparation for skin beautification comprising the liquid skin external preparation according to any one of claims 1 to 7 and a skin beautifying component.
The invention according to claim 11 is characterized in that the beautifying skin component is one or more adenylic acid derivatives and salts thereof selected from deoxyribonucleic acid and salts thereof, adenosine triphosphate and salts thereof, adenosine monophosphate and salts thereof, ribonucleic acid and its salts, guanine and derivatives thereof, xanthine and one or more nucleic acid-related substance selected from the derivatives, serum deproteinized extract, spleen extract, placenta extract, cockscomb extract, from one or more animals selected from royal jelly Extracts from one or more microorganisms selected from extracts, yeast extracts, lactic acid bacteria extracts, bifidobacteria extracts, carrot extracts, assembly extracts, ginkgo biloba extracts, rosemary extracts, buckwheat extracts, hornon extracts things, garlic extract, Ganoderma extracts, extracts from one or more plants selected from cepharanthin, alpha-or - linolenic acid and derivatives thereof, eicosapentaenoic acid and derivatives thereof, succinic acid and salts thereof, glycolic acid and its salts, lactic acid and salts thereof, malic acid and its salts, of one or more kinds selected from salicylic acid and its salts α The liquid skin external preparation for beautiful skin according to claim 10, which is one or more selected from -hydroxy acids and derivatives thereof.
本発明のグルタチオン安定化剤は、乳清分画物及び糖蜜分画物が配合されてなり、溶液状態におけるグルタチオンの安定性改善効果に優れる。従って、グルタチオンが本来有する抗酸化作用、活性酵素捕捉作用、抗アレルギー作用、解毒作用、メラニン生成抑制作用等を溶液状態であっても長時間得ることができる。
本発明のグルタチオン安定化組成物は、グルタチオンとともにグルタチオン安定化剤が含有されてなり、長期間にわたり、溶液状態におけるグルタチオンの安定性に優れる。
本発明の美白用皮膚外用剤は、グルタチオン安定化組成物に、更に美白成分が配合されてなるから、安定性に優れたグルタチオンと美白成分の相乗効果により、優れた美白効果を有し、かつ、長時間その効果が維持される。
本発明の美肌用皮膚外用剤は、グルタチオン安定化組成物に、更に美肌成分が配合されてなるから、安定性に優れたグルタチオンと美肌成分の相乗効果により、優れた美肌効果を有し、かつ、長時間その効果が維持される。
The glutathione stabilizer of the present invention comprises a whey fraction and a molasses fraction, and is excellent in the effect of improving the stability of glutathione in a solution state. Therefore, the antioxidant action, the active enzyme capturing action, the antiallergic action, the detoxifying action, the melanin production inhibiting action, etc. inherent to glutathione can be obtained for a long time even in the solution state.
The glutathione stabilizing composition of the present invention contains a glutathione stabilizer together with glutathione, and is excellent in glutathione stability in a solution state over a long period of time.
Since the skin whitening preparation for whitening of the present invention further comprises a whitening component in the glutathione stabilizing composition, it has an excellent whitening effect due to the synergistic effect of glutathione and whitening component with excellent stability, and The effect is maintained for a long time.
Since the skin external preparation for skin beautification according to the present invention further comprises a beautifying skin component in the glutathione stabilizing composition, it has an excellent beautifying effect due to the synergistic effect of glutathione and the beautifying skin component with excellent stability, and The effect is maintained for a long time.
まず、本発明のグルタチオン安定化剤について説明する。
本発明のグルタチオン安定化剤は、乳清分画物及び糖蜜分画物からなる。
First, the glutathione stabilizer of the present invention will be described.
The glutathione stabilizer of the present invention comprises a whey fraction and a molasses fraction.
本発明のグルタチオン安定化剤に用いる乳清分画物は、ヒト、ウシ、ヤギ、ヒツジ、ブタ等の哺乳動物から採取された乳汁、或いはその乳汁を予め乾燥粉末化した後、水に溶解したものが用いられ、通常、遠心分離によって最上層の脂肪分を取り除いた後、種々の方法でカゼイン画分を除去して得られる。 The whey fraction used in the glutathione stabilizer of the present invention is milk collected from mammals such as humans, cows, goats, sheep, pigs, or the milk previously dried and dissolved in water. In general, the uppermost fat content is removed by centrifugation, and then the casein fraction is removed by various methods.
カゼイン画分の除去は通常、大きく二つの方法に分けられる。一つは乳酸、塩酸、硫酸等の酸の添加によりｐＨ４．４〜４．６程度の酸性でカゼインを等電点沈殿させる方法である。もう一つはキモシン等の酵素の作用により、カゼインを凝固させ、いずれも不溶化したカゼイン画分を濾過、遠心分離、あるいはデカンテーション等により除去する方法である。得られるカゼイン画分は前者を酸カゼイン、後者をレンネットカゼインと呼ぶ。 The removal of the casein fraction is generally divided into two methods. One is a method in which casein is isoelectrically precipitated at an acidity of about pH 4.4 to 4.6 by adding an acid such as lactic acid, hydrochloric acid or sulfuric acid. The other is a method of coagulating casein by the action of an enzyme such as chymosin and removing the insoluble casein fraction by filtration, centrifugation or decantation. In the casein fraction obtained, the former is called acid casein and the latter is called rennet casein.
尚、哺乳動物の分娩後５日以内に採取される初乳から得られる初乳清中の画分のもつコラーゲン合成亢進作用が特に高いことが明らかになり、生理学上、重要な意味をもつと考えられている。 In addition, it has been clarified that the collagen synthesis enhancing action of the fraction in colostrum obtained from colostrum collected within 5 days after delivery of mammals is particularly high, and has an important physiological meaning. It is considered.
また、本発明者らはコラーゲン合成亢進作用をもつ乳清画分がグルタチオンの安定化に非常に有効であることを見出し、乳清中のコラーゲン合成亢進作用をもつ画分の分画法について検討した。その結果、乳清の酸・アルコール処理により、その可溶画分が極めて効率的に移行することが判明した。 In addition, the present inventors have found that a whey fraction having an action of enhancing collagen synthesis is very effective for stabilizing glutathione, and examining a method for fractionating a fraction having an action of enhancing collagen synthesis in whey. did. As a result, it was found that the soluble fraction was transferred very efficiently by the acid / alcohol treatment of whey.
この際、酸・アルコール処理条件はｐＨ１〜５、アルコール濃度は１０〜５０％（ｖ／ｖ）、好ましくはｐH２．０〜４．５、アルコール濃度３０〜４０％（ｖ／ｖ）に調整する。使用するアルコールはメタノール、エタノール、イソプロパノール、ｎ-ブタノール等任意のものが用いられるが、好ましくはエタノールが用いられる。これは、安全性が高い点が優れる。使用する酸も特に限定しない。酸・アルコール処理の結果生ずる不溶物は、濾過、遠心分離、あるいはデカンテーション等により除去され、コラーゲン合成亢進作用に優れる可溶画分が得られる。酸・アルコール可溶画分は必要に応じてｐＨを調整し、減圧濃縮、限外濾過、あるいは凍結濃縮の方法により、濃縮してもよく、また、凍結乾燥、噴霧乾燥あるいは平板乾燥等の方法により乾燥粉末化することも出来る。 In this case, the acid / alcohol treatment conditions are adjusted to pH 1 to 5, alcohol concentration is 10 to 50% (v / v), preferably pH 2.0 to 4.5, alcohol concentration 30 to 40% (v / v). . The alcohol to be used is any one such as methanol, ethanol, isopropanol, n-butanol, etc., but ethanol is preferably used. This is excellent in terms of high safety. The acid used is not particularly limited. The insoluble matter resulting from the acid / alcohol treatment is removed by filtration, centrifugation, decantation, or the like, and a soluble fraction excellent in collagen synthesis enhancing action is obtained. The acid / alcohol soluble fraction may be concentrated by adjusting the pH as necessary and concentrated under reduced pressure, ultrafiltration, or freeze concentration, and may be freeze-dried, spray-dried, or plate-dried. Can also be made into a dry powder.
本発明のグルタチオン安定化剤に用いる糖蜜分画物は、特に限定されないが、メラニン生成抑制成分がグルタチオンの安定化に有効であるため、この成分を抽出できる方法で得られるものであることが好ましい。 The molasses fraction used in the glutathione stabilizer of the present invention is not particularly limited, but since the melanin production inhibitor component is effective for stabilizing glutathione, it is preferably obtained by a method capable of extracting this component. .
糖蜜分画物を得るための抽出溶媒としては、水、メタノール、エタノール、ｎ-ブタノール、イソプロピルアルコール、１，３-ブチレングリコール、プロピレングリコール、グリセリン、酢酸エチル、ヘキサン、アセトン、ベンゼン、トルエン、クロロホルム、ジエチルエーテル、メチルセルソルブ等、またはこれらの混液を抽出溶媒として使用することが出来る。好ましくは、エタノールと水の混液を用いる。これらは、安全性が高いため好ましい。 As extraction solvents for obtaining molasses fractions, water, methanol, ethanol, n-butanol, isopropyl alcohol, 1,3-butylene glycol, propylene glycol, glycerin, ethyl acetate, hexane, acetone, benzene, toluene, chloroform , Diethyl ether, methyl cellosolve, etc., or a mixture thereof can be used as the extraction solvent. Preferably, a mixed solution of ethanol and water is used. These are preferable because of their high safety.
抽出する溶媒により、糖蜜中に存在する着色成分が同時に抽出される場合が多い。フェニルグルコースなどの着色成分はグルタチオンを不安定化させるため、除去する必要がある。着色成分を除去する手段としては、活性炭、活性白土、またはシリカゲル、活性アルミナ、合成樹脂吸着剤、逆浸透膜等を用いる方法を選択することが出来る。また、必要に応じてスプレードライ、凍結乾燥等により乾燥して使用することも可能である。 Depending on the solvent to be extracted, colored components present in molasses are often extracted at the same time. Colored components such as phenyl glucose destabilize glutathione and need to be removed. As a means for removing the coloring component, a method using activated carbon, activated clay, silica gel, activated alumina, synthetic resin adsorbent, reverse osmosis membrane or the like can be selected. Moreover, it can also be used by drying by spray drying, freeze drying or the like, if necessary.
本発明のグルタチオン安定化剤において、乳清分画物と、糖蜜分画物の配合比率は、重量比で好ましくは１：０．５〜６、望ましくは１：１〜２とされる。この配合比率で両者が配合された場合、安定性に優れる。 In the glutathione stabilizer of the present invention, the mixing ratio of the whey fraction and the molasses fraction is preferably 1: 0.5 to 6, and desirably 1: 1 to 2 by weight. When both are blended at this blending ratio, the stability is excellent.
次に、本発明のグルタチオン安定化組成物について説明する。
本発明のグルタチオン安定化組成物は、前記グルタチオン安定化剤とグルタチオンが配合されてなり、含まれるグルタチオンは、本発明のグルタチオン安定化剤により、溶液状態であっても、優れた安定性を示す。
Next, the glutathione stabilizing composition of the present invention will be described.
The glutathione stabilizing composition of the present invention comprises the above-mentioned glutathione stabilizer and glutathione, and the glutathione contained therein exhibits excellent stability even in a solution state due to the glutathione stabilizer of the present invention. .
本発明に係るグルタチオンとしては、好ましくは化式１で示す還元型グルタチオンを用い、常法の分析によると、純度９０％以上、好ましくは純度９８％以上を有する。これは、９０％未満であると水溶液での安定性が著しく悪いため好ましくないからである。 The glutathione according to the present invention is preferably reduced glutathione represented by the chemical formula 1, and has a purity of 90% or more, preferably a purity of 98% or more according to a conventional analysis. This is because if it is less than 90%, the stability in an aqueous solution is remarkably poor, which is not preferable.
本発明のグルタチオン安定化組成物に用いるグルタチオンは、通常グルタチオン安定化組成物中０．０１〜１０．０％、好ましくは０．１〜５．０％配合される。これは、０．０１％未満であると、グルタチオンの効果が充分発現しないため、また１０．０％を超えると経時的に着色する傾向があるため好ましくないからである。
また、本発明のグルタチオン安定化組成物のｐＨは３〜６、好ましくはｐＨ４〜５に調整する。これは、ｐＨ３未満、或いはｐＨ６を超えると安定性が著しく悪くなるため好ましくないからである。
Glutathione used in the glutathione stabilizing composition of the present invention is usually added in an amount of 0.01 to 10.0%, preferably 0.1 to 5.0% in the glutathione stabilizing composition. This is because if it is less than 0.01%, the effect of glutathione is not sufficiently exhibited, and if it exceeds 10.0%, it tends to be colored over time, which is not preferable.
The pH of the glutathione stabilizing composition of the present invention is adjusted to 3 to 6, preferably pH 4 to 5. This is because if the pH is less than 3 or exceeds 6, the stability is significantly deteriorated, which is not preferable.
前記ｐＨの調整には、有機酸とそのアルカリ金属塩の組合せの中から任意に選ぶことが出来るが、好ましくはクエン酸とクエン酸ナトリウム、アスコルビン酸とアスコルビン酸ナトリウムの組合せであり、望ましくはアスコルビン酸とアスコルビン酸ナトリウムの組合せである。この理由は、両者とも還元力がありグルタチオンの安定化にも寄与するため好ましい。 For the adjustment of the pH, it can be arbitrarily selected from a combination of an organic acid and an alkali metal salt thereof, preferably a combination of citric acid and sodium citrate, ascorbic acid and sodium ascorbate, and desirably ascorbine. A combination of acid and sodium ascorbate. This is preferable because both have a reducing power and contribute to the stabilization of glutathione.
グルタチオン安定化組成物中のグルタチオンの配合量は、グルタチオン安定化剤に用いる乳清分画物の配合量が、グルタチオン安定化組成物中のグルタチオン量の２〜１０倍、好ましくは４〜６倍量となるように調整される。これは、２倍未満であるとグルタチオンの安定性が維持できないため、１０倍を超えるとグルタチオンの効果が充分発現しないため好ましくないからである。 The amount of glutathione in the glutathione stabilizing composition is such that the amount of whey fraction used in the glutathione stabilizer is 2 to 10 times, preferably 4 to 6 times the amount of glutathione in the glutathione stabilizing composition. It is adjusted to be a quantity. This is because if it is less than 2 times, the stability of glutathione cannot be maintained, and if it exceeds 10 times, the effect of glutathione is not sufficiently exhibited, which is not preferable.
グルタチオン安定化組成物中のグルタチオンの配合量は、グルタチオン安定化剤に用いる糖蜜分画物の配合量が、グルタチオン安定化組成物中のグルタチオン量の５〜２０倍、好ましくは８〜１２倍となるように調整される。これは、５倍未満であるとグルタチオンの安定性が維持できないため、２０倍を超えるとグルタチオンの効果が充分発現しないため好ましくないからである。 The amount of glutathione in the glutathione stabilizing composition is such that the amount of the molasses fraction used in the glutathione stabilizer is 5 to 20 times, preferably 8 to 12 times the amount of glutathione in the glutathione stabilizing composition. It is adjusted to become. This is because if it is less than 5 times, the stability of glutathione cannot be maintained, and if it exceeds 20 times, the effect of glutathione is not sufficiently exhibited, which is not preferable.
次に、本発明の美白用皮膚外用剤について説明する。
本発明の美白用皮膚外用剤は美白成分として、システイン及びその誘導体、アスコルビン酸及びその誘導体、グラブリジン、グラブレン、リクイリチン、イソリクイリチン、胎盤抽出物、アルブチン、ハイドロキノン及びその誘導体、レゾルシン及びその誘導体、フェルラ酸及びその誘導体、カフェー酸及びそれらの誘導体が挙げられ、このうち、アスコルビン酸及びその誘導体としては、Ｌ-アスコルビン酸及びＬ-アスコルビン酸アルキルエステル、Ｌ-アスコルビン酸リン酸エステル、Ｌ-アスコルビン酸硫酸エステル等の誘導体等、更にこれらの塩であるナトリウム塩、カリウム塩等のアルカリ金属塩、カルシウム塩、マグネシウム塩等のアルカリ土類金属塩等でも良く、また、抽出物では、蝉退抽出物、プラセンタ抽出物、カンゾウ抽出物、カミツレ抽出物、カロテノイド類、アスパラガス抽出物、エンドウ豆抽出物、エイジツ抽出物、ウワウルシ抽出物、オウゴン抽出物、オノニス抽出物、海藻抽出物、キイチゴ抽出物、クジン抽出物、クララ抽出物、ケイケットウ抽出物、ゴカヒ抽出物、コーヒー抽出物、コメヌカ抽出物、小麦胚芽抽出物、サイシン抽出物、サンザシ抽出物、サンペンズ抽出物、シラユリ抽出物、シャクヤク抽出物、センプクカ抽出物、大豆抽出物、茶抽出物、トマト抽出物、ノイバラ抽出物、ビャクレン抽出物、ブナの芽抽出物、ブドウ抽出物、フローデマニータ抽出物、ホップ抽出物、マイカイカ抽出物、モッカ抽出物、ユキノシタ抽出物、ユーカリ抽出物、ヨクイニン抽出物、グァバ抽出物、愛玉子抽出物、ラカンカ抽出物から選ばれる一種または二種以上が配合され、好ましくはアルブチン、レゾルシン、ハイドロキノン、フェルラ酸、カフェー酸、システインであり、より好ましくは、アルブチン、レゾルシン、ハイドロキノンが用いられる。これらの成分は、グルタチオン安定化組成物と併用した場合、特に美白効果に優れるため好ましい。
Next, the skin whitening external preparation for whitening of this invention is demonstrated.
The topical skin whitening agent of the present invention contains cysteine and derivatives thereof, ascorbic acid and derivatives thereof, grabridine, glabrene, liquiritin, isoliquiritin, placental extract, arbutin, hydroquinone and derivatives thereof, resorcin and derivatives thereof, ferulic acid And derivatives thereof, caffeic acid and derivatives thereof, among which ascorbic acid and derivatives thereof include L-ascorbic acid and L-ascorbic acid alkyl ester, L-ascorbic acid phosphate, L-ascorbic acid sulfate Derivatives such as esters, etc., and alkali metal salts such as sodium salts and potassium salts, and alkaline earth metal salts such as calcium salts and magnesium salts, etc., such as salts thereof. Placenta extract, licorice extract , Chamomile extract, Carotenoids, Asparagus extract, Pea extract, Age extract, Walnut extract, Ogon extract, Onionis extract, Seaweed extract, Raspberry extract, Kuji extract, Clara extract , Caquette extract, gokahi extract, coffee extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, sunpens extract, shirayuri extract, peonies extract, sempukuka extract, soybean extract, Tea extract, Tomato extract, Neubara extract, Byaclen extract, Beech bud extract, Grape extract, Flow demanita extract, Hop extract, Mikaika extract, Mokka extract, Yukinoshita extract, Eucalyptus extract A kind selected from products, Yokuinin extract, guava extract, love egg extract, Lacanka extract or Or formulated seed, preferably arbutin, resorcinol, hydroquinone, ferulic acid, caffeic acid, cysteine, and more preferably, arbutin, resorcinol, hydroquinone is used. These components are preferable because they are particularly excellent in the whitening effect when used in combination with the glutathione stabilizing composition.
美白用皮膚外用剤中、美白成分の配合量は０．０１〜１０．０％、好ましくは０．１〜５．０％である。これは、０．０１％未満であると充分な美白効果が発現しないため好ましくなく、１０．０％を超えるとグルタチオンの安定性を悪化させるため好ましくないからである。 In the skin external preparation for whitening, the blending amount of the whitening component is 0.01 to 10.0%, preferably 0.1 to 5.0%. This is because it is not preferable if it is less than 0.01% because a sufficient whitening effect is not exhibited, and if it exceeds 10.0%, it is not preferable because the stability of glutathione is deteriorated.
次に、本発明の美肌用皮膚外用剤について説明する。
本発明の美肌用皮膚外用剤に含まれる美肌成分は、例えば、細胞賦活効果を有するものが挙げられる。本発明に係る美肌成分としては、デオキシリボ核酸及びその塩、アデノシン三リン酸及びその塩、アデノシン一リン酸及びその塩などのアデニル酸誘導体及びその塩、リボ核酸及びその塩、グアニン及びその誘導体、キサンチン及びその誘導体などの核酸関連物質、血清除蛋白抽出物、脾臓抽出物、胎盤抽出物、鶏冠抽出物、ローヤルゼリーなどの動物由来の抽出物、酵母抽出物、乳酸菌抽出物、ビフィズス菌抽出物などの微生物由来の抽出物、ニンジン抽出物、センブリ抽出物、イチョウ抽出物、ローズマリー抽出物、オウバク抽出物、オウゴン抽出物、ニンニク抽出物、レイシ抽出物、セファランチンなどの植物由来の抽出物、α-またはγ-リノレン酸及びそれらの誘導体、エイコサペンタエン酸及びそれらの誘導体、コハク酸及びその塩、グリコール酸及びその塩、乳酸及びその塩、リンゴ酸及びその塩、サリチル酸及びその塩などのα-ヒドロキシ酸及びそれらの誘導体の中から選ばれる一種または二種以上が挙げられ、好ましくは、ビフィズス菌抽出物、イチョウ抽出物、オウバク抽出物、オウゴン抽出物、ニンニク抽出物、レイシ抽出物であり、より好ましくは、ビフィズス菌抽出物、イチョウ抽出物、オウゴン抽出物が挙げられる。これらの成分は、グルタチオン安定化組成物と併用した場合、特に美肌効果に優れるため好ましい。
Next, the skin external preparation for beautifying skin of the present invention will be described.
Examples of the skin beautifying component contained in the skin external preparation for skin beautification according to the present invention include those having a cell activation effect. Examples of skin beautifying ingredients according to the present invention include deoxyribonucleic acid and salts thereof, adenosine triphosphate and salts thereof, adenylic acid derivatives and salts thereof such as adenosine monophosphate and salts thereof, ribonucleic acid and salts thereof, guanine and derivatives thereof, Nucleic acid-related substances such as xanthine and its derivatives, serum deproteinized extract, spleen extract, placenta extract, chicken crown extract, royal jelly extract, etc., yeast extract, lactic acid bacteria extract, bifidobacteria extract, etc. Extracts from microorganisms, carrot extract, assembly extract, ginkgo extract, rosemary extract, buckwheat extract, gourd extract, garlic extract, litchi extract, cephalanthin and other plant-derived extracts, α -Or γ-linolenic acid and derivatives thereof, eicosapentaenoic acid and derivatives thereof, succinic acid and salts thereof Glycolic acid and its salt, lactic acid and its salt, malic acid and its salt, α-hydroxy acid such as salicylic acid and its salt, and one or more kinds thereof, preferably bifidobacteria An extract, a ginkgo extract, a buckwheat extract, a gourd extract, a garlic extract, and a litchi extract, and more preferably a bifidobacteria extract, a ginkgo extract, and a gourd extract. These components are preferable when used in combination with the glutathione stabilizing composition because they are particularly excellent in skin beautifying effects.
美肌用皮膚外用剤中、美肌成分の配合量は０．０１〜１０．０％、好ましくは０．１〜５．０％である。これは、０．０１％未満であると美肌効果が不充分であるため、１０．０％を超えるとグルタチオンの安定性を悪化させるため好ましくないからである。 In the skin external preparation for beautifying skin, the blending amount of the beautifying skin component is 0.01 to 10.0%, preferably 0.1 to 5.0%. This is because if it is less than 0.01%, the skin-beautifying effect is insufficient, and if it exceeds 10.0%, the stability of glutathione is deteriorated, which is not preferable.
本発明のグルタチオン安定化組成物及びそれを含有する美白用皮膚外用剤、美肌用皮膚外用剤は上記の成分の他、化粧料の配合成分として一般に用いられる界面活性剤、油脂類、多価アルコール、低級アルコール、増粘剤、紫外線吸収剤、散乱剤、防腐剤、酸化防止剤、キレート剤、香料、色素等を適宜配合することができる。
これらの配合成分の具体例を以下に示す。
The glutathione stabilizing composition of the present invention and the skin external preparation for whitening and skin external preparation containing the same are the above-mentioned components, surfactants generally used as cosmetic ingredients, oils and fats, polyhydric alcohols , Lower alcohols, thickeners, ultraviolet absorbers, scattering agents, preservatives, antioxidants, chelating agents, fragrances, dyes, and the like can be appropriately blended.
Specific examples of these blending components are shown below.
界面活性剤としては、ポリオキンエチレン（以下ＰＯＥ-と略す）オクチルドデシルアルコール、ＰＯＥ-２-デシルテトラデシルアルコール等のＰＯＥ分岐アルキルエーテル類、ＰＯＥ-オレイルアルコールエーテル、ＰＯＥ-セチルアルコールエーテル等のＰＯＥ−アルキルエーテル類、ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート等のソルビタンエステル類、ＰＯＥ-ソルビタンモノオレエート、ＰＯＥ-ソルビタンモノイソステアレート、ＰＯＥ-ソルビタンモノラウレート等のＰＯＥ-ソルビタンエステル類、グリセリルモノオレート、グリセリルモノステアレート、グリセリルモノミリステート等のグリセリン脂肪酸エステル類、ＰＯＥ-グリセリルモノオレート、ＰＯＥ-グリセリルモノステアレート、ＰＯＥ-グリセリルモノミリステート等のＰＯＥ-グリセリン脂肪酸エステル類、ＰＯＥ-ジヒドロコレステロールエステル、ＰＯＥ-硬化ヒマシ油、ＰＯＥ-硬化ヒマシ油イソステアレート等のＰＯＥ-硬化ヒマシ油脂肪酸エステル類、ＰＯＥ-オクチルフェノールエーテル等のＰＯＥ-アルキルアリールエーテル、グリセロールモノイソステアレート、グリセロールモノミリステート等のグリセロールエーテル類、ＰＯＥ-グリセロールモノイソステアレート、ＰＯＥ-グリセロールモノミリステート等のＰＯＥ-グリセロールエーテル類、ジグリセリルモノステアレート、デカグリセリルデカステアレート、デカグリセリルデカイソステアレート、ジグリセリルジイソステアレート等のポリグリセリン脂肪酸エステル類等の非イオン界面活性剤、またはミリスチン酸、ステアリン酸、パルミチン酸、ベヘン酸、イソステアリン酸、オレイン酸等の高級脂肪酸のカリウム、ナトリウム、ジエタノールアミン、トリエタノールアミン、アミノ酸等の塩、エーテルカルボン酸の上記アルカリ塩、Ｎ-アシルアミノ酸塩、Ｎ-アシルサルコン塩、高級アルキルスルホン酸塩等の陰イオン界面活性剤、更にはアルキルアミン酸、ポリアミン、アミノアルコール脂肪酸有機シリコーン樹脂、アルキル４級アンモニウム塩等の陽イオン界面活性剤あるいは両性界面活性剤等が例示できる。 Examples of the surfactant include POE branched alkyl ethers such as polyoxyethylene (hereinafter abbreviated as POE-) octyldodecyl alcohol and POE-2-decyltetradecyl alcohol, POE such as POE-oleyl alcohol ether and POE-cetyl alcohol ether. -POE such as alkyl ethers, sorbitan monooleate, sorbitan monoisostearate, sorbitan esters such as sorbitan monolaurate, POE-sorbitan monooleate, POE-sorbitan monoisostearate, POE-sorbitan monolaurate -Glycerin fatty acid esters such as sorbitan esters, glyceryl monooleate, glyceryl monostearate, glyceryl monomyristate, POE-glyceryl monooleate, POE-glyceryl monostea POE-glyceryl fatty acid esters such as POE-glyceryl monomyristate, POE-dihydrocholesterol ester, POE-hardened castor oil, POE-hardened castor oil isostearate, POE-hardened castor oil fatty acid esters, POE POE-alkyl aryl ethers such as octylphenol ether, glycerol ethers such as glycerol monoisostearate and glycerol monomyristate, POE-glycerol ethers such as POE-glycerol monoisostearate and POE-glycerol monomyristate, di Nonionic surfactants such as polyglyceryl fatty acid esters such as glyceryl monostearate, decaglyceryl decastearate, decaglyceryl decaisostearate, diglyceryl diisostearate Or salts of higher fatty acids such as myristic acid, stearic acid, palmitic acid, behenic acid, isostearic acid and oleic acid, such as potassium, sodium, diethanolamine, triethanolamine, amino acids, the above alkali salts of ether carboxylic acids, N-acylamino acids Anionic surfactants such as salts, N-acyl sarcon salts, higher alkyl sulfonates, and other cationic surfactants such as alkylamine acids, polyamines, amino alcohol fatty acid organic silicone resins, alkyl quaternary ammonium salts, or amphoteric interfaces An activator etc. can be illustrated.
油脂類としては、ヒマシ油、オリーブ油、カカオ油、椿油、ヤシ油、木ロウ、ホホバ油、グレープシード油、アボカド油等の植物油脂類、ミンク油、卵黄油等の動物油脂類、ミツロウ、鯨ロウ、ラノリン、カルナウバロウ、キャンデリラロウ等のロウ類、流動パラフィン、スクワレン、マイクロクリスタリンワックス、セレシンワックス、パラフィンワックス、ワセリン等の炭化水素類、ラウリン酸、ミリスチン酸、ステアリン酸、オレイン酸、イソステアリン酸、ベヘニン酸等の天然及び合成脂肪酸類、セタノール、ステアリルアルコール、ヘキシルデカノール、オクチルデカノール、ラウリルアルコール等の天然及び高級アルコール類、ミリスチル酸イソプロピル、パルミチン酸イソプロピル、ミリスチン酸オクチルドデシル、オレイン酸オクチルドデシル、コレステロールオレート等のエステル類等が例示できる。多価アルコールとしては、エチレングリコール、ポリエチレングリコール、プロピレングリコール、１，３-ブチレングリコール、１，４-ブチレングリコール、ジプロピレングリコール、グリセリン、ジグリセリン、トリグリセリン、テトラグリセリン等のポリグリセリン類、グルコース、マルトース、マルチトース、ショ糖、フルクトース、キシリトース、ソルビトール、マルトトリオース、スレイトール、エリスリトール等の糖類が例示できる。 Fats and oils include castor oil, olive oil, cacao oil, coconut oil, palm oil, tree wax, jojoba oil, grape seed oil, avocado oil and other animal fats such as mink oil and egg yolk oil, beeswax, whale Waxes such as wax, lanolin, carnauba wax, candelilla wax, hydrocarbons such as liquid paraffin, squalene, microcrystalline wax, ceresin wax, paraffin wax, petrolatum, lauric acid, myristic acid, stearic acid, oleic acid, isostearic acid Natural and synthetic fatty acids such as behenic acid, natural and higher alcohols such as cetanol, stearyl alcohol, hexyl decanol, octyl decanol, lauryl alcohol, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, olein Octyldodecyl, esters such as cholesterol oleate and the like. Examples of the polyhydric alcohol include ethylene glycol, polyethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, dipropylene glycol, glycerin, diglycerin, triglycerin, tetraglycerin and other polyglycerins, glucose Saccharides such as maltose, maltose, sucrose, fructose, xylitolose, sorbitol, maltotriose, threitol and erythritol.
増粘剤としては、アルギン酸ナトリウム、キサンタンガム、珪酸アルミニウム、マルメロ種子抽出物、トラガントガム、デンプン等の天然高分子物質、メチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルセルロース、可溶性デンプン、カチオン化セルロース等の半合成高分子物質、カルボキシビニルポリマー、ポリビニルアルコール等の合成高分子物質等が挙げられる。 Thickeners include natural polymer materials such as sodium alginate, xanthan gum, aluminum silicate, quince seed extract, tragacanth gum, starch, and semi-synthetic polymer materials such as methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, soluble starch, and cationized cellulose. And synthetic polymer substances such as carboxyvinyl polymer and polyvinyl alcohol.
紫外線吸収剤としては、パラアミノ安息香酸、パラメトキシケイ皮酸−２-エトキシエチル、パラメトキシケイ皮酸イソプロピル、ブチルメトキシベンゾイルメタン、グリセリル-モノ-２-エチルヘキサノイル-ジ-パラメトキシベンゾフェノン、ジガロイルトリオレエート、２-２'-ジヒドロキシ-４-メトキシベンゾフェノン、エチル-４-ビスヒドロキシプロピルアミノベゾエート、２-エチルヘキシル-２-シアノ-３、３'-ジフェニルアクリレート、パラメトキシケイ皮酸エチルヘキシル、サリチル酸-２-エチルヘキシル、グリセリルパラアミノベンゾエート、サリチル酸ホモメチル、オルトアミノ安息香酸メチル、２-ヒドロキシ-４-メトキシベンゾフェノン、アミル-パラ-ジメチルアミベンゾエート、２-フェニルベンゾイミダゾール-５-スルフォン酸、２-ヒドロキシ-４-メトキシベンゾフェノン-５-スルフォン酸等が例示できる。 Examples of UV absorbers include paraaminobenzoic acid, 2-methoxyethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, butylmethoxybenzoylmethane, glyceryl-mono-2-ethylhexanoyl-di-paramethoxybenzophenone, diga Royltrioleate, 2-2'-dihydroxy-4-methoxybenzophenone, ethyl-4-bishydroxypropylaminobenzoate, 2-ethylhexyl-2-cyano-3, 3'-diphenylacrylate, ethylhexyl paramethoxycinnamate , Salicylic acid-2-ethylhexyl, glyceryl paraaminobenzoate, homomethyl salicylate, methyl orthoaminobenzoate, 2-hydroxy-4-methoxybenzophenone, amyl-para-dimethylamibenzoate, 2-phenylbenzimidazole-5-sulfonic acid And 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid can be exemplified.
防腐剤としては、安息香酸塩、サリチル酸塩、ソルビン酸塩、デヒドロ酢酸塩、パラオキシ安息香酸エステル、２、４，４'-トリクロロ-２'-ヒドロキシジフェニルエーテル、３，４，４'-トリクロロカルバニリド、塩化ベンザルコニウム、ヒノキチオール、レゾルシン、エタノール等が例示できる。 Examples of preservatives include benzoate, salicylate, sorbate, dehydroacetate, p-hydroxybenzoate, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbani Examples thereof include lido, benzalkonium chloride, hinokitiol, resorcin, and ethanol.
以下にこの発明に係る実施例を示すことにより、この発明を明確に説明するが、本発明はこれらの実施例のみに限定されない。 The present invention will be clearly described below by showing examples according to the present invention, but the present invention is not limited only to these examples.
＜試料の調製＞
（ウシ初乳清分画物の調製）
ウシの分娩後１〜５日経過時に採取された初乳１０Ｌを遠心分離（１５０００ｇ×３０min）し最上層の脂肪分を除去した後、３０℃に加温、適量のキモシンを加えて２時間攪拌後、遠心分離（７２０ｇ×３０min）し、その上清をメンブランフィルターにて濾過し、清澄な初乳清５Lにエタノール３Lを混和し、酢酸でｐH３．０とし、更にホモミキサーで２時間混和した。その後デカンテーションにより上清を分取し、分画分子量１万の限外濾過膜で２倍濃縮し、セライト濾過により清澄な初乳清分画物を得た。
<Preparation of sample>
(Preparation of bovine colostrum fraction)
Centrifugation (15000g x 30min) of colostrum collected at 1-5 days after calf delivery to remove the uppermost fat, warm to 30 ° C, add appropriate amount of chymosin and stir for 2 hours Thereafter, the mixture was centrifuged (720 g × 30 min), the supernatant was filtered with a membrane filter, 3 L of ethanol was mixed with 5 L of clear colostrum, adjusted to pH 3.0 with acetic acid, and further mixed with a homomixer for 2 hours. . Thereafter, the supernatant was collected by decantation, concentrated twice with an ultrafiltration membrane having a fractional molecular weight of 10,000, and a clear colostrum fraction was obtained by celite filtration.
（糖蜜分画物の調製）
糖蜜１ｋｇに７０％エタノール水溶液５Ｌを加え、攪拌抽出した後、濾過により不溶物を取り除く。濾液を減圧濃縮しエタノールを取り除く。これに水４Ｌ、活性炭１２０ｇを加えて１時間攪拌する。次にこれを濾過して分画物４Ｌを得た。
(Preparation of molasses fraction)
Add 5 L of 70% ethanol aqueous solution to 1 kg of molasses, extract with stirring, and then remove insolubles by filtration. The filtrate is concentrated under reduced pressure to remove ethanol. 4 L of water and 120 g of activated carbon are added to this and stirred for 1 hour. Next, this was filtered to obtain a fraction 4L.
＜試験例１：グルタチオン安定化組成物の安定性評価試験＞
以下の表１に示す組成に従い、実施例１（グルタチオン安定化組成物）及び比較例１〜３を調製した。
安定性試験は化粧品等で通常実施される加速試験を実施し、４０℃での安定性を６ヶ月間測定した。その結果を表２に示す。
本試験例１では、協和発酵（株）製の純度９９．０％のグルタチオンを用いた。グルタチオンの定量は、精密に量った各試料１０．０ｇに水１０ｍLを加えて溶かしたものを、以下に示す０．１Ｎヨウ素液で滴定することで行った。
０．１Ｎヨウ素液１ｍL＝３０．７３３ｍｇＣ10Ｈ17Ｎ3Ｏ6Ｓ
指示薬には、デンプン試液１ｍLを用いた。
同様の方法で空試験を行い、補正した。
各測定時のグルタチオン量は、数式１により表した。
尚、表２中の※は、着色が著しく、滴定不可能であることを示す。
<Test Example 1: Stability evaluation test of glutathione stabilizing composition>
In accordance with the composition shown in Table 1 below, Example 1 (glutathione stabilizing composition) and Comparative Examples 1 to 3 were prepared.
The stability test was an accelerated test that is usually performed for cosmetics and the like, and the stability at 40 ° C. was measured for 6 months. The results are shown in Table 2.
In Test Example 1, glutathione with a purity of 99.0% manufactured by Kyowa Hakko Co., Ltd. was used. Glutathione was quantified by titrating a precisely weighed 10.0 g sample with 10 mL of water and dissolving with 0.1 N iodine solution shown below.
0.1N iodine solution 1 mL = 30.733 mg C 10 H 17 N 3 O 6 S
As an indicator, 1 mL of starch test solution was used.
A blank test was performed in the same manner and corrected.
The amount of glutathione at each measurement was expressed by Equation 1.
In addition, * in Table 2 indicates that coloring is remarkable and titration is impossible.
表２の結果より、ウシ初乳清分画物及び糖蜜分画物を配合した実施例１（グルタチオン安定化組成物）は比較例に対し、グルタチオンの安定性が非常に優れていることが判る。 From the results shown in Table 2, it can be seen that Example 1 (glutathione stabilizing composition) containing bovine colostrum fraction and molasses fraction is very excellent in stability of glutathione compared to the comparative example. .
＜試験例２：美白用皮膚外用剤及びその評価試験＞
以下、表３に示す実施例２（グルタチオン安定化組成物）、実施例３（美白用皮膚外用剤）、比較例４及び５を調整した。
本試験例２では、協和発酵（株）製の純度９８．０％のグルタチオンを用いた。
美白効果は下記のメラニン生成抑制効果試験にて評価した。尚、比較例４は各試料の代わりに減菌精製水を用いた。
メラニン生成抑制効果試験は、B16メラノーマ細胞２×１０５個を径６ｃｍの培養シャーレ中、各試料５ｍLを添加したウシ胎児血清加イーブルMEM培地を用い、５％炭酸ガスを含有する空気下３７℃で、７日間培養して行った。
その後、細胞は０．０２５％トリプシンを含むダルベッコリン酸緩衝液で剥離し、細胞数の測定を行い、遠心分離し得られた細胞の白色化の程度を目視にて観察し、以下の評価基準で評価した。結果を表４に示す。
<Test Example 2: Whitening skin external preparation and its evaluation test>
Hereinafter, Example 2 (glutathione stabilizing composition), Example 3 (skin external preparation for whitening), and Comparative Examples 4 and 5 shown in Table 3 were prepared.
In Test Example 2, glutathione having a purity of 98.0% manufactured by Kyowa Hakko Co., Ltd. was used.
The whitening effect was evaluated by the following melanin production inhibitory effect test. In Comparative Example 4, sterilized purified water was used instead of each sample.
In the melanin production inhibitory effect test, 2 × 10 5 B16 melanoma cells were cultured in a petri dish with a diameter of 6 cm using fetal bovine serum-added MEM medium supplemented with 5 mL of each sample at 37 ° C. in air containing 5% carbon dioxide. And cultured for 7 days.
Thereafter, the cells were detached with Dulbecco's phosphate buffer containing 0.025% trypsin, the number of cells was measured, the degree of whitening of the cells obtained by centrifugation was visually observed, and the following evaluation criteria It was evaluated with. The results are shown in Table 4.
（評価基準）
＋＋：白色化顕著
＋：やや白色化
−：白色化せず
(Evaluation criteria)
++: Whitening remarkable +: Slight whitening-: No whitening
表４に示したように、比較例と実施例との間に殆ど細胞数に変化は無かった。白色化度ではグルタチオン安定化組成物を含有する実施例２と美白成分を含有する比較例４で白色化度（＋）が観察された。即ち、実施例２は、汎用される美白成分を含む溶液である比較例４と同等の美白効果を有するのである。これは、実施例２は、グルタチオンの本来有する効果である抗酸化作用、活性酵素捕捉作用、抗アレルギー作用、解毒作用及びメラニン生成抑制作用等を、溶液状態で実現するばかりでなく、優れた美白効果をも提供することができることを表している。さらに、グルタチオン安定化組成物と美白成分を含有する実施例３（美白用皮膚外用剤）では白色化度（＋＋）が観察され、グルタチオンと美白成分の相乗効果による優れた美白効果が確認できる。 As shown in Table 4, there was almost no change in the number of cells between the comparative example and the example. Regarding the degree of whitening, a degree of whitening (+) was observed in Example 2 containing the glutathione stabilizing composition and Comparative Example 4 containing a whitening component. That is, Example 2 has a whitening effect equivalent to that of Comparative Example 4, which is a solution containing a whitening component that is widely used. This is because Example 2 not only realizes an antioxidant effect, an active enzyme capturing action, an antiallergic action, a detoxifying action, and a melanin production inhibiting action, which are inherent effects of glutathione, in a solution state, but also an excellent whitening effect. This means that an effect can also be provided. Furthermore, the whitening degree (++) is observed in Example 3 (skin external preparation for whitening) containing the glutathione stabilizing composition and the whitening component, and an excellent whitening effect due to the synergistic effect of glutathione and the whitening component can be confirmed.
＜試験例３：美肌用皮膚外用剤及びその評価試験＞
以下の表５に示す組成に従い、実施例４（グルタチオン安定化組成物）、実施例５（美肌用皮膚外用剤）及び比較例６、７を調整した。尚、実施例５は乳液状態であった。
本試験例３では、協和発酵（株）製の純度９８％のグルタチオンを用いた。
評価は以下の方法による官能評価試験で実施した。
肌のみずみずしさを消失し、小じわの発生に悩む５０才代女性１０名をパネラーとして、１日２回（朝、夕）各試料を連続１ヶ月間塗布し、使用せしめた後、「みずみずしさ」「小じわ」につき５段階で以下の評価基準で官能的に自己評価した。評価結果を表６に示す。
<Test Example 3: Skin external preparation for beautifying skin and evaluation test thereof>
In accordance with the composition shown in Table 5 below, Example 4 (glutathione stabilizing composition), Example 5 (skin external preparation for beautifying skin) and Comparative Examples 6 and 7 were prepared. In addition, Example 5 was an emulsion state.
In Test Example 3, glutathione with a purity of 98% manufactured by Kyowa Hakko Co., Ltd. was used.
Evaluation was carried out by a sensory evaluation test according to the following method.
After applying and using each sample twice a day (morning and evening) for 10 consecutive months with 10 females in their 50s suffering from the generation of fine wrinkles that disappeared from the freshness of the skin, "Small wrinkles" were self-assessed sensorially according to the following evaluation criteria in five stages. The evaluation results are shown in Table 6.
（評価基準）
＋＋＋：顕著に改善
＋＋：明らかに改善
＋：わずかに改善
±：変化無し
−：悪化した
(Evaluation criteria)
++++: Remarkably improved ++: Clearly improved +: Slightly improved ±: No change −: Deteriorated
表６に示した通り、実施例４（グルタチオン安定化組成物）で優れた美肌効果が認められた。更に美肌成分を配合した実施例５（美肌用皮膚外用剤）では、より顕著に優れた美肌効果が認められた。 As shown in Table 6, an excellent skin beautifying effect was observed in Example 4 (glutathione stabilizing composition). Furthermore, in Example 5 (skin external preparation for beautifying skin) in which a skin beautifying component was blended, the skin beautifying effect was more significantly improved.
本発明は、グルタチオンを溶液状態で安定化させるグルタチオン安定化剤及びそれを含有するグルタチオン安定化組成物を提供するとともに、この安定化組成物に美白成分、美肌成分を配合したことにより有用な皮膚外用剤を提供する。
The present invention provides a glutathione stabilizer that stabilizes glutathione in a solution state and a glutathione stabilizing composition containing the same, and a skin useful by blending a whitening component and a skin-beautifying component into the stabilizing composition. Provide external preparations.
Claims (11)
前記糖蜜分画物が、アルコールまたはアルコールと水の混液での抽出によって得られたものであり、かつ着色成分が除去されたものであることを特徴とする液状皮膚外用剤。 A liquid skin external preparation containing whey fraction and molasses fraction, and glutathione ,
A liquid skin external preparation, wherein the molasses fraction is obtained by extraction with alcohol or a mixture of alcohol and water, and from which coloring components have been removed .
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008303180A (en) * | 2007-06-08 | 2008-12-18 | Noevir Co Ltd | Skin-lightening agent, skincare preparation for external use, and functional oral composition |
| CN103141838A (en) * | 2013-03-10 | 2013-06-12 | 吉林省中韩动物科学研究院 | Preparation method and application of female calcium supplementing product |
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| KR101604778B1 (en) | 2007-08-06 | 2016-03-18 | 오츠카 세이야쿠 가부시키가이샤 | Gel composition for external application containing an adenine compound |
| WO2014205808A1 (en) * | 2013-06-28 | 2014-12-31 | L'oreal | Topical composition for preventing or decreasing skin pigmentation and/or lightening skin tone and use thereof |
| KR101725101B1 (en) | 2015-03-20 | 2017-04-11 | 주식회사 비에이치랩 | Compositions and Methods for skin whitening comprising glutathione |
| KR101827330B1 (en) * | 2016-07-13 | 2018-02-09 | 주식회사 비에이치랩 | Composition comprising gold, and manufacturing method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008303180A (en) * | 2007-06-08 | 2008-12-18 | Noevir Co Ltd | Skin-lightening agent, skincare preparation for external use, and functional oral composition |
| CN103141838A (en) * | 2013-03-10 | 2013-06-12 | 吉林省中韩动物科学研究院 | Preparation method and application of female calcium supplementing product |
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