JP3880622B2 - 生物細胞を維持及び培養に使用するポータブルカセット - Google Patents
生物細胞を維持及び培養に使用するポータブルカセット Download PDFInfo
- Publication number
- JP3880622B2 JP3880622B2 JP50199497A JP50199497A JP3880622B2 JP 3880622 B2 JP3880622 B2 JP 3880622B2 JP 50199497 A JP50199497 A JP 50199497A JP 50199497 A JP50199497 A JP 50199497A JP 3880622 B2 JP3880622 B2 JP 3880622B2
- Authority
- JP
- Japan
- Prior art keywords
- cell culture
- cassette
- portable
- culture
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000012258 culturing Methods 0.000 title claims description 36
- 238000000034 method Methods 0.000 claims abstract description 94
- 230000008569 process Effects 0.000 claims abstract description 59
- 238000011081 inoculation Methods 0.000 claims abstract description 23
- 238000004113 cell culture Methods 0.000 claims description 426
- 239000001963 growth medium Substances 0.000 claims description 319
- 239000007789 gas Substances 0.000 claims description 80
- 239000002699 waste material Substances 0.000 claims description 76
- 239000007788 liquid Substances 0.000 claims description 44
- 238000000338 in vitro Methods 0.000 claims description 34
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 29
- 239000001301 oxygen Substances 0.000 claims description 29
- 229910052760 oxygen Inorganic materials 0.000 claims description 29
- 230000033001 locomotion Effects 0.000 claims description 15
- 230000006870 function Effects 0.000 claims description 14
- 239000012528 membrane Substances 0.000 claims description 12
- 238000009826 distribution Methods 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 9
- 239000007924 injection Substances 0.000 claims description 9
- 230000004044 response Effects 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 5
- 238000003825 pressing Methods 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 230000032258 transport Effects 0.000 claims description 5
- 230000002452 interceptive effect Effects 0.000 claims description 3
- 238000012423 maintenance Methods 0.000 claims 83
- 238000012136 culture method Methods 0.000 claims 17
- 239000012530 fluid Substances 0.000 claims 11
- 230000037361 pathway Effects 0.000 claims 2
- 230000003750 conditioning effect Effects 0.000 claims 1
- 239000012466 permeate Substances 0.000 claims 1
- 230000036962 time dependent Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 abstract description 7
- 238000003306 harvesting Methods 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 180
- 210000001519 tissue Anatomy 0.000 description 54
- 239000003153 chemical reaction reagent Substances 0.000 description 31
- 238000004519 manufacturing process Methods 0.000 description 24
- 210000000130 stem cell Anatomy 0.000 description 17
- 210000001185 bone marrow Anatomy 0.000 description 13
- 238000011282 treatment Methods 0.000 description 12
- 238000002659 cell therapy Methods 0.000 description 10
- 238000011109 contamination Methods 0.000 description 10
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 238000002054 transplantation Methods 0.000 description 10
- 238000011534 incubation Methods 0.000 description 9
- 210000000056 organ Anatomy 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
- 238000012790 confirmation Methods 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 230000004888 barrier function Effects 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000036512 infertility Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000012549 training Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 102000004142 Trypsin Human genes 0.000 description 4
- 108090000631 Trypsin Proteins 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 238000001415 gene therapy Methods 0.000 description 4
- 238000009434 installation Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000012266 salt solution Substances 0.000 description 4
- 239000012588 trypsin Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 238000010322 bone marrow transplantation Methods 0.000 description 3
- 238000012832 cell culture technique Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 238000004886 process control Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011194 good manufacturing practice Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011476 stem cell transplantation Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000004114 suspension culture Methods 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000003070 Statistical process control Methods 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 230000004397 blinking Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- HFNQLYDPNAZRCH-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O.OC(O)=O HFNQLYDPNAZRCH-UHFFFAOYSA-N 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 238000011072 cell harvest Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000004656 cell transport Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003636 conditioned culture medium Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013479 data entry Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000008611 intercellular interaction Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002433 mononuclear leukocyte Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 238000012776 robust process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000012414 sterilization procedure Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003634 thrombocyte concentrate Substances 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 230000025366 tissue development Effects 0.000 description 1
- 230000030968 tissue homeostasis Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/54—Constructional details, e.g. recesses, hinges hand portable
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Computer Hardware Design (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48351695A | 1995-06-07 | 1995-06-07 | |
| US48351795A | 1995-06-07 | 1995-06-07 | |
| US48351895A | 1995-06-07 | 1995-06-07 | |
| US48351995A | 1995-06-07 | 1995-06-07 | |
| US48352095A | 1995-06-07 | 1995-06-07 | |
| US483,520 | 1995-06-07 | ||
| US483,519 | 1995-06-07 | ||
| US483,518 | 1995-06-07 | ||
| US483,517 | 1995-06-07 | ||
| US483,516 | 1995-06-07 | ||
| PCT/US1996/009770 WO1996040858A1 (en) | 1995-06-07 | 1996-06-07 | Apparatus and method for maintaining and growing biological cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11507229A JPH11507229A (ja) | 1999-06-29 |
| JPH11507229A5 JPH11507229A5 (https=) | 2004-10-14 |
| JP3880622B2 true JP3880622B2 (ja) | 2007-02-14 |
Family
ID=27541734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50199497A Expired - Fee Related JP3880622B2 (ja) | 1995-06-07 | 1996-06-07 | 生物細胞を維持及び培養に使用するポータブルカセット |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0832182B1 (https=) |
| JP (1) | JP3880622B2 (https=) |
| AT (1) | ATE204322T1 (https=) |
| CA (1) | CA2223525C (https=) |
| DE (1) | DE69614535T2 (https=) |
| ES (1) | ES2162081T3 (https=) |
| WO (1) | WO1996040858A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825169B1 (en) | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US5965532A (en) * | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
| US6100234A (en) | 1997-05-07 | 2000-08-08 | Tufts University | Treatment of HIV |
| US6040145A (en) | 1997-05-07 | 2000-03-21 | Tufts University | Potentiation of the immune response |
| CA2304206A1 (en) | 1997-09-29 | 1999-04-08 | Point Therapeutics, Inc. | Stimulation of hematopoietic cells in vitro |
| CA2331122A1 (en) | 1998-05-04 | 1999-11-11 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| AU765370B2 (en) | 1998-06-05 | 2003-09-18 | Point Therapeutics, Inc. | Cyclic boroproline compounds |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| FR2794130B1 (fr) * | 1999-05-26 | 2003-01-03 | Bertin Technologies Sa | Procede et dispositif de culture de cellules a applications multiples |
| DE60043640D1 (de) * | 1999-10-11 | 2010-02-25 | Dsm Ip Assets Bv | Kontinuierliche Fermentation |
| WO2003087292A2 (en) * | 2002-04-08 | 2003-10-23 | Millenium Biologix Inc. | Automated tissue engineering system |
| JP4751566B2 (ja) * | 2002-04-09 | 2011-08-17 | オリンパス株式会社 | 細胞培養システム、培養細胞照合装置および細胞培養装置 |
| JP2004073187A (ja) * | 2002-06-18 | 2004-03-11 | Olympus Corp | 培養関連容器管理方法および培養関連容器 |
| WO2005068608A1 (ja) * | 2004-01-14 | 2005-07-28 | Daikin Industries, Ltd. | 温度制御装置 |
| GB0603965D0 (en) | 2006-02-28 | 2006-04-05 | Centeo Biosciences Ltd | Incubator apparatus and method |
| KR100946643B1 (ko) * | 2007-11-30 | 2010-03-09 | 코아스템(주) | 세포배양장치 및 이를 구비한 대용량 자동화 세포배양기 |
| KR100932861B1 (ko) * | 2007-11-30 | 2009-12-21 | 코아스템(주) | 세포배양플라스크 |
| EP2392640A1 (en) | 2009-01-30 | 2011-12-07 | Emilio Mateu Sentamans | Method and modular equipment for the processing and storage of cell cultures |
| DE102009029305A1 (de) | 2009-09-09 | 2011-03-10 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Analysegerät zur automatisierten Bestimmung einer Messgröße einer Flüssigkeitsprobe |
| WO2011130865A2 (en) * | 2010-04-21 | 2011-10-27 | Yves Larcher | Automated cell culture system |
| JP5351823B2 (ja) * | 2010-04-28 | 2013-11-27 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| DE102012013267A1 (de) | 2012-07-04 | 2014-01-09 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Substrateinrichtung, Konservierungsgerät und Verfahren zur Kryokonservierung einer biologischen Probe |
| JP6051730B2 (ja) | 2012-09-24 | 2016-12-27 | 東洋製罐グループホールディングス株式会社 | 気泡除去方法、及び気泡除去装置 |
| WO2016005971A1 (en) * | 2014-07-06 | 2016-01-14 | Fertilesafe Ltd | Devices for culturing a biological sample in a culturing liquid |
| JP6339432B2 (ja) * | 2014-07-16 | 2018-06-06 | オリンパス株式会社 | 細胞観察情報処理システム、細胞観察情報処理方法、細胞観察情報処理プログラム |
| FR3053051B1 (fr) * | 2016-06-24 | 2022-11-11 | Cellprothera | Cassette et automate de culture cellulaire |
| EP3505615A4 (en) * | 2016-08-26 | 2020-05-27 | IHI Corporation | CELL CULTURE SYSTEM, CULTURE UNIT, AUTOMATIC CELL CULTURE DEVICE, AND TRANSPORT CELL CULTURE DEVICE |
| US10406252B2 (en) | 2017-01-19 | 2019-09-10 | Curium Us Llc | Systems and methods for autoclave cart loading and unloading system |
| CA3248436A1 (en) | 2017-09-01 | 2025-02-21 | Lonza Walkersville, Inc. | END-TO-END AUTOMATION OF CELL THERAPY |
| DE102018000561B4 (de) | 2018-01-24 | 2019-11-07 | Zellwerk Gmbh | Mäander-Bioreaktor und Verfahren für die Isolierung und Vermehrung von Zellen aus Gewebeteilen von Tumoren, Metastasen und anderen Geweben |
| DE202018000370U1 (de) | 2018-01-24 | 2018-04-12 | Zellwerk Gmbh | Mäander-Bioreaktor für die Isolierung und Vermehrung von Zellen aus Gewebeteilen von Tumoren, Metastasen und anderen Geweben |
| EP3556841A1 (en) * | 2018-04-19 | 2019-10-23 | Aglaris Ltd | Disposable cartridge cooperating with a platform in a flexible system for handling and/or manipulating fluids |
| JP7396777B2 (ja) | 2018-09-28 | 2023-12-12 | オクタン バイオテック インコーポレーテッド | 磁気分離 |
| DE202018004857U1 (de) | 2018-10-20 | 2019-01-14 | Zellwerk Gmbh | Mäander-Perfusions-Bioreaktor für die Differenzierung, Aktivierung, Stimulierung und Abtrennung von Zellen |
| KR20210108406A (ko) | 2018-12-21 | 2021-09-02 | 론자 워커스빌 아이엔씨. | 바이러스 벡터의 자동화된 생산 |
| IL284214B2 (en) | 2018-12-21 | 2025-03-01 | Octane Biotech Inc | Carousel for modular biologic production units |
| SG11202106652WA (en) | 2018-12-28 | 2021-07-29 | Octane Biotech Inc | Cell culture and tissue engineering systems with controlled environmental zones |
| IL285288B2 (en) | 2019-02-08 | 2026-04-01 | Lonza Walkersville Inc | Cell concentration methods and devices for use in automated bioreactors |
| JP7698625B2 (ja) * | 2019-07-15 | 2025-06-25 | ロンザ ウォーカーズヴィル，インコーポレーテッド | 自動細胞工学システム用のプロセス制御システム |
| CN114729292A (zh) | 2019-10-24 | 2022-07-08 | 奥克泰生物科技股份有限公司 | 具有经改进的细胞接触表面的细胞培养室 |
| EP4058563A4 (en) | 2019-11-11 | 2023-12-06 | Lonza Walkersville, Inc. | QUALITY CONTROL PROCEDURES FOR AUTOMATED CELL PROCESSING |
| EP3933479A1 (en) * | 2020-07-03 | 2022-01-05 | Leica Microsystems CMS GmbH | Microscope for microscopic examination of a sample |
| WO2025202170A1 (en) * | 2024-03-25 | 2025-10-02 | The Automation Partnership (Cambridge) Limited | Mobile bioprocessing module, bioprocessing unit and bioprocessing system for performing a bioprocess |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3476895D1 (en) * | 1984-11-22 | 1989-04-06 | Personal Diagnostics Inc | Self-sufficient incubation assembly |
| AU6355790A (en) * | 1989-08-04 | 1991-03-11 | Peter Grandics | An integrated cell culture-protein purification system for the automated production and purification of cell culture products |
| EP0620939A4 (en) * | 1991-11-25 | 1996-05-29 | Cornell Res Foundation Inc | Automated multicompartmental cell culture system. |
| US5612188A (en) * | 1991-11-25 | 1997-03-18 | Cornell Research Foundation, Inc. | Automated, multicompartmental cell culture system |
| US5352414A (en) * | 1992-12-30 | 1994-10-04 | Rothenberg Barry E | Incubator unit and filter system |
| US5424209A (en) * | 1993-03-19 | 1995-06-13 | Kearney; George P. | Automated cell culture and testing system |
-
1996
- 1996-06-07 AT AT96921439T patent/ATE204322T1/de not_active IP Right Cessation
- 1996-06-07 DE DE69614535T patent/DE69614535T2/de not_active Expired - Lifetime
- 1996-06-07 CA CA002223525A patent/CA2223525C/en not_active Expired - Fee Related
- 1996-06-07 WO PCT/US1996/009770 patent/WO1996040858A1/en not_active Ceased
- 1996-06-07 EP EP96921439A patent/EP0832182B1/en not_active Expired - Lifetime
- 1996-06-07 JP JP50199497A patent/JP3880622B2/ja not_active Expired - Fee Related
- 1996-06-07 ES ES96921439T patent/ES2162081T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0832182B1 (en) | 2001-08-16 |
| EP0832182A1 (en) | 1998-04-01 |
| CA2223525A1 (en) | 1996-12-19 |
| DE69614535D1 (de) | 2001-09-20 |
| CA2223525C (en) | 2008-12-23 |
| ES2162081T3 (es) | 2001-12-16 |
| ATE204322T1 (de) | 2001-09-15 |
| DE69614535T2 (de) | 2002-06-06 |
| WO1996040858A1 (en) | 1996-12-19 |
| JPH11507229A (ja) | 1999-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3880622B2 (ja) | 生物細胞を維持及び培養に使用するポータブルカセット | |
| US5985653A (en) | Incubator apparatus for use in a system for maintaining and growing biological cells | |
| US5994129A (en) | Portable cassette for use in maintaining and growing biological cells | |
| US6228635B1 (en) | Portable cell growth cassette for use in maintaining and growing biological cells | |
| US6096532A (en) | Processor apparatus for use in a system for maintaining and growing biological cells | |
| US7906323B2 (en) | Automated bioculture and bioculture experiments system | |
| KR100674788B1 (ko) | 세포 또는 조직의 배양방법 및 그 장치 | |
| JP4195287B2 (ja) | 自動化されたバイオカルチャー及びバイオカルチャー実験システム | |
| ES2761938T3 (es) | Método y sistema para la producción de células | |
| JP3784414B2 (ja) | ほ乳類細胞の成長および維持のためのバイオリアクター | |
| JP2012506257A (ja) | 細胞および細胞由来生成物の産生のための、灌流バイオリアクター、細胞培養システム、および方法 | |
| AU687531B2 (en) | Flow-through bioreactor with grooves for cell retention | |
| JP2025134748A (ja) | 改善された細胞接触面を有する細胞培養チャンバ | |
| JPH10512159A (ja) | 生物人工肝臓のための培養製品 | |
| JPH11513247A (ja) | 可撓性の容器を運搬するための装置および流体を容器に移動させる方法 | |
| CN1740314A (zh) | 持续灌注式自动细胞培养系统 | |
| TWI834133B (zh) | 細胞培養系統 | |
| US20230416669A1 (en) | Cassette and system for growth and treatment of cells | |
| Armstrong et al. | Clinical systems for the production of cells and tissues for human therapy | |
| WO2024121923A1 (ja) | 細胞培養容器、細胞培養装置及び細胞培養方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060516 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060808 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20061024 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20061108 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101117 Year of fee payment: 4 |
|
| LAPS | Cancellation because of no payment of annual fees |