JP3670211B2 - Lotion preparation containing powder - Google Patents

Description

【００１１】
＜実施例６〜９＞
実施例１〜５と同様に、下記に処方を示す如く、脂肪酸金属石鹸の種類を変えて、本発明の効果を調べた。結果を表２に示す。これより、脂肪酸金属石鹸としてはステアリン酸の金属石鹸が好ましいことが判る。
イ
エタノール １０ 重量部
１，３−ブタンジオール ５ 重量部
メチルパラベン ０．１重量部
ポリオキシエチレン硬化ひまし油 ０．１重量部
水 ８３．８重量部
ロ
タルク ０．９重量部
脂肪酸金属石鹸＊＊ ０．１重量部
＊＊詳細は表２に記す。
【００１２】
【表２】

【００１３】
＜実施例１０＞
上記実施例と同様に金属石鹸の量を変動させて検討を行った。結果を表３に示す。これより、本発明の皮膚外用剤に於いて、脂肪酸金属石鹸は０．１重量％を中心とした含有量が特に好ましいことが判る。
イ
エタノール １０ 重量部
１，３−ブタンジオール ５ 重量部
メチルパラベン ０．１重量部
ポリオキシエチレン硬化ひまし油 ０．１重量部
水 ８３．８重量部
ロ
タルク ０．９重量部
ステアリン酸マグネシウム ＊＊＊重量部
＊＊＊詳細は表３に記す。
【００１４】
【表３】

【００１５】
＜実施例１２＞
下記に示す処方に従って、本発明の皮膚外用剤である、抗炎症医薬ローション製剤を作成した。製造方法は上記化粧料の実施例と同様に行った。このものの粘度は４００センチストークスであり、上記ケーキング試験による沈降の長さは５ｍｍであった。
イ
エタノール １０ 重量部
１，３−ブタンジオール ５ 重量部
メチルパラベン ０．１重量部
ポリオキシエチレン硬化ひまし油 ０．１重量部
ヘパリン類似物質 ０．２重量部
水 ８３．６重量部
ロ
タルク ０．３重量部
酸化亜鉛 ０．６重量部
ステアリン酸マグネシウム ０．１重量部
【００１６】
【発明の効果】
本発明によれば、ローション製剤などの水系製剤形に於いて、ケーキングを起こさずに粉体を含有させる技術が提供できる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin in a lotion dosage form containing powder.
[0002]
[Prior art]
Powders are often contained in cosmetics because they have the action of concealing skin troubles in foundations and the like, protecting the skin from ultraviolet rays, and being beautifully worn by optical effects. In addition, since some of them have physiological effects such as anti-inflammatory effects such as zinc oxide, they are contained as they are in medicines for external use as a skin. Many of such powders are metal oxides, and their specific gravity is extremely high. When they are contained in an aqueous preparation, they cause sedimentation and the so-called caking phenomenon in which the powders are strongly bonded via a dispersion medium. Is often caused. Therefore, in water-based powder-containing preparations, means for increasing the redispersion by blending a powder redispersion accelerator or adding a stirrer such as a sterle ball is taken. As such a redispersion accelerator, a water-soluble phosphate such as sodium polyphosphate is used. However, since many powders have an isoelectric point, the salt concentration suitable for caking and redispersibility varies depending on the powder, and the addition of phosphate uniquely improves the redispersibility. On the other hand, it was difficult to say that it was a solution because there was even a strong bond between powders during caking, and the stirrer had a risk of elution of metal ions into the composition, The ability to redistribute strong caking to its original state could not be expected. That is, there has been a demand for the development of a technique for incorporating powder without causing caking in an aqueous preparation such as a lotion preparation.
[0003]
On the other hand, there is no example in which a fatty acid metal soap is contained in a lotion dosage form skin external preparation containing powder, and in a lotion dosage form skin external preparation containing such a fatty acid metal soap, It is not known at all that caking is suppressed when the body is contained.
[0004]
[Problems to be solved by the invention]
The present invention has been made under such circumstances, and an object of the present invention is to provide a technique for containing powder without causing caking in an aqueous preparation such as a lotion preparation.
[0005]
In order to solve the problems]
In view of such a situation, the present inventors have made intensive research efforts in search of a technique for incorporating powder without causing caking in an aqueous preparation such as a lotion preparation. It has been found that such a technique can be realized by including a fatty acid metal soap in the external preparation for skin containing a lotion dosage form, and has completed the invention. That is, the present invention relates to the following technique.
(1) In the skin external preparation of the lotion formulation containing powder, characterized in that it contains a fatty acid metal soaps, skin external preparation.
(2) fatty Sankin genus soap, characterized in that zinc stearate, the one to be selected from aluminum stearate and magnesium stearate is more, the skin external preparation as described in (1).
(3) The external preparation for skin according to (1) or (2), wherein caking of the powder is suppressed.
(4) The skin external preparation according to any one of (1) to (3), which is a cosmetic.
Hereinafter, the present invention will be described in detail with a focus on embodiments.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
(1) skin external preparation of the fatty acid metal soaps present invention is an essential component of the skin external preparation of the present invention is characterized by containing a fatty acid metal soap. The fatty acid metal soap referred to in the present invention is the same as the fatty acid metal soap defined in cosmetics and the like, and the hydrogen atom of the carboxyl group of the fatty acid is a metal other than an alkali metal, preferably magnesium. Alkaline earth metals, salts in the form of substitution with amphoteric metals such as zinc and aluminum, particularly preferred are salts of palmitic acid, stearic acid, behenic acid and magnesium, zinc or aluminum, and these Of these, magnesium stearate, zinc stearate or aluminum stearate can be particularly preferably exemplified. It These fatty Sankin genera soaps may also be included only one, can be contained in combination of two or more. Such fat Sankin genus soaps, precipitated particulate materials are strongly coupled to each other, excellent effect of inhibiting the occurrence of so-called caking, by shaking the powder-containing cosmetic powder had settled, sedimented The powder can be easily redispersed. In the skin external preparation of the present invention, preferably the content of the fatty Sankin genus soaps, to the total amount of the skin treatment composition is 0.01 to 5 wt% in total, more preferably 0.05 to 1 The weight% can be exemplified. This may not be suppressed when such a fat Sankin genus soap is too small caking is because too much of fat Sankin genus soap might look separated it becomes dirty.
[0007]
(2) the external preparation for skin external preparation for skin of the Invention The present invention contain fat Sankin genus soaps are the essential components, characterized in that it is a lotion form. Here, the lotion dosage form referred to in the present invention is a low-viscosity composition having a viscosity of 1000 centistokes or less, and the form thereof is not particularly limited. Emulsified dispersion type, solubilized dispersion type, simple dispersion type Etc. can be preferably exemplified. In addition, since the powder containing the characteristics of the external preparation for skin of the present invention is less susceptible to caking, the powder is also an essential component. The powder that can be contained in the external preparation for skin according to the present invention is not particularly limited as long as it is usually used in cosmetics and external pharmaceutical compositions for skin. For example, titanium dioxide, zinc oxide, iron oxide, silica Metal oxides such as calcium silicate, silicates such as calcium silicate and magnesium silicate, and minerals such as talc, kaolin, mica, sericite, and titanium mica are preferable and can be specifically exemplified. In addition to these, organic substances that are hardly soluble in the solvent of the lotion agent can also be handled as powder. Of course, these powders may be each other is the processing on the front surface. The preferred content in, the powder in the skin external preparation of the present invention, with respect to the total amount of the skin treatment composition is 0.01 to 20 wt%, more preferably from 0.05 to 5% by weight. In the external preparation for skin of the present invention, in addition to the above-mentioned components, any components that are usually used in external preparations for skin can be contained. Examples of such optional components include hydrocarbons such as squalane, petrolatum, and microcrystalline wax, jojoba oil, carnauba wax, esters such as octyldodecyl oleate, silicones such as dimethicone and femethicone, olive oil, Triglycerides such as beef tallow and coconut oil, fatty acids such as stearic acid, oleic acid and lithinolic acid, higher alcohols such as oleyl alcohol, stearyl alcohol and octyldodecanol, anionic surface activity such as sulfosuccinic acid ester and sodium polyoxyethylene alkyl sulfate Agents, amphoteric surfactants such as alkylbetaine salts, cationic surfactants such as dialkylammonium salts, sorbitan fatty acid esters, fatty acid monoglycerides, polyoxyethylene adducts thereof, polymers Nonionic surfactants such as oxyethylene alkyl ethers and polyoxyethylene fatty acid esters, polyhydric alcohols such as polyethylene glycol, glycerin and 1,3-butanediol, ethanol, aqueous thickening and gelling agents, and antioxidants Moisturizing effect of chemicals, ultraviolet absorbers, colorants, preservatives, hyaluronic acid and its salts, trehalose and its analogs, chondroitin sulfate and its salts, heparin-like substances, polymers having sugar chains in the side chain or collagen Ingredients can be included. The external preparation for skin of the present invention can be produced by treating these components according to a conventional method. Here, the external preparation for skin referred to in the present invention is a general term for compositions in the form of external administration to the skin, and examples thereof include cosmetics, external preparations for skin, and antibacterial agents for external use. Of these, application to cosmetics is particularly preferred. This is because the powder content is large.
[0008]
【Example】
Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.
[0009]
<Examples 1-5>
A lotion cosmetic, which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. That is, the component (b) was pulverized with a pulverizer equipped with a 0.9 mm round hole screen and stirred with the component (a) to obtain a two-phase type lotion cosmetic. Take 5 cc of this in a test tube, centrifuge for 5 minutes at 3000 rpm for 1 minute, and then stir for 30 minutes in a test tube mixer to measure the length of the part that was not redispersed. . At the same time, Comparative Example 1 in which the magnesium stearate of the lotion cosmetic of Example 1 of the present invention was replaced with water, Comparative Example 1 in which sodium polyphosphate was replaced, and Comparative Example 2 in which sodium laurate was replaced were also prepared. Study was carried out. The results are shown in Table 1. From this, it can be seen that the lotion cosmetic which is an external preparation for skin of the present invention is excellent in the redispersibility of the blended powder.
Iethanol 10 parts by weight 1,3-butanediol 5 parts by weight methylparaben 0.1 part by weight polyoxyethylene hydrogenated castor oil 0.1 part by weight water 83.8 parts by weight B powder * 0.9 part by weight magnesium stearate 0 .1 part by weight * Details are given in Table 1.
[0010]
[Table 1]

[0011]
<Examples 6 to 9>
As in Example 1-5, as shown the formulation below, by changing the type of fat Sankin genus soaps, we examined the effect of the present invention. The results are shown in Table 2. From this, the fatty acid metal soaps seen that metal soaps stearic acid is preferred.
Lee ethanol 10 parts by weight 1,3-butanediol 5 parts by weight methyl paraben 0.1 part by weight of polyoxyethylene hydrogenated castor oil 0.1 parts by weight of water 83.8 parts by weight b Talc 0.9 parts by weight fatty Sankin genus soaps ** 0.1 parts by weight ** Details are given in Table 2.
[0012]
[Table 2]

[0013]
<Example 10>
As in the above example, the amount of metal soap was varied and examined. The results are shown in Table 3. From this, in the skin external preparation of the present invention, fatty Sankin genus soap it can be seen that particularly preferable content around 0.1 wt%.
(A) Ethanol 10 parts by weight 1,3-butanediol 5 parts by weight Methylparaben 0.1 part by weight Polyoxyethylene hydrogenated castor oil 0.1 part by weight Water 83.8 parts by weight Rotalc 0.9 part by weight Magnesium stearate *** weight Part
*** Details are given in Table 3 .
[0014]
[Table 3]

[0015]
<Example 12>
In accordance with the formulation shown below, an anti-inflammatory pharmaceutical lotion preparation, which is an external preparation for skin of the present invention, was prepared. The production method was the same as in the cosmetic examples. The viscosity of this product was 400 centistokes, and the length of sedimentation by the caking test was 5 mm.
Iethanol 10 parts by weight 1,3-butanediol 5 parts by weight methylparaben 0.1 part by weight polyoxyethylene hydrogenated castor oil 0.1 part by weight heparin-like substance 0.2 part by weight water 83.6 parts by weight rotalc 0.3 part by weight Zinc oxide 0.6 parts by weight Magnesium stearate 0.1 parts by weight
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, the technique which makes a powder contain without causing caking in aqueous | water-based formulation forms, such as a lotion formulation, can be provided.

Claims (5)

In the external preparation for skin of a lotion preparation containing a powder and having a viscosity of 1000 centistokes or less and used by redispersing the powder, it contains 0.01 to 5% by weight of a fatty acid metal soap, Skin external preparation.   The skin external preparation according to claim 1, wherein the fatty acid metal soap is one or more selected from zinc stearate, aluminum stearate and magnesium stearate.   The external preparation for skin according to claim 1 or 2, wherein powder caking is suppressed.   The external preparation for skin according to any one of claims 1 to 3, which is a cosmetic. A powder containing 0.1 to 5% by weight of a fatty acid metal soap in a skin external preparation of a lotion preparation containing a powder and having a viscosity of 1000 centistokes or less and used by redispersing the powder. To improve redispersibility