JP3621072B2 - Lyophilized product, production method and apparatus thereof - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a freeze-dried product obtained by removing refrigerant and moisture from an object to be treated that has been cooled and frozen by a refrigerant such as dry ice, and a manufacturing method and apparatus therefor.
[0002]
[Prior art]
There has been proposed a method in which dry ice and ice are removed from an object to be processed by cooling with dry ice to obtain a freeze-dried product. For example, Japanese Patent No. 30056557 discloses a method of freeze-drying a processed object obtained by mixing dry ice and a processed object such as raw biological material, drug, food, industrial raw material and the like while being pressed and crushed in a frozen state under a vacuum condition. Has been proposed.
[0003]
In this way, the object to be treated is mixed with dry ice, the gas phase is replaced with the generated carbon dioxide gas, and the gas phase is frozen substantially instantaneously, and the frozen material is vacuum-dried. In addition, the object to be treated can be freeze-dried while maintaining the quality, properties, etc. before the treatment without undergoing alteration due to heat or the like. The resulting lyophilized product is an inert lyophilized product that retains the quality, properties, etc. before processing without being altered by oxygen, heat, etc., and can be stored, transported and used as it is, and has no alteration. Can be used in the state.
[0004]
A conventional freeze-drying apparatus used in such a method is provided with a plurality of multi-stage heating shelves in a sealed chamber having an exhaust manifold and an openable / closable sealed door connected to an opening. The workpiece is placed on each shelf board from the opening, and after the sealed chamber is evacuated in this state, the shelf board is heated to freeze-dry the workpiece, and from the workpiece The sublimated water is guided to a cold trap connected to an exhaust manifold to aggregate the water, and the object to be processed is freeze-dried.
[0005]
However, in such a conventional freeze-drying apparatus, the space volume between the shelves is narrow due to the plurality of heating shelves in the sealed chamber, and the overall volume is reduced, the shape and amount of the object to be processed are limited, and mass processing is possible. Have difficulty. In addition, since the object to be processed is installed in a narrow space on the shelf board in the sealed room, the heat transfer is uneven, and the part near the heating surface of the object to be processed may be altered by partial heating. It is difficult to make uniform. And when frozen objects such as slices of strawberry overlap in a stacked state, the contact surfaces of a plurality of objects to be processed adhere to each other and become a bonded state, and the surface area may decrease and drying efficiency may be significantly reduced. . A rotary pump is conventionally used as the vacuum pump connected to the exhaust manifold. When the object to be processed is frozen in a mixed state with dry ice, a large amount of carbon dioxide gas sublimated from the dry ice is released. Therefore, it is difficult to reduce the pressure in the sealed chamber, the vacuum drying efficiency of the object to be processed is lowered, and efficient lyophilization is difficult.
[0006]
[Problems to be solved by the invention]
An object of the present invention, when preparing a freeze-dried product was efficiently removed refrigerant and moisture from the object to be treated which has been frozen by the refrigerant containing dry ice, the efficiency a large amount of carbon dioxide gas produced by the sublimation of dry ice It can be removed well, and it is possible to prevent adhesion between processed objects by drying while rotating the processed objects, shortening the drying time of the frozen objects, and heating the frozen objects uniformly, so that the quality is high. It is to provide a method and an apparatus for producing a freeze-dried product capable of obtaining a freeze-dried product, and a freeze-dried product obtained thereby.
[0007]
[Means for Solving the Problems]
The present invention is the following freeze-dried product, production method and apparatus thereof.
(1) A refrigerant containing dry ice is mixed with an object to be processed, and the gas phase is replaced with generated carbon dioxide and frozen.
A breathable object container for storing a frozen object in which the object to be processed and dry ice are mixed ,
Housed in a rotating cage in the lyophilizer,
The workpiece is heated by a heating device under vacuum conditions,
Sublimate dry ice and moisture in the workpiece,
With the dry ice sublimation, the objects to be processed are separated from each other, and heated and dried uniformly while preventing the overlapping of the objects to be processed in the object container by rotating the cage.
Freeze-drying by changing the heating conditions according to the dry ice sublimation state,
A method for producing a freeze-dried product to obtain a freeze-dried product.
(2) The method according to (1) above, wherein the objects to be processed are accommodated in the object container in a state where the objects to be processed are not bonded to each other.
(3) The method according to (1) or (2) above, wherein the heating device is a heating lamp.
(4) The method according to any one of (1) to (3) above, wherein the refrigerant is dry ice.
(5) The method according to any one of (1) to (4) above, wherein the object to be processed is accommodated in the container to be processed in a state of being mixed with the refrigerant.
(6) The method according to any one of (1) to (5) above, wherein freeze-drying is performed by changing heating conditions before and after the completion of sublimation of dry ice.
(7) The method according to any one of (1) to (6) above, wherein freeze-drying is performed by changing the vacuuming conditions according to the sublimation state of the dry ice.
(8) The method according to (6) above, wherein when the sublimation of dry ice is almost finished, the heating is switched to a weak setting and lyophilization is performed.
(9) an apparatus body having a sealed chamber;
A refrigerant containing dry ice is mixed with the object to be processed, the gas phase is replaced with the generated carbon dioxide gas, and a frozen object to be processed and a frozen object containing dry ice in a mixed state are accommodated. A rotating cage provided in a sealed chamber to accommodate and rotate the container,
Rotating means for rotating the rotating cage so that the objects to be processed are separated from each other along with the sublimation of the dry ice, while preventing the overlapping of the objects to be processed in the object container, and heating and drying uniformly.
A heating device provided in the main body so as to heat the workpiece;
A control device that controls to change the heating conditions of the heating device according to the state of sublimation of dry ice;
A cold trap connected to a sealed chamber and equipped with a cooling section;
A freeze-drying apparatus including a vacuum generator for depressurizing a sealed chamber through a cold trap.
(10) The apparatus according to (9), wherein power transmission for rotating the rotating cage is performed by magnet coupling.
(11) The apparatus according to (9) or (10), wherein the heating device is a heating lamp.
(12) The device according to any one of (9) to (11), wherein the control device is configured to switch the heating device to a weak setting when the sublimation of dry ice is almost completed.
(13) The apparatus according to any one of (9) to (12), wherein the vacuum generator is configured to be able to change a vacuuming condition according to a sublimation state of dry ice.
(14) A lyophilized product produced by the method according to any one of (1) to (8) above.
(15) A food or pharmaceutical comprising the lyophilized product according to (14).
[0008]
In the present invention, the objects to be processed for lyophilization are all objects for ordinary lyophilization, such as organic substances, inorganic substances and mixtures thereof. In particular, organisms, organic substances, foods, drugs, biological samples, feeds, industrial materials, etc. that are easily denatured are suitable, and examples include substances containing organic substances having functional groups that are easily denatured by oxygen, heat, enzymes, etc. . These objects to be treated include those in any form such as a lump, liquid, jelly, and slurry, and may be crushed or powdered. These are typically water-containing materials to be treated, but even dry materials can be applied when mixed with water or water-containing materials and homogenized.
[0009]
As the refrigerant used in the present invention, a refrigerant containing dry ice that can freeze the object to be processed can be used without limitation. Specific ones, dry eye scan, such as a mixture of dry ice and acetone or ethyl alcohol. Among these, dry eye scan is preferable.
[0010]
Although the following description demonstrates the case where the dry ice which can be used preferably as a refrigerant | coolant is demonstrated, it is not limited only to dry ice, The refrigerant | coolant containing other dry ice can also be used similarly to dry ice.
[0011]
Dry ice Ri Oh those were compacted carbon dioxide solid, the carbon dioxide sublimes at -78.5 ° C. under atmospheric pressure. As such dry ice, what is generally marketed as a coolant etc. can be used. Since this dry ice can be easily crushed when pressure is applied by a mixing and crushing apparatus, it can be used in any shape and size. For example, those having a particle size of about 1 to 5 cm are preferable. The amount of dry ice used varies depending on the type, moisture content, properties, etc. of the object to be treated, but is 0.01 to 100 parts by weight, preferably about 0.1 to 10 parts by weight with respect to 1 part by weight of the object to be treated. be able to.
[0012]
In the present invention, the above-mentioned object to be treated is cooled by a refrigerant such as dry ice and then frozen, and then freeze-dried in a freeze-drying apparatus. In freezing, for example, the object to be treated can be mixed with dry ice, the gas phase can be replaced with the generated carbon dioxide gas, and the object can be frozen substantially instantaneously. It is preferable that the mixture is crushed and the gas phase is replaced with carbon dioxide gas generated at this time to expel oxygen, and at the same time, the object to be processed is frozen to produce a frozen substance. In this case, dry ice is easily crushed by a mixing and crushing device and mixed with the object to be processed and fine particles. At this time, carbon dioxide generated by endotherm is replaced with air to form an inert atmosphere, and the object to be processed Objects can be frozen virtually instantaneously. In such a frozen product, the object to be processed and dry ice exist in a mixed state. In the present invention, it is preferable that such a mixture of the object to be processed and dry ice is accommodated in the object to be processed and freeze-dried. When a mixture of the object to be processed and dry ice is used, when heated by a heating device, the objects to be processed become separated with the sublimation of the dry ice, and in this state, lyophilized while rotating and inverting, Increases drying efficiency.
[0013]
In the present invention, the object to be treated, which is cooled by a refrigerant such as dry ice and frozen, is flexible such as a bag made of a breathable material such as a gas, moisture, or non-woven fabric that can be freely passed through by the refrigerant. The product is stored in a container to be treated and freeze-dried with a freeze-drying apparatus.
[0014]
The freeze-drying apparatus includes an apparatus main body having a sealed chamber, accommodates an air-permeable processed object container that stores a frozen processed object in contact with a refrigerant, and moves the processed object by rotation, inversion, or the like. A rotating cage is provided in the sealed chamber, a heating device is provided in the apparatus main body so as to heat the object to be processed, and a vacuum generator for reducing the pressure of the sealed chamber through a cold trap provided with a cooling unit is provided.
[0015]
The main body having the sealed chamber of the freeze-drying apparatus may be any structure that can be heated and depressurized while rotating the rotating cage, and the shape thereof is not limited.
The rotating cage accommodates the container to be processed and is configured to rotate in a sealed chamber. However, since the rotating cage is heated by heat radiated from a heating device, it easily passes through radiant heat made of stainless steel, plastic, or the like. It is preferably formed in a cage shape with a material such as a net or a punching plate. The rotating cage is preferably one that rotates or reverses at a low speed of 1 to 10 rpm by a motor in order to uniformly irradiate the processing object accommodated in the processing object container with the radiant heat of the heating device. The rotating cage can be, for example, a magnet driven cage configured to rotate by transmitting the power of the motor by magnetic coupling (magnetic coupling), or between the sealed chamber and the rotating cage. the rotating roller is provided may be configured to rotate the rotating roller the power of the motor directly Sedden Ete.
[0016]
The heating device is preferably installed inside and / or outside the sealed chamber so as to heat the rotating cage from the outside. When the object to be processed is heated by the heating device, the dry ice mixed with the object to be processed also sublimes. Therefore, it is preferable that the heating device is configured so that the heating conditions can be changed in the state of sublimation of the dry ice. In this case, heating is performed so as to maintain 30 to 100 ° C., preferably 60 to 80 ° C. before the end of sublimation of dry ice, and to maintain 20 to 80 ° C., preferably 20 to 40 ° C. after the end of sublimation. Thus, the temperature suitable for the sublimation of dry ice and the temperature passed through the sublimation of ice can be switched, and the dry ice and moisture can be efficiently removed. Whether or not the dry ice sublimation is completed can be determined by detecting a change in the temperature of the container to be processed, a change in the pressure in the sealed chamber, or a change in the concentration of carbon dioxide in the exhaust gas.
[0017]
In order to efficiently remove dry ice mixed with the object to be processed inside the object container, the above heating device is heated with a heating lamp or a far infrared ceramic heater having high spectral radiation characteristics in the carbon dioxide absorption region. After sublimating the dry ice, the change in carbon dioxide gas accompanying the disappearance of the dry ice or the temperature rise of the object to be treated is detected with a CO ₂ gas sensor, thermocouple, thermistor, thermography, etc. It is preferable to control with a control device provided with a sequence that allows drying while preventing thermal denaturation of the processed product. When a heating lamp is used, it is excellent in that rapid heating by radiant heat and overall heating by reflection can be performed . When a heating lamp is used, the inner surface of the sealed chamber is preferably made of a material that can be mirror-reflected, such as stainless steel.
[0018]
The vacuum generator is preferably constructed so that the vacuuming conditions can be changed before and after the end of dry ice sublimation. For freeze-drying, it is preferable to maintain the pressure in the sealed chamber at 0.1 to 1000 Pa, preferably 0.1 to 100 Pa, and more preferably 0.1 to 10 Pa. Since a large amount of gas is generated, a large amount of gas can be discharged by a vacuum pump having a large gas discharge capacity, and after completion of sublimation of dry ice, a high vacuum can be maintained by a vacuum pump that maintains a high vacuum. In this case, the vacuum generator is a combination of a high displacement vacuum pump such as a mechanical booster pump for discharging a large amount of carbon dioxide gas sublimated from dry ice by heating, and a normal rotary vacuum pump. It is preferable that these are provided and controlled by a control device.
[0019]
The freeze-drying by the above-described freeze-drying apparatus is such that the object to be processed that accommodates the object to be processed cooled by the refrigerant and stored in the rotating cage in the freeze-drying apparatus, and the object to be processed in the rotating cage is rotated. Rotating while moving by reversal, etc., and reducing the pressure with a vacuum device, maintaining the vacuum state, heating the object to be processed with a heating device, sublimating the moisture contained in the object to be processed, and freeze-drying To obtain a lyophilized product.
[0020]
In the above method, the frozen material is stored in a breathable processed object container, and vacuum drying is performed while rotating in a rotating cage, so that a large amount of processed object can be stored and mixed with dry ice. A large amount of carbon dioxide gas generated by sublimation of dry ice and water in the frozen material can be efficiently removed from the object to be frozen in step 1 to improve the efficiency of lyophilization. Also, by drying while rotating the objects to be processed, it is possible to prevent the surface area from being reduced due to adhesion between the objects to be processed, shortening the drying time of the frozen objects, and heating the frozen objects uniformly, thereby uneven heating. It is possible to prepare a high-quality lyophilized product by preventing the quality deterioration due to.
[0021]
By changing the heating conditions of the heating device before and after the completion of sublimation of dry ice, freeze drying can be performed at a temperature at which sublimation can be made efficient and the quality of the object to be processed can be prevented. Further, by changing the vacuuming conditions according to the state of sublimation of dry ice, vacuuming can be performed under conditions suitable for discharging sublimated carbon dioxide gas and moisture, and freeze-drying can be performed efficiently.
[0024]
The lyophilized product obtained as described above may be stored as a dried product such as foods, pharmaceuticals, biological samples, feeds, industrial materials, etc. Transported. Further, it can be restored by adding water again, and can be used as, for example, foods, pharmaceuticals, biological samples, feed, industrial raw materials and the like.
[0025]
【The invention's effect】
According to the present invention, a refrigerant containing dry ice is mixed with an object to be processed, the gas phase is replaced with the generated carbon dioxide gas, and the frozen object is frozen, and the object to be processed and dry ice are present in a mixed state. The stored air-permeable object container is housed in a rotating cage in a sealed chamber and heated to sublimate dry ice and moisture in the object to be processed, and the objects to be processed are separated as dry ice sublimates. As a result of uniform heating and drying and freeze-drying while preventing the overlap of the objects to be processed in the object container by rotating the cage , sublimation of dry ice from the frozen object to be processed A large amount of carbon dioxide gas generated and moisture from the frozen material can be removed efficiently, and by drying while rotating the processed material, adhesion between the processed materials can be prevented, and the drying time of the frozen material can be reduced. It is possible to shrinkage, frozen products it is possible to obtain a high quality freeze-dried product for a can be uniformly heated.
[0026]
DETAILED DESCRIPTION OF THE INVENTION
Embodiments of the present invention will be described below with reference to the drawings.
FIG. 1 is a front view of a freeze-drying apparatus of the embodiment, and FIG. 2 is a perspective view in which a part of the apparatus main body is cut away.
The apparatus main body 1 is formed in a cylindrical shape, and a sealed chamber 2 is formed inside. A rotating cage 3 is rotatably provided in the sealed chamber 2 via a rotating roller 5 so that the rotating cage 3 rotates in a state in which the object container 4 is accommodated. A heating device 6 is provided on the inner wall of the apparatus main body 1 so that the frozen material in the object container 4 can be heated through the rotating cage 3. The apparatus main body 1 is supported by a support base 7 and has a sealed door 8 at one end and an electric motor 9 that rotates the rotating cage 3 at the other end. It is preferable to transmit the power of the electric motor 9 to the rotating cage 3 through a magnet coupling because a vacuum leak can be prevented. In this case, a drive magnet (not shown) is provided outside the sealed chamber 2 and a driven magnet (not shown) is provided in the sealed chamber 2, and the drive magnet is rotated by the power of the electric motor 9 and follows the rotation of the drive magnet. Thus, the drive magnet and the driven magnet can form a magnet coupling so that the driven magnet rotates, and the rotating cage can be rotated by the rotation of the driven magnet. Further, the electric motor 9 may transmit power directly to the rotating roller 5 provided between the sealed chamber 2 and the rotating cage 3 to rotate the rotating cage 3.
[0027]
An exhaust port 10 for exhausting carbon dioxide gas sublimated from dry ice and frozen material and moisture is provided at the end of the apparatus main body 1, and a conduit 11 having a valve V1 and valves V2 and V3 are provided. Cold traps 13a and 13b are connected via conduits 12a and 12b. Cooling pipes 15a and 15b are provided in the cold traps 13a and 13b so that the water collecting refrigerant cooled by the refrigerator 16 can circulate and collect the water discharged from the sealed chamber 2 by freezing. It has become. A mechanical booster type vacuum pump 17a and an oil rotary vacuum pump 17b are connected in series to the cold traps 13a and 13b via conduits 14a and 14b having valves V4 and V5, and the final vacuum degree in the sealed chamber 2 is determined. Preferably, the vacuum is set to about 0.1 to 10 Pa.
[0028]
The heating device 6 may be a normal one, and may be a radiant heat type, a conduction heat type, or a convection type, but a radiant heat type device is preferable. In FIG. 2, a plurality of ceramic heaters are provided on the inner wall of the sealed chamber 2 as the heating device 6, and are uniformly distant from the frozen material and dry ice inside the processing object container 4 accommodated therein as the rotating cage 3 rotates. Irradiation with infrared rays or the like. As the heating device 6, a flat heater may be installed instead of the far infrared ceramic heater.
[0029]
Reference numeral 20 denotes a control device, which is a heating device 6 by a temperature signal from a CO ₂ gas sensor 24, a temperature detection device 21a provided in the vicinity of the exhaust port 10 or a temperature detection window 23 provided in the device main body 1 and a radiation thermometer 21b. The power supply device 22 is configured to be controlled.
[0030]
Next, a method of performing freeze-drying with the above apparatus will be described. First, the refrigerator 16 is turned on, and when the temperature of the cold traps 13a and 13b reaches −40 ° C. or lower, the frozen material of the material to be treated frozen with dry ice is placed in the material container 4 to be opened. After closing 4a, the rotating cage 3 is accommodated. Then, after closing the sealed door 8, the vacuum pumps 17a and 17b are operated, and when the degree of vacuum reaches about 50 Pa, the rotating cage is rotated at 1 to 10 rpm while operating the heating device 6 so that the radiant heat is made uniform. Irradiate. As the dry ice is sublimated by heating, the objects to be processed easily move, and the rotation of the rotating cage prevents the objects to be processed from being bonded to each other. Before the end of dry ice sublimation, a large amount of carbon dioxide generated by sublimation is efficiently exhausted mainly by the mechanical booster 17a. The temperature detection device 21a provided in the vicinity of the exhaust port 10 monitors the sublimation state of the dry ice, and when the sublimation of the dry ice is almost finished and a rapid temperature rise of about 20 ° C. is detected, the control signal from the control device 20 Is sent to the power supply device 22 and the heating by the heating device 6 is switched to a weak setting to prevent quality deterioration. After the dry ice sublimation is finished, only the moisture is sublimated, so that the high-efficiency is mainly exhausted by the oil-rotating vacuum pump 17b and the high vacuum degree is maintained. The water sublimated from the frozen material is frozen and collected in the cold traps 13a and 13b, the drying of the frozen material proceeds, and the processed material after the drying is stored in the processed material container 4 as a product.
[0031]
In the above apparatus, the rotating cage 3 and the heating device 6 for supplying sublimation latent heat are installed inside the sealed chamber 2, and a highly air permeable processing object container for storing dry ice and a frozen material to be processed. 4 is accommodated in the rotating cage 3 and gently rotated to prevent the objects to be processed inside the object container 4 from overlapping due to the rotation of the cage, thereby improving the drying effect and uniforming the radiant heat from the heating device 6. It is possible to prevent deterioration of quality due to partial heating. By rotating the rotating cage 3 inside the sealed chamber 2 in this way, it is possible to increase the drying efficiency and prevent the quality of the material from deteriorating. The object to be processed is taken out from the sealed chamber 2 when it is dried and stored in a dry state.
[0032]
FIG. 3 is a front view of a freeze-drying apparatus according to another embodiment, and shows an example in which a heating lamp such as a halogen lamp is used as an apparatus for heating an object to be processed. In FIG. 3, the heating lamp 25 is provided outside the sealed chamber 2, and the object to be processed in the sealed chamber 2 is irradiated with light through a heating window 26 made of transparent heat-resistant tempered glass provided in a part of the apparatus body 1. And configured to heat. The inner surface of the sealed chamber 2 is made of stainless steel so that the light emitted from the heating lamp 25 is specularly reflected. The control device 20 is configured to control the heating lamp 25, and when a temperature rise is detected when the sublimation of the dry ice is almost finished, a control signal is sent from the control device 20 to the heating lamp 25 to switch the heating to a weak setting. One or two or more heating lamps 25 can be provided. When the heating lamp 25 is provided, the heating device 6 in the sealed chamber 2 shown in FIG. 2 can be omitted.
[Brief description of the drawings]
FIG. 1 is a front view of a freeze-drying apparatus according to an embodiment.
FIG. 2 is a perspective view in which a part of the apparatus main body is cut away.
FIG. 3 is a front view of a freeze-drying apparatus according to another embodiment.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Apparatus main body 2 Sealed chamber 3 Rotating cage 4 To-be-processed container 5 Rotating roller 6 Heating device 7 Support stand 8 Sealed door 9 Electric motor 10 Exhaust port 11, 12a, 12b, 14a, 14b Conduit 13a, 13b Cold trap 15a, 15b Cooling Tube 16 Refrigerators 17a, 17b Vacuum pump 20 Control device 21a Temperature detection device 21b Radiation thermometer 22 Power supply device 23 Temperature detection window 24 CO ₂ gas sensor 25 Heating lamp 26 Heating window

Claims (15)

Mix the refrigerant containing dry ice with the object to be processed, replace the gas phase with the generated carbon dioxide gas, and freeze it.
A breathable object container for storing a frozen object in which the object to be processed and dry ice exist in a mixed state .
Housed in a rotating cage in the lyophilizer,
The workpiece is heated by a heating device under vacuum conditions,
Sublimate dry ice and moisture in the workpiece,
With the dry ice sublimation, the objects to be processed are separated from each other, while the cage is rotated to prevent the objects to be processed in the object container from overlapping, and heated uniformly to dry.
Freeze-drying by changing the heating conditions according to the dry ice sublimation state,
A method for producing a freeze-dried product to obtain a freeze-dried product. The method of Claim 1 accommodated in a to-be-processed container in the state which to-be-processed objects have not adhere | attached. The method according to claim 1 or 2, wherein the heating device is a heating lamp. The method according to claim 1, wherein the refrigerant is dry ice. The method according to any one of claims 1 to 4, wherein the object to be processed is accommodated in a container to be processed while being mixed with a refrigerant. The method according to any one of claims 1 to 5, wherein freeze-drying is performed by changing heating conditions before and after the completion of sublimation of dry ice. The method according to any one of claims 1 to 6, wherein freeze-drying is performed by changing a vacuuming condition according to a sublimation state of dry ice. The method according to claim 6, wherein when the sublimation of dry ice is almost finished, freeze-drying is performed by switching the heating to a weak setting. An apparatus body having a sealed chamber;
A refrigerant containing dry ice is mixed with the object to be processed, the gas phase is replaced with the generated carbon dioxide gas, and a frozen object to be processed and a frozen object containing dry ice in a mixed state are accommodated. A rotating cage provided in a sealed chamber to accommodate and rotate the container,
Rotating means for rotating the rotating cage so that the objects to be processed are separated from each other along with the sublimation of dry ice, while preventing the overlapping of the objects to be processed in the object container, and heating and drying uniformly.
A heating device provided in the main body so as to heat the workpiece;
A control device that controls to change the heating conditions of the heating device according to the state of sublimation of dry ice;
A cold trap connected to a sealed chamber and equipped with a cooling section;
A freeze-drying apparatus including a vacuum generator for depressurizing a sealed chamber through a cold trap. The apparatus according to claim 9, wherein power transmission for rotating the rotating cage is performed by a magnet coupling. The apparatus according to claim 9 or 10, wherein the heating device is a heating lamp. The apparatus according to any one of claims 9 to 11, wherein the control device is configured to switch the heating device to a weak setting when the sublimation of the dry ice is almost finished. The apparatus according to any one of claims 9 to 12, wherein the vacuum generator is configured to be able to change a vacuuming condition according to a sublimation state of dry ice. A freeze-dried product produced by the method according to any one of claims 1 to 8. A food or pharmaceutical product comprising the freeze-dried product according to claim 14.

Images