KR100801562B1 - Combined heating type freezer dryer - Google Patents

Combined heating type freezer dryer Download PDF

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KR100801562B1
KR100801562B1 KR1020060114877A KR20060114877A KR100801562B1 KR 100801562 B1 KR100801562 B1 KR 100801562B1 KR 1020060114877 A KR1020060114877 A KR 1020060114877A KR 20060114877 A KR20060114877 A KR 20060114877A KR 100801562 B1 KR100801562 B1 KR 100801562B1
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South Korea
Prior art keywords
freeze
spray
freezing
drying
vacuum
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KR1020060114877A
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Korean (ko)
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송치성
박성제
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한국기계연구원
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/40—Heating or cooling means; Combinations thereof
    • A61J2200/44—Cooling means

Abstract

A combined heating type spray freeze dryer is provided to obtain a drug powder of desired particle size through a combined system of preliminary freezing and drying at high efficiency. A combined heating type spray freeze dryer includes: a sample supply part(20) for storing and supplying a fluid sample; a freeze drying part(30) having an internal heater(1) inside a conveyor(2) to transfer a prepared powder material; a freezing part(40) placed in the vicinity of a spray nozzle(6) at the top of a spray freeze chamber(5) of the freeze drying part(30) to create a freezing environment in a cold trap(4); a vacuum part(50) installed to one side of the freeze drying part to create a vacuum environment by vacuum exhausting the air to the outside; and a powder dry tank(12) for storing prepared powder.

Description

복합 가열형 분무식 동결건조기{Combined Heating Type Freezer Dryer}Combined Heating Type Freezer Dryer

도 1은 본 발명에 따른 복합 가열형 분무식 동결건조기를 나타낸 개략도.1 is a schematic view showing a composite heated spray freeze dryer according to the present invention.

< 도면의 주요부분에 대한 부호의 설명 ><Description of Symbols for Major Parts of Drawings>

1: 내부히터 2: 이송컨베이어1: internal heater 2: transfer conveyor

3:적외선 히터 4: 콜드트랩3: infrared heater 4: cold trap

5: 분무동결실 6: 분무노즐5: Spray Freezing Room 6: Spray Nozzle

7: 진공펌프 8: 수증기용 포집실7: vacuum pump 8: steam collecting chamber

9: 시료탱크 10: 액체펌프9: sample tank 10: liquid pump

12: 분말건조탱크12: powder drying tank

20: 시료공급부 30: 동결건조부20: sample supply unit 30: freeze drying unit

40: 냉동부 50: 진공부40: freezer 50: vacuum

본 발명은 호흡을 통해 약물 투여가 가능한 분말 의약품 및 생물학 제제분말로 제조하기 위한 호흡식 분말 의약품용 분무식 동결건조기에 관한 것으로서, 더욱 상세하게는, 분무식 동결건조기에 있어서, 시료용액을 저장하며, 공급하도록 마련 된 시료공급부와; 상기 시료공급부로부터 시료용액을 공급받고, 분무화시키도록 형성되며, 동결환경조건을 형성하도록 형성되며, 제조된 분말재료를 이송하도록 길이방향으로 형성된 이송컨베이어의 내부에 내부히터가 장착한 동결건조부와; 상기 동결건조부내에 동결환경조건을 형성하도록 마련된 콜드트랩에 냉동환경을 형성하도록 형성된 냉동부와; 상기 동결건조부의 일측에 장착되어, 충진된 공기를 외부로 진공토출하여 진공환경을 조성하도록 형성된 진공부)와; 상기 동결건조부로부터 제조된 분말화된 분말을 저장하도록 형성된 분말건조탱크;로 이루어진 복합가열형 분무식 동결건조기에 관한 것이다.The present invention relates to a spray lyophilizer for respiratory powder medicine for the manufacture of a powder medicine and a biological preparation powder capable of administering drugs through respiration, and more particularly, in a spray lyophilizer, storing a sample solution. A sample supply unit provided to supply; The sample solution is supplied to the sample solution from the sample supply, is sprayed, formed to form a freezing environmental conditions, the freeze-drying unit equipped with an internal heater inside the conveying conveyor formed in the longitudinal direction to convey the manufactured powder material Wow; A freezing unit formed to form a freezing environment in a cold trap provided to form a freezing environment condition in the freeze-drying unit; A vacuum unit mounted on one side of the freeze-drying unit and configured to discharge the filled air to the outside to create a vacuum environment; It relates to a complex heating spray lyophilizer consisting of; powder drying tank formed to store the powdered powder produced from the freeze-drying unit.

일반적으로 진공을 이용한 기계 장치는 건조, 냉각, 포장, 농축 등 많은 부분에 응용되고 있으며 냉동 분야에서는 냉동 원리를 접합시켜 식품의 저장에 주요한 기기로서 이용되고 있다.In general, a mechanical apparatus using a vacuum is applied to many parts such as drying, cooling, packaging, and concentration, and in the refrigeration field, it is used as a major device for food storage by bonding the principle of freezing.

다른 건조 방법에 비해 진공 동결 건조 방법의 특징은 (1) 물리적 구조의 보존성, (2) 화학적인 안정성, (3) 생물학적인 활동의 보존성, (4) 제품의 높은 복원성 및 재생성 등의 4가지로 요약할 수 있으며, 진공 동결 건조 기술은 크게 진공, 동결, 건조, 멸균 4가지 요소기술의 복합기술이라 할 수 있다Compared with other drying methods, the vacuum freeze drying method has four characteristics: (1) preservation of physical structure, (2) chemical stability, (3) preservation of biological activity, and (4) high resilience and reproducibility of the product. In summary, vacuum freeze-drying technology is a complex technology of four element technologies: vacuum, freeze, dry, and sterilization.

진공 동결 건조기의 건조실 진공도는 10-3Torr이하의 조건에서 운전되어야 하고, 동결 및 수증기 포집을 위한 냉동 온도는 -40℃ ∼ -80℃ 이어야 하며, 건조를 위한 가열 시스템은 의약용의 0℃ 부근에서 식품용의 +80℃ 까지 조절 가능하여야 한다.Drying chamber vacuum of the vacuum freeze dryer should be operated under the condition of 10 -3 Torr or less, freezing temperature for freezing and steam collection should be between -40 ℃ and -80 ℃ and heating system for drying should be around 0 ℃ for medical use. It should be adjustable up to + 80 ℃ for food.

일반적인 진공동결건조기는 건조실에 있는 선반위의 트레이에 있는 피건조물이 벌크 형태로 건조되고, 한 사이클의 건조가 완료되면 건조된 피건조물을 출고하여 분쇄한 다음 활용하는 단계를 거치지만, 이러한 진공동결건조방식은 배치 방식으로서 한 사이클의 건조과정이 끝난 후 출고하는 과정에 의해 새로운 건조 사이클을 위해 세척, 동결, 진공배기, 건조 과정을 다시 거쳐야 하므로써 매우 비효율적이고, 에너지 소비형 건조과정이 된다. In general, the vacuum freeze dryer is dried in a bulk form in the tray on the shelf in the drying chamber, and when one cycle of drying is completed, the dried product is shipped out, pulverized, and then utilized. The drying method is a batch method, which is a very inefficient and energy-consuming drying process by having to go through washing, freezing, evacuation, and drying for a new drying cycle by leaving the plant after one cycle of drying.

진공동결건조 방법의 단점을 보완한 분무(진공)동결건조 방법은 액체 상태의 원료를 진공챔버내에 분무시킴 으로써 동결된 미립자로 형성되어지며, 동결된 미립자는 콘베이어에 의해 이동되면서 적외선 가열기를 통해 적정한 승화열을 공급받음으로써 원료가 분무후 건조 완료까지의 과정이 1분 이내로 이루어 진다. 분쇄 과정이 필요 없는 분말 상태로 건조 완료된 분말은 진공 상태의 용기에 저장된다. Spray freeze drying method, which complements the shortcomings of the vacuum freeze drying method, is formed into frozen fine particles by spraying a liquid raw material into a vacuum chamber. By receiving the sublimation heat, the raw material is sprayed and dried to within 1 minute. The powder, which has been dried in a powder state that does not require a grinding process, is stored in a vacuum container.

또한 분무동결건조기와 유사한 기술로서 분무건조는 고온에서 처리하고, 건조제품은 조밀구조로 직경이 5μm 이하도 가능하지만, 공기동력학적인 직경이 크고 살포성도 낮다. 이에 비해 분무동결건조기술은 저온처리가 가능하고, 건조제품이 porous 구조로 공기동력학적인 직경이 작으며 살포성이 높으며 생산성도 매우 높다In addition, spray drying is a technique similar to spray freeze dryers, and drying is performed at a high temperature, and the dried product has a compact structure, which may be 5 μm or less in diameter, but has a large aerodynamic diameter and low spraying ability. Compared with spray freeze drying technology, low temperature treatment is possible, and dry product is porous structure, which has small aerodynamic diameter, high spraying ability, and high productivity.

본 발명은 상기의 필요성을 감안하여 창출된 것으로서, 본 발명은 분무동결실의 내부에 분무노즐을 장착하고, 일측에 콜드트랩을 설치하여 원하는 입경의 분말형태의 유용물질을 건조, 추출하고, 동결건조부에 이송장치, 복사 가열장치 및 내부히터를 장착하며, 선택적으로 콜드트랩을 부착하여 효율적인 승화열 공급과 전 도열에 의한 완전 건조를 이루는 복합가열형 분무식 동결건조기를 제공하는데 목적이 있다.The present invention was created in view of the above necessity, the present invention is equipped with a spray nozzle inside the spray freezing chamber, by installing a cold trap on one side to dry, extract and freeze the useful material in the form of powder of a desired particle size The purpose of the present invention is to provide a combined heating type spray lyophilizer which is equipped with a transfer device, a radiant heating device and an internal heater, and optionally attaches a cold trap to provide efficient sublimation heat supply and complete drying by conduction heat.

이하 첨부된 도면을 참조하면서 본 발명에 따른 바람직한 실시예를 상세히 설명하기로 한다. Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

도 1은 본 발명에 따른 복합가열형 분무식 동결건조기를 나타낸 개략도로서, 이를 상세히 설명하면 아래와 같다.1 is a schematic view showing a composite heating spray freeze dryer according to the present invention, which will be described in detail below.

분무식 동결건조기에 있어서In the spray freeze dryer

시료용액을 저장하며, 공급하도록 마련된 시료공급부(20)와;A sample supply unit 20 for storing and supplying a sample solution;

상기 시료공급부(20)로부터 시료용액을 공급받고, 분무화시키도록 형성되며, 동결환경조건을 형성하도록 형성되며, 제조된 분말재료를 이송하도록 길이방향으로 형성된 이송컨베이어(2)의 내부에 내부히터(1)가 장착한 동결건조부(30)와;The sample solution is supplied to the sample solution from the sample supply unit 20, is formed to atomize, formed to form a freezing environmental conditions, the inner heater in the conveying conveyor (2) formed in the longitudinal direction to convey the manufactured powder material A freeze-drying unit 30 mounted with (1);

상기 동결건조부(30)내에 동결환경조건을 형성하도록 마련된 콜드트랩(4)에 냉동환경을 형성하도록 형성된 냉동부(40)와;A freezing unit 40 formed to form a freezing environment in the cold trap 4 provided to form a freezing environment condition in the freeze-drying unit 30;

상기 동결건조부(30)의 일측에 장착되어, 충진된 공기를 외부로 진공토출하여 진공환경을 조성하도록 형성된 진공부(50)와; A vacuum unit 50 mounted on one side of the freeze-drying unit 30 to form a vacuum environment by evacuating the filled air to the outside;

상기 동결건조부(30)로부터 제조된 분말화된 분말을 저장하도록 형성된 분말건조탱크(12);로 이루어진 것이다. Powder drying tank 12 formed to store the powdered powder produced from the freeze-drying unit 30;

이는 피 건조물이 1차 및 2차 건조되며, 이송하는 장치의 상측에 복사히터를 설치하며, 이송하는 장치의 내부에 내부히터를 장착하며, 분말 동결된 분말재료 가 복사열과 하단으로부터 전도열을 동시에 받으며, 건조효율이 증가되며, 재질이 우수한 분말제조가 이루어지도록 하는 것이다.It is the first and second dry items to be dried, the radiant heater is installed on the upper side of the conveying device, the inner heater is mounted inside the conveying device, and the powder frozen powder material receives radiant heat and conduction heat from the bottom at the same time. , The drying efficiency is increased, and the powder is made to be excellent material.

본 발명을 이루는 개개의 구성요소에 대한 상세한 실시예는 아래와 같다.Detailed embodiments of the individual components of the present invention are as follows.

상기 시료공급부(20)는 시료탱크(9)로부터 저장된 시료용액을 액체펌프(10)에 의하여 상기 동결건조부(30)의 분무동결실(5)내의 상단부에 위치한 분무노즐(6)에 의하여 하향분무하도록 하며, 상기 분무노즐은 필요한 피 건조물의 요구 입경에 따라 원하는 사양의 분무노즐을 선택하여 장착할 수 있는 것이다.The sample supply unit 20 downwards the sample solution stored from the sample tank 9 by the spray nozzle 6 located at the upper end of the spray freezing chamber 5 of the freeze-drying unit 30 by the liquid pump 10. In order to spray, the spray nozzle is to be equipped with a spray nozzle of the desired specification according to the required particle size of the dry material required.

상기 냉동부(40)에 연결된 콜드트랩(4)이 동결건조부(30)내부의 일측에 위치하도록; 이루어진 것이며, 더욱 구체적인 실시예로서는, 상기 콜드트랩(4)은 상기 동결건조부(30)의 분무동결실(5)내의 상단부에 위치한 분무노즐(6)의 인접부에 위치하여, 분무된 용액을 신속하게 동결하도록 하는 것이다. A cold trap 4 connected to the freezing unit 40 is located at one side of the freeze-drying unit 30; In a more specific embodiment, the cold trap 4 is located in the vicinity of the spray nozzle 6 located at the upper end of the spray freezing chamber 5 of the freeze-dried portion 30, to quickly spray the sprayed solution To freeze.

상기 콜드트랩(4)은 초저온 냉동기와 같은 저온용도의 냉동기를 사용하여 분무동결부(30)의 내부 냉동 온도는 -40℃ ∼ -80℃ 범위가 되도록 작동하여, 분무된 시료용액을 신속하게 동결하도록 하는 것이다.The cold trap 4 is operated by using a freezer for a low temperature, such as a cryogenic freezer, so that the internal freezing temperature of the spray freezing unit 30 is in the range of -40 ° C to -80 ° C, thereby rapidly freezing the sprayed sample solution. To do that.

상기 동결건조부(30)의 분무동결실(5)내에 위치한 이송컨베이어(2)의 길이방향으로 대향 이격되어 상측에 적외선 히터(3)가 설치되도록 이루어진 것이며, 건조를 위한 가열 시스템은 공정 온도 부근에서 0℃ 부근까지 조절 가능하여야 하는 것이 바람직하다.The infrared heater 3 is installed on the upper side of the freeze-drying unit 30 in the spray freezing chamber 5 of the freeze-drying unit 30 so as to be spaced apart from each other in the longitudinal direction, and the heating system for drying is near the process temperature. It should be possible to control the temperature to near 0 ° C.

상기 이송컨베이어(2)의 길이방향으로 대향 이격되어 하측에 콜드트랩(4)이 부가하도록 하는 것이며, 이는 이송컨베이어(2)에 의해 이송되는 과정에 하단으로 낙하된 일부의 분말재료의 수분입자를 건조하도록 하는 것이다. The cold trap 4 is added to the lower side to be spaced apart in the longitudinal direction of the conveying conveyor (2), which is a part of the water particles of the powder material dropped to the lower end in the process of conveying by the conveying conveyor (2) To dry.

상기 진공부(50)의 진공펌프(7)에 의하여 외부로 공기를 토출하되; 중간 일측에 수증기용 포집실(8)을 부착하여 공기에 포함된 수분을 제거하여 진공펌프(7)의 내부에 수분이 흡입되지 않도록; 이루어진 것이며, 이는 진공펌프(7)내에 수분이 흡수되면, 진공펌프의 작동이 원활하지 못하거나, 수명이 단축되는 것이다. Discharging air to the outside by the vacuum pump 7 of the vacuum unit 50; Attaching the steam collection chamber 8 to the middle one to remove moisture contained in the air so that moisture is not sucked into the vacuum pump 7; If moisture is absorbed in the vacuum pump 7, the operation of the vacuum pump is not smooth or the life is shortened.

상기 진공펌프(7)에 의하여 진공상태를 유지하는 분무동결실(5)내부의 진공도는 통상 4.7Torr이하의 조건에서 운전되어야 필요로 하는 냉동온도를 조성하는 것이다.The degree of vacuum in the spray freezing chamber 5 which maintains the vacuum state by the vacuum pump 7 is to create a freezing temperature which is normally required to be operated under the condition of 4.7 Torr or less.

종래의 동결건조기는 예비동결과 건조 분쇄과정을 거치며, 별도의 예비동결과정과, 별도의 분쇄과정이 필요하나, 상술한 바와 같이 본 발명의 호흡식 분말의약품용 분무식 동결건조기는 액체 상태의 원료를 진공 챔버내에 분무시킴으로써 동결된 미립자로 형성되어지며, 동결된 미립자는 이송 컨베이어에 의해 이동되면서 상측에 위치한 적외선 가열기를 통해 적정한 승화열을 공급받으며, 이송 컨베이어의내부에 장착된 내부히터에 의한 전도열에 의하여, 건조 완료까지의 과정이 신속하게 이루어지며, 분쇄 과정이 필요 없는 분말 상태로 건조 완료된 분말은 진공 상태의 용기에 저장되며, 분말 형태로 예비동결과 건조가 동시에 이루어지게 되고, 건조효율도 증가하며, 관성 추종성이 낮고, 살포성이 높으며, 공기동력학적인 입경이 작은 매우 우수한 건조물이 생성되며, 수증기 응축 포집장치를 동결건조실과 건조실내에 설치하여 예비동결과정과 건조가 동시에 이루어지며, 분쇄과정이 전혀 필 요 없는 동결건조장치를 제공하고자 하는 것이다. Conventional lyophilizer undergoes preliminary synchronism and dry grinding process, but requires a separate preliminary synchronism and a separate grinding process, as described above, the spray freeze dryer for respiratory powder medicine of the present invention is a liquid raw material Is formed into frozen particulates by spraying them in a vacuum chamber, and the frozen particulates are moved by the conveying conveyor to receive an appropriate sublimation heat through the infrared heater located on the upper side, and to the conduction heat by the internal heater mounted inside the conveying conveyor. As a result, the process to complete the drying is performed quickly, and the powder which is dried in a powder state that does not require a pulverization process is stored in a container in a vacuum state. Very low inertia followability, high spreadability, small aerodynamic particle size And dried product is created, composed of the condensation collecting device is pre-freezing process to install the freeze drying chamber and the drying room and drying at the same time, it is to provide a freeze-drying apparatus without the grinding process, not at all necessary.

Claims (7)

분무식 동결건조기에 있어서In the spray freeze dryer 시료용액을 저장하며, 공급하도록 마련된 시료공급부(20)와;A sample supply unit 20 for storing and supplying a sample solution; 상기 시료공급부(20)로부터 시료용액을 공급받고, 분무화시키도록 형성되며, 동결환경조건을 형성하도록 형성되며, 제조된 분말재료를 이송하도록 길이방향으로 형성된 이송컨베이어(2)의 내부에 내부히터(1)가 장착한 동결건조부(30)와;The sample solution is supplied to the sample solution from the sample supply unit 20, is formed to atomize, formed to form a freezing environmental conditions, the inner heater in the conveying conveyor (2) formed in the longitudinal direction to convey the manufactured powder material A freeze-drying unit 30 mounted with (1); 동결건조부(30)내부의 일측에 위치되어 상기 동결건조부(30)내에 동결환경조건을 형성하도록 상기 동결건조부(30)의 분무동결실(5)내의 상단부에 위치한 분무노즐(6)의 인접부에 위치하여, 분무된 용액을 신속하게 동결하도록 마련된 콜드트랩(4)에 냉동환경을 형성하도록 형성된 냉동부(40)와;The spray nozzle (6) is located on one side of the freeze-drying unit (30) and located at the upper end of the spray freezing chamber (5) of the freeze-drying unit (30) to form a freeze environmental condition in the freeze-drying unit (30). A freezing section 40 positioned adjacent to and formed to form a freezing environment in a cold trap 4 provided to quickly freeze the sprayed solution; 상기 동결건조부(30)의 일측에 장착되어, 충진된 공기를 외부로 진공토출하여 진공환경을 조성하도록 형성된 진공부(50)와; A vacuum unit 50 mounted on one side of the freeze-drying unit 30 to form a vacuum environment by evacuating the filled air to the outside; 상기 동결건조부(30)로부터 제조된 분말화된 분말을 저장하도록 형성된 분말건조탱크(12);로 이루어진 것을 특징으로 하는 복합가열형 분무식 동결건조기.And a powder drying tank (12) formed to store the powdered powder produced from the freeze drying unit (30). 제1항에 있어서,The method of claim 1, 상기 시료공급부(20)는 시료탱크(9)로부터 저장된 시료용액을 액체펌프(10)에 의하여 상기 동결건조부(30)의 분무동결실(5)내의 상단부에 위치한 분무노즐(6)에 의하여 하향분무하도록; 이루어진 것을 특징으로 하는 복합가열형 분무식 동결건조기.The sample supply unit 20 downwards the sample solution stored from the sample tank 9 by the spray nozzle 6 located at the upper end of the spray freezing chamber 5 of the freeze-drying unit 30 by the liquid pump 10. To spray; Composite heating spray lyophilizer, characterized in that made. 제1항에 있어서,The method of claim 1, 상기 동결건조부(30)의 분무동결실(5)내에 위치한 이송컨베이어(2)의 길이방향으로 대향 이격되어 상측에 적외선 히터(3)가 설치되도록; 이루어진 것을 특징으로 하는 복합가열형 분무식 동결건조기.The infrared heater 3 is installed above and spaced apart from each other in the longitudinal direction of the transfer conveyor 2 located in the spray freezing chamber 5 of the freeze-drying unit 30; Composite heating spray lyophilizer, characterized in that made. 제3항에 있어서,The method of claim 3, 상기 이송컨베이어(2)의 길이방향으로 대향 이격되어 하측에 콜드트랩(4)이 부가하도록; 이루어진 것을 특징으로 하는 복합가열형 분무식 동결건조기.A cold trap 4 is added below and spaced apart from each other in the longitudinal direction of the conveying conveyor 2; Composite heating spray lyophilizer, characterized in that made. 제1항에 있어서, The method of claim 1, 상기 진공부(50)의 진공펌프(7)에 의하여 외부로 공기를 토출하되; 중간 일측에 수증기용 포집실(8)을 부착하여 공기에 포함된 수분을 제거하여 진공펌프(7)의 내부에 수분이 흡입되지 않도록; 이루어진 것을 특징으로 하는 복합가열형 분무식 동결건조기.Discharging air to the outside by the vacuum pump 7 of the vacuum unit 50; Attaching the steam collection chamber 8 to the middle one to remove moisture contained in the air so that moisture is not sucked into the vacuum pump 7; Composite heating spray lyophilizer, characterized in that made. 삭제delete 삭제delete
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101003562B1 (en) * 2008-08-11 2010-12-30 김종회 Powder manufacturing apparatus and method for manufacturing powder using the same
KR200456042Y1 (en) 2010-03-26 2011-10-10 (주)백웅 Equipment for freezer
KR101536184B1 (en) * 2013-12-30 2015-07-13 한국기계연구원 Spray freezing drier for uniform drying performance
KR20160090208A (en) 2015-01-21 2016-07-29 주식회사 일신바이오베이스 Freeze dryer
KR20200086313A (en) * 2017-11-09 2020-07-16 비엘에이치 이콜로지 컨셉츠, 엘엘씨 Nanoparticle manufacturing process

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105253A1 (en) 2004-05-01 2005-11-10 Agresearch Limited Drying process and apparatus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105253A1 (en) 2004-05-01 2005-11-10 Agresearch Limited Drying process and apparatus

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101003562B1 (en) * 2008-08-11 2010-12-30 김종회 Powder manufacturing apparatus and method for manufacturing powder using the same
KR200456042Y1 (en) 2010-03-26 2011-10-10 (주)백웅 Equipment for freezer
KR101536184B1 (en) * 2013-12-30 2015-07-13 한국기계연구원 Spray freezing drier for uniform drying performance
KR20160090208A (en) 2015-01-21 2016-07-29 주식회사 일신바이오베이스 Freeze dryer
KR20200086313A (en) * 2017-11-09 2020-07-16 비엘에이치 이콜로지 컨셉츠, 엘엘씨 Nanoparticle manufacturing process
CN111447991A (en) * 2017-11-09 2020-07-24 Blh生态概念有限责任公司 Method for producing nanoparticles
US11298668B2 (en) * 2017-11-09 2022-04-12 Blh Ecology Concepts, Llc Process to produce nanoparticles
CN111447991B (en) * 2017-11-09 2022-07-26 Blh生态概念有限责任公司 Method for producing nanoparticles
KR102623216B1 (en) * 2017-11-09 2024-01-10 비엘에이치 이콜로지 컨셉츠, 엘엘씨 Nanoparticle manufacturing process

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