JP3604699B2 - 多外傷後の多発性臓器不全の防止のための及び体外血液循環後の急性臓器損傷の防止のための抗−セレクチン抗体 - Google Patents
多外傷後の多発性臓器不全の防止のための及び体外血液循環後の急性臓器損傷の防止のための抗−セレクチン抗体 Download PDFInfo
- Publication number
- JP3604699B2 JP3604699B2 JP50943897A JP50943897A JP3604699B2 JP 3604699 B2 JP3604699 B2 JP 3604699B2 JP 50943897 A JP50943897 A JP 50943897A JP 50943897 A JP50943897 A JP 50943897A JP 3604699 B2 JP3604699 B2 JP 3604699B2
- Authority
- JP
- Japan
- Prior art keywords
- selectin
- antibody
- antibodies
- dose
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000004221 Multiple Trauma Diseases 0.000 title claims description 19
- 208000010718 Multiple Organ Failure Diseases 0.000 title claims description 14
- 208000034486 Multi-organ failure Diseases 0.000 title claims description 13
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 title claims description 13
- 230000008816 organ damage Effects 0.000 title description 17
- 230000001154 acute effect Effects 0.000 title description 12
- 230000002265 prevention Effects 0.000 title description 7
- 230000017531 blood circulation Effects 0.000 title description 4
- 210000002966 serum Anatomy 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 206010053159 Organ failure Diseases 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 description 37
- 239000008280 blood Substances 0.000 description 37
- 108010092694 L-Selectin Proteins 0.000 description 31
- 102000016551 L-selectin Human genes 0.000 description 30
- 241001465754 Metazoa Species 0.000 description 26
- 210000000265 leukocyte Anatomy 0.000 description 21
- 238000000034 method Methods 0.000 description 21
- 230000027455 binding Effects 0.000 description 16
- 210000004072 lung Anatomy 0.000 description 16
- 102000003800 Selectins Human genes 0.000 description 14
- 108090000184 Selectins Proteins 0.000 description 14
- 108060003951 Immunoglobulin Proteins 0.000 description 12
- 230000004087 circulation Effects 0.000 description 12
- 102000018358 immunoglobulin Human genes 0.000 description 12
- 208000014674 injury Diseases 0.000 description 12
- 238000011282 treatment Methods 0.000 description 11
- 241000282520 Papio Species 0.000 description 10
- 230000008733 trauma Effects 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 9
- 210000002216 heart Anatomy 0.000 description 9
- 210000000440 neutrophil Anatomy 0.000 description 9
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 230000002612 cardiopulmonary effect Effects 0.000 description 8
- 230000035939 shock Effects 0.000 description 8
- 108010024212 E-Selectin Proteins 0.000 description 7
- 102100023471 E-selectin Human genes 0.000 description 7
- 208000032843 Hemorrhage Diseases 0.000 description 7
- 150000001413 amino acids Chemical group 0.000 description 7
- 238000010171 animal model Methods 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 229920001184 polypeptide Polymers 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 208000032456 Hemorrhagic Shock Diseases 0.000 description 6
- 206010049771 Shock haemorrhagic Diseases 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 239000000902 placebo Substances 0.000 description 6
- 229940068196 placebo Drugs 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 206010002091 Anaesthesia Diseases 0.000 description 5
- 108010035766 P-Selectin Proteins 0.000 description 5
- 102100023472 P-selectin Human genes 0.000 description 5
- 230000037005 anaesthesia Effects 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 230000004872 arterial blood pressure Effects 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 230000002526 effect on cardiovascular system Effects 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 229940072221 immunoglobulins Drugs 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 210000000709 aorta Anatomy 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 210000001147 pulmonary artery Anatomy 0.000 description 4
- 230000036387 respiratory rate Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 208000004852 Lung Injury Diseases 0.000 description 3
- 241001529936 Murinae Species 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 206010069363 Traumatic lung injury Diseases 0.000 description 3
- 206010044541 Traumatic shock Diseases 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 231100000515 lung injury Toxicity 0.000 description 3
- 230000009325 pulmonary function Effects 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 101100399480 Caenorhabditis elegans lmn-1 gene Proteins 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010021137 Hypovolaemia Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 2
- 241001504519 Papio ursinus Species 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 101710181904 Venom factor Proteins 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 238000009530 blood pressure measurement Methods 0.000 description 2
- 210000002302 brachial artery Anatomy 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 210000003191 femoral vein Anatomy 0.000 description 2
- 230000000893 fibroproliferative effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000004868 gas analysis Methods 0.000 description 2
- 210000003709 heart valve Anatomy 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 102000006495 integrins Human genes 0.000 description 2
- 108010044426 integrins Proteins 0.000 description 2
- 229960003299 ketamine Drugs 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000004768 organ dysfunction Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 229960001412 pentobarbital Drugs 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000004088 pulmonary circulation Effects 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000010410 reperfusion Effects 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 239000003998 snake venom Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 206010003591 Ataxia Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000003930 C-Type Lectins Human genes 0.000 description 1
- 108090000342 C-Type Lectins Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010051093 Cardiopulmonary failure Diseases 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101100066651 Escherichia phage K1E GP90 gene Proteins 0.000 description 1
- 238000000729 Fisher's exact test Methods 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- -1 HuDreg 55 Chemical compound 0.000 description 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000010836 Lymphocyte Homing Receptors Human genes 0.000 description 1
- 208000023637 Multiple injury Diseases 0.000 description 1
- 238000011887 Necropsy Methods 0.000 description 1
- 241000156302 Porcine hemagglutinating encephalomyelitis virus Species 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000002637 fluid replacement therapy Methods 0.000 description 1
- 230000010005 growth-factor like effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 description 1
- 206010024378 leukocytosis Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000001325 log-rank test Methods 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000010503 organ complication Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 210000004896 polypeptide structure Anatomy 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 210000000264 venule Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95112895 | 1995-08-17 | ||
| EP95114696 | 1995-09-19 | ||
| US57895395A | 1995-12-27 | 1995-12-27 | |
| US08/578,953 | 1995-12-27 | ||
| US95114696.8 | 1995-12-27 | ||
| US95112895.8 | 1995-12-27 | ||
| PCT/US1996/013152 WO1997006822A1 (en) | 1995-08-17 | 1996-08-14 | Anti-selectin antibodies for prevention of multiple organ failure and acute organ damage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10510553A JPH10510553A (ja) | 1998-10-13 |
| JP3604699B2 true JP3604699B2 (ja) | 2004-12-22 |
Family
ID=27236574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50943897A Expired - Fee Related JP3604699B2 (ja) | 1995-08-17 | 1996-08-14 | 多外傷後の多発性臓器不全の防止のための及び体外血液循環後の急性臓器損傷の防止のための抗−セレクチン抗体 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0868197B1 (enExample) |
| JP (1) | JP3604699B2 (enExample) |
| AT (1) | ATE265861T1 (enExample) |
| AU (1) | AU6773596A (enExample) |
| CA (1) | CA2229140A1 (enExample) |
| CZ (1) | CZ45498A3 (enExample) |
| DE (1) | DE69632407T2 (enExample) |
| HU (1) | HUP9901673A3 (enExample) |
| PL (1) | PL187090B1 (enExample) |
| WO (1) | WO1997006822A1 (enExample) |
| ZA (1) | ZA966954B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| US6172213B1 (en) | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| GB9919713D0 (en) * | 1999-08-19 | 1999-10-20 | Queen Mary & Westfield College | New medical use of high density lipoprotein |
| EP2336185A1 (en) | 2002-03-13 | 2011-06-22 | Biogen Idec Inc. | Anti- alpha v beta 6 antibodies |
| CN102875681A (zh) * | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| JP2009542810A (ja) | 2006-07-10 | 2009-12-03 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Ｓｍａｄ４欠損癌の増殖を阻害するための組成物および方法 |
| US10035859B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
| WO2014143739A2 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| CN116726362A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993000111A1 (en) * | 1991-06-25 | 1993-01-07 | Dana-Farber Cancer Institute | Monoclonal antibody to lymphocyte-associated cell surface protein |
| AU2410292A (en) * | 1991-07-29 | 1993-03-02 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies to leukocyte adhesion molecule-1 |
| JPH08503617A (ja) * | 1992-12-01 | 1996-04-23 | プロテイン デザイン ラブズ、インコーポレーテッド | Ｌ−セレクチンに反応性のヒト化抗体 |
| AU2185195A (en) * | 1993-11-30 | 1995-06-19 | Protein Design Labs, Inc. | Reperfusion therapy using antibodies to L-selectin |
-
1996
- 1996-08-14 HU HU9901673A patent/HUP9901673A3/hu unknown
- 1996-08-14 AU AU67735/96A patent/AU6773596A/en not_active Abandoned
- 1996-08-14 AT AT96928160T patent/ATE265861T1/de not_active IP Right Cessation
- 1996-08-14 JP JP50943897A patent/JP3604699B2/ja not_active Expired - Fee Related
- 1996-08-14 PL PL96325012A patent/PL187090B1/pl not_active IP Right Cessation
- 1996-08-14 CZ CZ98454A patent/CZ45498A3/cs unknown
- 1996-08-14 DE DE69632407T patent/DE69632407T2/de not_active Expired - Fee Related
- 1996-08-14 CA CA002229140A patent/CA2229140A1/en not_active Abandoned
- 1996-08-14 EP EP96928160A patent/EP0868197B1/en not_active Expired - Lifetime
- 1996-08-14 WO PCT/US1996/013152 patent/WO1997006822A1/en not_active Ceased
- 1996-08-16 ZA ZA9606954A patent/ZA966954B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10510553A (ja) | 1998-10-13 |
| PL187090B1 (pl) | 2004-05-31 |
| EP0868197A1 (en) | 1998-10-07 |
| AU6773596A (en) | 1997-03-12 |
| DE69632407T2 (de) | 2005-06-02 |
| ZA966954B (en) | 1998-02-16 |
| CA2229140A1 (en) | 1997-02-27 |
| EP0868197B1 (en) | 2004-05-06 |
| WO1997006822A1 (en) | 1997-02-27 |
| DE69632407D1 (de) | 2004-06-09 |
| EP0868197A4 (enExample) | 1998-11-18 |
| PL325012A1 (en) | 1998-07-06 |
| HUP9901673A2 (hu) | 1999-08-30 |
| CZ45498A3 (cs) | 1999-01-13 |
| ATE265861T1 (de) | 2004-05-15 |
| HUP9901673A3 (en) | 2001-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2565215C (en) | Method and system to remove soluble tnfr1, tnfr2, and il2 in patients | |
| Kroshus et al. | Complement inhibition with an anti-C5 monoclonal antibody prevents acute cardiac tissue injury in an ex vivo model of pig-to-human xenotransplantation. | |
| JP3604699B2 (ja) | 多外傷後の多発性臓器不全の防止のための及び体外血液循環後の急性臓器損傷の防止のための抗−セレクチン抗体 | |
| US6866845B1 (en) | Compositions and methods for the treatment of sepsis | |
| JP2002504831A (ja) | 自己抗体の除去による心筋症の処置 | |
| JPS62502616A (ja) | 成入呼吸困難症の処置 | |
| US6994970B1 (en) | Peptides for combating the autoantibodies that are responsible for dilatative cardiomyopathy (DCM) | |
| US20200362041A1 (en) | Anti-flt-1 antibodies in treating bronchopulmonary dysplasia | |
| CZ20011272A3 (cs) | Použití činidla, které blokuje vazbu lymfotoxinu-beta na jeho receptor, pro výrobu protivirového léku | |
| TW202143996A (zh) | 使用可溶性ｃｄ２４治療病毒性肺炎之方法 | |
| EP2143436B1 (en) | Cd6 product for treatment of infectious diseases and related inflammatory processes | |
| AU746888B2 (en) | Anti-selectin antibodies for prevention of multiple organ failure and acute organ damage | |
| TW520289B (en) | Anti-selectin antibodies for prevention of multiple organ failure after polytrauma and for prevention of acute organ damage after extracorporeal blood circulation | |
| US20020098183A1 (en) | Anti-selectin antibodies for prevention of multiple organ failure after polytrauma and for prevention of acute organ damage after extracorporeal blood circulation | |
| US5843441A (en) | Use of endothelial-leukocyte adhesion molecule-1 specific antibodies in the treatment of asthma | |
| AU3088501A (en) | Use of emap ii receptor antagonist composition for treating pulmonary hypertension | |
| US20130089551A1 (en) | Treatment of pulmonary edema | |
| JPH09512252A (ja) | 呼吸性ウイルス感染の処置における細胞間接着分子／受容体相互作用を遮断する薬剤の使用 | |
| Wang et al. | Experience with ABO-incompatible kidney transplantation | |
| JPWO2021211418A5 (enExample) | ||
| GRAVIS | Intravenous immunoglobulin in the management of myasthenia gravis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040714 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20040930 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |