JP3595445B2 - Reagent processing equipment - Google Patents

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a reagent processing apparatus, and more particularly, to an apparatus for processing a biological tissue sample using a small amount of a reagent.
[0002]
[Prior art]
Various proposals have been made as treatment apparatuses for biological tissues. Some reagents require a very small amount of treatment, and particularly in the case of expensive reagents, there is a strong demand to reduce the amount used in the reagent treatment as much as possible. Accordingly, the applicant of the present application has proposed a reagent processing apparatus in Japanese Patent Application Laid-Open No. 9-281017. The reagent processing apparatus brings a reagent supply plate provided with a reagent tank and a reagent discharge port communicating with the reagent tank close to (or in contact with) a slide glass (sample plate), and utilizes a surface tension or a capillary phenomenon to make a connection between the two. A small amount of reagent is developed and introduced into the gap. The sample on the slide glass is treated with the reagent. In such an apparatus, a mechanism for moving the reagent supply plate close to or away from the slide glass is required.
[0003]
[Problems to be solved by the invention]
However, when the above-described mechanism is driven by using a motor as a main drive source, there arises a problem that control becomes complicated or the mechanism becomes complicated. If such a mechanism becomes contaminated, it is necessary to clean it. However, if the mechanism is complicated, the labor for disassembling and cleaning the mechanism increases. Further, unless the reagent supply plate is moved forward / backward in a reliable manner in association with the elevation of the slide glass, there is a problem in that the sample attached to the slide glass is damaged.
[0004]
The present invention has been made in view of the above-mentioned conventional problems, and an object of the present invention is to provide a reagent processing apparatus capable of reliably and easily moving a reagent supply plate forward and backward in conjunction with a vertical movement of a sample plate. It is in.
[0005]
[Means for Solving the Problems]
In order to achieve the above object, the present invention provides an elevating mechanism for elevating and lowering at least one sample plate to which a sample is attached, at least a reagent tank into which a reagent is injected, and a discharge port communicating therewith. One reagent supply plate and the reagent supply plate are supplied with the ejection hole forming surface of the reagent supply plate close to the sample attachment surface of the sample plate when the sample plate is lowered, and the sample plate is lifted when the sample plate is raised. Means for stopping the reagent supply by separating the ejection hole forming surface of the reagent supply plate from the sample attachment surface, and causing the reagent supply plate to move using magnetic force in conjunction with the elevation of the sample plate. And a magnetic mechanism.
[0006]
According to the above configuration, for example, when the sample plate on which the flaky sample is attached is lowered, the reagent supply plate is positioned such that the ejection hole forming surface approaches (including bonding) the sample attachment surface. . At this time, the reagent supply plate is moved (including a horizontal movement) while utilizing the magnetic force by the magnetic mechanism. The discharge hole communicating with the reagent tank is desirably a minute opening, and in a normal state, the reagent is prevented from flowing out to the outside due to the surface tension of the reagent. When the ejection hole forming surface is brought close to the sample attachment surface to form, for example, a minute gap, the reagent flows out of the ejection hole between the plates and the reagent spreads between the plates, similarly to the capillary phenomenon. That is, the sample is immersed in the reagent. After the reagent treatment, when the reagent supply plate is separated from the sample plate, the outflow of the reagent is prevented at the ejection holes by, for example, the effect of surface tension.
[0007]
As described above, using the magnetic action, the reagent supply plate can be moved toward and away from the sample supply plate in conjunction with the vertical movement of the sample plate. The magnetic mechanism preferably includes a permanent magnet, and is preferably driven using magnetic force in both the vertical and horizontal directions with respect to the reagent supply plate. For example, a magnetic elastic biasing force can be obtained by using a solenoid, but using a permanent magnet has the advantage that a power supply and the like are unnecessary and the configuration can be simplified.
[0008]
In the reagent supply plate and its surrounding mechanism, a portion that does not exert a magnetic effect is desirably made of a non-magnetic material. In addition, it is desirable to form a minute projection functioning as a spacer on the reagent supply plate to protect the sample on the sample plate.
[0009]
In order to achieve the above object, the present invention provides a lifting mechanism for lifting and lowering at least one sample plate on which a sample is attached, a reagent tank into which a reagent is injected, and a sample plate insertion communicating therewith. A movable unit comprising: at least one reagent supply plate having a discharge hole facing a space; and a guide mechanism for moving the reagent supply plate toward and away from the sample plate inserted into the sample plate insertion space. And a unit storage tank in which the movable unit is stored, fixed magnetic means provided in the unit storage tank, and movable magnetic means provided in the reagent supply plate, and a downward movement of the sample plate The movable unit is lowered, and at this time, by the magnetic interaction of the fixed magnetic means and the movable magnetic means, The reagent supply plate is driven close to the sample plate, and the movable unit is raised by the upward movement of the sample plate. At this time, the reagent plate is moved by the magnetic interaction between the fixed magnetic unit and the movable magnetic unit. It is characterized by being driven to be detached from the sample plate.
[0010]
According to the above configuration, the reagent supply plate can be driven by utilizing the magnetic interaction between the movable magnetic means provided on the reagent supply plate and the fixed magnetic means provided on the unit storage tank. A sample plate insertion space is formed in the movable unit, and when the sample plate is inserted into the insertion space, the reagent supply plate descends following the downward movement of the sample plate. In the process, both plates come close to or join. If the sample plate is lifted after the completion of the reagent processing, the reagent supply plate is also moved up to the origin position following the lift. In the process, the reagent supply plate is horizontally separated from the sample plate.
[0011]
In a preferred aspect of the present invention, the movable unit is floated and held in the unit storage tank in a non-inserted state of the sample plate by a magnetic interaction between the fixed magnetic unit and the movable magnetic unit. If the movable unit is magnetically levitated, it is possible to reduce the collision of the lower end when the sample plate is inserted, and to prevent problems such as breakage of both members.
[0012]
In a preferred aspect of the present invention, the fixed magnetic means and the possible magnetic means exert a magnetic horizontal suction action mutually in a state where the movable unit is at an upper position in the unit insertion tank, When the movable unit is located at a lower position in the unit insertion tank, the movable units are arranged with a magnetic pole pattern that exerts a magnetic horizontal repulsion action.
[0013]
The fixed magnetic means and the movable magnetic means function as means for generating a biasing force in the vertical direction with respect to the movable unit, and also as positioning biasing means for the reagent supply plate in the horizontal direction. By appropriately setting the magnetic pole patterns, the reagent supply plate can be positioned at a desired position in conjunction with the elevating movement of the sample plate.
[0014]
In a preferred aspect of the present invention, the movable magnetic means is embedded in the reagent supply plate. Preferably, the movable magnetic means is provided on a member that is detachable from the main body of the reagent supply plate. If the movable magnetic means is configured to be detachable, the movable magnetic means can be reused even when the main body of the reagent supply plate is discarded, and the reagent processing cost can be reduced.
[0015]
In a preferred aspect of the present invention, the elevating mechanism holds a sample plate pair in which surfaces opposite to the sample attachment surface are joined to each other, and the movable unit includes both sides of an insertion space into which the sample plate pair is inserted. Has a pair of reagent supply plates.
[0016]
By controlling the pair of back-to-back sample plates by a magnetic mechanism, it is possible to solve the problem that an excessive load in the horizontal direction is applied to the sample plate, particularly by balancing the driving force in the horizontal direction.
[0017]
In a preferred aspect of the present invention, when vertically pulling up the sample plate from the proximity of the sample plate and the reagent supply plate, the reagent supply plate joined thereto is separated obliquely. According to this configuration, when the sample plate is pulled up after the reagent processing, breakage or detachment of the sample can be effectively prevented.
[0018]
In a preferred aspect of the present invention, the fixed magnetic unit and the movable magnetic unit have a magnetic pole pattern that changes a magnetic interaction in a vertical direction according to a height of the movable unit. When the movable unit is at the highest position, a magnetic levitation force is exerted on the movable unit to stably maintain the balance with its own gravity, and the magnetic levitation force is weakened when the movable unit descends from that position. If, for example, the magnetic levitation force becomes weak at the lowermost position of the movable unit, the driving force for pushing the sample plate downward can be reduced. Further, if the magnetic levitation force becomes zero at the lowest position, it is basically unnecessary to suspend the sample plate during the reagent processing. Further, if a downward pulling force is applied to the movable unit by magnetic action at the lowermost position, the movable unit at the lowermost position is coupled with the support of the bottom surface (or pedestal) of the unit storage tank. Stable holding can be achieved. In that case, an initial lifting action of lifting the movable unit upward together with the lifting of the sample plate after the reagent processing is required.
[0019]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, a preferred embodiment of the present invention will be described with reference to the drawings.
[0020]
FIG. 1 shows a preferred embodiment of a reagent processing apparatus according to the present invention, and FIG. 1 is a cross-sectional view showing a configuration of a main part thereof.
[0021]
A flaky sample S is attached to the slide glass 10. The sample S is, for example, a biological tissue sample. In the present embodiment, two slide glasses 10 are joined to each other back to back, thereby forming a slide glass pair 12. The slide glass pair 12 is transported by the holder 14. The holder 14 is held by a transport mechanism (not shown), and can freely transport the slide glass pair 12 up, down, left, and right. Incidentally, the transport mechanism supports a plurality of holders 14 and can simultaneously execute a plurality of reagent processes in units of the slide glass pair 12 as shown in FIG. In the present embodiment, the slide glass pair 12 is held by the holder 14. However, the present invention is of course applicable to the case where the reagent processing is performed on the sample S on one slide glass.
[0022]
The holder 14 has a holding plate 16 for holding an upper end portion 12A of the slide glass pair 12 and a pressing roller 18. The pressing roller 18 is rotatably supported by a leaf spring 20 provided on the holder body. That is, the upper end portion 12A of the slide glass pair 12 is held by pressing the pressing roller 18 against the holding plate 16 side. Here, since the pressing roller 18 is configured to be rotatable, it is possible to smoothly insert the upper end portion 12A of the slide glass pair 12 into a slit between the pressing roller 18 and the holding plate 16. As described above, the slide glass pair 12 is suspended and held by the holder 14. When the reagent processing is performed, the slide glass pair 12 is positioned above the movable unit 22 described in detail below, and from this state, the slide glass pair 12 is pulled down and the slide glass pair is placed inside the movable unit 22. The reagent processing is executed by inserting the “12”.
[0023]
The two movable units 22 are levitated and held in a unit storage tank 26 by a magnetic mechanism 24 described later. Incidentally, FIG. 1 shows a state in which the movable unit 22 is held at the highest position.
[0024]
Each movable unit 22 is roughly composed of two reagent supply plates 28 and a frame 31 that supports the reagent supply plates 28 movably in the horizontal direction. The reagent supply plate 28 has a reagent tank 30 into which a reagent is injected. Using the upper opening 30A of the reagent layer 30, a reagent is injected by a dispensing mechanism (not shown). A discharge hole 32 is formed at the lower end of the reagent tank 30. Specifically, the discharge holes 32 are minute holes communicating with the reagent tank 30, and both of the two reagent supply plates 28 are provided with the discharge holes 32 facing the sample attachment surface of the slide glass 10. I have. That is, the ejection holes 32 are formed inside the reagent supply plate 28.
[0025]
The discharge hole 32 is a minute hole having a diameter of, for example, about 1 mm. In a state where the reagent supply plate 28 is close to or not joined to the slide glass 10, the reagent is prevented from flowing out from the discharge hole 32 due to the surface tension of the reagent. I have. On the other hand, when the reagent supply plate 28 approaches or comes into contact with the slide glass 10, a minute gap is formed between the two, and the reagent flows out of the discharge hole 32 by a so-called capillary phenomenon, and the reagent spreads between those plates. Thus, the reagent is supplied to the sample S. Here, the discharge hole 32 is desirably provided at the center of the reagent supply plate 28 or slightly above it, and may be provided at a position facing the sample S. The sample S has a thickness of, for example, 10 μm, and does not hinder the formation of the minute gap described above. The diameter or the like of the ejection hole 32 may be appropriately set based on the relationship between the viscosity and the surface tension of the reagent. If the vicinity of the outlet of the discharge hole 32 protrudes slightly outward, the reagent can be more smoothly flowed out.
[0026]
As described above, the frame 31 is a means for holding the pair of reagent supply plates 28 so as to be movable in the horizontal direction. The frame body 31 is roughly composed of a base 34, a pair of upright plates 36 standing from both ends thereof, and arms 38 provided at upper and lower ends thereof, respectively. Each arm 38 is formed with a slide guide 40 as a groove extending in the horizontal direction, and a slide pin 42 formed on the side surface of the reagent supply plate 28 is movable in the slide guide 40 in the horizontal direction. That is, each reagent supply plate 28 has a slide pin 42 protrudingly formed at the center and the lower end on the side of the reagent supply plate 28. Is held.
[0027]
The interval between the two upright plates 36 is set to be equal to or slightly larger than the width of the slide glass 10, the width in the Y direction (perpendicular to the paper surface) in the figure. The same applies to the width of the reagent supply plate 28 in the Y direction. The inner surface (proximal surface) 28B of the reagent supply plate 28 is formed to have a size that covers at least the entire sample S when the slide glass pair 12 is inserted into the insertion space 44 of the movable unit 22. When the slide glass pair 12 is inserted into the insertion space 44, the lower end portion 12B of the slide glass pair 12 comes into contact with the base 34, and when the slide glass pair 12 is further pulled down, the movable unit 22 is pulled down. Will be.
[0028]
As shown in FIG. 1, the movable unit 22 is magnetically held by a magnetic mechanism 24 in a unit storage tank 26. Here, in the present embodiment, the magnetic mechanism 24 includes a movable MG (magnet) row 46 formed on an outer surface (non-ejection hole forming surface) 28C of each reagent supply plate 28 and the outer surface of the unit storage tank 26. And a fixed MG row 48 provided on the inner side surface 26A opposed to 28C. In the example shown in the figure, the movable MG row 46 is configured with four permanent magnets arranged in the vertical direction, while the fixed MG row 48 is configured with four permanent magnets arranged in the vertical direction. Other configurations may be adopted as long as a vertical magnetic action and a horizontal magnetic action described later can be obtained.
[0029]
Here, the magnetic pole pattern in the magnetic mechanism 24 will be described. In the movable MG row 46, the magnetic poles of the permanent magnets are set so as to be alternated from above to below. This is the same in the fixed MG row 48, and the magnetic poles of the permanent magnets are set so as to be alternated from above to below. The magnetic poles are set such that the permanent magnets face each other and magnetically repel when the movable unit 22 is pulled down to the lowermost position. That is, both the movable MG row 46 and the fixed MG row 48 have four permanent magnets, and the magnetic pole patterns from above to below are reversed from each other.
[0030]
Therefore, as shown in FIG. 1, when the movable unit 22 is at the highest position, the movable MG row 46 and the fixed MG row 48 exert a suction action mutually in the horizontal direction, while the movable unit 22 is in the lowermost position. In this state, the movable MG row 46 and the fixed MG row 48 exert a repulsive action on each other. As a result, each reagent supply plate 28 is magnetically driven toward the insertion space 44 as the movable unit 22 is pulled down. In addition, when attention is paid to the magnetic action of the magnetic mechanism 24 in the vertical direction, when the movable unit 22 is at the highest position, the movable MG row 46 and the fixed MG row 48 attract each other, and the movable unit 22 The levitation is maintained, and a stable state is established. That is, the magnetic floating action and the load action of the movable unit 22 are balanced, so that the movable unit 22 is held in the floating state. On the other hand, when the movable unit 22 is pulled down, the magnetic levitation force in the upward direction is weakened, and the movable unit 22 reaches the lowermost position, and each permanent magnet of the movable MG array 46 and the fixed MG array 48 When the respective permanent magnets face each other, the magnetic levitation action becomes minimal. As will be described later, whether the magnetic action in the vertical direction is positive, zero, or negative at the lowermost position of the movable unit 22 can be appropriately set according to the specifications of the apparatus.
[0031]
Therefore, as long as the horizontal and vertical magnetic effects as described above can be obtained, various configurations can be adopted as the magnetic mechanism 24. For example, the movable MG array 46 can be substantially composed of one permanent magnet. In this case, one fixed MG row 48 may be configured by two permanent magnets. In the embodiment shown in FIG. 1, the bottom surface 50 of the unit storage tank 26 defines the lowermost position of the movable unit 22, and in this state, the base 34 of the movable unit 22 contacts the bottom surface 50. Of course, the movable unit 22 may be held by the magnetic action and the action of the transport mechanism even at the lowermost position without substantially providing the bottom surface 50.
[0032]
FIG. 2 shows a state where the slide glass pair 12 is inserted into the insertion space 44 of the movable unit 22, and the movable unit 22 is positioned at the lowest position by further pulling down the slide glass pair 12. I have. In the example shown in FIG. 2, the permanent magnets of the movable MG row 46 and the fixed MG row 48 are not completely opposed at such a lowermost position, and the movable MG row 46 is slightly opposed to the fixed MG row 48. It is positioned upward. That is, a slight shift amount 100 is set between the two. For example, if a few mm is set as such a shift amount, a slight magnetic levitation force in the vertical direction with respect to the movable unit 22 even at the lowest position. Can be given. As a result, the movable unit 22 can be stably held by the balance between the holding by the holder 14 and the magnetic levitation force. Alternatively, the self-weight of the movable unit 22 and the magnetic levitation force at the lowest position may be balanced, and the driving action of the transport mechanism on the holder 14 may be completely eliminated. According to such a configuration, there is an advantage that power consumption for driving can be reduced.
[0033]
In the state shown in FIG. 2, a driving force in the horizontal direction is generated by the repulsion of the magnetic mechanism 24 on each reagent supply plate 28, and as a result, the reagent supply plate 28 approaches the slide glass 10. In such a state, the reagent flows out of the ejection holes between the two plates and expands. As a result, the sample S is immersed in the reagent, and the reagent processing is performed. By driving the holder 14 upward after the elapse of a predetermined reagent processing time, the slide glass pair 12 is pulled upward, and the movable unit 22 is also pulled upward in conjunction therewith. In that case, the magnetic levitation force of the magnetic mechanism 24 is used.
[0034]
That is, according to the magnetic mechanism 24, the movable unit 22 is moved vertically and the reagents are supplied without the need for an electric driving force, completely in conjunction with the vertical movement of the slide glass pair 12 by the transport mechanism. Both horizontal movements of the plate 28 can be performed.
[0035]
Incidentally, after the execution of the reagent processing, the reagent is replenished into the reagent tank 30 if necessary. In this case, a dispensing mechanism not shown is used. If necessary, the entire reagent storage tank or the unit storage tank 26 including the movable unit 22 is washed, and the reagent processing for the next reagent is executed.
[0036]
In the present embodiment, as each of the permanent magnets constituting the magnetic mechanism 24, a strong rare earth magnet such as neodymium is used. Of course, the solenoid can be used as an alternative or auxiliary as needed. In the present embodiment, portions other than the magnetic mechanism 24 are made of, for example, a resin that is a nonmagnetic material, or made of aluminum or the like. The above-mentioned slide pin 42 is desirably made of, for example, a rust-resistant material such as stainless steel.
[0037]
3 and 4 show an example of the reagent supply plate 28. FIG. 3 shows the configuration as viewed from the inner side surface 28B of the reagent supply plate 28, and FIG. 4 shows the configuration as viewed from the outer side surface 28C of the reagent supply plate 28.
[0038]
3 and 4, the reagent supply plate 28 is roughly composed of a plate body 60 and a cassette 62. The cassette 62 is removably attached to the cassette mounting portion 64 of the plate main body 60, and the first engagement portion 66 and the second engagement portion 68 are used for the attachment and detachment. The first engaging portion 66 includes a projection 70 formed on the plate main body 60 and a groove 72 that engages with the projection 70. The second engaging portion 68 includes a hook 74 formed on the plate main body 60, A hook hole 76 engaged with the hook 74. The movable MG array 46 described above is arranged in the cassette 62 (see FIG. 4). As shown in FIG. 3, spacers 78 functioning as pedestals are formed on both side ends of the inner side surface 28 </ b> B of the plate main body 60. The surface of the spacer 78 is set to project slightly forward from the inner side surface 28B, and the step 102 between the two is, for example, 50 to 70 μm. The step 102 protects the sample when executing the reagent processing. That is, if the reagent supply plate 28 is strongly joined to the slide glass, there is a concern that the sample may be damaged due to the joining operation. Therefore, the sample is protected by the spacer 78. Further, according to such a spacer 78, there is an advantage that the above-mentioned capillary gap can be formed reliably and easily.
[0039]
According to the reagent supply plate shown in FIGS. 3 and 4, only the portion contaminated by the reagent can be used as a disposable, that is, the cassette 62 can be mounted on another plate body 60 and reused. .
[0040]
Incidentally, by appropriately adjusting the position, interval, and size of each permanent magnet in the movable MG row 46 and the fixed MG row 48, it is also possible to obtain the action shown in FIG. That is, when the slide glass 10 is pulled up from below, the reagent supply plate 28 may be separated not obliquely but horizontally. According to such a configuration, it is possible to prevent, for example, a problem that the sample S is peeled or damaged due to the action of the surface tension of the reagent between the plates, for example.
[0041]
FIG. 6 shows the vertical magnetic force at the lowermost position of the movable unit 22. Here, as shown in the graph 110, a floating force greater than its own weight may be applied to the movable unit 22 at the lowermost position. In this case, the downward pushing force of the slide glass pair 12 and such a floating force are balanced, and the movable unit 22 is stably held at the lowest position. Further, as shown by the graph 112, the weight of the movable unit 22 (including the slide glass pair 12) and the magnetic levitation force are balanced at the lowermost position, and the holding action of the slide glass pair 12 by the transport mechanism is reduced to zero. You may do so. Alternatively, as shown by the graph 114, the magnetic levitation action may be completely zero at the lowest position, and the movable unit 22 may be supported by the bottom surface 50 of the unit storage tank 26 substantially. Alternatively, as shown in the graph 116, a downward pulling force is exerted on the movable unit 22 at the lowermost position, and the movable unit 22 is stably held by an action / reaction relationship between the force and the bottom surface 50. Good. When the configuration shown by the graphs 114 and 116 is adopted, when the slide glass pair 12 is lifted upward, it is necessary to exert a slight initial lifting force as shown by reference numerals 200 and 202.
[0042]
【The invention's effect】
As described above, according to the present invention, it is possible to reliably and easily move the reagent supply plate forward and backward in conjunction with the vertical movement of the sample plate.
[Brief description of the drawings]
FIG. 1 is a cross-sectional view showing a preferred embodiment of a reagent processing apparatus according to the present invention.
FIG. 2 is a cross-sectional view showing a state where a movable unit is at a lowermost position.
FIG. 3 is a diagram showing another embodiment of the reagent supply plate.
FIG. 4 is a diagram showing another embodiment of the reagent supply plate.
FIG. 5 is a diagram showing an embodiment in which a reagent supply plate is separated obliquely.
FIG. 6 is a diagram illustrating a magnetic action at a lowermost position of the movable unit.
[Explanation of symbols]
10 slide glasses, 12 slide glass pairs, 14 holders, 22 movable units, 24 magnetic mechanisms, 28 reagent supply plates, 30 reagent tanks, 32 discharge holes, 44 insertion spaces, 46 movable MG rows, 48 fixed MG rows.

Claims (9)

An elevating mechanism for elevating and lowering at least one sample plate to which a sample is attached,
At least one reagent supply plate having a reagent tank into which a reagent is injected and a discharge hole communicating therewith,
When the sample plate is lowered, the reagent supply plate is caused to supply the reagent by bringing the ejection hole forming surface of the reagent supply plate close to the sample attachment surface of the sample plate, and when the sample plate is raised, the reagent supply is performed from the sample attachment surface of the sample plate. Means for stopping the reagent supply by releasing the ejection hole forming surface of the plate, a magnetic mechanism for performing the movement of the reagent supply plate using a magnetic force in conjunction with the elevation of the sample plate,
A reagent processing apparatus comprising: An elevating mechanism for elevating and lowering at least one sample plate to which a sample is attached,
At least one reagent supply plate having a reagent tank into which a reagent is injected and a discharge port communicating therewith and facing the sample plate insertion space, and the reagent supply for the sample plate inserted into the sample plate insertion space A movable unit including a guide mechanism for moving the plate toward and away from the plate,
A unit storage tank in which the movable unit is stored,
Fixed magnetic means provided in the unit storage tank,
Movable magnetic means provided on the reagent supply plate,
Including
The movable unit is lowered by the downward movement of the sample plate, and at this time, the reagent supply plate is driven close to the sample plate by magnetic interaction of the fixed magnetic means and the movable magnetic means,
The reagent, wherein the movable unit is lifted by the upward movement of the sample plate, and at this time, the reagent plate is driven to be detached from the sample plate by magnetic interaction between the fixed magnetic means and the movable magnetic means. Processing equipment. The device according to claim 2,
A reagent processing apparatus, wherein the movable unit is floated and held in the unit storage tank in a state where the sample plate is not inserted by a magnetic interaction between the fixed magnetic unit and the movable magnetic unit. The device according to claim 2 or 3,
The fixed magnetic means and the possible magnetic means mutually exert a magnetic horizontal suction action in a state where the movable unit is located at an upper position in the unit insertion tank, and move to a lower position in the unit insertion tank. A reagent processing apparatus, wherein the movable units are arranged with a magnetic pole pattern that exerts a magnetic horizontal repulsion in a state where the movable units are present. The device according to claim 4,
The reagent processing device, wherein the movable magnetic means is embedded in the reagent supply plate. 5. The reagent processing apparatus according to claim 4, wherein said movable magnetic means is provided on a member detachable from a main body of said reagent supply plate. The device according to claim 2,
The lifting mechanism holds a sample plate pair in which surfaces opposite to the sample attachment surface are bonded to each other,
The reagent processing device, wherein the movable unit has a pair of reagent supply plates on both sides of an insertion space into which the sample plate pair is inserted. The device according to claim 2,
The reagent processing apparatus according to claim 1, wherein when the sample plate is vertically lifted from the proximity of the sample plate and the reagent supply plate, the reagent supply plate is separated obliquely. The device according to claim 4,
The reagent processing apparatus according to claim 1, wherein the fixed magnetic unit and the movable magnetic unit have a magnetic pole pattern that changes a magnetic interaction in a vertical direction according to a height of the movable unit.

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