JP3471291B2 - Food composition - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a diet food composition.

[0002]

2. Description of the Related Art It is well known that obesity and overweight, which have been increasing in recent years, cause not only various diseases such as diabetes but also a great social and economic burden and loss. However, dieting requires a major change in the current lifestyle and is therefore difficult. Therefore, materials from the viewpoint of low-calorie alternative foods, fat absorption inhibition, appetite suppression, fat accumulation inhibition, and metabolism promotion are desired. Although their formulations exist as pharmaceuticals, their use in daily foods is prohibited by the Food Sanitation Law, so natural substances that can be used as foods in place of these pharmaceuticals are desired.

[0003] Hitherto, gymnema sylvestre which suppresses sugar absorption, chitosan which inhibits lipid absorption, garcinia cambogia which inhibits fat synthesis and the like are known, and diet supplements using these are also known. There is. Particularly, Garcinia cambogia, also known as malavar tamarind, which is known as a material for suppressing the production of fatty acids that cause obesity, contains (−)-hydroxycitric acid. This substance is a citric acid derivative, which suppresses the production of fatty acids by inhibiting ATP citrate lyase, which is an enzyme that converts citric acid produced from glucose into acetyl CoA, which is one of the fatty acid synthesis pathways in the body. It has been shown to suppress accumulation.
At this time, the remaining glucose is accumulated as glycogen, which is said to give a feeling of fullness and relieve fatigue. Garcinia cambogia is known as a kind of Indian spice and is now used as a diet ingredient in many foods.

In order to decompose fat accumulated in adipose tissue, sympathetic nerve is stimulated and noradrenaline,
It is necessary to stimulate the release of adrenaline and thereby stimulate adipose tissue. Amphetamine, ephedrine and the like are known as substances that stimulate the sympathetic nerve, but they are substances that are highly abused and are rarely used, and are not suitable for use in foods. On the other hand, synephrine contained in citrus is a substance synthesized as a sympathomimetic in the 1930s, and it has been clarified that it is contained in citrus (The Journal of Biologic.
al Chemistry Volume 239 Issue 3 Pages 930-932 1964) (Lloydia 3
Volume 3, No. 2, pages 244-254, 1970). It is also known that these components stimulate mammalian adipocytes and promote lipolysis (CR Acad Sci III 316, No. 5, pages 519-523, 1993).

[0005]

[Problems to be Solved by the Invention] Since the treatment and prevention of obesity require various efforts such as diet restriction and exercise,
It was hard to do. However, if it is possible to treat and prevent obesity without changing lifestyle by simultaneously ingesting a specific natural product, we will provide effective means for treating and preventing obesity without consideration of diet. be able to. However, Garcinia cambogia extract, which is used in many diet foods, is poorly soluble in water and has little effect by oral ingestion, so the intake is high and the effective ingredient (-)-hydroxycitric acid is effective. It is difficult to make the intake amount, and it is desired to reduce the intake amount in terms of manufacturing cost. In recent years, water-soluble Garcinia cambogia peel extract has been developed (Journal of Japan Oil Chemists' Society Vol. 46 No. 12 1
467-28 1997). However, despite the fact that Garcinia cambogia extract alone takes 2500 mg or more per day, the effect of weight loss is not sufficient.
On the other hand, when using citrus fruits, the daily intake is 50 g or more in dry weight, and it is impossible to use it for food.

[0006]

Means for Solving the Problems In order to solve these problems, the present inventors have studied the enhancing effect of other substances on the diet effect of Garcinia cambogia peel,
It has been found that the combined use of citrus fruits produces a diet effect at a lower dose, and the present invention has been completed. That is, the present invention is a diet food composition comprising a Garcinia cambogia peel extract and citrus fruits. More preferred is a diet food composition containing a water-soluble Garcinia cambogia peel extract and citrus fruits as active ingredients.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. The Garcinia cambogia peel extract, which is a component used in the present invention, is extracted from Garcinia cambogia peel with water or a solvent, and if necessary, appropriately separated and concentrated liquid product, or sugar is added to obtain a powder by drying. It is a thing. As the solvent, a low boiling point organic solvent such as water or a lower alcohol, or a mixed solvent thereof can be used. After extraction with these solvents, if necessary, appropriate concentration, purification, sterilization, drying, etc. are performed for use. To be done. The Garcinia cambogia peel extract is preferably water-soluble. A water-soluble Garcinia cambogia extract is an extract that is completely soluble in water and gives an insoluble solution. The insoluble Garcinia cambogia peel extract is an extract in which insoluble matter is not completely dissolved in water.

The other citrus fruits used in the present invention include Daidai (Citrus Aurantium L.), Unshiu mandarin orange (Citrus unshiu Marcov), and Ponkan (Citrus reti).
culata Blanco), incense circle (Citrus wilsonii Tanaka),
Orange (Citrus sinensis Osbeck), lemon (Citrus me
yeri Y. Tanaka), Cleopatra mandarin (Citrus re
shni Hort.), Kabuyao (Citrus macroptera Mon)
t.), Tahitian lime (Citruslatiforia Tanaka), sweet lemon (Citrus limetta Risso), kinukawa (Citr)
us glaberrima Hort.ex Tanaka), Japanese orange (Ci)
trus tangerina Hort.ex Tanaka), Hassaku (Citrus
hassaku Hort.ex Tanaka), Sampoukan (Citrus sul)
cate Hort.ex Takahashi), Coven mandarin orange (Citrus eryt
hrosahiu Marcov), Citrus citrus kinokuni H
ort.ex Tanaka), Yatsushiro (Citrus yatsushiro Hort.ex
Tanaka), Keraji (Citrus keraji Hort.ex Tanaka),
Citrus tachibana Tanaka, Citrus
rus sunki Hort.ex Tanaka), Shiikuwasha (Citrus
deprssa Hayata), Koji (Citrus leiocarpa Hort.e
xTanaka), Yuzu (Citrus junos Sieb.ex Tanaka), Bergamot (Citrus bergamia Risso et Poit), Iyokan (Citrus iyo Hort.ex Tanaka), Hyuganatsu (C
itrus tamurana Hort.ex Tanaka), Shunkoukan (Ci
trus shunkokan Hort.ex Tanaka), Toukinkan (Citr
us madurensis Lour.), Sudachi (Citrus sudachi Hor
t.ex Shirai), Kabosu (Citrus sphaerocarpa Hort.ex
Tanaka), Natsumikan (Citrus natsudaidai Hayata)
Etc., but is not particularly limited as long as it contains a sympathomimetic substance such as synephrine. Of these, die is especially preferable.

Further, the citrus fruits of the present invention include mature or immature fruits, fruit skins, seeds of the above-mentioned citrus fruits,
A raw material such as leaves, petioles, branches, roots and flowers, squeezed, an extract extracted with a dry powder or a solvent, a liquid product or a dried product obtained by separating and concentrating the extract is used. Preference is given to fruits, pericarps, leaves or extracts thereof extracted with raw, squeezed, dry powder or solvent, and particularly preferably liquid or dried products obtained by separating and concentrating these extracts. Examples of the solvent in the case of extraction include low boiling point organic solvents such as water or lower alcohols, or mixed solvents thereof, and after extraction with these solvents, if necessary, concentration, purification, sterilization and drying are appropriately performed. It is used after being applied.

The amounts of the Garcinia cambogia peel extract and the citrus fruits in the present invention are calculated in terms of dry state,
It is desirable that 0.1 to 2 parts by mass of citrus fruits be contained per 1 part by mass of the Garcinia cambogia peel extract. If the amount of citrus is less than 0.1 parts by mass, the effect aimed at by the present invention is not always sufficient, and if it exceeds 2 parts by mass, further improvement of the effect cannot be expected.

In the present invention, if necessary, galenical ingredients,
Additives such as vitamins, stabilizers, preservatives, antioxidants, colorants, flavors, fruit juices, sugars, starches, celluloses, cellulose derivatives, excipients such as dextrin, adsorbents and the like can be used as additives.

To produce the food composition of this product, for example, in the case of making a tablet, the Garcinia cambogia peel extract is mixed with citrus fruits and, if necessary, the above additives,
If necessary, add a lubricant to the dried and crushed product,
You just have to tablet it. The food composition of the present invention is not limited to tablets, but can be used for any food such as capsule foods, granule foods, general beverages, baked confectionery, bread, etc. by a conventional method.
The food composition according to the present invention exerts a diet effect far more effectively than in the case where Garcinia cambogia peel extract and citrus fruits are individually ingested as shown in the following Examples and Comparative Examples.

[0013]

The present invention will be described in detail below with reference to examples, but the technical scope of the present invention is not limited thereto.

Examples 1 and 2 and Comparative Examples 1 to 4 Garcinia cambogia used is obtained by separating, concentrating and drying an extract obtained by extracting water from Garcinia cambogia pericarp. As the citrus fruits, an extract extracted with a solvent from a dried and shredded die was used. The raw materials were mixed according to the formulation shown in Table 1, granulated, and dried to give tablets, each having a mass of 220 mg. Example 1 is a tablet containing a water-soluble Garcinia cambogia peel extract and citrus fruits, and Example 2 is a tablet containing an insoluble Garcinia cambogia peel extract and citrus fruits. As Comparative Example 1, only the water-soluble Garcinia cambogia peel extract, Comparative Example 2 contained only the insoluble Garcinia cambogia peel extract, Comparative Example 3 contained only citrus fruits, and Comparative Example 4 contained both Garcinia cambogia peel extract and citrus fruits. Not supposed to.

The body weight and body fat were evaluated as follows.
25% or more by men and women with a BMI of 25 or more (weight (kg) divided by height (m) squared; if this number is 25 or more, obesity) or body impedance measurement by impedance method ( For people who are obese and are 30% or more (female) and 30% or more (female), the tablets of Examples 1-2 and Comparative Examples 1-4 are divided into 15 tablets 3 times a day and 30
It was carried out by measuring the body weight and body fat for 5 weeks before ingestion (5 persons / group).

[0016]

[Table 1]

[0017]

[Table 2]

As is clear from Table 2, in the group using the clinical trial tablets of Example 1 and Example 2 containing the Garcinia cambogia peel extract and citrus fruits, both the body weight and body fat were in the groups using Comparative Examples 1 to 4. It was confirmed that there was a significant decrease in comparison. Furthermore, in the group using the clinical trial tablet of Example 1 containing the water-soluble Garcinia cambogia peel extract and citrus fruits, other examples of body weight and body fat were obtained.
It was confirmed that there was a marked decrease compared to the group using the comparative example, and it was confirmed that there was a diet effect.

[0019]

The composition of the present invention contains Garcinia cambogia peel extract and citrus fruits as active ingredients, more preferably water-soluble Garcinia cambogia peel extract and citrus fruits as active ingredients. Due to the synergistic effect of the extract and citrus fruits, the dieting purpose can be achieved much more effectively than if they were taken alone.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Nobuyuki Matsushima 12-13 Kamishinano, Totsuka-ku, Yokohama-shi, Kanagawa Inside FANCL Central Research Institute Co., Ltd. (56) Reference JP-A-10-265397 (JP, A) JP Hei 11-1431 (JP, A) JP 62-87071 (JP, A) 2000 Vitamin guide, Sankei Shimbun Medics, October 1999, p. 115 (58) Fields investigated (Int. Cl. ⁷⁾ , DB name) A23L 1/30-1/308 A62K 35/78

Claims (2)

(57) [Claims] 1. A part by weight of water or a low-boiling organic solvent of Garcinia cambogia peel or a mixed solvent extract thereof and 0.1 to 0.1 parts by weight of a synephrine-containing citrus lower alcohol or a mixed solvent extract of a lower alcohol and water. Two
A composition for weight loss and / or body fat reduction, characterized in that it contains 100 parts by weight (excluding those containing coffee). 2. Citrus fruits are citrus fruits (CitrusAur).
antimL. ) Fruit, pericarp, seed, leaf, petiole,
The composition for weight loss and / or body fat reduction according to claim 1, which is a branch, a root or a flower.