JP3329395B2 - テトラサイクリンのスクリーニング法 - Google Patents

テトラサイクリンのスクリーニング法

Info

Publication number
JP3329395B2
JP3329395B2 JP35012692A JP35012692A JP3329395B2 JP 3329395 B2 JP3329395 B2 JP 3329395B2 JP 35012692 A JP35012692 A JP 35012692A JP 35012692 A JP35012692 A JP 35012692A JP 3329395 B2 JP3329395 B2 JP 3329395B2
Authority
JP
Japan
Prior art keywords
tetracycline
gene
coli
efflux pump
teta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP35012692A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05317093A (ja
Inventor
デイビツド・マイケル・ロスステイン
ゴードン・ジエラルド・グアイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Wyeth Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC filed Critical Wyeth Holdings LLC
Publication of JPH05317093A publication Critical patent/JPH05317093A/ja
Application granted granted Critical
Publication of JP3329395B2 publication Critical patent/JP3329395B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP35012692A 1991-12-06 1992-12-04 テトラサイクリンのスクリーニング法 Expired - Fee Related JP3329395B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80363491A 1991-12-06 1991-12-06
US803634 1991-12-06

Publications (2)

Publication Number Publication Date
JPH05317093A JPH05317093A (ja) 1993-12-03
JP3329395B2 true JP3329395B2 (ja) 2002-09-30

Family

ID=25187068

Family Applications (1)

Application Number Title Priority Date Filing Date
JP35012692A Expired - Fee Related JP3329395B2 (ja) 1991-12-06 1992-12-04 テトラサイクリンのスクリーニング法

Country Status (8)

Country Link
US (1) US5789188A (https=)
EP (1) EP0547403A1 (https=)
JP (1) JP3329395B2 (https=)
KR (1) KR100245831B1 (https=)
AU (1) AU670551B2 (https=)
CA (1) CA2084404A1 (https=)
NO (1) NO304489B1 (https=)
TW (1) TW318189B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5989832A (en) * 1995-04-21 1999-11-23 Microcide Pharmaceuticals, Inc. Method for screening for non-tetracycline efflux pump inhibitors
US6068972A (en) 1997-10-03 2000-05-30 Trustees Of Tufts College Methods and compositions for reducing bacterial tolerance to antibacterials, disinfectants and organic solvents
US6436694B1 (en) * 1998-01-09 2002-08-20 Cubist Pharmaceuticals, Inc. Regulable gene expression in gram-positive bacteria
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
GB0123401D0 (en) * 2001-09-28 2001-11-21 Novartis Forschungsstiftung Methods of inducing gene expression
EP2361933A3 (en) 2005-01-26 2012-05-02 Amgen Fremont Inc. Antibodies against interleukin-1 beta
GB0806803D0 (en) * 2008-04-15 2008-05-14 Scottish Biomedical Ltd Reverse reporter assay
US9518283B1 (en) 2012-02-27 2016-12-13 Paradigm Diagnostics, Inc. Selective enrichment media and uses thereof
CN110257471B (zh) * 2019-06-06 2020-08-18 南京农业大学 利用生物传感器检测土壤中可提取态四环素类抗生素的试纸条及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US4911924A (en) * 1987-04-17 1990-03-27 University Of New Mexico Induction of antibiotic hypersensitivity in tetracycline-resistance microorganisms
US5001230A (en) * 1988-02-18 1991-03-19 Schering Corporation T cell activation markers
EP0468220A3 (en) * 1990-07-26 1992-09-23 American Cyanamid Company Cloning of the biosynthetic pathway genes for chlortetracycline production from streptomyces aureofaciens & their expression in steptomyces lividans
EP0468217B1 (en) * 1990-07-26 1998-05-20 American Cyanamid Company A bifunctional cosmid useful for cloning actinomycete DNA

Also Published As

Publication number Publication date
JPH05317093A (ja) 1993-12-03
EP0547403A1 (en) 1993-06-23
NO924705D0 (no) 1992-12-04
CA2084404A1 (en) 1993-06-07
TW318189B (https=) 1997-10-21
AU670551B2 (en) 1996-07-25
AU2989692A (en) 1993-06-10
NO924705L (no) 1993-06-07
US5789188A (en) 1998-08-04
NO304489B1 (no) 1998-12-28
KR100245831B1 (ko) 2000-04-01

Similar Documents

Publication Publication Date Title
Reddy Role of FtsEX in cell division of Escherichia coli: viability of ftsEX mutants is dependent on functional SufI or high osmotic strength
Wiegert et al. Alkaline shock induces the Bacillus subtilisσW regulon
Huang et al. Bacillus subtilis MntR coordinates the transcriptional regulation of manganese uptake and efflux systems
Bae et al. Two targets in pCF10 DNA for PrgX binding: their role in production of Qa and prgX mRNA and in regulation of pheromone-inducible conjugation
Bianchi et al. Stress responses as a tool to detect and characterize the mode of action of antibacterial agents
US20020058260A1 (en) Method for identifying microbial proliferation genes
Deighan et al. Three‐way interactions among the Sfh, StpA and H‐NS nucleoid‐structuring proteins of Shigella flexneri 2a strain 2457T
Haldimann et al. Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12
Bailey et al. Induction of erm (C) expression by noninducing antibiotics
Rosner et al. Posttranscriptional activation of the transcriptional activator Rob by dipyridyl in Escherichia coli
JP3329395B2 (ja) テトラサイクリンのスクリーニング法
EP0922106B1 (en) Light emitting biosensor
Griffith et al. Two functions of the C-terminal domain of Escherichia coli Rob: mediating “sequestration–dispersal” as a novel off–on switch for regulating Rob’s activity as a transcription activator and preventing degradation of Rob by Lon protease
Wang et al. Regulation mechanism of nicotine catabolism in Sphingomonas melonis TY by a dual role transcriptional regulator NdpR
Lilic et al. Identification of the CysB-regulated gene, hslJ, related to the Escherichia coli novobiocin resistance phenotype
Rothstein et al. Detection of tetracyclines and efflux pump inhibitors
FI88309C (fi) Ny biotest
Mani et al. Screening Systems for Detecting Inhibitors of Cell Wall Transglycosylation in Enterococcus Cell Wall Transglycosylation Inhibitors in Enterococcus
Bachmann et al. High-throughput identification and validation of in situ-expressed genes of Lactococcus lactis
Becker et al. An ABC transporter of Streptococcus pneumoniae involved in susceptibility to vancoresmycin and bacitracin
JP4245477B2 (ja) 大環状ポリケチドを特定するための方法
US5384259A (en) Construct and method for expression of tetracycline resistance genes in E. Coli
US6309817B1 (en) Identification of virulence determinants activators in prokaryotic pathogens
US20060035365A1 (en) Method for identifying cellular growth inhibitors
Moyse et al. Phenotypic characterization of a comprehensive set of bicyclomycin-resistant mutants

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees