KR100245831B1 - 테트라사이클린유출펌프저해체의검출방법 - Google Patents

테트라사이클린유출펌프저해체의검출방법 Download PDF

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Publication number
KR100245831B1
KR100245831B1 KR1019920023449A KR920023449A KR100245831B1 KR 100245831 B1 KR100245831 B1 KR 100245831B1 KR 1019920023449 A KR1019920023449 A KR 1019920023449A KR 920023449 A KR920023449 A KR 920023449A KR 100245831 B1 KR100245831 B1 KR 100245831B1
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KR
South Korea
Prior art keywords
tetracycline
gene
teta
microorganism
assay
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KR1019920023449A
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English (en)
Korean (ko)
Inventor
데이빗마이클로스스타인
고오든제랄드거이
Original Assignee
윌리암 에이취 캘넌, 에곤 이 버그
아메리칸사이아나미드컴파니
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Application granted granted Critical
Publication of KR100245831B1 publication Critical patent/KR100245831B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1019920023449A 1991-12-06 1992-12-05 테트라사이클린유출펌프저해체의검출방법 Expired - Fee Related KR100245831B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80363491A 1991-12-06 1991-12-06
US7/803,634 1991-12-06

Publications (1)

Publication Number Publication Date
KR100245831B1 true KR100245831B1 (ko) 2000-04-01

Family

ID=25187068

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920023449A Expired - Fee Related KR100245831B1 (ko) 1991-12-06 1992-12-05 테트라사이클린유출펌프저해체의검출방법

Country Status (8)

Country Link
US (1) US5789188A (https=)
EP (1) EP0547403A1 (https=)
JP (1) JP3329395B2 (https=)
KR (1) KR100245831B1 (https=)
AU (1) AU670551B2 (https=)
CA (1) CA2084404A1 (https=)
NO (1) NO304489B1 (https=)
TW (1) TW318189B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5989832A (en) * 1995-04-21 1999-11-23 Microcide Pharmaceuticals, Inc. Method for screening for non-tetracycline efflux pump inhibitors
US6068972A (en) 1997-10-03 2000-05-30 Trustees Of Tufts College Methods and compositions for reducing bacterial tolerance to antibacterials, disinfectants and organic solvents
US6436694B1 (en) * 1998-01-09 2002-08-20 Cubist Pharmaceuticals, Inc. Regulable gene expression in gram-positive bacteria
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
GB0123401D0 (en) * 2001-09-28 2001-11-21 Novartis Forschungsstiftung Methods of inducing gene expression
EP2361933A3 (en) 2005-01-26 2012-05-02 Amgen Fremont Inc. Antibodies against interleukin-1 beta
GB0806803D0 (en) * 2008-04-15 2008-05-14 Scottish Biomedical Ltd Reverse reporter assay
US9518283B1 (en) 2012-02-27 2016-12-13 Paradigm Diagnostics, Inc. Selective enrichment media and uses thereof
CN110257471B (zh) * 2019-06-06 2020-08-18 南京农业大学 利用生物传感器检测土壤中可提取态四环素类抗生素的试纸条及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US4911924A (en) * 1987-04-17 1990-03-27 University Of New Mexico Induction of antibiotic hypersensitivity in tetracycline-resistance microorganisms
US5001230A (en) * 1988-02-18 1991-03-19 Schering Corporation T cell activation markers
EP0468220A3 (en) * 1990-07-26 1992-09-23 American Cyanamid Company Cloning of the biosynthetic pathway genes for chlortetracycline production from streptomyces aureofaciens & their expression in steptomyces lividans
EP0468217B1 (en) * 1990-07-26 1998-05-20 American Cyanamid Company A bifunctional cosmid useful for cloning actinomycete DNA

Also Published As

Publication number Publication date
JPH05317093A (ja) 1993-12-03
EP0547403A1 (en) 1993-06-23
NO924705D0 (no) 1992-12-04
CA2084404A1 (en) 1993-06-07
TW318189B (https=) 1997-10-21
AU670551B2 (en) 1996-07-25
JP3329395B2 (ja) 2002-09-30
AU2989692A (en) 1993-06-10
NO924705L (no) 1993-06-07
US5789188A (en) 1998-08-04
NO304489B1 (no) 1998-12-28

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