JP3283553B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic comprising a water extract or an organic solvent extract from rice as such or containing the same, which has an excellent moisturizing effect on human skin and is smooth and smooth. The present invention relates to a cosmetic that not only has an effect but also has an excellent whitening effect, an ultraviolet absorbing effect, and an anti-aging effect.

[0002]

2. Description of the Related Art Conventionally, cosmetics have been provided with moisturizing properties by mainly blending oils, amino acids and polysaccharides. More recently, the safety of cosmetics has become a problem, and products containing natural moisturizers such as natural oils, hyaluronic acid, and placenta extract have been developed, but they have disadvantages such as stickiness and At present, the effect of smoothing the skin is not clearly understood. Recently, cosmetics with added value, such as whitening cosmetics containing kojic acid and UV cosmetics containing UV absorbers or UV-blockers, have been released, but natural products have a moisturizing effect (moisturizing effect). )
Excellent, has a remarkably smooth skin effect,
Moreover, cosmetics having a whitening effect, an ultraviolet absorbing effect and an antiaging effect have not yet been known.

On the other hand, rice has been developed for use as sake, shochu, amazake, mirin, vinegar, koji and the like in addition to the staple food, and has been indispensable to daily life. In addition, bran bags are known for cosmetic use. These may be due to the fact that rice was viewed as merely a staple food, or at best as a source of starch. In addition, even though the bran bag is considered to be good for the skin, it has only been conventionally used as it is, and there is no concept of an active ingredient and no concept of extraction.

[0004]

At present, the safety of the human body has become a problem even in cosmetics, and moreover, the pursuit of added value such as whitening, stain removal, aging prevention (anti-aging) and wrinkle removal has been made. I have. Therefore, it is safe for the human body, has no stickiness to the skin, and also has a moisturizing effect (moistness) and an effect of making the skin slippery, and also has a whitening effect, ultraviolet absorption effect, and anti-aging effect. There is a demand for cosmetics having excellent properties.

[0005]

Means for Solving the Problems The present inventors have been studying various plant components, mainly rice, which is a staple food, from the viewpoint of blending animals and plants. In the process, it has become clear that rice has many possibilities and effects that could not be predicted until now. Therefore, we have taken up the theme of rice, which is used as a staple food and proved to be the safest, and conducted comprehensive research on rice utilization.

As one of the themes, intensive studies have been made on cosmetics from rice. In the process, when the rice extract is used as it is or when it is applied to the skin, it not only has a moisturizing effect and a slippery effect, but also has an excellent whitening effect, ultraviolet absorption effect, and anti-aging effect. It has been found that the present invention has been completed.

[0007] That is, the present invention relates to a cosmetic comprising, as it is, an alcohol extract or lactic acid fermented water extract or organic solvent extract from rice, or containing the same. The rice is extracted with water (including acid and alkali extraction) or organic solvent such as alcohol, and then further subjected to alcohol fermentation or lactic acid fermentation. You can get cosmetics.

When the extraction operation of the present invention is performed, first, when rice is crushed or pulverized, the surface area is increased, so that the extraction efficiency is improved. This method may be performed by a general method using a crusher or a rice mill. It is not necessary to grind, but in this case, it takes a long time to decompose and extract the rice tissue.

In the water extraction, rice is added as it is, preferably to ground or powdered rice. The rice may be brown rice or white rice. About the amount of water, 2 to rice
Extraction is efficient with a 5-fold amount, but may be appropriately selected according to the yield, workability, end use purpose, and the like. Thereafter, the mixture is heated, and the extraction is completed when the mixture becomes a boiling state. After the extraction is completed, depending on the purpose of use, if squeezed and filtered,
A clear extract is obtained. The extraction may be performed by adding hot water from the beginning.

As for the extraction temperature at the time of water extraction, although the active ingredient in the extract has not been elucidated, it has been confirmed that this unknown active ingredient is stable to heat, so that a high temperature is efficient. If left at a low temperature for a long time, extraction can be sufficiently performed. However, when the temperature is as low as 40 ° C. or lower, it is necessary to make the pH acidic or alkaline or to add a preservative. The extraction time may be several minutes in the case of boiling extraction, but in the case of a medium temperature lower than that, several hours to one day and night are required. When the temperature is low, it takes several days to one month, depending on the crushed state of rice. However, also in this case, it is more effective to heat at the end as much as possible.

In the case of water extraction, the most problematic is the gelatinization phenomenon. If it becomes glue-like, not only does the extraction efficiency deteriorate, but it becomes extremely difficult in actual work. In order to prevent this, starch may be decomposed by adding an amylase to the reaction or making it acidic with hydrochloric acid or the like. This method can be sufficiently solved and has no practical problem at all.

It is effective to perform acid extraction or alkali extraction, probably because the active ingredient in the extract is stable to acids and alkalis. In the case of water extraction, it is efficient to perform pretreatment with an acid or alkali, or to perform pretreatment by reacting with an enzyme (for example, amylase) that acts on rice tissue to perform extraction. This seems to be because the pretreatment makes it easier to extract the active ingredient.

Further, it has been found that an extract having this effect can be extracted by organic solvent extraction. This is extremely effective in elucidating the active ingredient, and also in extracting the active ingredient into conch and blending it with one that is insoluble in water. In this case, it is preferable to pulverize or powder as much as possible. Further, it is desirable to use an organic solvent such as alcohol which is safe even when administered to the human body.

In order to extract the product of the present invention from rice, it is more effective if the organic solvent or water is extracted as described above and the active ingredient in the extract is further subjected to solvent extraction. However, this is presumably because a concentrated state is obtained, and the same effect can be obtained by concentration. In addition, depending on the application, the presence of sugar may cause stickiness or hinder the effect. In that case, the sugar may be removed by feeding the sugar to yeast, fractionating the active ingredient with an adsorbent, or extracting with an organic solvent. In any case, effects can be obtained only by extracting, so that unnecessary components may be removed by various methods depending on the application. Furthermore, the same effect was obtained by combining the extract with fermentation such as alcohol fermentation and lactic acid fermentation.

[0015] Rice is eaten every day as a staple food, and it is too close to the concept of using it as a cosmetic in this way, and it was unexpected. It has been used for sake, shochu, vinegar, etc. except for eating, but no idea or method of extracting rice has been adopted. This is presumably due to the fact that rice is paste-like as a characteristic of rice when it is tried to be extracted by heating, which was very difficult with conventional thinking. Therefore, in the present invention, the organic solvent, extraction,
Using acid or alkali extraction, and in the case of water extraction, by allowing amylase or the like to act to facilitate extraction,
The goal was achieved.

Only when the extraction operation is sufficiently performed in this way, a very excellent active ingredient as a cosmetic can be extracted. The specific effects will be described based on experimental results. First, in order to demonstrate the strength of the moisturizing effect of the product of the present invention in terms of data, a single coating test was performed using a moisture meter (SKICON 200). Room temperature 20
The environment was set at a temperature of 65 ° C. and a relative humidity of 65%, and the panelists were allowed to rest in the above environment about 10 minutes before the measurement. The test site (bilateral) was selected at the flexion side of the forearm without any rash. The panelists went with five people.

The present test (using the product of the present invention obtained in Example 1) read from a moisture meter and a control test (using water)
FIG. 1 shows the average value of the change in the water content of the stratum corneum. 1
The measuring method of the one-time application test is as follows.

Measurement method 1) A 5 × 5 cm test site and a control site are set on the forearm flexion side of the panel. 2) Measure the water content of the stratum corneum at each site. 3) Measure the water content of the stratum corneum immediately after application of the sample, 30, 60, 90 and 120 minutes later.

FIG. 1 shows that the test site to which the product of the present invention was applied immediately after application showed a water content of the stratum corneum of about 13
A two-fold increase was observed. In addition, from 30 minutes after application,
It can be seen from the observation up to 20 minutes that the application site of the present invention maintains a water content two to three times that of the control. From this, it was found that the product of the present invention was extremely rich in moisturizing effect.

Next, the effects of making the skin smooth and fine-grained are exemplified. In the test method, the product of the present invention was applied to the right arm of a panel twice a day for one month, and the application site of the product of the present invention was measured with a dynamic friction meter. The control used the same site on the left arm. The panelists went with six people. The measurement conditions are as follows.

Temperature 25 ° C. Humidity 60% Sensor used KES-SE friction tester SE-2 type (using 0.5 mm piano wire) Static friction load 50 gf Measurement speed 1 mm / sec Measurement distance 30 mm (integral effective range 20 mm)

The results are shown in FIGS. 2 and 3. As shown in FIG. 2, in the part of the left arm where the product of the present invention is not applied,
Although the MMD (coefficient of variation) was 0.0172, the MMD (coefficient of variation) was reduced to 0.0042 in the right arm portion where the product of the present invention was applied for one month, as shown in FIG. The average values of the six persons were almost the same. This is thought to be due to the fact that the fluctuation due to the surface irregularities was reduced, and from this,
It turned out that the texture of the skin became fine. The MIU (coefficient of friction) was also measured at the same time.
Although it was 3, the skin after one month application was reduced to 0.073, and it was found that the skin had an effect of making the skin smooth.

Further, in order to exemplify data on the ultraviolet absorption effect of the product of the present invention, the absorption spectrum of the product of the present invention was measured. The result is shown in FIG. From FIG. 4, the product of the present invention has a UVB region of 280 to 320 nm and 320 to 320 nm.
Low wavelength region of 380 nm UVA (about 320 to 3
40 nm).

Although the product of the present invention has a sufficient absorption only in the vicinity of the UVB region, it may be considered that the effect is not sufficient. However, the shortest wavelength of the ultraviolet ray reaching the ground surface is 295.
Since the longest wavelength is said to be 320 to 330 nm in nm, it can be said that the ultraviolet absorbing ability in a substantial sense is sufficient. In addition, it deserves about three times the absorption capacity of the crude drug extracts and crude drug components (oil-soluble licorice extract PU, lycochalcone A, baicalein, γ-oryzanol, etc.) which are currently used and have a natural ultraviolet absorbing ability. . This also proves that the product of the present invention has an excellent ultraviolet absorbing ability. Further, to illustrate the whitening effect of the present invention,
A test of the tyrosinase activity inhibitory effect was performed.

As the operation method, a substrate solution (0.04% tyrosine solution) and a buffer solution (Mcllvaine Buffer pH6.
8) Accurately take 1 ml each in the absorption cell, and add water and Example 1
Put exactly 1 ml of the product of the present invention obtained in
After stirring and mixing at 35 ° C., after 5 minutes, the absorbance scale was adjusted to zero by adjusting the wavelength to 475 nm, and then a tyrosinase solution (5.3 mg of tyrosinase was added to 0.9% NaCl).
0.02 ml (dissolved in the solution) was added exactly and stirred immediately to incubate. The absorbance at this time was measured over time (every 3 minutes) and is shown in Table 1.

[0026]

[Table 1]

As can be seen from Table 1, the product of the present invention was found to have a tyrosinase activity inhibitory action. From this, it can be said that the product of the present invention has a whitening effect. next,
In order to examine the effect of skin rejuvenation, the product of the present invention was applied to the back of the hand for one week on six female monitors aged 70 to 80 years, the portion was collected by the sump method, and the sump image was taken with a micrograph, and A comparison was made with skin not using the invention.

As shown in FIG. 5, on the skin of a 21-year-old female monitor, not only are the skin grooves 1 clearly recognized in multiple directions, but also the skin hills (turtle shell prints) 2 are clearly visible. However, as shown in FIG. 6, the monitor at the age of 71 shows only the skin ridge 1 ′ in one direction, and no skin hills. As the skin grew older, the skin became less elastic, the crevices became shallower due to squeezing, and the skin hills gradually disappeared.

However, in the case where the product of the present invention was applied for one week, as shown in FIG. 7, the skin groove 1 ', which was recognized only in one direction before use, was recognized in multiple directions, which was also clearly recognized. Was. Not only that, the skin crest (turtle crest) 2 ', which was not seen at all before application, was clearly recognized, and hardly replaced the skin of a 21-year-old woman. In addition, elasticity was improved in feel, and a rejuvenating effect was recognized. This phenomenon was similarly observed on the remaining five monitors. This means that by using the product of the present invention, the original function of the skin tends to recover, and a clear and well-defined skin pattern appears.
From this, it was proved that the product of the present invention had a clear rejuvenating effect.

Next, in order to demonstrate the anti-aging effect, 4
The product of the present invention was continuously used on the back of the hand for three weeks by three female monitors in their 0s for one week, and microscopic observation by the Sump method was performed.
As the product of the present invention, the product according to Example 1 was used.

As shown in FIG. 8, in the skin not coated with the product of the present invention, only the skin groove 3 in one direction is conspicuous, and the skin groove 3 'orthogonal to the skin groove is unclear, As shown in FIG. 9, not only the unclear skin crevices 3 ′ clearly appeared, but also fine skin crevices were observed on the skin on which the product of the present invention was continuously used for one week. This phenomenon also appeared on the other two monitors. From this, it was proved that the product of the present invention has an effect useful for prevention of skin aging. Furthermore, when the skin to which the product of the present invention was continuously applied for one month was observed, the effect was further recognized.

Next, the effectiveness of the product of the present invention in actual use was examined. First, the products of the present invention obtained in Example 1 were applied twice a day for one month to 15 panelists, and the effectiveness in actual use was examined.

As a result, 12 of the 15 persons were found to have the effect of clearly whitening their skin. In addition, about the remaining three people, the skin was originally white,
The effect was not clearly understood. However, all said that the skin was moist, slippery and the texture of the skin seemed to be getting better. As a result, even in actual use, it was found that a clear effect was obtained, and it was found that there was an effect as a very excellent cosmetic.

[0034]

As can be seen from the above results, by extracting rice with water or an organic solvent, the effect of moisturizing and smoothing the skin easily and completely safely and improving the texture of the skin can be obtained. A very good cosmetic having a whitening effect, an ultraviolet absorbing effect and an anti-aging effect was obtained.

Since rice has been a staple food, a new method of production and use have hardly been developed. In addition, rice has been a staple food and its safety has been proven. That is, the present invention not only has a very excellent effect as a cosmetic,
It has been found that the safety has been sufficiently demonstrated, and it can be said that this is a very significant invention that can be used for various cosmetics.

At present, it is said that rice is overproduced,
It is extremely meaningful to find new uses for rice and to increase consumption by improving rice image.

[0037]

Next, an embodiment of the present invention will be described. Example 1 15 kg of white rice was pulverized well, 45 liters of warm water at 60 ° C. and 50 g of liquefied enzyme were added thereto, and the mixture was stirred well. afterwards,
Gradually raise the temperature and extract by boiling for 5 minutes.
Cooled to ° C. Then, it was squeezed with a squeezing machine to obtain 41 liters of the product of the present invention and 16 kg of residue.

Example 2 1 kg of white rice was pulverized well, 5 liters of 0.1% hydrochloric acid was added well, stirred well, and left for 6 hours. Then, it was squeezed with a squeezing machine to separate 4.6 liters of the squeezed liquid and 1.2 kg of residue. This pressed solution was neutralized with 1N NaOH to obtain 4.7 liters of the product of the present invention.

Example 3 1 kg of white rice was pulverized well, 3 liters of 95% alcohol was added, and the mixture was stirred well and allowed to stand. Four days later, the mixture was squeezed with a squeezer to obtain 2.5 liters of a squeezed liquid and 1.2 kg of a residue. 500 ml of water was added to one liter of the squeezed liquid and the alcohol was completely removed by a rotary evaporator to obtain 480 ml of the product of the present invention.

[Brief description of the drawings]

FIG. 1 shows a moisture meter (S)
9 is a graph showing the results of a single application test performed using KICON200).

FIG. 2 is a graph showing the result of measuring the skin to which the product of the present invention has not been applied using a dynamic friction meter.

FIG. 3 is a graph showing the results obtained by measuring the skin on which the product of the present invention was applied twice a day for one month using a dynamic friction meter.

FIG. 4 is a graph showing a result of measuring an absorption spectrum with respect to an ultraviolet absorbing effect of the product of the present invention.

FIG. 5 is a photomicrograph of a sump image of the skin of a 21-year-old female monitor collected by the sump method.

FIG. 6 is a photomicrograph of a sump image of the skin of a 71-year-old female monitor collected by the sump method.

FIG. 7 is a photomicrograph of a sump image of the skin of a 71-year-old female monitor to which the product of the present invention was applied for one week, which was collected by the sump method.

FIG. 8 is a micrograph of a sump image of the skin of a 40-year-old female monitor collected by the sump method.

FIG. 9 is a micrograph of a sump image of the skin of a 40-year-old female monitor to which the product of the present invention has been applied for one week, which is collected by the sump method.

Continuation of the front page (56) References JP-A-4-117318 (JP, A) JP-A-61-87615 (JP, A) JP-A-61-68404 (JP, A) JP-A-63-264511 (JP, A) , A) (58) Fields surveyed (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (1)

(57) [Claims] 1. A cosmetic comprising a water extract or an organic solvent extract from rice that has been subjected to alcohol fermentation or lactic acid fermentation as it is or contains the same.