JP3115598B2 - １’−アミノスピロ［イソキノリン−４（１ｈ），３’−ピロリジン］−１，２’，３，５’（２ｈ）−テトラオンおよびその類似体 - Google Patents

１’−アミノスピロ［イソキノリン−４（１ｈ），３’−ピロリジン］−１，２’，３，５’（２ｈ）−テトラオンおよびその類似体

Info

Publication number
JP3115598B2
JP3115598B2 JP03518368A JP51836891A JP3115598B2 JP 3115598 B2 JP3115598 B2 JP 3115598B2 JP 03518368 A JP03518368 A JP 03518368A JP 51836891 A JP51836891 A JP 51836891A JP 3115598 B2 JP3115598 B2 JP 3115598B2
Authority
JP
Japan
Prior art keywords
aryl
carbon atoms
lower alkyl
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP03518368A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06502175A (ja
Inventor
マラマス，マイケル・ソティリオス
Original Assignee
アメリカン・ホーム・プロダクツ・コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アメリカン・ホーム・プロダクツ・コーポレイション filed Critical アメリカン・ホーム・プロダクツ・コーポレイション
Publication of JPH06502175A publication Critical patent/JPH06502175A/ja
Application granted granted Critical
Publication of JP3115598B2 publication Critical patent/JP3115598B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP03518368A 1990-10-12 1991-10-10 １’−アミノスピロ［イソキノリン−４（１ｈ），３’−ピロリジン］−１，２’，３，５’（２ｈ）−テトラオンおよびその類似体 Expired - Fee Related JP3115598B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/596,266 US5102886A (en) 1990-10-12 1990-10-12 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US596,266 1990-10-12
PCT/US1991/007473 WO1992006975A1 (en) 1990-10-12 1991-10-10 1'-aminospiro[isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
JPH06502175A JPH06502175A (ja) 1994-03-10
JP3115598B2 true JP3115598B2 (ja) 2000-12-11

Family

ID=24386645

Family Applications (1)

Application Number Title Priority Date Filing Date
JP03518368A Expired - Fee Related JP3115598B2 (ja) 1990-10-12 1991-10-10 １’−アミノスピロ［イソキノリン−４（１ｈ），３’−ピロリジン］−１，２’，３，５’（２ｈ）−テトラオンおよびその類似体

Country Status (19)

Country Link
US (1) US5102886A (ru)
EP (1) EP0553263B1 (ru)
JP (1) JP3115598B2 (ru)
KR (1) KR100228842B1 (ru)
AT (1) ATE169300T1 (ru)
AU (1) AU645865B2 (ru)
CA (1) CA2093794C (ru)
DE (1) DE69129941T2 (ru)
DK (1) DK0553263T3 (ru)
ES (1) ES2120966T3 (ru)
FI (1) FI103045B1 (ru)
HK (1) HK1009601A1 (ru)
HU (2) HU214874B (ru)
MX (1) MX9101543A (ru)
PT (1) PT99179B (ru)
RU (1) RU2110518C1 (ru)
SG (1) SG47809A1 (ru)
TW (1) TW200484B (ru)
WO (1) WO1992006975A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG47554A1 (en) * 1991-11-25 1998-04-17 American Home Prod 1'-amino-2-[(benzothiazolyl)methyl)]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5189168A (en) * 1991-11-25 1993-02-23 American Home Products Corporation 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
EP1400244A1 (en) 2002-09-17 2004-03-24 Warner-Lambert Company LLC New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
JPH0426510A (ja) * 1990-05-18 1992-01-29 Tonen Corp 炭素系粒子、その製造方法及びその用途
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
JPH06502175A (ja) 1994-03-10
WO1992006975A1 (en) 1992-04-30
FI103045B (fi) 1999-04-15
EP0553263A1 (en) 1993-08-04
HU211601A9 (en) 1995-12-28
PT99179B (pt) 1999-04-30
FI931601A0 (fi) 1993-04-08
HK1009601A1 (en) 1999-06-04
SG47809A1 (en) 1998-04-17
PT99179A (pt) 1992-09-30
AU645865B2 (en) 1994-01-27
DE69129941D1 (de) 1998-09-10
CA2093794C (en) 2002-01-22
ES2120966T3 (es) 1998-11-16
TW200484B (ru) 1993-02-21
US5102886A (en) 1992-04-07
HU214874B (hu) 1998-07-28
HU9301042D0 (en) 1993-07-28
FI103045B1 (fi) 1999-04-15
AU8902691A (en) 1992-05-20
KR930702346A (ko) 1993-09-08
EP0553263B1 (en) 1998-08-05
RU2110518C1 (ru) 1998-05-10
ATE169300T1 (de) 1998-08-15
DE69129941T2 (de) 1999-02-18
HUT67017A (en) 1995-01-30
DK0553263T3 (da) 1999-05-10
KR100228842B1 (ko) 1999-11-01
MX9101543A (es) 1992-06-05
FI931601A (fi) 1993-04-08
CA2093794A1 (en) 1992-04-13

Similar Documents

Publication Publication Date Title
KR0143998B1 (ko) 알도스 환원효소 억제제로서 유용한 스피로-이소퀴놀린-피롤리딘 테트론 및 이의 동족체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
JP3244283B2 (ja) アルドースレダクターゼ抑制剤として有用なスピロ−イソキノリン−ピロリジン類およびその類似体
EP0365324B1 (en) Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
JP3115598B2 (ja) １’−アミノスピロ［イソキノリン−４（１ｈ），３’−ピロリジン］−１，２’，３，５’（２ｈ）−テトラオンおよびその類似体
JP3115597B2 (ja) １’−アミノスピロ〔イソキノリン−４（１ｈ），３’−ピロリジン〕−１，２’，３，５’（２ｈ）−テトラオンのアルキリデン類似体
JP3398391B2 (ja) アルドースレダクターゼ抑制剤として有用なｎ’−アルキル−スピロ−イソキノリン−ピロリジン テトラオン類およびその類似体
US5130425A (en) Spiro-lactams and analogs thereof useful as aldose reductase inhibitors
US5081241A (en) Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors
US5189168A (en) 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US4983613A (en) Isoquinoline acetic acids and acetyl carbamates useful as aldose reductase inhibitors
AU665796B2 (en) 1'-amino-2-((benzothiazolyl)methyl)spiro (isoquinoline-4(1H),3'-pyrrolidine)-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5189044A (en) Isoquinoline-1,3-dione acetyl carbamates useful as aldose reductase inhibitors
US5189167A (en) Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5093496A (en) Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
IE913604A1 (en) 1'-aminospiro[isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'¹(2h)-tetrones and analogs thereof useful as aldose reductase¹inhibitors
GB2252321A (en) Isoquinoline intermediates preparation
CA2324636A1 (en) 1, 2, 3, 4 - tetrahydro - 1, 3 - dioxo - 4 - isoquinolinecarboxylic acid methyl esters

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees