JP3110056B2 - Reagent heating method - Google Patents
Reagent heating methodInfo
- Publication number
- JP3110056B2 JP3110056B2 JP03006243A JP624391A JP3110056B2 JP 3110056 B2 JP3110056 B2 JP 3110056B2 JP 03006243 A JP03006243 A JP 03006243A JP 624391 A JP624391 A JP 624391A JP 3110056 B2 JP3110056 B2 JP 3110056B2
- Authority
- JP
- Japan
- Prior art keywords
- reagent
- nozzle
- temperature
- heating
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00425—Heating or cooling means associated with pipettes or the like, e.g. for supplying sample/reagent at given temperature
Description
【０００１】[0001]
【産業上の利用分野】本発明は血液凝固能検査装置や免
疫反応装置等の臨床検査装置に適用される試薬の加熱方
法に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for heating a reagent applied to a clinical test device such as a blood coagulation test device or an immunoreaction device.
【０００２】[0002]
【従来の技術】例えば血液凝固能検査の一例では、患者
から採取した血しょう（検体）に特定の凝固因子を除去
した試薬を注入して凝固時間を測定し、患者の病状を検
査するが、その検査は体温に近い３７℃で行なわれる。
一方、試薬は劣化を防止するために１５℃程度に冷蔵保
存しておかなければならない。したがって、この種の検
査では、冷蔵された試薬を所要温度に加熱して迅速に使
用する必要がある。このような試薬の加熱方法として
は、従来、第一に、所要温度に維持された恒温槽に試薬
供給パイプを入れ、該パイプ内に試薬を通過させて熱交
換により加熱する方法や、第二に試薬吸引ノズルに設け
た加熱用ヒータにより吸引時に加熱する方法、第三に試
薬ボトルを恒温槽に入れ、ボトル内の試薬全体を加熱す
る方法がある。2. Description of the Related Art For example, in an example of a blood coagulation test, a reagent from which a specific coagulation factor has been removed is injected into a plasma (specimen) collected from a patient to measure the coagulation time and examine the patient's condition. The test is performed at 37 ° C., close to body temperature.
On the other hand, the reagent must be kept refrigerated at about 15 ° C. to prevent deterioration. Therefore, in this type of inspection, it is necessary to heat the chilled reagent to a required temperature and use it promptly. Conventionally, as such a method of heating a reagent, first, a method of putting a reagent supply pipe into a constant temperature bath maintained at a required temperature, passing a reagent through the pipe and heating by heat exchange, There is a method in which heating is performed at the time of suction by a heating heater provided in a reagent suction nozzle, and a third method in which a reagent bottle is placed in a thermostat and the entire reagent in the bottle is heated.
【０００３】[0003]
【発明が解決しようとする課題】しかしながら、前記第
一の方法では、試薬供給パイプが長くなるうえ、当該パ
イプ内に残留した試薬が無駄になる。第二の方法では、
試薬吸引ノズルに設けたヒータやセンサより電気接続用
ケーブルを配線しなければならないし、当該ケーブルが
ノズルの動作の邪魔になる。また、第三の方法では、試
薬ボトル内の試薬全体が昇温するのに時間がかかり、さ
らに当該試薬は長時間高温にさらされて劣化してしまう
等の問題があった。本発明はかかる問題点を解決するの
を課題とし、吸引した所要量の試薬を非接触で迅速に加
熱することができる試薬の加熱方法を提供するものであ
る。However, in the first method, the reagent supply pipe becomes long, and the reagent remaining in the pipe is wasted. In the second method,
A cable for electrical connection must be routed from a heater or a sensor provided on the reagent suction nozzle, and the cable hinders the operation of the nozzle. Further, in the third method, it takes time to raise the temperature of the entire reagent in the reagent bottle, and further, the reagent is exposed to a high temperature for a long time and deteriorates. An object of the present invention is to solve such a problem and to provide a reagent heating method capable of rapidly heating a required amount of sucked reagent without contact.
【０００４】[0004]
【課題を解決するための手段】前記課題を解決するた
め、本発明は、所定温度に冷蔵保存された試薬を使用前
に所要温度に加熱する試薬の加熱方法において、図１に
示すように、予めノズル１を所要温度Ｔに温度調節して
おき、該ノズル１により所定温度Ｔ0に冷蔵保存された
試薬２を所要量吸引した後、当該ノズル１を電磁誘導加
熱装置３の中に挿入して、吸引時に低下したノズル１の
温度を回復するのに必要な熱量に相当する電力量を当該
加熱装置３に供給してノズル１内の試薬２を前記所要温
度Ｔに加熱するものである。According to the present invention, there is provided a method for heating a reagent refrigerated and stored at a predetermined temperature to a required temperature before use, as shown in FIG. The temperature of the nozzle 1 is previously adjusted to the required temperature T, and the required amount of the reagent 2 refrigerated and stored at the predetermined temperature T 0 is suctioned by the nozzle 1, and then the nozzle 1 is inserted into the electromagnetic induction heating device 3. Then, an amount of electric power corresponding to the amount of heat necessary to recover the temperature of the nozzle 1 that has dropped during suction is supplied to the heating device 3 to heat the reagent 2 in the nozzle 1 to the required temperature T.
【０００５】[0005]
【作用】所要温度Ｔに保持されたノズル１で試薬２を吸
引すると、ノズル１は試薬２により冷却されてαだけ温
度低下する。一方、試薬２は当該ノズル１の保有熱で加
熱されてＴ−αまで温度上昇する。そして、ノズル１を
加熱装置３に挿入すると、電磁誘導作用によりノズル１
が発熱して所要温度Ｔに回復する結果、内部の試薬２は
当該所要温度Ｔに加熱される。When the reagent 2 is sucked by the nozzle 1 maintained at the required temperature T, the nozzle 1 is cooled by the reagent 2 and its temperature is decreased by α. On the other hand, the reagent 2 is heated by the heat held by the nozzle 1 and rises in temperature to T-α. Then, when the nozzle 1 is inserted into the heating device 3, the nozzle 1 is
Generates heat and recovers to the required temperature T, so that the internal reagent 2 is heated to the required temperature T.
【０００６】[0006]
【実施例】次に、本発明の実施例を図面に従って説明す
る。図２は、本発明に係る方法が適用される血液凝固能
自動検査装置５を示し、この装置５は、ベース６に試薬
ターンテーブル７と、反応ターンテーブル８と、電磁誘
導加熱装置９と、先端に外径８ｍｍ，内径２ｍｍのノズ
ル１０を有するノズルアーム１１とを有している。試薬
ターンテーブル７には、平面形状が扇形の複数の試薬ボ
トル１２が環状に配列されて載置されている。この各試
薬ボトル１２には、血液凝固能検査用の異なった試薬が
それぞれ収容され、約１５℃に冷蔵保存されている。ま
た、試薬ターンテーブル７の外周には、複数の挿入穴１
３を有する環状のインキュベータ１４が載置されてい
る。このインキュベータ１４はヒータにより約３７℃に
保持されている。Next, an embodiment of the present invention will be described with reference to the drawings. FIG. 2 shows a blood coagulation ability automatic testing device 5 to which the method according to the present invention is applied. The device 5 comprises a base 6, a reagent turntable 7, a reaction turntable 8, an electromagnetic induction heating device 9, A nozzle arm 11 having a nozzle 10 having an outer diameter of 8 mm and an inner diameter of 2 mm is provided at the tip. On the reagent turntable 7, a plurality of reagent bottles 12 having a fan-shaped planar shape are placed in an annular arrangement. Each of the reagent bottles 12 contains a different reagent for blood coagulation test, and is refrigerated at about 15 ° C. Further, a plurality of insertion holes 1 are provided on the outer periphery of the reagent turntable 7.
An annular incubator 14 having 3 is mounted. The incubator 14 is maintained at about 37 ° C. by a heater.
【０００７】反応ターンテーブル８には、検体を収容す
る試験管状のセル１５が保持される複数のセルホルダ１
６が周方向に列設されている。この反応ターンテーブル
８の左側には、セルケース１７内のセル１５を前記反応
ターンテーブル８のセルホルダ１６に供給するセル供給
装置１８が設けられている。また、反応ターンテーブル
８の前方には、検体ホルダ１９に保持された検体容器２
０内の検体を反応ターンテーブル８のセルホルダ１６に
保持されたセル１５内に分注する検体分注装置２１が設
けられている。この検体分注装置２１と前記セル供給装
置１８の間には、供給されたセル１５内に磁性体からな
る図示しない撹拌用ビーズを投入するビーズ供給装置２
２が設けられている。The reaction turntable 8 has a plurality of cell holders 1 for holding test tubular cells 15 for accommodating specimens.
6 are arranged in the circumferential direction. On the left side of the reaction turntable 8, a cell supply device 18 for supplying the cells 15 in the cell case 17 to the cell holder 16 of the reaction turntable 8 is provided. Further, in front of the reaction turntable 8, the sample container 2 held in the sample holder 19 is provided.
There is provided a sample dispensing device 21 for dispensing a sample in 0 into the cell 15 held in the cell holder 16 of the reaction turntable 8. Between the sample dispensing device 21 and the cell supply device 18, a bead supply device 2 for supplying a stirring bead (not shown) made of a magnetic material into the supplied cell 15.
2 are provided.
【０００８】電磁誘導加熱装置９は、前記試薬ターンテ
ーブル７と反応ターンテーブル８の間に設けられ、その
加熱コイル内に挿入されるノズル１０を電磁誘導作用に
より発熱させるようになっている。ノズルアーム１１
は、ベース６に軸２３を中心に回動可能に設けられると
ともに、先端のノズル１０が昇降することにより、前記
試薬ターンテーブル７の試薬ボトル１２の口、インキュ
ベータ１４の挿入穴１３、反応ターンテーブル８のセル
１５及び誘導加熱装置９の加熱コイル内に抜脱して、試
薬ボトル１２内の試薬を吸引し、さらに当該試薬をセル
１５内に注入可能になっている。このノズル１０は、電
磁誘導作用による渦電流によって発熱を生じる材料から
なり、具体的には耐蝕性にも優れ、かつ、熱容量も高い
ステンレス鋼が好ましいが、他の同様な性質を有する合
金やチタン等の金属も有用である。なお、２４は血液凝
固を測定する光学測定装置である。The electromagnetic induction heating device 9 is provided between the reagent turntable 7 and the reaction turntable 8, and causes a nozzle 10 inserted in the heating coil to generate heat by electromagnetic induction. Nozzle arm 11
Is provided on the base 6 so as to be rotatable about a shaft 23, and the nozzle 10 at the tip is moved up and down, so that the mouth of the reagent bottle 12 of the reagent turntable 7, the insertion hole 13 of the incubator 14, the reaction turntable 8 is drawn into the cell 15 and the heating coil of the induction heating device 9, the reagent in the reagent bottle 12 is sucked, and the reagent can be injected into the cell 15. The nozzle 10 is made of a material that generates heat due to eddy current due to electromagnetic induction. Specifically, stainless steel having excellent corrosion resistance and high heat capacity is preferable, but other alloys and titanium having similar properties are preferable. And the like are also useful. Reference numeral 24 denotes an optical measurement device for measuring blood coagulation.
【０００９】以上の構成からなる血液凝固能自動検査装
置５は、各部分が所定の動作を行うように、マイクロコ
ンピュータにより制御される。以下、その動作を説明す
る。セル供給装置１８によりセルケース１７内の一個の
セル１５が反応ターンテーブル８のセルホルダ１６に供
給されると、反応ターンテーブル８が図中反時計回りに
所定角度回動し、ここで、検体分注装置２１により当該
セル１５内に検体が分注される。この後、反応ターンテ
ーブル８が時計周りに所定角度回動してビーズ供給装置
２２により当該セル１５内に図示しないビーズが投入さ
れると同時に、当該セル１５に隣接するセルホルダ１６
に新たなセル１５が供給される。この動作が繰り返され
ることにより、反応ターンテーブル８のセルホルダ１６
に順次セル１５が供給されて当該セル１５に検体が分注
されてゆく。The automatic blood coagulation test apparatus 5 having the above configuration is controlled by a microcomputer so that each part performs a predetermined operation. Hereinafter, the operation will be described. When one cell 15 in the cell case 17 is supplied to the cell holder 16 of the reaction turntable 8 by the cell supply device 18, the reaction turntable 8 rotates a predetermined angle counterclockwise in the figure, and the sample The sample is dispensed into the cell 15 by the injection device 21. Thereafter, the reaction turntable 8 is rotated clockwise by a predetermined angle, and beads (not shown) are inserted into the cell 15 by the bead supply device 22 and at the same time, the cell holder 16 adjacent to the cell 15 is placed.
Is supplied with a new cell 15. By repeating this operation, the cell holder 16 of the reaction turntable 8 is
Are sequentially supplied to the cell 15 and the sample is dispensed into the cell 15.
【００１０】一方、ノズルアーム１１の先端のノズル１
０は、予めインキュベータ１４の挿入穴１３に挿入され
て３７℃に加温され、ノズルアーム１１の動作により試
薬ボトル１２内の１５℃に冷蔵された試薬を所要量（１
０〜１０００μｌ）だけ吸引する。このとき、ノズル１
０は冷蔵された試薬により冷却されてαだけ温度が低下
し、試薬はノズル１０の保有熱により加熱されて（３７
−α）℃に温度上昇する。この後、ノズル１０はノズル
アーム１１の動作により、誘導加熱装置９の加熱コイル
内に所定時間挿入される。On the other hand, the nozzle 1 at the tip of the nozzle arm 11
No. 0 is inserted into the insertion hole 13 of the incubator 14 and heated to 37 ° C. in advance, and the required amount (1) of the reagent refrigerated to 15 ° C. in the reagent bottle 12 by the operation of the nozzle arm 11
(0-1000 μl). At this time, nozzle 1
0 is cooled by the chilled reagent and the temperature is lowered by α, and the reagent is heated by the heat retained in the nozzle 10 (37
-Α) Temperature rise to ° C. Thereafter, the nozzle 10 is inserted into the heating coil of the induction heating device 9 for a predetermined time by the operation of the nozzle arm 11.
【００１１】ここで、前記吸引時にα℃低下したノズル
１０の温度を回復するのに必要な熱量Ｑに相当する電力
量が加熱装置に供給される。ノズル１０は最終的に吸引
前の温度と同一になるので、前記熱量Ｑは試薬のみを当
初の冷蔵温度（Ｔ0）から所要温度（Ｔ）まで加熱する
のに要する熱量に等しく、次式で求められる。 （試薬の比熱）×（試薬の比重）×（試薬の吸引量）×
（所要温度−冷蔵温度） 例えば、１５℃の試薬（比熱；比重を１とする。）が２
００μｌ吸引された場合を考えると、必要熱量Ｑは ０．２×（３７−１５）＝４．４ｃａｌ である。従って、この熱量Ｑに相当する電力量は４．４
×４．２＝１８．５Ｗ秒となる。実際にはこれに損失を
考慮した電力量が供給される。この結果、誘導加熱作用
によりノズル１０は加熱されてα℃温度上昇し、３７℃
に回復する。これにより、ノズル１０内の試薬は所要の
３７℃に加熱される。続いて、ノズルアーム１１の動作
により、ノズル１０内の試薬が反応ターンテーブル８の
セル１５内に注入され、試薬と検体との凝固の前処理反
応が行われる。Here, an electric energy corresponding to the amount of heat Q required to recover the temperature of the nozzle 10 which has decreased by α ° C. during the suction is supplied to the heating device. Since the temperature of the nozzle 10 finally becomes the same as the temperature before suction, the heat quantity Q is equal to the heat quantity required to heat only the reagent from the initial refrigeration temperature (T 0 ) to the required temperature (T). Desired. (Specific heat of reagent) x (specific gravity of reagent) x (aspirated amount of reagent) x
(Required temperature-refrigeration temperature) For example, 2 reagents at 15 ° C (specific heat; specific gravity is 1)
Considering the case where 00 μl is sucked, the required heat quantity Q is 0.2 × (37−15) = 4.4 cal. Therefore, the electric energy corresponding to the heat quantity Q is 4.4.
× 4.2 = 18.5 Wsec. Actually, an electric power amount considering the loss is supplied thereto. As a result, the nozzle 10 is heated by the induction heating action to increase the temperature by α ° C.
To recover. Thereby, the reagent in the nozzle 10 is heated to a required 37 ° C. Subsequently, by the operation of the nozzle arm 11, the reagent in the nozzle 10 is injected into the cell 15 of the reaction turntable 8, and a pretreatment reaction of coagulation between the reagent and the sample is performed.
【００１２】次に、ノズルアーム１１の動作によりノズ
ル１０がインキュベータ１４の挿入穴１３に戻されて３
７℃に保温される。このようにして、一種類の試薬が検
体に注入されると、試薬ターンテーブル７が回動して次
の検体に必要な試薬の試薬ボトル１２がノズル１０の下
に移動し、同様の動作が繰り返される。一方、セル１５
は投入されたビーズと図示しない磁石との作用により撹
拌されながら、図示しない適宜機構により光学測定装置
２４に移動され、凝固時間が計測される。Next, the nozzle 10 is returned to the insertion hole 13 of the incubator 14 by the operation of the nozzle arm 11,
Keep at 7 ° C. In this way, when one type of reagent is injected into the sample, the reagent turntable 7 rotates and the reagent bottle 12 of the reagent required for the next sample moves below the nozzle 10, and the same operation is performed. Repeated. On the other hand, cell 15
While being stirred by the action of the charged beads and the magnet (not shown), it is moved to the optical measuring device 24 by an appropriate mechanism (not shown), and the coagulation time is measured.
【００１３】なお、前記実施例における装置５におい
て、電磁誘導加熱装置９の加熱コイル内に挿入するノズ
ル１０の昇降位置を調整することにより、試薬を部分的
に加熱することも可能である。この場合、ノズル１１の
材料としては、熱伝導率が小さく、かつ、熱容量が大き
いステンレス鋼を採用して、加熱する必要のない部分に
熱が移動しないようにするとともに、加熱部分に蓄熱さ
れた熱が逃げにくいようにする必要がある。本発明は、
前記実施例のような血液凝固能検査だけでなく、抗原−
抗体反応による免疫測定や一般の臨床検査装置にも適用
できることは言うまでもない。In the apparatus 5 in the above embodiment, the reagent can be partially heated by adjusting the elevation position of the nozzle 10 inserted into the heating coil of the electromagnetic induction heating device 9. In this case, as a material of the nozzle 11, stainless steel having a small heat conductivity and a large heat capacity is adopted so that heat does not move to a portion that does not need to be heated, and heat is stored in the heated portion. It is necessary to make it difficult for heat to escape. The present invention
In addition to the blood coagulation ability test as in the above embodiment, antigen-
It is needless to say that the present invention can be applied to an immunoassay by an antibody reaction and a general clinical test apparatus.
【００１４】[0014]
【発明の効果】以上の説明から明らかなように、本発明
によれば、試薬は吸引された所要量のみが加熱されるの
で、劣化することなく迅速に所要温度まで温度上昇し、
無駄なく使用される。また、試薬は、ノズルの保有熱に
より加熱された後、電磁誘導加熱装置により発熱したノ
ズルによって所要温度に加熱されるので、加熱が非接触
状態で行なわれ、電気接続ケーブルが不要で、ノズルの
吸引や注入動作を妨げることがない等の効果を有してい
る。As is apparent from the above description, according to the present invention, only the required amount of the sucked reagent is heated, so that the temperature quickly rises to the required temperature without deterioration.
Used without waste. In addition, the reagent is heated to the required temperature by the nozzle heated by the electromagnetic induction heating device after being heated by the retained heat of the nozzle, so that the heating is performed in a non-contact state, and the electric connection cable is unnecessary, and the nozzle is not heated. It has effects such as not hindering suction and injection operations.
【図１】 本発明に係る試薬加熱方法の説明図である。FIG. 1 is an explanatory diagram of a reagent heating method according to the present invention.
【図２】 本発明に係る試薬加熱方法を適用する血液凝
固能検査装置の平面図である。FIG. 2 is a plan view of a blood coagulation ability test apparatus to which the reagent heating method according to the present invention is applied.
１…ノズル、２…試薬、３…誘導加熱装置。 1 ... nozzle, 2 ... reagent, 3 ... induction heating device.
Claims (1)
に所要温度に加熱する試薬の加熱方法において、予めノ
ズルを所要温度に温度調節しておき、該ノズルにより所
定温度に冷蔵保存された試薬を所要量吸引した後、当該
ノズルを電磁誘導加熱装置の中に挿入して、吸引時に低
下したノズルの温度を回復するのに必要な熱量に相当す
る電力量を当該加熱装置に供給してノズル内の試薬を前
記所要温度に加熱することを特徴とする試薬の加熱方
法。In a reagent heating method for heating a reagent refrigerated and stored at a predetermined temperature to a required temperature before use, the temperature of the nozzle is previously adjusted to the required temperature, and the nozzle is refrigerated and stored at the predetermined temperature by the nozzle. After aspirating the required amount of the reagent, the nozzle is inserted into the electromagnetic induction heating device, and an amount of power corresponding to the amount of heat necessary to recover the temperature of the nozzle reduced during suction is supplied to the heating device. A method for heating a reagent, comprising heating the reagent in the nozzle to the required temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03006243A JP3110056B2 (en) | 1991-01-23 | 1991-01-23 | Reagent heating method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03006243A JP3110056B2 (en) | 1991-01-23 | 1991-01-23 | Reagent heating method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04243548A JPH04243548A (en) | 1992-08-31 |
| JP3110056B2 true JP3110056B2 (en) | 2000-11-20 |
Family
ID=11633063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP03006243A Expired - Fee Related JP3110056B2 (en) | 1991-01-23 | 1991-01-23 | Reagent heating method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3110056B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150224503A1 (en) * | 2012-08-29 | 2015-08-13 | Siemens Healthcare Diagnostics Inc. | Pipettor, reagent, and wash solution heater |
| US9126261B2 (en) | 2012-05-29 | 2015-09-08 | Flavio Mancini | Injection pump for the hot-chamber die casting of corrosive light alloys |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4009684B2 (en) | 2002-10-28 | 2007-11-21 | アークレイ株式会社 | Temperature control method for liquid component in analysis tool, and analysis tool |
| JP6758227B2 (en) * | 2017-03-06 | 2020-09-23 | テラメックス株式会社 | Temperature control system |
| CN107737617B (en) * | 2017-10-09 | 2019-10-25 | 辽宁科技大学 | A kind of high-temperature heating liquid-transfering gun and its application method |
| ES2925266T3 (en) * | 2017-10-16 | 2022-10-14 | Otsuka Pharma Co Ltd | reaction method |
| CN110849701B (en) * | 2019-11-04 | 2023-02-28 | 山东见微生物科技有限公司 | Sample processing apparatus |
| US11571677B2 (en) * | 2020-10-28 | 2023-02-07 | CSBio Instrumentation Co. | Peptide synthesis instrumentation |
-
1991
- 1991-01-23 JP JP03006243A patent/JP3110056B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9126261B2 (en) | 2012-05-29 | 2015-09-08 | Flavio Mancini | Injection pump for the hot-chamber die casting of corrosive light alloys |
| US20150224503A1 (en) * | 2012-08-29 | 2015-08-13 | Siemens Healthcare Diagnostics Inc. | Pipettor, reagent, and wash solution heater |
| EP2891381A4 (en) * | 2012-08-29 | 2016-06-01 | Siemens Healthcare Diagnostics | Pipettor, reagent, and wash solution heater |
| US9616426B2 (en) | 2012-08-29 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Pipettor, reagent, and wash solution heater |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04243548A (en) | 1992-08-31 |
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