JP3092674B2 - How to connect a medical tube - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for connecting a medical tube such as a blood collecting bag.

[0002]

BACKGROUND OF THE INVENTION When collecting blood from a donor, the cellular components of whole blood are usually separated from the plasma portion prior to storage and use. Separation is effected by sedimentation or, most often, by centrifugation, resulting in an upper plasma layer, an intermediate thin layer containing leukocytes and possibly platelets (so-called buffy coat layer), and a lower layer of red blood cells. Many different methods and devices for collecting, separating, and storing blood components are known. Currently the most commonly used is the well-known multiple blood bag consisting of a blood collection bag and at least one transition bag.

[0003] The blood collection bag is made of polyvinyl chloride containing a plasticizer. Blood bags made from this material are very useful for the storage and processing of blood and blood components, and have shown high survival rates, for example, after 21 days of storage, with low plasma hemoglobin content.

[0004] The transition bag is made of a material that exhibits good carbon dioxide transport properties. An example of this material is polyolefin.

[0005] Thus, the blood collection bag and the transfer bag are:
Each bag material is made of a plastic material consisting of a heterogeneous polymer composition such that each material exhibits a heterogeneous property specially selected to have a beneficial effect on the specific function of the migration and blood collection bag.

[0006] The blood collection bag and the transfer bag are connected by conduit means that provide sealed fluid communication therebetween. In many cases, the connection between the bag and the communication pipe is made by bringing the communication pipe into contact with a flow port provided in the bag and bringing the joining pipe into close contact with the outer periphery thereof, and an adhesive is used for the close contact.

The material of the communication tube is preferably the same as the material of the blood collection bag or the material of the transfer bag in consideration of the manufacturing process and the connection strength between the bag and the communication tube. The same case is common.

[0008]

[0003] When blood is collected from a donor in such a multi-bag and centrifuged,
A problem often occurs that blood leaks at the connection between the communication port and the communication port provided in the bag. This is because the connection part is made of a different kind of material, for example, when the blood collection bag and the communication pipe are made of polyvinyl chloride, and when the transfer bag and the flow port provided in the transfer bag are made of polyolefin, the connection part is made between the flow port and the communication pipe. Can be seen.

The present invention has been made to solve the problem of blood leakage during centrifugation of the multi-bag.

[0010]

According to the present invention, when a polyolefin tube and a polyvinyl chloride tube are joined with a curable adhesive, a plasma treatment is applied to the bonding surface of the polyolefin tube in advance, and The gist of the present invention is a method for connecting medical tubing, characterized by using non-plasticizer soft polyvinyl chloride.

In the present invention, the plasticizer-free soft polyvinyl chloride means a polyvinyl chloride which does not contain a plasticizer.

[0012]

According to the present invention, a polyolefin tube and a polyvinyl chloride tube are hardened adhesives so that a medical tube which is subjected to a severe condition such as centrifugal separation does not peel off at a connection portion. When joining with
(1) Plasma treatment is applied to the bonding surface of the polyolefin tube in advance to increase the number of functional groups at the bonding interface of the polymer. (2) Also, by using a plasticizer-free soft polyvinyl chloride for the tube involved in connection, Adhesion strength between polyvinyl chloride, especially peel strength is remarkably improved.

[0013]

The present invention will be described below in more detail with reference to examples. FIG. 1 is a plan view showing a state where a communication pipe is connected to a transition bag according to an embodiment of the present invention.

[0014] The material of the transfer bag is a flexible, transparent, sterilizable, liquid-eluting plasticizer-free plastic composition, of which polyolefins are preferred.

The bag body 1 in this embodiment is composed of 40% by weight of poly (ethylene butylene) polystyrene block copolymer (Clayton G-1650 manufactured by Ciel Chemical Co., Ltd.), 30% by weight of polypropylene (FL-6711N manufactured by Sumitomo Chemical Co., Ltd.), Ethyl acrylate copolymer (ethyl acrylate content 15 mol%, Nippon Unicar DPDJ6
182) A sheet formed by mixing 30% by weight with a mixer and melt-extruding at 200 ° C. to form a thickness of 250 μm was used.

The bag body 1 has a distribution port 4. A part of the circulation port 4 is fixed between the sheets of the bag body 1 by heat fusion. For that purpose, the material of the distribution port 4 is preferably the same as or similar to the chemical structure of the bag body 1.

In the present embodiment, the distribution port 4 contains 54% by weight of a poly (ethylene butylene) polystyrene block copolymer (Clayton G-1650 manufactured by Ciel Chemical Co., Ltd.), 23% by weight of polypropylene (FL-6711N manufactured by Sumitomo Chemical Co., Ltd.),
Ethylene ethyl acrylate copolymer (ethyl acrylate content 15 mol%, Nippon Unicar DPDJ618
2) A tube having an inner diameter of 3.6 mm, an outer diameter of 4.8 mm, and a length of 4 cm obtained by injection-molding a polymer mixed with 23% by weight was used.

Before being thermally fused to the bag body 1, the distribution port 4 uses a microwave plasma processing machine manufactured by Toshiba Corporation to set the microwave output to 1.5 kW and the gas ratio of oxygen / nitrogen to 9/9. Plasma treatment was performed under the following conditions: 1. vacuum degree: 1 Torr; treatment time: 30 seconds.

A joint pipe 2 (inner diameter 4.1 mm, outer diameter 6.1 mm, made of plasticizer-free soft polyvinyl chloride (Esmedica V manufactured by Sekisui Chemical Co., Ltd.) is inserted into a flow port 4 provided in the bag.
(Length 2 cm) was fitted using an epoxy resin as a curable adhesive .

This epoxy resin is manufactured by Sekisui Chemical Co., Ltd. and uses Esdine 3120A as a main agent and Esdine 3120B as a hardener, and has a hardening time of 8 hours for bonding a fitting portion.
The temperature was set to 0 ° C. for 30 minutes. Further, the joint pipe 2 and the communication pipe 3 were bonded with cyclohexanone.

In order to test liquid leakage due to the centrifugal separation operation, 50 transfer bags prepared as described above were prepared. Each sample was filled with 560 cc of water, the communication tube was sealed with heat, and housed in a polyethylene bag.
A centrifugation operation was performed for 7 minutes. The liquid leakage was determined with the naked eye, and the joining force between the distribution port 4 and the joining tube 2 was measured with an autograph manufactured by Shimadzu Corporation. No liquid leakage was observed, and the bonding strength was 11.5 kg on average.

As Comparative Example 1, the same process as in the example was carried out except that the distribution port 4 was not subjected to the plasma treatment and polyvinyl chloride containing a plasticizer was used for the joining pipe 2, and the same evaluation as the example was performed. 38 out of 50 liquid leaks were found, and the bonding strength was 7.1 kg on average. As Comparative Example 2, the same process as in the example was performed except that the distribution port 4 was not subjected to the plasma treatment and the non-plasticizer soft polyvinyl chloride was used for the joining tube 2, and the same evaluation as the example was performed. 1 out of 50 leaks
0 were found, and the bonding strength was 8.9 kg on average. As Comparative Example 3, the same plasma treatment as in the example was applied to the flow opening 4 and the same pipe as that of the example was used except that the joining pipe 2 was made of polyvinyl chloride containing a plasticizer, and the same evaluation was performed as in the example.
Two out of 50 liquid leaks were observed, and the bonding strength was 1 on average.
It was 0.2 kg.

[0023]

According to the present invention, when joining a polyolefin tube and a polyvinyl chloride tube with a hardening type adhesive, a plasma treatment is performed in advance on a bonding surface of the polyolefin tube to connect the polyolefin tube and the polyvinyl chloride tube. The non-plasticizer soft polyvinyl chloride is used only for the tube concerned. Therefore, according to the present invention, the joining force between the polyolefin tube and the polyvinyl chloride tube is increased. For example, when used for a medical tube such as a multi-bag, the effects of the present invention are exhibited.

[Brief description of the drawings]

FIG. 1 is a plan view showing a state in which a communication pipe is connected to a transition bag according to an embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Bag main body 2 Joining pipe 3 Communication pipe 4 Distribution port

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-2-123140 (JP, A) JP-A-50-73976 (JP, A) JP-A-1-255789 (JP, A) 192739 (JP, U) Japanese Patent Publication No. 1-36385 (JP, B2) Japanese Utility Model Publication No. 4-16673 (JP, Y2) (58) Field surveyed (Int. Cl. ⁷ , DB name) A61M 1/02 A61J 1 / 10 A61M 39/02

Claims (1)

(57) [Claims] When joining a polyolefin tube and a polyvinyl chloride tube with a hardening adhesive, a plasma treatment is applied to the bonding surface of the polyolefin tube in advance, and a plasticizer-free soft polyvinyl chloride is applied to the polyvinyl chloride tube. A method for connecting medical tubing, which is used.