JP2951640B1 - Skin lotion derived from milk and method for producing the same - Google Patents

Abstract

The present invention relates to a skin lotion, which is composed of a composition obtained by removing a high molecular weight component having a molecular weight of 10,000 or more from milk and has almost no odor, and a method for producing the same. [Effect] It is possible to provide a colorless and transparent water-type skin lotion containing a moisturizing component derived from milk by removing a polymer component which is an allergenic substance from milk.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to the production of skin lotion, and more particularly to a composition containing a high-molecular substance having a molecular weight of 10,000 or more removed from raw milk or casein whey. Decolorize it to make it colorless and transparent,
It relates to the production of a water-type skin lotion that is almost odorless. The low-molecular fraction obtained by removing high-molecular substances from raw milk etc. contains minerals similar to natural moisturizing factors present in the skin of healthy subjects, humectants such as urea and organic acids,
It is very valuable as a cosmetic material. Further, according to the present invention, a lotion free from the risk of developing skin allergies is provided by removing a polymer substance.

[0002]

2. Description of the Related Art It has been known for a long time that milk has not only nutrition as a food, but also has cosmetic effects such as prevention of rough skin, fine lines and spots, and smoothing of the skin. In ancient times, in Europe, milk baths were known for their ability to restore function after illness and keep their skin young, and have been used for treatment in clinics and bathing upstream women. On the other hand, dermatologically, it is important to maintain a proper amount of water in the skin in order to maintain healthy skin, and it is known that natural moisturizing factors present in the skin play a role. I have. Further, various humectants have been developed for the purpose of preventing skin from drying out.

[0003] We have already found that low-molecular components present in milk are very similar to the contents of natural moisturizing components present in the skin, and based on this finding, whey minerals Succeeded in creating skin cosmetics containing
Patent application completed (JP-A-6-48932).

[0004] The invention according to the prior application is not necessarily intended to use the obtained substance as it is as a cosmetic, but is made mainly on the assumption that a small amount is added to an existing lotion or the like. On the contrary,
The present invention aims to provide a processed product derived from milk as it is as a cosmetic, and to achieve this purpose,
This is not possible with the treatment method described in the invention of the prior application, and the desired milk-derived transparent skin cosmetic cannot be obtained.

[0005] Further, there is disclosed a technique relating to cosmetics, which comprises blending a composition obtained by removing a high molecular substance having a molecular weight of 13,000 or more from milk (Japanese Patent Laid-Open No. 1-2).
54610). The present invention is to provide a cosmetic and a method for producing the same that do not cause skin allergy by removing a polymer component, and completely disclose the point of providing a transparent cosmetic according to the present invention. Not.
Therefore, the content of the invention according to the earlier application is completely different from the object of the present invention.

[0006] Also, milk has a unique odor, which can be divided into good and bad odors. In spite of the fact that aroma is one of the important factors in the technical field of cosmetics, At present, no consideration is given to this odor in the inventions described above.

[0007] On the other hand, various types of clear skin water have been put on the market from the lotion boom using natural water. If these water-type lotions are described for each raw material used,
Classified as a mixture of natural water, vinegar, Junmaishu, rice bran extract, seaweed extract, etc. Since no product using milk raw materials was found in these existing products, the cosmetic according to the present invention is very novel in terms of product characteristics.

[0008] The cosmetics of the present invention not only have an excellent characteristic of being derived from milk, but also have a characteristic that the high molecular component is removed and the solid content is 2.0%.
Less than the following. In terms of content, it is a mineral that has a high moisturizing effect as a main component, and because it contains trace amounts of lactose and nitrogen-containing low molecular weight substances, there is no danger of skin allergy and it can be used with confidence. Such excellent skin lotion is not known so far and is novel.

[0009]

SUMMARY OF THE INVENTION The present invention has been made in view of the state of the art, and has an excellent moisturizing effect, excellent skin lotion, and safety without skin allergy. It was made for the purpose of newly producing high skin lotion.

[0010]

Means for Solving the Problems The present invention has been made to achieve the above-mentioned object, and it has been determined that it is derived from natural products from the viewpoint of safety, and has focused on milk. As a result of examinations from various directions, it was found that whey protein isolate (WPI), whey protein concentrate (WPC), milk protein concentrate (TMP, MPC), etc. were produced from raw milk, cheese whey, casein whey, etc. I paid attention again to the low-molecular-weight fraction discharged in large quantities as a by-product. As a result of intensive studies, they have found that this low-molecular fraction has a moisturizing effect, and based on this useful new finding, have completed the present invention relating to skin lotion. Hereinafter, the present invention will be described in detail.

In practicing the present invention, at least one of raw milk, skim milk, casein whey and cheese whey is used.
Removing the material on a molecular weight of 10,000 or more, clarifying the resulting composition. The removal of the polymer substance is appropriately performed by ultrafiltration, microfiltration, or other known polymer substance removal treatment methods. The clarification treatment is appropriately performed by a known clarification treatment method such as centrifugation or filtration, in addition to activated carbon treatment and diatomaceous earth treatment.

The skin lotion according to the present invention is based on the transparent liquid obtained after the decolorization and deodorization treatment thus obtained, and is a mineral similar to a natural moisturizing factor present in healthy adults. It contains moisturizing components such as urea and organic acids, and is characterized by being decolorized, deodorized and transparent. In addition, according to the present invention, through the ultrafiltration step, the sterilized low molecular permeate fraction, heat sterilization is not required after activated carbon treatment,
Usually, by adding a preservative such as phenonip used in cosmetics, it is characterized in that it can be stored at room temperature for one year or more.

[0013] Calcium phosphate, which may precipitate, cannot be removed only by removing the high molecular component from raw milk or the like. Therefore, in the present invention, a chelating agent and / or a pH adjuster is added to the obtained low-molecular-weight fraction to stabilize this substance and to produce a transparent cosmetic for the first time despite using milk as a raw material. Obtainable.
Furthermore, in the present invention, since milk has a unique odor, it can be decolorized and deodorized by treating the composition derived from raw milk from which the high molecular component has been removed with activated carbon.

As described above, the low molecular permeate fraction obtained according to the present invention contains calcium phosphate and may become cloudy or precipitate during storage, which is not preferable in quality. This was thought to be due to the fact that calcium in the whey that had been protected and stabilized by the protein was destabilized by the removal of the protein and the accompanying increase in pH, resulting in cloudiness. It is believed that the cloudy substance is due to complex formation between calcium and phosphoric acid. In the present invention, a chelating agent is added to prevent the formation of a complex with phosphoric acid by sequestering calcium, to prevent cloudy precipitation, or by adding a pH adjuster to suppress the fluctuation of pH. , Preventing the formation of a complex of calcium phosphate and preventing cloudy precipitation.

Examples of the chelating agent include 1-hydroxyethane-1,1-diphosphonic acid (salt), ethylenediaminetetraacetic acid derivative (EDTA), tripolyphosphate, hexametaphosphate, dihydroxyethylglycine, citric acid,
Tartaric acid, gluconic acid, and other chelating agents commonly used in cosmetics are appropriately used. As the pH adjuster, lactic acid (calcium salt, sodium salt), citric acid (sodium salt, potassium salt), other organic acids (salts), and a pH adjuster commonly used in cosmetics are appropriately used.

In the present invention, if necessary, a preservative may be added. Preservatives include paraoxybenzoic acid esters (parabens: methylparaben, ethylparaben, propylparaben, butylparaben, etc.), phenonip (paraben solution in phenoxyethanol), phenoxyethanol, phenol, resorcinol, hinokitiol, benzoic acid (salt), salicylic acid (salt) ), Sorbic acid (salt), hexachlorophene, benzalkonium chloride, phenols, acids, halogenated bisphenols, amides, quaternary ammonium compounds, surfactants, etc. Various sterilizing and preservatives commonly used in the cosmetics industry. Can be used as appropriate.

Further, in the present invention, if desired, the lotion obtained as described above may be used as it is, and the treated product may be added to various cosmetics as it is or as a raw material component of the cosmetic. You can also. Examples of the processed product include a concentrate (reduced pressure), a pasted product, a dried product (eg, spray-dried, freeze-dried), and a diluted product.

Hereinafter, the present invention will be described more specifically with reference to examples. Note that the present invention is not limited to this. Note that the lotion of the present invention is characterized by being uncolored and unscented, but it is possible to add a scent, an ultraviolet absorber, a dye, and the like as necessary, as described above.

For example, humectants such as glycerin, propylene glycol, and citric acid, pH adjusters, and the like are dissolved in purified water, surfactants, preservatives, and fragrances are dissolved in alcohol, and the two are mixed and solubilized. In the production of a general lotion, the active ingredient of the present invention is added to the water-soluble part in an amount of 0.01 to 10
% Lotion.

[0020]

Example 1 1 L of whey liquid derived from Gouda cheese was filtered through an ultrafiltration (UF) membrane having a molecular weight cut-off of 10,000, and the permeated liquid was passed through an activated carbon column (5.5 cm in inner diameter × 27 cm in length). Through both steps, 2 L of purified water was added to prepare about 3 L of decolorized and deodorized transparent diluted whey solution.

As a preservative, fenonip (paraben dissolved in phenoxyethanol), which is widely used in the cosmetics industry, was examined in the range of 0.25 to 1.0% (upper limit of specification). As a result of a 3-month accelerated test (RH 75%, 40 ° C .; equivalent to one year at room temperature), no bacterial growth was observed at any phenonip concentration, so the minimum amount was 0.25%. However, white turbidity and white precipitation were observed during storage.

[0022]

Example 2 The content of the precipitate generated in Example 1 was analyzed. That is, the cloudy precipitated sample was collected at 12,600 rpm.
m, 10 minutes of centrifugation, and the contents of protein, ash, calcium, and phosphorus before and after centrifugation were measured. As a result, a decrease in ash, calcium and phosphorus was observed in the supernatant liquid after centrifugation, so that the precipitate was considered to be a compound mainly composed of calcium and phosphorus. Further, in the sample in which the cloudy precipitation occurred, the pH slightly increased. Therefore, it was determined that the cloudy substance was calcium phosphate mainly composed of calcium and phosphorus generated by the slight increase in pH due to the UF treatment.

[0023]

Example 3 In order to prevent the formation of a cloudy precipitate generated in Example 1, a chelating agent and a pH approved for cosmetics were used.
Modifiers were considered. 5mM, 10m as chelating agent
M, 100 mM EDTA, 0.5%, 50% “Ter
pinal SL "(Henkel Japan K.K.), pH
0.5%, 5.0% sodium lactate, 5m as modifier
M, 10 mM, 100 mM citric acid, 0.5%, 5.0
% “Clewat-T” (Teikoku Chemical Industry Co., Ltd.).

The above chelating agent and pH adjuster were added to the transparent whey solution prepared in the same manner as in Example 1 to adjust the pH of the whey solution to 6.3 (pH before adjustment: 6.1). 3
As a result of a monthly accelerated test (RH 75%, 40 ° C .; equivalent to one year at room temperature), a cloudy precipitate was generated in the control, whereas the precipitate was added to all products to which a chelating agent or a pH adjusting agent was added. It was good without being seen.

[0025]

Example 4 A transparent whey solution was prepared in the same manner as in Example 1. 0.25% of "Fenonip" as a preservative and "Clew" as a pH adjuster were added to this whey solution.
at-T "(Teikoku Chemical Industry Co., Ltd.) was added at 0.5%. This product is a three-month accelerated test (RH 75%, 40 ° C;
Room temperature 1 year) and room temperature 1 year storage test results,
No cloudy precipitation or bacterial growth was observed, and the state of a good transparent liquid was maintained. In addition, no off-flavor was generated, which was favorable.

The composition of this product is 1.8% solids (0.1% ash).
5%, lactose 1.0%, and others 0.3%). The composition of the prototype is shown in Table 1 in comparison with the composition of the existing lotion. Ready-made water type lotion is compositionally,
Those with a solid content of around 0.1%, around 1.0%,
And about 3.0%, which were high, and could be classified into three types.
The prototype obtained by the present invention had a solid content of about 2.0%, and was located between these, and was characterized by a high content of minerals as moisturizing components. This product was odorless, light and fresh on the skin, and had a good use feeling.

[0027]

Example 6 A whey solution was produced as a trial in the same manner as in Example 4, and a transparent whey solution was further produced by diluting it twice with purified water. To this whey solution, 0.25% of "Fenonip" as a preservative and "Turpi" as a chelating agent
nal "was added at 0.5%. As a result of a 3-month accelerated test (RH 75%, 40 ° C .; equivalent to 1 year at room temperature) and a storage test at room temperature for 1 year, no cloudy sedimentation or bacterial growth was observed. The state was maintained. In addition, no off-flavor was generated, which was favorable.

The composition of this product is as follows: a solid content of 1.2% (ash content of 0.1%).
5%, lactose 0.6%, and other 0.1%). The composition of the prototype is shown in Table 1 in comparison with the composition of the existing lotion. It has a solid content of 1.0% among commercially available products (Table 1).
% Corresponding to a slightly lower type. This product was odorless, light and fresh on the skin, and had a good use feeling.

[0029]

[Table 1]

[0030]

According to the present invention, it is possible to provide a colorless and transparent water-type skin lotion containing a moisturizing component derived from milk by removing the polymer component which is an allergenic substance from milk.

Another feature of the present invention is to provide an effective method of utilizing low molecular components passing through an ultrafiltration membrane generated during the production of various milk protein concentrates. Conventionally, these low molecular components discharged from raw milk or whey processing plants,
Except for limited use as feed, most of them are discarded in large quantities and cause environmental pollution. Therefore, the effects of the present invention are significant from the viewpoint of resource utilization and environmental protection.

Continuation of front page (56) References JP-A-1-254610 (JP, A) JP-A-6-48932 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 7 / 00-7/50

Claims (5)

(57) [Claims] 1. A skin lotion comprising a composition obtained by removing substances having a molecular weight of 10,000 or more from raw milk, a chelating agent and a pH adjuster, and being transparent for a long period of time. 2. A composition comprising a composition obtained by removing a substance having a molecular weight of 10,000 or more from at least one of skim milk produced from raw milk, casein whey obtained from skim milk, and cheese whey, a chelating agent and a pH adjuster. Skin lotion characterized by being transparent for a period. 3. The skin lotion according to claim 1, which has a moisturizing effect. 4. The method for producing skin lotion according to claim 1, wherein a substance having a molecular weight of 10,000 or more is removed by an ultrafiltration method. 5. The skin according to claim 1, wherein the composition from which the substance having a molecular weight of 10,000 or more has been removed is treated with activated carbon to decolorize, deodorize, or clarify. Production method of lotion.