JP2941160B2 - Relief agent for shingles pain - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agent for alleviating pain caused by herpes zoster, comprising a plant of black crab sprouts or an extract thereof.

[0002]

BACKGROUND OF THE INVENTION Shingles, also known as herpes zoster or simply herpes, is a varicella-zoster virus infection, characterized by a combination of rash arranged in a band and peripheral nerve symptoms. May be seen, but rather frequently in the elderly. It often occurs suddenly without triggers or prodromes. It may have a bleeding or necrotic course and is a disease that is most likely to be watched for.

[0003] The pain associated with shingles is said to be mild in the young, but tends to be severe in the elderly. In addition, the pain does not decrease as a sequela even after healing of the eruption, and many cases persist for several years. This is said to be postherpetic neuralgia, and although there is a slight difference in the theory on average among all patients, it is around 10%, but it is cautioned that it will occur in all cases over the age of 60. The mechanism is unknown, and no preventive or therapeutic methods have been established.

As antiviral agents for herpes virus infections, acyclovir, vidarabine and the like have recently been developed and have greatly contributed to treatment. However, as unsolved problems, neuralgia associated with shingles or postherpetic neuralgia has been solved. What remains of treatment is the current state of medical practice.

[0005] with respect to pain associated with herpes zoster, oral and anti-inflammatory agent and vitamin B _12, the dosage of lidocaine local anesthetic agents, although such oral neurotropins is being performed, attempts various analgesics Nevertheless, no analgesic has been found to be effective at least in the majority of patients.

For example, narcotics, which are analgesics used for terminal cancer patients, are useful, but it is extremely difficult to find an appropriate amount for each individual patient. Because it is inevitable, unlike in terminal cancer patients, narcotics cannot be heavily used in shingles patients who have an overwhelming possibility of cure.

[0007] Moreover, morphine, which is said to have an excellent analgesic effect, is not a panacea, and is not effective against post-herpetic neuralgia along with muscle spasm and gastric bloating. Under these conditions, there is no other way but to endure the shingles pain of patients with herpes zoster, with little hope that it will be slightly alleviated by usual painkillers and tranquilizers. At present, there is no therapy for preventing neuralgia as a sequela of herpes zoster.

[0008]

DISCLOSURE OF THE INVENTION The present invention relates to a medicament for effectively relieving or eliminating pain and suffering caused by herpes zoster and having no side effects, and a medicament which does not cause herpes zoster to have neuralgia of sequelae. , In view of the current strong demands,
It is intended to provide a medicine which solves these problems.

[0009]

Means for Solving the Problems In the course of examining the medicinal properties of a black clover plant from various aspects, the present inventor found that a plant or an extract thereof suffered from pain or suffering due to herpes zoster, It is extremely effective in relieving severe pain that cannot be tolerated, has no side effects, and in patients who have taken the plant or its extract and escaped the pain caused by herpes zoster, neuralgia of herpes zoster sequelae. The present inventors have found the surprising fact that they cannot be seen at all, and completed the present invention.

[0010] Accordingly, the present invention provides a medicament comprising a plant of Chlamydomonas reinhardtii or an extract thereof, for alleviating or eliminating the symptoms of pain and / or suffering due to and subsequent to shingles. Is what you do.

[0011]

[Detailed description] The Kurobana chickpea plant is Rabdosia trichocarba.
rpa) and has the scientific name of Isodon japonics Kara.
a), Plectranthus Japonics Koitsu (Pl
Ectranthus japonicus Koid
z), Amesis Sansas Japonica (Amethys)
anthanus japonica, Isodon trichocarpu
s) and the like.

[0012] Kurobana Hikiokoshi is a perennial perennial plant that grows naturally in the ancient mountains and is sometimes referred to as prolonged life grass, and is used as a private stomachic. In the present invention, it is possible to use a plant of Kurobana chickpea or an extract thereof, from the viewpoint of the intended medicinal effect and the like,
It is particularly preferred to use plants. The plant part to be used is not particularly limited, and any of roots, leaves, stems and the like may be used.

[0013] However, Kurobana Hikiokoshi is a perennial plant of the root, and can of course be propagated by seeds. However, after cutting the aerial part, a sprout is formed from the remaining roots in the next year and the plant body is formed again. It is preferable from the practical point of view that the plant body is stably collected every year using the above-ground part while leaving. In the production of the medicament of the present invention, for example, dirt and foreign matters are removed from the mown plants, preferably dried, and then subjected to treatment such as cutting, crushing, and crushing.

[0014] It can be used as a powder, or it can be filled in a capsule and provided as a capsule. Further, the pulverized product may be tabletted as it is or with a binder commonly used in the production of pharmaceuticals, for example, starch, etc., and the tablet may be coated with a sugar-coated tablet or the like. In formulating these preparations, it is possible to use only a plant of black crab sprouts as a medicinal ingredient or to use a combination of other appropriate medicinal ingredients.

[0015] To obtain an extract of Kurobana cypress, the plant is dried, preferably cut or broken into small pieces, and then extracted with hot water, for example, boiling water. What is called a decoction may be used. If desired, the extract thus prepared can be concentrated by a conventional method, for example, concentration under reduced pressure to obtain a concentrated solution or a concentrate, and further, can be made into a dry extract by freeze-drying, spray-drying or the like.

When it is intended to relieve or eliminate the pain and / or suffering caused by herpes zoster and the neuralgia after herpes zoster, which is a sequela thereof, with the medicament of the present invention, one adult person
1 per day in terms of dried black clover plant
Orally, 10 to 10 g, usually 2 to 5 g. It is preferable to administer this amount in two or three times a day, but it may be administered once or in a number of times.

The black clover which is used in the present invention is
Clearly, it has very low toxicity since it has been used as a stomachic in folk medicine since ancient times.

[0018]

EFFECT OF THE INVENTION When the medicament of the present invention is administered to a patient with shingles concurrently with an antiviral drug treatment currently being carried out, if the effect is early, it is not immediately after the start of administration, and the effect is late. However, from about the second week, the pain caused by shingles is remarkably reduced and eliminated. There are no side effects. Patients who have escaped the shingles pain by administration of the medicament of the present invention do not experience any neuralgia as a sequela of shingles after the rash has been cured by treatment with an antiviral agent or the like.

[0019]

Next, the present invention will be described more specifically with reference to examples. In clinical cases, more than 30 successful cases have already been obtained without exception, and representative examples are described below.

Embodiment 1 About 10 kg of above-ground plants of Kurobana HIOKIKO of the production example of this agent were collected,
Foreign matter was removed, then washed with water, drained, and then sufficiently dried with a hot air drier. At this time, to speed up drying,
Plants were shredded during drying. After the drying was completed, the shredded plants were pulverized to obtain a dry powder (about 3 kg).

This powder can be used as a powder. On the other hand, 0.25 to 0.5 g of this powder is preferably used.
By filling the capsules one by one, a capsule can be produced. The powder was mixed with an appropriate amount of water, kneaded, granulated, dried and tableted with a tableting machine to produce a tablet containing 0.25 g of a dry plant powder.

Embodiment 2 FIG. Clinical case of this drug (1) A 75-year-old boy Two years ago, he felt some inconvenience in his daily life due to cerebral infarction. Herpes was diagnosed. Antivirals (Asik
Robil (800 mg each, three times a day after each meal) continued to be severely painful during treatment, but the administered analgesic (Tiaprof
(200 mg each, three times a day after each meal) had no effect. On day 10 after the diagnosis, the administration of the analgesics was stopped, and 0.25 g of the Kurobana sprouts plant of the present invention was added to 1
This tablet was taken orally three times a day for 4 tablets each.
From the day, I did not notice any pain.

After taking this drug for an additional week, she stopped taking it when healing of the eruption began, but she did not see any recurrence of the pain. She was concerned about postherpetic neuralgia. There was no.

(2) 63-year-old woman Pain was felt in the chest, and after 2-3 days, a rice-grain-sized blister occurred, and she was diagnosed with shingles. Treatment (800mg each of acyclovir
And after each meal, by 3:00 pm, and before going to bed one day a total of five times), rash began to heal after two weeks, since the rash Pang then also persisted, diagnosed with post-herpetic neuralgia Was.
Painkiller (50 mg of diclofen sodium, 1 after each meal)
(Three times a day) was attempted, but there was no apparent relief.

After the second half of the healing of the eruption, the tablet of the present invention, 0.25 g, was orally taken three times a day, 5 tablets each, and the pain was rapidly reduced from the third day and disappeared soon.
After taking this drug for about one month and taking the drug off, there was no recurrence of pain.

(3) A 67-year-old girl had undergone surgery for gastric cancer three years ago and was completely cured because of her early cancer. However, her symptoms of stomatitis were intermittent, and her abdomen became painful. She developed blisters and was diagnosed with shingles. Was done. Antiviral agent
Treatment with acyclovir (800 mg, three times a day after each meal) and an analgesic (thiaprofen 200 mg, three times a day after each meal) lasted one month, but the pain was particularly severe and persistent. .

Administration of the drug was started by taking 0.25 g tablets three times a day four times each. After 10 days, the pain was significantly reduced and disappeared. I took it for one month, during which time the rash healed. There was no recurrence of pain and no signs of postherpetic neuralgia.

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. ⁶ , DB name) A61K 35/78 CA (STN) CAOLD (STN) MEDLINE (STN)

Claims (2)

(57) [Claims] 1. A medicament for alleviating or eliminating the symptoms of pain and / or suffering caused by shingles, comprising a plant of black crab sprouts or an extract thereof. 2. The medicament according to claim 1, which is a dry powder or granules of the plant according to claim 1, or a tablet or capsule containing them.